newsletter department of biochemistry and …...newsletter: july 2012, issue 25 department of...

Newsletter Department of Biochemistry and Molecular Biology

www.med.monash.edu.au/biochem

NEWS AND EVENTS

Xiaoyu Hu Memorial Award

Issue 25: July 2012

Professor Ed Nice was recently awarded the 2012 Xiaoyu Hu Memorial Award from the Chinese Peptide Society in recognition of his significant achievements in Peptide Science. This award was presented at the recent 12th Chinese Peptide Symposium in Shenyang, China. It is awarded biennially to one International and one Chinese scientist eminent in the Peptide Science field.

Monash “Team TAM”, consisting of Professor Trevor Lithgow, Joel Selkrig, Dr Matthew Belousoff, Dr Chaille Webb, Dr Andrew Perry and Dr Hsin-Hui Shen, has been selected as a finalist for the 2012 Australian Museum Eureka Prize for Infectious Diseases Research. This prize is awarded to an individual, group or team for an outstanding recent contribution to infectious diseases research.

Team TAM has discovered a machine of molecular scale in bacteria, the Translocation and Assembly Module (TAM), which enables bacteria to cause disease. The discovery of TAM will allow new strategies to be developed for preventing a range of bacterial infections and the emergence of antibiotic resistance.

Winners of the Australian Museum Eureka Prizes will be announced at an Award Dinner in Sydney on Tuesday 28 August at the Royal Hall of Industries.

Team TAM: 2012 Australian Museum Eureka Prize Finalist

Trevor Lithgow Chaille WebbAndrew PerryHsin-Hui ShenMatt BelousoffJoel Selkrig

Seminars in AugustFood and drink will follow the seminar in the foyer of building 76/77

August 22nd, 4pm Building 11, H1

Lee Wong (Monash Uni) Telomere Epigenetics in stem cells and cancers

August 29th, 4pm Building 13A, M3

Paul Gleeson (Melb Uni) Intracellular transport of membrane receptors and enzymes: relevance to

development and disease

Department of Biochemistry and Molecular BiologyNewsletter: July 2012, Issue 25

LAB HEAD: Professor David Jans

David is originally from Melbourne. After graduating (BSc. Hons) from the University of Melbourne Microbiology Dept. in 1980, he joined the Dept. of Biochemistry at the John Curtin School of Medical Research (JCSMR) to carry out his Ph.D. studies with Graeme Cox and Frank Gibson on bacterial ATPase (completed 1984). He then took up a research scientist position at the Friedrich Miescher Institut in Basel (Switzerland), followed by a visiting fellowship at the Max Planck Institut für Biophysik in Frankfurt am Main (Germany), working in the area of phosphorylation and signal transduction in mammalian cells. In 1990, he became a Senior Scientist at the Institut für Medizinische Physik und Biophysik, Westfälische Wilhelms-Universität in Münster (Germany), turning his focus to the use of quantitative fluorescent microscopic techniques, including the fluorescence recovery after photobleaching technique, to investigate transport processes. He returned in 1993 to the JCSMR (Division of Biochem. & Mol. Biol.), initially as a Fellow, to establish the Nuclear Signalling Laboratory, with a strong focus on the processes of protein transport into the nucleus. He rose to Senior Fellow in 1998, Full Professor in 2000, and has held a conjoint Professorial appointment at the James Cook University of North Queensland (Townsville, Australia) since 1998. He has been at Monash since 2002, as an NHMRC Senior Principal Research Fellow (SPRF), with a personal chair.

David’s research endeavour encompasses analysis of (a) mammalian signal transduction from membrane to nucleus, (b) signalling at the cell membrane using biophysical imaging techniques, (c) the regulation by phosphorylation of transport into and out of the nucleus, using quantitative microscopic analysis, (d) nucleocytoplasmic transport kinetics in dynamic living cell systems using single cell confocal microscopic measurements, and the importance thereof in the function of proteins regulating cancer and development (d) the molecular basis of sex determination through impaired nuclear import, (e) microtubule-dependent “fast track” nuclear transport of cancer regulatory and viral proteins, and (f) nuclear import of specific viral proteins and its critical importance to infection by the lethal human viral pathogens Dengue, HIV, Rabies, and Respiratory Syncytial Virus.

