novus biologicals antibodies for neuroscience

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Table of ContentsG-Protein Coupled Receptors .. 2-6Signal Transduction .............. 7-8Epigenetic Regulation .........9-10

Neurogenesis and Gliogenesis ....................11-12

Axon Function and Structure ...13

Sensory Systems: Auditory & Olfactory ..............14Sensory Systems: Vision ...15-16 CNS Control of Metabolism ....17Alzheimer’s Disease ...............18Parkinson’s Disease .........19-20Huntington’s Disease .............21

Multiple Sclerosis ...................22

Stroke, Epilepsy & Traumatic Brain Injury ............................22

Neuronal Markers ...........23-24

Antibody Support Products ......25

Technical Support ...................26

Application KeyChIP - Chromatin Immunoprecipitation

DB - Dot Blot

ELISA - Enzyme-linked Immunosorbent Assay

FACS - Fluorescent Activated Cell Sorting

ICC - Immunocytochemistry

IF - Immunofluorescence

IHC - Immunohistochemistry

IHC-Fr - Immunohistochemistry Frozen

IHC-P - Immunohistochemistry Paraffin

IP - Immunoprecipitation

PEP-ELISA - Peptide Enzyme-linked Immunosorbent Assay

RIA - Radioimmunoassay

WB - Western Blot

Reactivity KeyAv - Avian

Am - Amphibian

Bv - Bovine

Ca - Canine

Ce - C. elegans

Ch - Chicken

Dr - Drosophila

Fe - Feline

Fi - Fish

GP - Guinea Pig

Hu - Human

Le - Leech

Ma - Mammal

Mk - Monkey

Mu - Mouse

Po - Porcine

Rb - Rabbit

Rt - Rat

Xp - Xenopus

Ze - Zebrafish

1

Making Your Success Our GoalNovus is committed to providing researchers with the highest quality antibodies so they may focus on their research. That’s why we’re continually working to provide the most comprehensive data available for our products.

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• 140,000+ images• 15,000+ publications• 650+ reviews • 180,000+ products • 31 applications covered• 46 species covered• 42,000+ gene IDs covered

In addition to our primary antibody products, we offer an array of related research tools including immunoprecipitation and labeling kits, stem cell lines and a variety of secondary antibodies, lysates, peptides and proteins.

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G-protein coupled receptors (GPCRs) have been implicated as signal transducers in a wide variety of physiological processes including sensory systems where they bind opsins, odorants and tastants. GPCRs also affect behavior and mood regulation through interaction with an array of neurotransmitters, including serotonin and dopamine.

G-Protein Coupled Receptors

Purinergic ReceptorsPurinergic receptors bind derivatives of the nucleotide adenosine. Purinergic receptors have been implicated in a wide array of biological processes including modulation of peripheral auditory and visual sensory systems.

Related Antibodies

• Adenosine A1 Receptor

• Adenosine A2a Receptor

• Adenosine A2b Receptor


• GPR17

• GPR86

• P2RY1

• P2Y2

• P2Y4

• P2Y6

• P2Y8

• P2Y10

• P2Y11

• P2Y12

GPR17 Antibody NLS4229

Immuno-histochemicalanalysis of humanbrain (neuronsand glia) usingNLS4229.

Species: HuApplications: IHC-P

Adenosine A2a Receptor (7F6-G5-A2) Antibody NBP1-39474

Immuno-histochemicalanalysis of human brainusing NBP1-39474.

Species: Hu, Mu, Rt, Ca, GP, RbApplications: WB, FACS, IHC-P

Adregergic ReceptorsThe adrenergic receptors (adrenoceptors) are targets of catecholamines, excluding dopamine.Binding of an agonist to one of these receptors generally triggers a sympathetic (fight-or-flight) response.

Related AntibodiesAlpha 2a Adrenergic Receptor Antibody NBP1-67832

Immuno-histochemicalanalysis of humantestis tissueusing NBP1-67832.

Species: Hu, Mu, RtApplications: WB, ELISA, IF, IHC-P

Calcium-Sensing ReceptorCalcium-sensing receptors (CaSRs) sense extracellular levels of calcium ions. The binding of calcium induces a conformational change in the receptor and triggers the phospholipase C pathway, ultimately increasing the intracellular concentration of calcium.

Immuno-histochemicalanalysis of humanpancreas usingNBP1-84687.

