nih ncrr - idea program purpose: to expand biomedical research infrastructure in arkansas
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NIH NCRR - IDeA Program
Purpose: to expand biomedical research infrastructure in Arkansas
A multidisciplinary research network with a thematic scientific focus
Cancer and Signaling MechanismsCancer and Signaling MechanismsDirector: Robert E. McGehee
Two Research Focus Groups
NeuroscienceNeuroscienceDirectors: Paul D. Drew & Robert D. Skinner
Cellular Signaling, Growth, and DifferentiationCellular Signaling, Growth, and Differentiation
• Promote networking among project leaders (PLs), their students and mentors through
Research Focus GroupsResearch Focus GroupsNeuroscienceCancer and Signaling Mechanisms
• Help monitor the PLs’ progress in becoming competitive for extramural research funding throughMentoring Advisory CommitteeMentoring Advisory Committee
1. review progress of PLs via annual reportsannual reports2. provide recommendations on continued support to Steering & External Advisory Committees
Mentoring Core Objectives
• Meet regularlyMeet regularly (3x/year) to promote informal, “friendly” critique of ongoing research activities in PLs’ labs
• meetings hosted by local PL(s) (Mentoring Core budget)
Research Focus Groups
• PLs required to present once a year overview of progressoverview of progress on research projects (informal seminar/lab meeting format)
• Seminar SeriesSeminar Series - to encourage formation of outside contacts (potential grant reviewers, editorial board members)
3 seminar speakers budgeted per Research Focus Group per year
Project Leaders, their Mentors, and Research Projects
Research Focus: NeuroscienceResearch Focus: Neuroscience
The effect of c-Myc expression on the activation of the gastrin promoter
Frank A. Simmen, PhDPatricia Marks, PhD
Translational regulation during Xenopus oocyte development
Angus MacNicol, PhDRobert Gregerson, PhD
p107 function in 3T3-L1 differentiationRobert E. McGehee, Jr., PhDTimothy Hayes, PhD
Signaling by non-classical ligands of estrogen receptor: novel approaches to detection and mechanism
Stavros C. Manolagas, MDBarry Gehm, PhD
Investigation of thermal effects in photodynamic therapy to treat solid tumors
Vladimir P. Zharov, PhDPradip Bandyopadhyay, PhD
Research Focus: Cancer and Signaling MechanismsResearch Focus: Cancer and Signaling Mechanisms
Cholinergic mechanisms in neuronal regenerationFang Zheng, PhD; Kevin Phelan, PhD
Malathi Srivatsan, PhD
Assessment of drug uptake and permeability properties of novel anticancer agents in the brainSteve W. Barger, PhDAntonie Rice, PhD
Effects of adverse perinatal experiences on cortical organization
Kanwaljeet S. Anand, MDBarbara Clancy, PhD
Effects of nicotine on processes mediated by the reticular activating system
Edgar Garcia-Rill, PhD; Robert D. Skinner, PhD; Bill Gurley, PhD
Roger Buchanan, PhD
Project Leaders, their Mentors, & Research Projects cont.
Research Focus: NeuroscienceResearch Focus: Neuroscience & & Cancer and Signaling MechanismsCancer and Signaling Mechanisms
The role of bone morphogenetic proteins in nociceptive neuron development
Patricia A. Wight, PhD Richard Murray, PhD
Molecular mechanisms contributing to gender disparity in multiple sclerosis
Paul D. Drew, PhD Lori Hensley, PhD
Transcriptional regulation of the myelin proteolipid protein gene: Effect of intron 1-binding factors on chromatin remodeling during oligodendrocyte differentiation
Patricia A. Wight, PhD; John Majors, PhD
Brian Greuel, PhD
Mentoring Advisory Committee
• Dennis A. BaeyensDennis A. Baeyens, Ph.D., Professor, Dept. of Biology, UALR
• Gwen V. ChildsGwen V. Childs, Ph.D., Professor & Chair, Dept. of Neurobiology & Developmental Sciences, UAMS
• Robert J. Shmookler-ReisRobert J. Shmookler-Reis, D.Phil., Professor, Depts. of Geriatrics, Medicine, Biochemistry & Molecular Biology, and Pharmacology & Toxicology, UAMS
• Michael S. OwensMichael S. Owens, Ph.D., Professor, Dept. of Pharmacology & Toxicology, UAMS
• Rose Marie McConnellRose Marie McConnell, Ph.D., Professor, Dept. of Chemistry, UA Monticello,
• Thomas E. GoodwinThomas E. Goodwin, Ph.D., Professor, Dept. of Chemistry, Hendrix College
MAC’S ROLE
• Meets as a study section annuallyannually to review annual progress reportsannual progress reports from the 14 UGI PLs
• Prepares short report on each PLshort report on each PL to the Steering Committee, External Advisory Committee, and INBRE PI (to advise on the continued support and retention of PLs)
Feb. 2006 – Yr. 1 report (after ~9 mos.) Feb. 2007 – Yr. 2 report (warning?) Aug. 2007 – Update on improvement May 2008 – Replacement? (reviewed by
P.I., Steering & EA Com.
Review of Annual Reports
Mentoring Plans of PLs
Research Mentor; Institutional Mentor; Annual Reports • mentor & PL/mentee develop timeline
(informally record meetings)
Commitments of UGI PLs as Mentees • research time protected & guaranteed by each UGI administration to commit 50% effort to research activities• meet one-on-one with Research Mentors (1-2X/month)
• attend 3 meetings per year of Research Focus Group and present 1X/year
• mentor own students• meet with Institutional Mentor (3X/year)
• submit Annual Report to INBRE MAC
Roles of Research Mentors
• help PL/mentee establish professional contacts
• host the mentee at mentor’s lab meetings (1X/month)
• make techniques & equipment from own laboratory available to the PL
• help PL develop timelines for manuscript, grant proposal submission, & help the PL keep on target in the accomplishment of the specific aims of project
• visit PL’s laboratory annually to give research seminar at PL’s UGI & interact with students
• attend the specific Research Focus Group meetings (when PL presents)
• meet with his/her mentee (at least quarterly) to discuss PL’s research progress
Mentoring Core Budget
• ~$18,000:$9,000 for Seminar Speakers$9,000 for Travel
$6,000 for Seminar Speakers’ travel $3,000 for Mentors’ and MAC travel