not another - cvicvisymposium.com/sitebuildercontent/sitebuilderfiles/cortelli.pdf · •polypoid...
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NOT ANOTHER
TALK ABOUT
A - FIB
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CASES
KUDOS
AND
A CHALLENGE
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Case 1
• 67 y/o female
• s/p R mastectomy 3 months earlier
• Second course of adjuvant chemotherapy
• Muga scan – E.F. 35%
What do we do next?
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Case 1
• Cardiology
• H & P
• Asymptomatic
• PMH: Htn → Atenolol
• Family history neg
• Normal physical exam
• ECHO
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Case 1
What next? MRI
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Case 1
THERE IS A LARGE MASS AS DESCRIBED ABOVE OCCUPYING AND SLIGHTLY DISTENDING THE LEFT ATRIUM. ON THE POSTCONTRAST IMAGES, THE MAJORITY OF THE MASS DOES NOT ENHANCE. THERE ARE SOME PATCHY AREAS OF INCREASED SIGNAL INTENSITY ON THE POSTCONTRAST IMAGES THAT MAY REPRESENT A SMALL AMOUNT OF INTERNAL ENHANCEMENT VERSUS ARTIFACT. THE FINDINGS AS DESCRIBED ABOVE FAVOR A LARGE LEFT ATRIAL THROMBUS. AS THE EXAMINATION DOES DEMONSTRATE A QUESTION OF SOME INTERNAL ENHANCEMENT CONTINUED FOLLOW-UP WITH REPEAT MR OR TRANSESOPHAGEAL ECHO IS RECOMMENDED FOLLOWING TREATMENT TO DOCUMENT IMPROVEMENT IN FINDINGS.
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Case 1
• What could this be?
• Blood clot
• Tumor
• Malignant (?metastatic)
• Benign
• What should we do?
Operate
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Case 1
-------------------------DIAGNOSIS---------------------------
A.\T\B. Left atrial mass, excision - Atrial myxoma
- No malignancy identified
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Myxomas
• Incidence
• Most common cardiac tumor
• 22 autopsy series: 75 per million autopsies
• 75% of benign
• 50% of all cardiac tumors
• Morphology
• Polypoid masses from endocardial surface
• Soft, gelatinous consistency
• Attached by fibrovascular stalk
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Myxomas
• Clinical features
• Commonly in women (60-70%)
• 4th – 6th decades
• Location
• Left atrium (75-80%)
• Right atrium (18%)
• Ventricles in remainder
• Valves – rare
• Carney complex – familial myxoma
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Myxomas
• Carney complex
• Inherited, autosomal dominant
• Multiple tumors
• Atrial & extracardiac myxomas
• Schwannomas
• Endocrine tumors
• Spotty mucocutaneous pigmentation
• Myxomas
• Young men
• Less commonly in left atrium
• Multicentric
• High recurrence after resection
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Myxomas
• Symptoms & signs:
1) Hemodynamic obstruction
2) Embolism
3) Constitutional effects
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Myxomas
• Hemodynamic obstruction
• Left: dyspnea
orthopnea
pnd
syncope
sudden death from arrhythmia
• Right: IVC obstruction
R heart failure
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Myxomas
• Embolism
• ½ of left atrial myxomas
• 50% brain
• Any organ (including coronary arteries)
• P.E. from right atrial myxomas
• <10% clinically detected
• Chronic pulmonary htn
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Myxomas
• Constitutional effects
• Fever
• Malaise
• Wt loss
• Fatigue
• Myalgias
• Arthralgias
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Myxomas
• Diagnosis
• P.E. – murmur
• Left: MV
• Right: TV & R heart failure
• EKG – NSR
• ECHO
• MRI
• Cardiac cath – age > 40
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Myxomas
• Treatment
• Surgery
• En bloc resection without fragmentation
• Irrigate to remove fragments
• Inspect chamber
• Inspect the valve
• Mortality: 0-6.2%
• Embolism
• MI
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Myxomas
• Recurrance
• Local: 1-3%
• Inadequate resection
• Tumor implantation
• Multicentric growth
• Extracardiac
• Not common
• Viable tumor at site of impaction
• Arterial pseudo-aneurysms
• Close follow-up for preoperative emboli
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Case 2
• 64 y/o male @MHM with 2 day h/o SOB, shoulder pain
• Htn, tobacco
• FH: neg
• P.E. : BP 74/26 HR96 RR34
III/VI sys murmur
• Labs: Bun 38 Cr 4.08
Trop T 7.78
• EKG
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Case 1
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Case 2
What next?