David’s work has led to a number of important paradigm shifts in signal transduction theory, including the “Mobile Receptor Hypothesis”, the concept of prNLSs (phosphorylation regulated nuclear localisation signals, including “the CcN motif”) that confer regulated signal dependent nuclear transport, and the idea that polypeptide ligands and their membrane receptors can traffic to the nucleus and modulate transcription directly. He has shown that the efficiency of nuclear transport is critical to development in flies and humans (sex determination/testis differentiation), cancer, and viral disease. Significantly, his recent work examining the transport of viral proteins into and out of the nucleus and regulation thereof by phosphorylation has led to novel approaches to identify specific inhibitors of viral protein nuclear transport. Excitingly, these inhibitors are able to block infection by HIV and Dengue, indicating that the development in the future of nuclear transport inhibitors as anti-viral agents is a viable and interesting proposition.

Prof Jans’ Laboratory: http://www.med.monash.edu.au/biochem/nuclear-signalling-page-jans.html

Professor David Andrew Jans is a leading cell biologist who is widely recognised internationally for his seminal accomplishment in elucidating the process of nucleocytoplasmic transport and signal transduction in health and disease. His research career includes the publication of more than 250 refereed scientific papers (16 with over 100 citations, and 3 with over 300; over 9000 citations in all), multiple invitations to present at international conferences (7 plenaries, 2 keynote addresses, and 2 closing remarks speeches in the last 12 years), editorial board memberships of several eminent journals, and a H-index of 54. His meritorious awards include: IRPC (International Research Progress Council) Eminent Scientist of the Year (1999), the Danny Thomas Lecture Series Visiting Professor (St. Jude Children’s Research Hospital, Memphis, 2005), Japan Society for the Promotion of Science Senior Short-term Fellowship (2008), the GE Healthcare Bio-Sciences Award for Innovation in Research, 2005, and Dean’s Award for Excellence in Research: Distinguished Research Career Award, Monash Uni. (2011). The most important motivation for his work is to try and “make a difference” to human health, by translating research contributions into tangible medical outcomes.

RSV budding out of an infected cell.

Vero cells were infected with RSV, fixed 24h later, probed for RSV proteins by immunofluorescence followed by confocal microscopy.

Image: Dr Leon Caly

RV replication complexes in an infected primary lung cell.

Primary cells were infected with RV, fixed 6h later, probed for dsRNA by immunofluorescence and confocal microscopy.

Image: Dr Leon Caly

Newsletter: July 2012, Issue 25 Department of Biochemistry and Molecular Biology

Environmental Sustainability At MonashAnyone concerned with any environmental issues should either contact Leigh Yang ([email protected]) or visit The Office of Environmental Sustainability (TOES) http://www.fsd.monash.edu.au/environmental-sustainability.

OHS MATTERSThere will be Lab Safety and Chemical Inspections carried out by the Biochem Safety Officer, Deputy Safety Officer Gavin Higgins and part-supervised by HoD Rod Devenish, BioSafety Officers Mark Prescott/Martin Stone and Staff Rep Alex Theodossis. We will be starting on Monday the 30th July and going through all the labs every day of next week from 9am - 12:30pm til we finish. As a department, we should be carrying out two of these a year, so this would be our first one for 2012.

This inspection is in preparation for the looming Monash OHS Chemical Segregation Inspection, scheduled for sometime in September/October 2012. The results of the inspection will indicate where we are all at with respect to overall safety in the labs, and especially the state of chemical segregation in the labs.

If anyone has sent me any chemical lists that I haven’t segregated for you yet, do not worry as I will attend to your specific lab needs after the inspection is completed.

Please note the inspection will cover all lab areas including cool-rooms, equipment rooms, fridges and freezers etc. Although not all fridges and freezers will be opened, there may be the random one we quickly open! We cannot guarantee when we will reach your lab, so if you see us down the corridor do not disappear as we would like to have at least one representative from each lab available to guide us through your lab spaces.

Lab work will not be disrupted, so please carry on as usual during the inspections.

All your questions can be answered on the day you see us during the inspection, so no need to bombard us with questions before then. You all know the drill by now! (see your green Safety Manual)

Those of us who reside on floors governed by Dept of Microbiology and Dept of Anatomy will not be included in this inspection round.