Species: HuApplications: WB, IHC-P

Calcium Sensing Receptor Antibody NBP1-84687

• Alpha 1 Adrenergic Receptor

• Alpha 1b Adrenergic Receptor

• Alpha 1d Adrenergic Receptor

• Alpha 2a Adrenergic Receptor

• Alpha 2b Adrenergic Receptor

• Alpha 2c Adrenergic Receptor

• Beta 1 Adrenergic Receptor




5-Hydroxytryptamine Receptors5-hydroxytryptamine (5-HT) receptors, also known as serotonin receptors, are found in the central and peripher-al nervous systems where they mediate neurotransmission and have been implicated in a wide array of biologi-cal and neurological processes including appetite, mood, nausea, sleep, and sexuality.

• 5HT1A

• 5HT1D

• 5HT1E

• 5HT1F

• 5HT2A

5-HTR2C Antibody NBP1-90317

Immuno-histochemicalanalysis of human pancreasusing NBP1-90317.

Species: HuApplications: WB, IF, IHC-P

5-HTR1A Antibody NBP1-90321

Immuno-histochemicalanalysis ofthymus, endothelialrecticular cellsusing NBP1-90321.


Neuropeptide ReceptorsNeuropeptides function as intracellular signaling molecules and affect gene expression, local blood flow, synaptogenesis and glial cell morphology. Neuropeptides are packaged in large, dense-core vesicles and are located on every part of a neuron, including the soma, dendrites, axonal swellings and nerve endings.

Related Antibodies

• GPR8

• GPR154

• Neurotensin Receptor 1

• Neurotensin

Receptor 2

• NMBR

• NMUR1

• NMUR2

• NPFFR1

• NPFFR2

• NPBWR1

• NPYR5

• NTSR2

NMBR AntibodyNBP1-89520

Immuno-fluorescent analysis showing positivityin plasmamembrane & cytoplasmusing NBP1-89520.


NMUR1 Antibody NBP1-83433

Immuno-histochemicalanalysis ofof human duodenumusing NBP1-83433.


Bombesin ReceptorsThis class of receptors is located largely in the central nervous system and the gastrointestinal tract. Bombesin receptors mediate the nuerological anxiety response as well as smooth muscle contraction and eating behavior. These ligands have also been implicated in many neurodegenerative diseases.

Immuno-histochemicalanalysis of placentausing NLS4915.


Bombesin Receptor 3 Antibody NB100-74372

Immuno-histochemicalanalysis ofhuman pancreaticcarcinoma tissuesections usingNB100-74372.

Species: HuApplications: WB, IHC, IHC-P

Bombesin Receptor 3 Antibody NLS4915

Related Antibodies

• 5HT2B

• 5HT2C

• 5HT5A

• 5HT6

• 5HTR7


GRPR Antibody NB100-74434

Immuno-histochemicalanalysis of humanmammary carcinomatissue usingNB100-74434.



Muscarinic Acetylcholine ReceptorsAcetylcholine (ACh) is an abundant neurotransmitter, found in the central nervous system, autonomic preganglia and spinal motor neurons. There are two main subtypes of ACh receptors – nicotinic and muscarinic. Muscarinic receptors (mAChRs) are responsible for the post stimulation hyperpolarization and slow depolarization of the postganglionic neuron. mAChRs modulate an array of physiological functions, including smooth muscle contractions, heart rate, and glandular secretions

Muscarinic Acetylcholine Receptor 2 Antibody NBP1-86351

Immuno-histochemicalanalysis of humankidney usingNBP1-86351.


Muscarinic Acetylcholine Receptor M4 Antibody NBP1-70994

Immuno-fluorescent analysis of LOVO cells usingNBP1-70994.

Species: Hu, Mu, RtApplications: ELISA, IF

Dopamine ReceptorsMany neurological responses are modulated by dopamine signaling. There are two families of dopamine receptors: the D1-like family (D1 and D5) and the D2-like family (D2 through D4). Activation of receptors in the D1-like family activates adenylyl cyclase, increasing the intracellular concentration of cAMP. Conversely, activation of receptors in the D2-like family inhibits the formation of cAMP by inhibiting adenylate cyclase.


Immuno-histochemicalanalysis of Kidney, Proximal & distal cinvoluted tubules using NLS44.

Species: HuApplications: ICC, IHC-P

Dopamine Receptor D1 Antibody NLS44

Customer Review

Dopamine Receptor D1 Antibody (SG2-D1a)(NB110-60017)Application: IHC-FrSample Tested: Rat retinal whole mounts and sectionsSpecies: RatLot: A1

Dopamine Receptor D1 Antibody NBP1-87577

Immuno-histochemicalanalysis of human skinusing NBP1-87577.


