From Nature the Synergic Natural Complex Developed

to Delay Skin Aging Fighting Free Radicals

Anti-Wrinkle Effect in 4 weeks

Skin Hydration +27%

Skin Elasticity +15%

NIO-AGE

Niosome Technology

PHLORETIN FROM APPLE SKIN

EXTRACT

ROS SCAVENGING & DERMAL MATRIX PROTECTION

Free radical scavenger, inhibitor of lipoxygenase and

cycloxygenase, inhibitor of collagenase and elastase

PUNICA GRANATUM

SEED EXTRACT

HYDRATION & ROS PROTECTION

Punicic Acid (~65%), an Omega-5 Fatty Acid

anti-oxidant and moisturizer

MAGNOLOL/

HONOKIOL

ANTI-OXIDANT & ANTI-INFLAMMATORY

Reduce inflammatory signals and dermal matrix

degradation

NIOSOME DELIVER ACTIVE INGREDIENTS

WHERE MUST BE REALLY EFFECTIVE

DRIVING THROUGH THE STRATUM CORNEUM

Ultra-Deformable Niosome are elastic vesicles able to

squeeze through Stratum Corneum reaching living cells inside

epidermis increasing the bioavailability of active ingredients

NIOSOME + FLUORESCEIN FLUORESCEIN ALONE

CLASSIC ACTIVE INGREDIENTS

NIO-AGE

NATURAL INGREDIENTS ARE ENCAPSULATED

INSIDE NIOSOME VESICLES

Phloretin

Punica Granatum

Seed Extract

Magnolol/

Honokiol

A NATURAL COMPLEX TO DELAY SIGNS OF AGING

NIO-ACTIVE NATURAL INGREDIENTS

ULTRA-DEFORMABLE NIOSOME The Most Advanced Skin Delivery System

NIO-AGE MODE OF ACTION

Soft and Smooth Skin Wrinkles, Laxity, Fragility

With NIO-AGE STRESS FACTORS

Chrono&Photo Aging, Pollution, Poor Nutrition

Inflammation Signals

Dermal Matrix

Degradation Enzymes

Dermal Matrix Alteration

Inflammation Signals

Dermal Matrix

Improvement

Hydration & Elasticity

NIO-AGE delays the process of skin aging defending cells from oxidative

metabolism and photo-aging at multiple levels.

Thanks to its specific composition, NIO-AGE fights free radicals, regulates

inflammation, inhibits lipoxygenase and cycloxigenase.

It reduces elastase and collagenase activity preventing degradation of dermal

matrix components responsible of wrinkles, skin laxity and fragility.

NIO-AGE IS THE ANTI-AGE COMPLEX DEVELOPED TO PROTECT SKIN HEALTH REDUCING FINE

LINES AND WRINKLES TO MAKE YOUR SKIN SOFT, ELASTIC, HYDRATED AND COMFORTABLE

i n fo @ n a t u r a l i s . i t

IN VIVO EFFICACY

NIO-AGE ON SKIN HYDRATION Measurement of Skin Hydration using Dermalab Combo tecnique

applying 3% NIO-AGE cream on face vs placebo twice daily for

45 days

NIO-ACTIVE ON SKIN ELASTICITY Measurement of Skin Elasticity using Cutometer MP580

(Courage&Khazaka, Cologne Germany) applying 3% NIO-

AGE cream on face vs placebo twice daily for 8 weeks

NIO-AGE ON WRINKLES APPEARANCE Assessment of skin condition applying 3% NIO-AGE twice daily for 28 days

NIO-AGE ON FIBROBLAST SURVIVAL Viability of HaCaT Human Keratinocyte Cells pre-treated 12 hours with 0-2 mg/ml NIO-AGE

solution after 2 hours H2O2 exposure

0

20

40

60

80

100

120

Fib

rob

last

Via

bili

ty

Ctrl 0,0 0,5 1,0 2,0

NIO-AGE mg/ml

H2O2 100 µmol/l

IN VITRO EFFICACY

100µM H2O2 100µM H2O2

2.0 mg/ml NIO-AGE

Control

+

NIO-AGE Placebo

0,0

10,0

20,0

30,0

40,0

50,0

NIO-AGE

Placebo

0 5 10 15 20

AFTER 4 WEEKS

% C

ha

ng

e c

om

pa

red

T0

% Change compared T0

Address: Via Ozanam, 4

20811 Cesano Maderno (MB) - Italy

Phone: +39 0362 545457

Fax: +39 0362 526364

Site: www.naturalis.it

Mail: info@naturalis.it

NIO-AGE

Niosome Technology

INCI NAME

Phloretin, Magnolol/Honokiol, Punica Granatum Seed Extract, Polyglyceryl-10 Oleate, Apricot Kernel Oil Polyglyceryl-6 Esters, Sorbitan Palmitate, Aqua/Water

SAFETY & TOXICITY

Reference COMMISSION REGULATION (EC) No 987/2008 of 8 October 2008 amending Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH):

• non-irritating

• non-toxic

FORMULATION SUGGESTIONS

Use Levels: 1 - 3%

pH range: 3,5 - 8,5

Incorporation: Diluite in water before blending. Do not heat above 50°C

Origin: Botanical

Application: Lotions, O/W and W/O emulsions, Gels

Preservative: None

Solubility: Dispersible in water

Compliant regulation: US - EU - China - Japan

Certification: COSMOS Approved

COSMETIC APPLICATION

• ANTI-AGE DAY AND NIGHT CARE

• ACTIVE MAKE-UP

• SUN CARE

CLAIMS

• ANTI-AGING

• ANTI FREE RADICAL

• MOISTURIZING

FOR WRINKLE PREVENTION

The brochure is not intended for consumers and any extract must be used to market products. No design, photography or other extract derived from this brochure are to be used without our prior written approval.

The person using the active ingredient set out in this brochure in the formulation of finished products is solely responsible for ensuring that the ingredient is in compliance with all applicable laws and regulations. We

hereby disclaim all warranties of suitability of the principle set out in this brochure for any porpouse. Any potential user of the principle must himself determine the suitability of the ingredient for its intended use.