Irene Hatzinisiriou Deptl Safety Officer

LATEST MEMBERS OF STAFF

Lab Head New Staff Member Position

Prof Anthony Purcell Natalie Lane RA

Prof Anthony Purcell Nathan Croft RF

Prof Anthony Purcell Nadine Dudek Senior RF

Newsletter: July 2012, Issue 25 Department of Biochemistry and Molecular Biology

SAFETY PROCEDURE

Dept of Biochemistry & Molecular Biology in association with Monash OHS have formulated the following procedure which MUST be followed when working in any lab space especially in closed lab rooms. Closed rooms include any lab room where the door is kept closed such as Microscope suits, Equipment rooms, Cool rooms, Animal rooms, Cryogenic rooms etc. This notice will be placed on all such rooms for all users to see.

ATTENTION ALL USERS OF CLOSED LAB/COOL ROOMSEMERGENCY PROCEDURE TO BE FOLLOWED IF ANY OF THE FOLLOWING OCCURS:

• Feeling unwell

• Feeling light headed

• Tingling of feet, hands

• Can hear a hissing noise

• Can smell noxious vapours

• Any accident

• Any incident which requires a first aider

• If a hazard in the room exists and which may pose a risk to your safety or others

NORMAL WORKING HOURS

1. EVACUATE room immediately

2. CALL 000 for Ambulance/Fire Brigade if required

3. Call Security 333 if you have dialled 000

4. Contact a First Aider

5. Contact Safety Officer Irene Hatzinisiriou ex 29255

AFTER HOURS

1. EVACUATE room immediately

2. CALL 000 for Ambulance/Fire Brigade if required

3. ALWAYS call Security on 333 no matter what!

4. Contact Safety Officer Irene Hatzinisiriou ex 29255

5. Contact Monash OHS ex 55174 if you can’t contact Safety Officer

Security will call Building Management if required to deal with the issues immediately. But the Safety Officer and Monash OHS should also be informed on the day of the incident. The Safety Officer in conjunction with Monash OHS should be able to deem the work area as ‘safe to re-enter’.


POSTGRADUATE MATTERS

PhD GraduatesWilissa D’Souza Thesis: “Testing novel apolipoprotein A-I mimetic peptides as a treatment of atherosclerosis” Supervisor: Dmitri Sviridov

Albert Wong Thesis: “Mechanisms of apoptosis and autophagy in cardiomyocytes” Supervisor: Liz Woodcock

Newly-enrolled studentsPankaj Deo Supervisors: Kip Gabriel, Trevor Lithgow and Thomas Naderer

Sam Palframan Supervisors: Kip Gabriel, Terry Kwok and Trevor Lithgow

2012 Postgraduate Research ConferencePre-submission seminars are being planned for the Dept of Biochemistry Postgraduate Research Conference, which will be held on the 22nd and 23rd November.

The conference provides an opportunity for 3rd year PhD students to present a talk and all students to present a poster to the Department.

STUDENT SOCIETY

Movie NightA movie night is planned for August. Please look out for details in the SOBS bulletin.

July Beer Club Snapshot

QUICK OVERVIEW OF WHAT TO DO WHEN AN EMERGENCY ARISES:

1. Remain CALM…

2. Yell out for a First Aider (don’t go looking for one yourself, get someone else to go looking)

3. First Aiders: Read MSDS before treating any chemical injury

4. First Aiders: Call Med Centre if necessary ext. 53175

5. First Aiders: Call the Safety Officer and/or Safety Representative as soon as possible

To find out more about NOTDRS please visit: http://www.med.monash.edu.au/biochem/student-society.html

Or find us on facebook: http://www.facebook.com/groups.php?id=695417331&gv=12#/group.php?gid=86877543416

3-Minute Thesis CompetitionThis year’s Biochemistry 3-Minute Thesis competition will be held this Wednesday (1st August) at 4.00 pm in Building 11 / Lecture Theatre H1.

For those unfamiliar with this competition, the 3-minute thesis competition challenges students to explain their thesis topic in general (non-specialist) terminology in 3 minutes with just a single slide.

The following six students will be competing in this friendly competition:

Michael Kraakman Shu-chin Lai Sarah Conduit Paige Everingham Justin Chen Adam Shahine

Prof Martin Stone

Link to MBio e-bulletin: http://www.med.monash.edu.au/mbio-gradschool/e-bulletin.html

All queries on Postgraduate matters: Please contact Prof Mibel Aguilar [email protected]

Necessary Outlets for Tertiary Doctoral Research Students

Mid Candidature Reviews and confirmations scheduled for August - stay tuned.

