1

Novel Drug Delivery System

Prepared By: Purvi SoniPresented By: Narmin Pirani

2

Need for NDDS

Drug absorption, distribution and

metabolism vary among individuals

Individualized therapy

3

Various types of Drug Delivery Systems

Oral Injection based

Transdermal

Carrier based

4

Here,We will mainly focus on Carrier Based DDS / Target Based DDS

Micells Vesicles

Liquid CrystalsNano carriers

Nanoparticle Nanodiamond

Nanocarriers

5

Approach for use of Nanoparticle

• One of the challenges of chemotherapy is delivery of sufficient quantities of drug to tumor cells for killing them while sparing healthy cells and tissues.

• One strategy for achieving this balance is to use small particles, only nanometers in size, to deliver drugs to tumors.

6

Nanoparticles The prefix nano means a billionth (10-9).

Nanoparticles defined as “particles with at least one dimension smaller than 100 nm or 0.1 μm, and with different properties than particles of larger diameters made of the same material”.

Nanoparticles are able to adsorb and/or encapsulate a drug, thus protecting it against chemical and enzymatic degradation.

The primary goals of Nanoparticles:More specific drug targeting and delivery,Reduction in toxicity while maintaining therapeutic effects,Greater safety and biocompatibility, andFaster development of new safe medicines.

7

8

Overview of nanoparticles and their applications in Life Sciences

Particle class Materials ApplicationNatural materials or derivatives

ChitosanDextranGelatineAlginatesLiposomesStarch

Drug/Gene deliveryDendrimers Branched polymersPolymer carriers Polylactic acid

Poly(cyano)acrylatesPolyethyleinemineBlock copolymersPolycaprolactone

Fullerenes Carbon based carriers PhotodynamicsDrug delivery

9

Nanodiamonds Nanodiamonds are much smaller than typical diamonds, at about 4-5

nm in diameter, have the shape of very tiny soccer balls, and are byproducts of mining and refining operations.

Nanodiamonds are carbon-based particles that can carry a broad range of drug compounds.

They are non-invasive, meaning they can penetrate cell membranes without damaging the cell’s functions.

In recent research, they have been found to have potential cancer treatment properties, and may also be used for dental implants.

10

Recently, scientists found yet another application for the tiny diamonds — as biosensors and drug delivery carriers that can penetrate cells without damaging them.

NDs are highly biocompatible and able to stay inside cells for long periods of time without affecting cellular mechanisms.

Drug–nanodiamond combinations remain in the cells much longer without affecting the tissue surrounding the tumor.

I.E. The researchers found that ND–DOX levels in the tumors were retained for a duration far beyond that of doxorubicin alone, showing that doxorubicin was taken into the tumor and remained their longer when attached to nanodiamonds.