Tuftelin 1 Antibody Antibody NBP1-87446


Immuno-histochemicalanalysis of human duodenum usingNBP1-87446.

GABA-B ReceptorsGABA-B receptors are inhibitory receptors found in the central and peripheral autonomic nervous systems. Ligand binding triggers a signaling cascade that ultimately inhibits neurotransmitter release. GABA-B receptors may play important roles in the development and sensation of pain.

GABA B Receptor 1 Antibody NBP1-19356

Immuno-histochemicalanalysis of humanbrain tissue usingNBP1-19356.

Species: Hu, Mu, RtApplications: WB, IHC-P


Immuno-histochemicalanalysis ofhuman duodenumusing NBP1-89803.



Immuno-histochemicalanalysis of humanbrain cortex usingNBP1-52389.

Species: Hu, Mu, Rt, Bv, CaApplications: IHC-P


Cannabinoid Receptors Cannabinoids are a group of terpenophenolic compounds present in the nervous and immune systems. There are two defined types of cannabinoid receptors, designated CB1 and CB2. CB1 receptors are considered the most widely expressed GPCRs in the brain.

Cannabinoid Receptor II Antibody NBP1-88175

Immuno-histochemicalanalysis of humanhippocampususing NBP1-88175.


Immuno-histochemicalanalysis of brain, neuronsusing NLS31.

Species: Hu, Rt, MkApplications: ICC, IHC-Fr, IHC-P

Cannabinoid Receptor I Antibody NLS31

Histamine ReceptorsHistamine is a biogenic amine that is involved in local immune responses, digestive regulation and neurotransmission.

Histamine H4 Receptor Antibody NBP1-90058

Immuno-histochemicalanalysis of humancorpus, uterineusing NBP1-90058.


Histamine receptor H3 Antibody NLS476

Immuno-histochemicalanalysis showingtransfection positiveusing NLS476.


Vasopressin ReceptorsVasopressin, also known as arginine vasopressin (AVP) or antidiuretic hormone (ADH), is a peptide hormone responsible for regulating the body’s retention of water, as well as a variety of neurological effects.

AVPR1B Antibody NB100-96917

Immuno-histochemicalanalysis of humananterior pituitary glandusing NB100-96917.

Species: HuApplications: IHC, PEP-ELISA

Western blotanalysis ofNIH3T3 lysateusing NBP1-00157.

Species: Hu, MuApplications: WB, PEP-ELISA

AVPR2 Antibody NBP1-71315

Immuno-fluorescent analysis of MCF7 cells usingNBP1-71315.

Species: HuApplications: WB, ELISA, IF

AVPR1A Antibody NBP1-00157

Somatostatin ReceptorsSomatostatin is a peptide hormone that interacts with G-protein coupled somatostatin receptors. Somatostatin is an inhibitory hormone that functions in regulation of the endocrine system, neurotransmission and cell proliferation.

Somatostatin Receptor 2 Antibody NB300-157

Immuno-histochemicalanalysis of rattissue usingNB300-157.

Species: Hu, Mu, RtApplications: WB, IF, IHC-Fr, IHC-P, IP

Western blotanalysis from rat pancreas using NB300-120.

Species: Hu, Mu, RtApplications: WB, IP


Immuno-histochemicalanalysis ofhuman pancreaticislands usingNB100-74538.

Species: HuApplications: WB, ICC, IHC-P



Histamine Antibody NBP1-78351

Immuno-histochemicalanalysis of of rat hypothalamus using NBP1-78351.

Species: Hu, Rt, Dr, Le, OtherApplications: IHC-Fr, IHC-P


Immuno-histochemicalanalysis of humanhippocampususing NBP1-88175.


Latrophilin ReceptorsLatrophilin receptors are brain-specific, calcium-independent orphan GPCRs of the secretin family. Latrophilin-1 and latrophilin-2 bind alpha-latrotoxin, a potent pre-synaptic neurotoxin present in the venom of black widow spiders.

LPHN2 Antibody NBP1-71100

Immuno-histochemicalanalysis of humanbreast carcinomatissue usingNBP1-71100.

Species: Hu, Mu, RtApplications: ELISA, IF, IHC

Immuno-fluorescent analysis ofLOVO cellsusing NBP1-71099.

Species: Hu, Mu, RtApplications: ELISA, IF

LPHN3 Antibody NLS1138

Immuno-histochemicalanalysis ofbrain, neurons andglia usingNLS1138.