For further Biochemistry news, please visit our website:

www.med.monash.edu.au/biochem


1. Atkinson, S.C., C. Dogovski, M.T. Downton, F.G. Pearce, C.F. Reboul, A.M. Buckle, J.A. Gerrard, R.C. Dobson, J. Wagner, and M.A. Perugini, Crystal, Solution and In silico Structural Studies of Dihydrodipicolinate Synthase from the Common Grapevine. PLoS One, 2012. 7(6): p. e38318 Category: Biology Impact Factor: 4.092 Ranking: 12/84

2. Caly, L., K.M. Wagstaff, and D.A. Jans, COMMENTARY: Nuclear trafficking of proteins from RNA viruses: potential target for antivirals? Antiviral Res, 2012. E-pub: p. 1-5 Category: Virology Impact Factor: 4.301 Ranking: 7/32

3. Devenish, R.J. and D.J. Klionsky, Autophagy: mechanism and physiological relevance ‘brewed’ from yeast studies. Front Biosci (Schol Ed), 2012. 4: p. 1354-1363 Category: Biochemistry & Molecular Biology Impact Factor: 3.520 Ranking: 104/289

4. Dunstone, M.A. and R.K. Tweten, Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins. Curr Opin Struct Biol, 2012. 22(3): p. 342-9 Category: Biochemistry & Molecular Biology Impact Factor: 9.424 Ranking: 19/289

5. Gabriel, K., COMMENTARY: Connecting the Points: Revealing the Bigger Picture. J Mol Biol, 2012. E-pub: p. 1-2 Category: Biochemistry & Molecular Biology Impact Factor: 4.001 Ranking: 80/289

6. Sim, C.H., K. Gabriel, R.D. Mills, J.G. Culvenor, and H.C. Cheng, REVIEW: Analysis of the regulatory and catalytic domains of PTEN induced kinase-1 (PINK1). Hum Mutat, 2012. E-pub: p. 1-15 Category: Genetics & Heredity Impact Factor: 5.686 Ranking: 19/157

7. Hatfaludi, T., K. Al-Hasani, L. Gong, J.D. Boyce, M. Ford, I.W. Wilkie, N. Quinsey, M.A. Dunstone, D.E. Hoke, and B. Adler, Screening of 71 P. multocida Proteins for Protective Efficacy in a Fowl Cholera Infection Model and Characterization of the Protective Antigen PlpE. PLoS One, 2012. 7(7): p. e39973.1-11 Category: Biology Impact Factor: 4.092 Ranking: 12/84 [BCH,MICRO]

8. Ho, B.K., D. Perahia, and A.M. Buckle, Hybrid approaches to molecular simulation. Curr Opin Struct Biol, 2012. 22(3): p. 386-93 Category: Biochemistry & Molecular Biology Impact Factor: 9.424 Ranking: 19/289

9. Hutt, D.M., D.M. Roth, M.A. Chalfant, R.T. Youker, J. Matteson, J.L. Brodsky, and W.E. Balch, FK506 Binding Protein 8 Peptidylprolyl Isomerase Activity Manages a Late Stage of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Folding and Stability. J Biol Chem, 2012. 287(26): p. 21914-21925 Category: Biochemistry & Molecular Biology Impact Factor: 4.773 Ranking: 66/289

10. Illing, P.T., J.P. Vivian, N.L. Dudek, L. Kostenko, Z. Chen, M. Bharadwaj, J.J. Miles, L. Kjer-Nielsen, S. Gras, N.A. Williamson, S.R. Burrows, A.W. Purcell, J. Rossjohn, and J. McCluskey, Immune self-reactivity triggered by drug-modified HLA-peptide repertoire. Nature, 2012. 486(7404): p. 554-558 Category: Multidisciplinary Sciences Impact Factor: 36.280 Ranking: 1/55

11. Johnson, J.L., T.E. Hall, J.M. Dyson, C. Sonntag, K. Ayers, S. Berger, P. Gautier, C. Mitchell, G.E. Hollway, and P.D. Currie, Scube activity is necessary for Hedgehog signal transduction in vivo. Dev Biol, 2012. E-pub: p. 1-10 Category: Developmental Biology Impact Factor: 4.069 Ranking: 7/40 [ARMI,BCH]

