What is Nexavar (Sorafenib)?

NEXAVAR is a prescription drug used to treat 3 kinds of cancer:

1. Hepatocellular carcinoma or HCC - Hepatocellular carcinoma is a cancer

that starts in your liver. Most cases of HCC are the result of infection with

hepatitis B or C, or cirrhosis of the liver caused by alcoholism. If caught early,

it can sometimes be cured with surgery or transplant.

2. Advanced renal cell carcinoma or RCC - Renal cell carcinoma is a type of

kidney cancer, develops in the lining of the kidney's tubes and grows into a

mass or tumor. RCC represents approximately 4% of all new cancers

worldwide, and accounts for 90% of cancerous kidney tumors. If left untreated,

RCC can become advanced or metastatic, meaning the cancer cells have spread

to other areas of the body. It is estimated that more than 30% of patients have

advanced or metastatic RCC at the time of diagnosis.

3. Differentiated thyroid carcinoma (DTC) - When cancer starts in the

thyroid gland, it is called thyroid cancer or DTC. Every year, about 12,000 men

and 35,000 women get thyroid cancer, and more than 900 men and 1,100

women die from the disease. If it's caught early, thyroid cancer is one of the

most treatable forms of cancer.

Information about Nexavar Medicine

Composition Sorafenib Tosylate

Manufacturer Bayer Pharmaceuticals, Inc.

Strength 200 mg

Dosage Form Tablet

Packaging Size 60 Tablets in one pack

Route of Administration Oral

Prescription Required Yes

What Nexavar looks like

Nexavar 200 mg film-coated tablets are red and round with the Bayer cross on

one side and “200” on the other side.

Approval & Usage

In 2005 - Approved for the treatment patients with advanced kidney cancer.

In 2007 - Approved for the treatment of patients with hepatocellular

carcinoma.

In 2013 - Approved for locally recurrent or metastatic, progressive,

differentiated thyroid carcinoma (DTC) refractory to radioactive iodine

treatment.

What are the common side-effects of Nexavar?

These are not all the side effects of NEXAVAR. Call your doctor or pharmacist

for medical advice about side effects. Your healthcare team has different ways

to help manage some of the side effects of NEXAVAR Tablets. One approach

your healthcare professional may take is to change your dose or stop your

treatment temporarily. This is a common way to help manage certain side

effects, and is generally not a cause for concern. Be sure to discuss any

questions that you have with your doctor.

Diarrhea (frequent or

loose bowel movements)

Hair thinning or

patchy hair loss

Loss of apetite Nausea

Stomach (abdominal)

painTiredness

RashLow blood calcium

levels in people

with thyroid cancer

Infection

This medicine is available only with your doctor's prescription.

How to take Nexavar (Sorafenib) Tablet?

Take NEXAVAR exactly as prescribed by your doctor. The usual dose of Nexavar is

2 tablets taken 2 times a day (for a total of 4 tablets each day). Your doctor may

change your dose, stop treatment for some time, or completely stop treatment with

Nexavar 200 mg if you have side effects.

Take 2 Tablets 2 Times a Day by

Mouth

— 2 tablets in the morning

— 2 tablets at night

Do Not Take Nexavar with Food

— Take Nexavar at least 1 hour

before you plan to eat

— Wait 2 hours after eating

before taking Nexavar

Forgot? If you miss a dose, skip the missed dose

and take your next dose at your regular

time. Do not double your dose of

Nexavar Sorafenib 200 mg.

Overdose? If you take too much NEXAVAR, call

your health care provider or go to the

nearest hospital emergency room right

away.

How long will you take Nexavar?

How to remember to take your Nexavar?

Make sure to ask your health care team how long they think you will take

NEXAVAR. The duration of your treatment with this cancer medicine may

depend on what type of cancer you have. Your health care team will decide what

is the best treatment duration for you.

After a while, taking NEXAVAR should become part of your daily routine. If

you need help remembering to take your dose, set up reminders. Maybe set

the alarm to go off on your cell phone, or ask someone to remind you.

Listen to your doctor or nurse and take NEXAVAR (sorafenib) When and how he or

she tells you to take it.

If you have any questions, the first thing you should do is talk to your doctor. If you

get any side effects from NEXAVAR, your doctor may change your dose, delay, or

stop treatment.

Do not take other medicines with NEXAVAR until you have talked to your doctor.

Nexavar Substitutes or Generic Alternatives at

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• Brand Name – Sorafenat

• Composition – Sorafenib

• Manufacturer – Natco Pharma

• Dosage Form – Tablet

• Packaging Size – 120 Tablets

• Route of Administration – Oral

• Prescription Required – Yes

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• Brand Name – Soranib

• Composition – Sorafenib

• Manufacturer – Cipla Ltd.

• Dosage Form – Tablet

• Packaging Size – 30 Tablets

• Route of Administration – Oral

• Prescription Required – Yes

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Cancer was once a word that people were afraid to speak in public, and people

rarely admitted to being a cancer survivor. Now, many celebrities and national

leaders very openly discuss and share their cancer experiences. The view that

cancer cannot be cured and the fears that have historically been attached to the

disease are slowly changing. Over the past decades, survival rates for children with

cancer have improved tremendously due to advances in treatment.

Helping Yourself

Stay as healthy as you can

Control what you can about your health. Try to eat a healthy diet, get enough

sleep, and exercise as often as you can. Cancer can make you feel tired and weak.

Exercise and “resistance training” may help. Do what you can, even if it’s just

taking a walk every day. If walking is difficult, sit in a chair and move your

muscles by pushing against something that offers resistance, like an elastic band.

Exercise may help improve your mood.

Prepare for your appointments

Keep an up-to-date calendar to track your appointments. Beforehand, write

down any changes or symptoms you have noticed since your last visit — both

physical and emotional.

Write down the questions you want to ask so you won’t forget them. It’s often good

to have someone go with you to the visit. They can help you remember everything

you need to say — get all your questions answered, take notes, and remember any

instructions. Bring something to keep you busy if you have to wait at the health

care provider’s office.

Speak Up

Sometimes it is hard to remember everything your health care provider tells

you. When you have an appointment, take a family member or friend with you—

two sets of ears are better than one. Take notes. Ask your health care provider to

explain anything you don’t understand. Speak up and be your own advocate; let

your health care provider know what you need.