LPHN1 Antibody NBP1-71099

Brain-Specific Angiogenesis InhibitorsBrain-specific angiogenesis inhibitors (BAIs) are orphan GPCRs with unknown ligands. There are three BAI genes, which have similar tissue specificities and structures. BAI expression has been reported primarily in the brain.

Immuno-histochemicalanalysis ofmouse brainusing NB110-81536.

Species: Hu, MuApplications: IHC-P

BAI3 Antibody NBP1-82996

Immuno-histochemicalanalysis ofhuman duodenumusing NBP1-82996.


BAI1 Antibody NB110-81586

Customer Reviews

BAI1 Antibody (NBP1-00723)Application: IFSample Tested: THP1 cell line Species: Human

GHRH Receptor Growth hormone releasing hormone receptor (GHRHR), stimulates growth hormone (GH) secretion and synthesis in the pituitary gland. Mutations in GHRHR can cause either GH deficiency, resulting in dwarfism, or excessive production of GH, leading to gigantism. GHRHR is primarily expressed in the brain.

Parathyroid Hormone ReceptorsParathyroid hormone receptors (PTHRs) bind parathyroid hormone (PTH), parathyroid hormone- related peptide (PTHRP), and tuberoinfundibular peptide 39. PTHR2 has only been identified in the brain. Due to its neuronal localization, PTHR2 is thought to function as a neurotransmitter receptor.

Immuno-histochemicalanalysis in human ovarian carcinoma samples usingNB100-74424.

Species: HuApplications: WB, ICC, IHC, IHC-P

GHRHR Antibody NB100-74424

Parathyroid Hormone Receptor 1 Antibody (4D2) NBP1-51640

Immuno-fluorescent analysisof SK-BR-3 cellsusing PTH1Rmouse mAb (green)using NBP1-51640.

Species: HuApplications: WB, ELISA, IF, IHC-P

Parathyroid Hormone Receptor 2 Antibody NLS250

Immuno-histochemicalanalysis ofbrain, neuronsand glia usingNLS250.




ChannelsChannels are especially important in transmitting signals from sensory organs to the brain. Channels act both as receptors that transfer signals and as openings in the plasma membrane to allow chemicals such as potassium and calcium to move into and out of a cell.

Signal TransductionRelated Antibodies

• 5HT3A Receptor

• ATP5E

• CACNB4

• Cav1.2

• KCNH1

• Kv1

• Kv1.2

• Kv1.3

• NMDAR1

• Potassium voltage- gated channel

• TREK 1

• TRPA1

• TRPC3

• TRPC4

• TRPC5

• TRPM2

TRPA1 Antibody NB110-40763

Immuno-histochemicalanalysis of mouseintestine usingNB110-40763.

Species: Hu, MuApplications: WB, IHC, IHC-P

TRPM2 Antibody NB110-81601

Immuno-cytochemicalanalysis ofrat hippocampususing NB110-81601.

Species: Mu, RtApplications: WB, ICC, IF, IHC

NMDA Receptors NMDA receptors are ionotropic glutamate receptors that regulate the opening and closing of ion channels that control the flux of Ca2+, K+, and Na+ into and out of cells. NMDA receptor interactions are crucial to proper cellular function and communication, especially in neurons. Malfunctioning NMDA receptors may be a crucial factor in Huntington’s Disease.

Related Antibodies

• NMDAR2B

• NMDA Receptor C1

• NMDA Receptor N1

• NMDAR1

• NMDAR2A

• NMDAR2C

• NMDAR2D

• NMDAR3A

• NMDAR3B

• NMDARA1

NMDA receptor N1 Antibody NB300-114

Western blotanalysis of HEK 293 cells using NB300-114.

Species: Hu, Mu, RtApplications: WB, DB, IHC-Fr

NMDAR1 AntibodyNBP1-20085

Immuno-histochemicalanalysis of human spinalcord tissue usingNBP1-20085.

Species: Hu, Mu, RtApplications: IHC-P

NMDAR2B Antibody NBP2-12999

Immuno-histochemicalanalysis of human braintissue usingNBP2-12999.


Customer Reviews

NMDAR1 Antibody (NB100-74473)Application: IHC-FrSample Tested: Tissue sections of mouse brainSpecies: Mouse

NMDAR1 Antibody (NB100-92192)Application: IHC-PSample Tested: RatSpecies: Rat

NMDAR2B Antibody (NB300-106)Application: IFSample Tested: Rat brain tissueSpecies: OtherOther Species: Donkey anti-rabbit

Kv1.2 AntibodyNBP1-42802

Immuno-cyctochemicalanalysis in 293 human embryonic kidney cells using NBP1-42802.