12. Kass, I., A.S. Knaupp, S.P. Bottomley, and A.M. Buckle, Conformational Properties of the Disease-Causing Z Variant of alpha1 Antitrypsin Revealed by Theory and Experiment. Biophys J, 2012. 102(12): p. 2856-2865 Category: Biophysics Impact Factor: 3.653 Ranking: 19/74

RECENT PUBLICATIONS


13. Klionsky, D.J., R.J. Devenish, D. Mijaljica, M. Prescott, G. Ramm, and B.A. Zuckerbraun, + 1264 Authors REVIEW: Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2012. 8(4): p. 445-544 Category: Cell Biology Impact Factor: 7.453 Ranking: 30/180 [BCH,MMI]

14. Lang, B.J., L. Nguyen, H.C. Nguyen, J.L. Vieusseux, R.C. Chai, C. Christophi, T. Fifis, M.M. Kouspou, and J.T. Price, Heat stress induces epithelial plasticity and cell migration independent of heat shock factor 1. Cell Stress Chaperones, 2012. E-pub: p. 1-14 Category: Cell Biology Impact Factor: 2.667 Ranking: 98/180

15. Lopez, J.A., A.J. Brennan, J.C. Whisstock, I. Voskoboinik, and J.A. Trapani, REVIEW: Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death. Trends Immunol, 2012. E-pub: p. 1-7 Category: Immunology Impact Factor: 10.403 Ranking: 8/139

16. McCabe, M.J., C.M. Allan, C.F. Foo, P.K. Nicholls, K.J. McTavish, and P.G. Stanton, Androgen Initiates Sertoli Cell Tight Junction Formation in the Hypogonadal (hpg) Mouse. Biol Reprod, 2012. E-pub: p. 1-16 Category: Reproductive Biology Impact Factor: 4.009 Ranking: 3/28

17. Mijaljica, D., M. Prescott, and R.J. Devenish, A Late Form of Nucleophagy in Saccharomyces cerevisiae. PLoS One, 2012. 7(6): p. e40013.1-16 Category: Biology Impact Factor: 4.092 Ranking:12/84

18. Oksayan, S., L. Wiltzer, C.L. Rowe, D. Blondel, D.A. Jans, and G.W. Moseley, A novel nuclear trafficking module regulates the nucleocytoplasmic localization of the rabies virus interferon antagonist, P protein. J Biol Chem, 2012. E-pub: p. 1-19 Category: Biochemistry & Molecular Biology Impact Factor: 4.773 Ranking: 66/289

19. Orengo, C. and J. Whisstock, Editorial Overview: Structural insights into multi-protein communication systems. Curr Opin Struct Biol, 2012. 22(3): p. 313-315 Category: Biochemistry & Molecular Biology Impact Factor: 9.424 Ranking: 19/289

20. Petersen, J., K. Forster, P. Turina, and P. Graber, Comparison of the H+/ATP ratios of the H+-ATP synthases from yeast and from chloroplast. Proc Natl Acad Sci U S A, 2012. 109(28): p. 11150-11155 Category: Multidisciplinary Sciences Impact Factor: 9.681 Ranking: 3/55

21. Mika, A., S.L. Reynolds, F.C. Mohlin, C. Willis, P.M. Swe, D.A. Pickering, V. Halilovic, L.C. Wijeyewickrema, R.N. Pike, A.M. Blom, D.J. Kemp, and K. Fischer, Novel scabies mite serpins inhibit the three pathways of the human complement system. PLoS One, 2012. 7(7): p. e40489.1-15 Category: Biology Impact Factor: 4.092 Ranking: 12/84

22. Pusnik, M., O. Schmidt, A.J. Perry, S. Oeljeklaus, M. Niemann, B. Warscheid, C. Meisinger, T. Lithgow, and A. Schneider, Response to Zarsky et al. [Letter to the Editor]. Curr Biol, 2012. 22(12): p. R481-2 Category: Biochemistry & Molecular Biology Impact Factor: 9.647 Ranking: 18/289

23. Qu, X., X. Zhang, J. Yao, J. Song, D.J. Nikolic-Paterson, and J. Li, Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation. J Pathol, 2012. E-pub: p. 1-38 Category: Pathology Impact Factor: 6.318 Ranking: 3/78 [ANT,BCH]

