Project CharterEBOCT TECHNOLOGIES

Project Name Autism Spectrum disorders

Project Number 1001

Project Manager Richard Johnson Prioritization HighOwner(s)

Department of Health and Human ServicesNational Institutes of Health (NIH)

Start Date: 01/01/2012

Scheduled Completion Date:

12/31/2012

MissionSupport the research designed to elucidate the etiology, epidemiology, diagnosis, treatment, and optimal means of service delivery in relation to autism spectrum disorders (ASD).

ScopeSet and Identify three stages that effect autism children that were designed to elucidate the etiology, epidemiology, diagnosis, treatment, and optimal means of service delivered in relations to autism spectrum disorders. The three stages that would be used are characterized as follow:

Deliverables:1) Mild case stage

Elucidate the etiology study Epidemiology study Diagnosis study Treatment study Optimal means of service study Results

2) Intermediate case stage Elucidate the etiology study Epidemiology study Diagnosis study Treatment study Optimal means of service study Results

3) Serious case stage Elucidate the etiology study

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Epidemiology study Diagnosis study Treatment study Optimal means of service study Results

Under these three stages, research would be done to facilitate whether or not the method being used is feasible to the condition of autism children and adults.

The research would be based on the service portion of obtaining information in the following manner:

Services Projects:

Studies to understand how specific types of services,

organizational processes and structures, financing

mechanisms and evolving technologies and policies affect

access to and delivery of services to people with ASD.

Studies that include children, as well as transition-age youth

and adults.

Studies on adults that include strategies that enable post-

secondary education, supported employment, health care and

community integration.

Other priorities include but are not limited to:

Identification of risk factors (e.g., viruses, medications,

immune dysfunctions, mitochondrial abnormalities,

environmental chemicals, genetics) that contribute to the

development of autism and their associated developmental

windows.

Identification of biological signatures for autism and their

relevance to prediction of treatment response and outcomes.

Assessment of characteristics and evaluation of interventions

in understudied populations (e.g. adults, individuals from

racial and ethnic minorities) and in those with comorbid

conditions (e.g. epilepsy).

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Studies that improve the understanding of underlying biologic

pathways that might lead to treatments for genetic conditions

related to autism.  NINDS is particularly interested in

mechanistic analyses of single gene disorders with autistic

features (e.g. Tuberous Sclerosis Complex, Rett syndrome,

Fragile X syndrome) that may shed light on pathways that are

relevant to autism.

EBOCT research center will collaborate with the Collaborative Programs of

Excellence in Autism (CPEA), the Studies to Advance Autism Research

and Treatment’ (STAART), and INTERNET to better understand the reason

and purpose for research that was designed to elucidate the etiology,

epidemiology, diagnosis, treatment, and optimal means of service rendered

through the ACE program. Our goals and objectives will be a collaboration

with other centers who can share information that will help establish the

three stages associated with this research. One key resource is the

Children Specialized Hospital for Autism, located in Mountainside New

Jersey.

ObjectivesSolidify the procedures used to elucidate the etiology, epidemiology, diagnosis, treatment, and optical means of services delivered in relations to autism spectrum disorders.

The estimated time would be 12 months from the awarding of the contract to EBOCT Technologies research center.

The cost would be estimated as being $607,660.00 Including expenses (allowed under the agreement of the contract).

Assumptions There would be three (3) investigators working on this project, and are listed as follow:

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1) Principal Investigator (PI) 2) Senior research person 3) Assistant research person

All work will be documented and reported (according to the specification listed in the contract) to the Department of Health and Human Services or according to their expectations in receiving these reports.

EBOCT research center will collaborate with the Collaborative Programs of Excellence in Autism (CPEA), the Studies to Advance Autism Research and Treatment’ (STAART), and INTERNET to better understand the reason and purpose for research that were designed to elucidate the etiology, epidemiology, diagnosis, treatment, and optimal means of service rendered through the ACE program. Our goals and objectives will be a collaboration with other centers who can share information that will help establish the three stages associated with this research. One key resource is the Children Specialized Hospital for Autism, located in Mountainside New Jersey.

Constraints In the case of bad weather or conditions that might prevent EBOCT from working on the project, within 48 hours, a written document would be created explaining reasons why during the period of down time such activity did occur and the consequences behind it.

Time/Decision Points During the research process, EBOCT plans to host a total of 5 group

meetings in the following manner.

1st group meeting month 3 2nd group meeting month 5 3rd group meeting month 8 4th group meeting month 10 5th group meeting month 12

During this time progress reports will be given and referenced to the findings and behavior of Autism in children and Adults. Each session will be recorded and presented to the NIH.

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Cost/Financial Assumptions

 Startup Cost: 2012

Budget itemRequested

Contributed

Labor:Principal Investigator (PI) $208,000

Labor:Research Investigator #1 $41,600

Labor:Research Investigator #2 $35,360

Labor:Secretary $31,200

Labor: N/A   0.00LABOR SUBTOTAL $316,160 $0Travel expenses (i.e. meals, lodging, etc): $10,000Field/site visits $20,000Conferences/meetings $6,000Miscellaneous cost $60,000TRAVEL SUBTOTAL $96,000 $0Capitalized equipment: $15,000Computers $12,000Software $10,000DSL Connection 1-yr $12,000EQUIPMENT SUBTOTAL $49,000 $0Materials and supplies $6,500MATERIALS AND SUPPLIES SUBTOTAL $6,500 $0Cable laying $6,000OTHER SUBTOTAL $6,000 $0TOTAL DIRECT COSTS $473,660 $0Indirect costs (no more than 20% of direct costs): $94,000

Pass-through if applicable (no more than 10% of direct costs): $40,000TOTAL INDIRECT COSTS $134,000 $0TOTAL REQUESTED FUNDING $607,660TOTAL CONTRIBUTED FUNDING $0

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User Acceptance Criteria/Quality Use state of the art equipment and tactics in researching and

completing data information that pertains to the development knowledge of understanding and identifying the three stages; Mild, Intermediate, and Serious cases involved in autism, and designed to elucidate the etiology, epidemiology, diagnosis, treatment, and optimal means of service delivered in relations to autism spectrum disorders. This research will determine whether or not the method used is feasible, and recognized in the above cases which are designed to elucidate the etiology, epidemiology, diagnosis, treatment, and optimal means of service. Our findings will be notarized, and presented to the NIH according to the contract agreement.

Major Risks 1) Bad weather may occur.

2) Research facility may be closed due to conditions uncontrolled by EBOCT.

3) Electrical outages, and or computer outages may occur.4) Misleading data information5) Theft may occur.

_________________________________________

SOLUTIONS:1) All efforts will be made to meet deadlines presented in the

contract.2) All dates will be governed for accuracy3) Backup UPS will be provided4) All data will be signed by the facility or persons in charge of such

data.5) EBOCT will be alarmed, and a backup data system will be put at a

secondary location for security purposes.

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KEY STAKEHOLDERSName

Project Core Team: Project Manager

Principal Investigator (PI)Senior research investigatorAssistant research investigator

Investigator Secretary

Subject Matter Experts (SME) (Include company & channel designations if applicable)

N/A

APPROVALSType Name Signature Date

Project Manager Approval:

Richard JohnsonOwner/Sponsor Approval:

National Institutes of Health (NIH)

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