new therapeutic approaches aimed at eliminating persistent hiv reservoirs in infected
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New Therapeutic Approaches Aimed at Eliminating Persistent HIV Reservoirs in Infected Individuals Receiving Antiretroviral Therapy. Tae-Wook Chun, Ph.D. Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases National Institutes of Health - PowerPoint PPT PresentationTRANSCRIPT
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New Therapeutic Approaches Aimed at Eliminating Persistent
HIV Reservoirs in InfectedIndividuals ReceivingAntiretroviral Therapy
Tae-Wook Chun, Ph.D.Laboratory of Immunoregulation
National Institute of Allergy and Infectious DiseasesNational Institutes of Health
Department of Health and Human Services
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Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
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Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
![Page 7: New Therapeutic Approaches Aimed at Eliminating Persistent HIV Reservoirs in Infected](https://reader035.vdocuments.net/reader035/viewer/2022062410/568161b7550346895dd17feb/html5/thumbnails/7.jpg)
Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
![Page 8: New Therapeutic Approaches Aimed at Eliminating Persistent HIV Reservoirs in Infected](https://reader035.vdocuments.net/reader035/viewer/2022062410/568161b7550346895dd17feb/html5/thumbnails/8.jpg)
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Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
![Page 13: New Therapeutic Approaches Aimed at Eliminating Persistent HIV Reservoirs in Infected](https://reader035.vdocuments.net/reader035/viewer/2022062410/568161b7550346895dd17feb/html5/thumbnails/13.jpg)
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Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
![Page 20: New Therapeutic Approaches Aimed at Eliminating Persistent HIV Reservoirs in Infected](https://reader035.vdocuments.net/reader035/viewer/2022062410/568161b7550346895dd17feb/html5/thumbnails/20.jpg)
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Persistence of HIV in Gut-Associated LymphoidTissue despite Long-Term Antiretroviral TherapyTae
Persistence of HIV in Gut-Associated Lymphoid
Tissue despite Long-Term Antiretroviral Therapy
Chun et al.
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Effect of Raltegravir Intensification on Immunologic and Virologic Parameters of HIV-Infected, Aviremic Individuals
Buzon et al., Nature Medicine, 16 (4): 460-5, 2010
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Changes in Levels of Cell-Associated Unspliced HIV RNA in Infected Individuals who Underwent Intensification of ART
Yukl et al., personal communication
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