RECENT PUBLICATIONS


24. Reboul, C.F., B.T. Porebski, M.D. Griffin, R.C. Dobson, M.A. Perugini, J.A. Gerrard, and A.M. Buckle, Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase. PLoS Comput Biol, 2012. 8(6): p. e1002537.1-12 Category: Biochemical Research Methods Impact Factor: 5.215 Ranking: 8/72

25. Reboul, C.F., K. Mahmood, J.C. Whisstock, and M.A. Dunstone, Predicting giant transmembrane beta-barrel architecture. Bioinformatics, 2012. E-pub: p. 1-4 Category: Biochemical Research Methods Impact Factor: 5.468 Ranking: 7/72

26. Sivaraman, K.K., C.A. Oellig, K. Huynh, S.C. Atkinson, M. Poreba, M.A. Perugini, K.R. Trenholme, D.L. Gardiner, G. Salvesen, M. Drag, J.P. Dalton, J.C. Whisstock, and S. McGowan, X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP. J Mol Biol, 2012. E-pub: p. 1-13 Category: Biochemistry & Molecular Biology Impact Factor: 4.001 Ranking: 80/289

27. Soares da Costa, T.P., W. Tieu, M.Y. Yap, N.R. Pendini, S.W. Polyak, D. Sejer Pedersen, R. Morona, J.D. Turnidge, J.C. Wallace, M.C. Wilce, G.W. Booker, and A.D. Abell, Selective inhibition of biotin protein ligase from Staphylococcus aureus. J Biol Chem, 2012. 287(21): p. 17823-32 Category: Biochemistry & Molecular Biology Impact Factor: 4.773 Ranking: 66/289

28. Smyth, R.P., M.P. Davenport, and J. Mak, The origin of genetic diversity in HIV-1. Virus Res, 2012. E-pub: p. 1-15 Category: Virology Impact Factor: 2.941 Ranking: 16/32 [BCH,MICRO]

29. Wiede, F., S.H. Chew, C. van Vliet, I.J. Poulton, K. Kyparissoudis, T. Sasmono, K. Loh, M.L. Tremblay, D.I. Godfrey, N.A. Sims, and T. Tiganis, Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice. PLoS One, 2012. 7(5): p. e36703.1-15 Category: Biology Impact Factor: 4.092 Ranking: 12/84

30. Wang, Y.Y., K.J. Xu, J. Song, and X.M. Zhao, Exploring drug combinations in genetic interaction network. BMC Bioinformatics, 2012. 13(Suppl 7): p. 57.1-7 Category: Mathematics & Computational Biology Impact Factor: 2.751 Ranking: 6/47

31. Webb, C.T., J. Selkrig, A.J. Perry, N. Noinaj, S.K. Buchanan, and T. Lithgow, Dynamic Association of BAM Complex Modules Includes Surface Exposure of the Lipoprotein BamC. J Mol Biol, 2012. E-pub: p. 1-11 Category: Biochemistry & Molecular Biology Impact Factor: 4.001 Ranking: 80/289

32. Wiltzer, L., F. Larrous, S. Oksayan, N. Ito, G.A. Marsh, L. Wang, D. Blondel, H. Bourhy, D.A. Jans, and G.W. Moseley, Conservation of a unique mechanism of immune evasion across the lyssavirus genus. J Virol, 2012. E-pub: p. 1-26 Category: Virology Impact Factor: 5.402 Ranking: 6/32

33. Winbanks, C.E., K.L. Weeks, R.E. Thomson, P.V. Sepulveda, C. Beyer, H. Qian, J.L. Chen, J.M. Allen, G.I. Lancaster, M.A. Febbraio, C.A. Harrison, J.R. McMullen, J.S. Chamberlain, and P. Gregorevic, Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin. J Cell Biol, 2012. 197(7): p. 997-1008 Category: Cell Biology Impact Factor: 10.264 Ranking: 16/180

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CONTACT US: Department of Biochemistry and Molecular Biology Monash University, Ground Floor, Building 77, Wellington Road, Clayton VIC 3800 Australia Content and Layout: [email protected] Photography: MNHS Multimedia Services

newsletter department of biochemistry and …...newsletter: july 2012, issue 25 department of...

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