non-invasive detection of intracranial pressure

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Non-invasive detection of intracranial pressure Invitation to ICP workshop in Trondheim in Norway June 18-19, 2019

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Non-invasive detection of intracranial pressure

Invitation to ICP workshop in Trondheim in NorwayJune 18-19, 2019

FAST ACCURATE EASY to USE COST EFFECTIVE

Agenda

New ICP method§ Developed by ultrasound

specialists at SINTEF (Norway) and neurosurgeons at Universityof Cape Town

§ Uses a novel quantitative surrogate marker for ICP based on the dynamics of the optic nerve sheath, in combination with the optic nerve sheath diameter

The measurement takes a few minutes and doesn't require specialized personnel

Nisonic ICP Measurement

1. Software with proprietary algorithms• Automated

measurements

• User guiding system

2. Optimized probe for imaging the optical nerve sheath

Nisonic P-100 ICP Scanner

CE marked andlaunched at MedicaNovember 2019

Clinical studies

7

1st Clinical Study2015

Animal Study2015

2nd Clinical study2016

Third clinical study2019

Operator Llewellyn Padayachy SINTEF Llewellyn Padayachy Dag Netteland and Eirik Helseth

Site UCT, South Africa SINTEF Trondheim UCT, South Africa Oslo University Hospital

Target group 15 pedriatric patients 4 pigs 28 pedriatric patients Adult TBI patients

Diagnosis hydrocephalus (8), trauma (2), tumor (3) & otherdiagnosis (4)

hydrocephalus (18), trauma (2), tumor (6) & otherdiagnosis (4)

TBI

Equipment and data processing

Philips, post-processingusing Nisonic SW

GE, post-processing usingNisonic SW

Philips, post-processingusing Nisonic SW

SonositeNisonic

Conclusion Conforming deformability(DI) of the ONS as a non-invasive marker of ICP

Good correlation between DI and ICP

DI: specificity of 88.9% and sensitivity of 89.5%DI + ONSD: Sensitivity 94.7, specificity 88.9%

On-going

New sites to be invited to participate in further clinical studies to enhance the concept

KEY PERSONNEL

Jan Biti CEO

Dr. Tormod SelbekkInventor & CTO

Dag BrurokClinical Product Specialist

Cornelia MenderVP Sales & Marketing

Team

Spencer LienUS Advisor

Eirik HelsethProfessor and Neurosurgeon

Oslo University Hospital

Llewellyn PadayachyNeurosurgeon & inventor

University of Cape Town / Oxford

Denise BarbutProfessor in neurology

Weill-Cornell Medical CollegeSerial entrepreneur

Stephan MayerProfessor in neurology

and specialist in neurocritical care

Henry Ford Health System

SCIENTIFIC ADVISORY BOARD