Transfer to MHW
Cardiac cath
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Case 2
Surgery
Dacron patch repair of post-infarction
infero-basilar vsd
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Case 2
Post-op
• Cargiogenic shock
• Resp failure – tracheostomy
• Renal failure – dialysis
• Shock liver
Now
• Tracheostomy out
• Off dialysis
• At home
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Case 3
• 75 y/o female with 2-day h/o dyspnea and fatigue
• E.R. with acute worsening SOB
• PMH: chronic asthma, hpl
• Surg: TAA aneurysm repair
• P.E.: SBP 60-70 mm Hg, HR 130-140, RR 30-40
B crackles
• Intubated, ventilated, resuscitated
• Norepinephrine & Neosynephrine
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Case 3
Labs
• BUN/CR – 24/1.46
• Trop T – 1.84
• Pro-BNP – 15234
• ABG’s: 6.9-7.27/38-78/35-54
• INR: 1.2 → 1.8
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Case 3
What next?
ECHO
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Case 3
What’s the diagnosis?
Flail MV
What next?
Operate
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Case 3
Surgery: MVR (27mm pericardial valve)
Cabg x 1 (Lima→LAD)
Post-op:
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Case 3
Post-op
• Cargiogenic shock
• Resp failure
• Renal failure – dialysis
• Shock liver
Now
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KUDOS
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Mechanical Complications of Acute Myocardial Infarction
I. Rupture of left ventricular free wall
II. Rupture of interventricular septum
III. Development of mitral regurgitation
All associated with cardiogenic shock
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Mechanical Complications of Acute Myocardial Infarction
Risk of rupture increased:
I. Delayed hospitalization (>24 hr)
II. Undo in-hospital physical activity
III. Post-infarction angina
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Postinfarction angina more common with mechanical complications
Among patients with a first transmural myocardial infarction, the incidence of postinfaction angina was higher in those with a mechanical complication, including septal rupture (SR), free wall rupture (FWR), and papillary muscle rupture (PMR) compared to the controls who did not have one of these complications. * P<0.0001. • P<0.04. Redrawn from Figueras, J, Cortadellas, J, Calvo, F, et al. J Am Coll Cardiol 1998; 32:135.
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Rupture of Left Ventricle
Incidence
• <1% in all patients with acute M.I.
• 14-26% in patients dying with acute M.I.
• Decline
• Reperfusion therapies
• Better blood pressure control
• B-blockers
• ACE-I’s
• ASA
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Rupture of Left Ventricle
Risk factors
• Absence of collateral blood flow
• Size of the infarct
• Persistent ST elevation
• Persistent or recurrent chest pain
• Anterior wall M.I.
• Age > 70
• Females
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Rupture of Left Ventricle
Clinical presentation
• Sudden death – hemopericardium and tamponade
• Right heart failure → PEA → death
• Incomplete or subacute rupture
• Persistent or recurrent chest pain
• Hypotension
• Pericarditis on EKG
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Rupture of Left Ventricle
Management: survival depends on fast action
• ECHO and pericardiocentesis
• Resuscitation
• Fluids
• Inotropes
• Pressors
• IABP
• Surgery
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Rupture of the Septum
Incidence
• ½ that of free wall rupture
• 3 – 5 days after acute M.I.
Risk factors
• Single-vessel disease (LAD)
• Extensive myocardial damage
• Poor septal collateral circulation
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Rupture of the Septum
Site of rupture
• Anterior = Non-anterior
• Anterior – apical septum
• Inferior – base
• Size determines shunting and survival
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Rupture of the Septum
Clinical manifestations
• Hypotension
• Bi-ventricular failure
• Murmur
• Harsh, loud, holosystolic
• Lower left and right sternal borders
• Thrill in up to 50% of patients
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Rupture of the Septum
Diagnosis
• Pulmonary artery catheter: L → R shunt
• ECHO
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Rupture of the Septum
Management
• Resuscitation
• Fluids
• Inotropes and Pressors
• IABP
• Cardiac catheterization – coronary anatomy
• Surgery – early
• Mortality 20-40%
• Survival improved with concomitant CABG
• Transcatheter closure
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Mitral Regurgitation
Incidence
• Ischemic MR – often managed conservatively
• Papillary muscle or chordal rupture
• 5% of acute MI deaths
• 2 - 7 days after infarct
• More common in prolonged admission delay
and recurrent chest pain
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Mitral Regurgitation
Location
• Posteromedial 6-12x more than Anterolateral
• Blood Supply
• Posteromedial – posterior descending artery
• Anterolateral – LAD and Cx
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Mitral Regurgitation
Clinical Manifestations
• Hypotension
• Pulmonary edema
• Active precordium
• Mid-, late-, or holosystolic murmur
• Little or no murmur at all
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Mitral Regurgitation
Diagnosis – suggested by
• Acute M.I.
• Hemodynamic compromise
• New murmur
Diagnosis – confirmed by
• ECHO
• Cardiac cath to define coronary anatomy
• TEE
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Mitral Regurgitation
Treatment
• Resuscitation
• Fluids
• Inotropes
• IABP
• Surgery
• Usually MVR
• 20-25% mortality
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More KUDOS
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CAB
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30 Day Readmission Rate
Discharge education lectures
Discharge process by cardiac surgery team
Follow up visit within 1 week of discharge by CTS team
Phone call to patients by Medical Director and nursing staff within 72 hrs.