non-invasive measurement of your antioxidant defense system
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Non-Invasive Measurement of Your Antioxidant Defense System. Presented by Joe Chang, Ph.D. President, Pharmanex. - PowerPoint PPT PresentationTRANSCRIPT
Non-Invasive Measurement of Your
Antioxidant Defense System Presented by Joe Chang, Ph.D.
President, Pharmanex
This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.
Problems with current technology
• Requires body fluids
• Take 14-21 days
• Cost $25.00 to $300.00 per test
• Complicated
LifePak $200,000 Clinical StudyFASEB Journal 1999 Vol.13(4): A546
(means +/- SD)
70.667.4
94.3
68.1
0
20
40
60
80
100
120
140
Baseline Endpoint
PLMVMS
p < 0.001
Blood Vitamin C
(means +/- SD)
70.667.4
94.3
68.1
0
20
40
60
80
100
120
140
Baseline Endpoint
PLMVMS
p < 0.001
Blood Vitamin E
(means +/- SD)
331299
335
716
0
200
400
600
800
1000
1200
Baseline Endpoint
PLMVMS
p < 0.001
Blood Carotenoids
Why Measure Carotenoids?
• Skin Carotenoids - An Important Indicator of the Body’s Antioxidant Defense System
– Site of action advantage of skin carotenoids– Carotenoids are an important part of the antioxidant
defense system– Skin carotenoids are influenced by oxidative stress
(smoking, sunlight exposure, urinary MDA)– Most convenient indicator of antioxidant defense– Same specificity issues as will other health tests
Body Defense IndexUnder 10 K: Weak Antioxidant Defense Reading may indicate conditions with high oxidative stress - example in smokers who have a poor diet and do not take antioxidant supplements. _
10 to 17.5 K: Marginal Antioxidant DefenseCommon reading for people who do not take antioxidant supplements regularly and/or who eat diets low in fruits and vegetables._
17.6 to 25 K: Average Antioxidant DefenseCommon reading for people who eat diets higher in fruits and vegetables and/or take antioxidant supplements._
Above 25 K: Optimum Antioxidant DefenseCommon reading for people who eat healthy diets high in fruits and vegetables and/or take antioxidant supplements.
Raman Scan
70,0
00
65,0
00
60,0
00
55,0
00
50,0
00
45,0
00
40,0
00
35,0
00
30,0
00
25,0
00
20,0
00
15,0
00
10,0
00
5,0
000
300
200
100
0
Std. Dev = 8768.65
Mean = 19281
N = 1266.00
Mean: 19,072Std.Dev.: 8,828N = 1,375
Weak |Mar. | Avg. | Optimum
Raman Scanner Results & Ethnicity(means +/- SD)
0
5000
10000
15000
20000
25000
30000
35000
40000
n = 1162
n = 71
n = 65 n = 25 n = 8n = 12 n = 25
Wea
k |
Mar
. | A
vg.|
Op
t.
Smoking
19890
13030
17600 17591
1305611593
0
5000
10000
15000
20000
25000
30000
Non-Smokers
Smokers(all)
PastSmokers
< 1/day 1-5/day > 5/day
n = 1047
n = 58
p < 0.01
n = 39 n = 10
n = 16
n = 32
Sunlight Exposure
20085 1866016446
0
5000
10000
15000
20000
25000
30000
Low Moderate High
p < 0.01 p < 0.05
n = 550n = 716
n = 96
Wea
k |
Mar
. | A
vg.|
Op
t.
Scanner Readings vs. Fruit & Vegetable Intake
1682719669
2537723997
0
5000
10000
15000
20000
25000
30000
35000
40000
1 or Less 2 to 3 4 to 5 6 or More
n = 534n = 649
n = 137n = 30
p < 0.01 p < 0.01
Wea
k |
Mar
. | A
vg.|
Op
t.
Scanner Readings vs. LifePak Usage
1788820193
2571728848
0
5000
10000
15000
20000
25000
30000
35000
40000
None Irregular One/Day Two/Day
n = 59
n = 89
n = 192
n = 800
p < 0.01 p < 0.01
Effect of LifePak Supplementation
19950
26858
29463
33173
0
5000
10000
15000
20000
25000
30000
35000
40000
45000
Time (weeks)
0 4 8 12
p < 0.01 p < 0.01
Wea
k
| Mar
. | A
vg.|
Op
t.
Individual Changes, Days 1-28
0
5,000
10,000
15,000
20,000
25,000
30,000
35,000
40,000
45,000
Day 1 Day 28
n = 25