Species: Hu, Mu, Rt, Bv, Ca, Po, Xp, ZeApplications: WB, ICC

Cav1.2 AntibodyNBP1-42817

Immuno-cyctochemicalanalysis in mouse 3T3 fibroblasts using NBP1-42817.

Species: Hu, Mu, Rt, Bv, Ca, RbApplications: WB, ICC, IF, IP

KCNH1 AntibodyNBP1-42816

Western blotanalysis in HEK cells using NBP1-42816.

Species: Hu, Mu, Rt, BvApplications: WB, ICC, IF, IP


Related Antibodies

Related Antibodies

Signaling ProteinsSignaling proteins facilitate the cellular implementation of messages received from other cells and organ systems, providing a transition between neurons and the cells that they affect.

Related Antibodies

• Calmodulin

• Calreticulin

• RGS1

• SNAP25

• Striatin

• Synaptotagmin

Calreticulin Antibody NB600-101

Western blot analysison human kidney lysate usingNB600-101.

Species: Hu, Mu, Rt, BvApplications: WB, ICC, IF, IHC

Striatin Antibody NB110-74571

Immuno-fluorescentanalysis ofNIH3T3 cells using NB110-74571.

Species: Hu, Mu, RtApplications: WB, IF, IP

[NMDAR1 (R1JHL) Antibody NB300-118] Tao P-L, Chen C-F, Huang EY-K. Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat off-spring. J Biomed Sci. 2011 Aug 23;18(1):64. [PMID: 21861871][NMDAR2B Antibody NB300-106] Tse YC, Bagot RC, Hutter JA, et al. Modulation of Synaptic Plasticity by Stress Hormone Associates with Plastic Alteration of Synaptic NMDA Receptor in the Adult Hippocampus. PLoS ONE. 2011 6(11). [PMID: 22069501][NMDAR2B Antibody NB300-106 and NMDAR2B Antibody NB300-116] Das SR, Magnusson KR. Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging. Behav. Brain Res. 2011 Sep 12;222(1):122-133. [PMID: 21443909][SNAP25 Antibody NB100-1492] Guedj F, Pereira PL, Najas S, et al. DYRK1A: A master regulatory protein controlling brain growth. Neurobiology of Disease. 2012 Jan 26. [PMID: 22293606][TRPM2 Antibody NB110-81601] Bai JZ, Lipski J. Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Neurotoxicology. 2010 Jan 12. [PMID: 20064552] [TRPM2 Antibody NB110-81601and TRPM2 Antibody NB500-242] Chung KK, Freestone PS, Lipski JL. The expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol. 2011 Sep 7. [PMID: 21900507]

Product Citations

SNAP25 Antibody NBP1-88769

Immuno-histochemicalanalysis of human cerebralcortex usingNBP1-88769.

Species: Hu Applications: WB, IHC-P

Calmodulin (2D1) Antibody NB120-2860

Immuno-fluorescentanalysis inrat brain usingNB120-2860.

Species: Rt, Ba, Bv, ChApplications: WB, ELISA, ICC, IF

Synaptotagmin 2 Antibody NBP1-90356

Immuno-histochemicalanalysis of human stomach using NBP1-90356.


RGS1 AntibodyNBP1-68645

Immuno-histochemicalanalysis of human coloncarcinoma tissueusing NBP1-68645.

Species: Hu, Mu, RtApplications: ELISA, IHC-P

Calreticulin (1G6A7) Antibody NBP1-47518

Immuno-fluorescentanalysis of 3T3-L1cells using NBP1-47518.

Species: Hu, Mu Applications: WB, ELISA, IF

Synaptotagmin 1 Antibody NBP1-61218

Immuno-histochemicalanalysis of human breastcarcinoma tissueusing NBP1-61218.

Species: Hu, Mu, RtApplications: WB, ELISA, IHC


Chromatin modification and DNA-modifying enzymes have been shown to regulate various pathways in the development and function of the nervous system. Several areas of epigentics control of neural activity actively studied include histone acetylation and DNA methylation in response to neutrotrophin signaling as well as how DNA methylation, histone modification and transcriptional feedback loops promote self-renewal and differentiation of adult neural stem cells. [PMID: 20975746]

Epigenetic Regulation

• alpha-Synuclein• Amyloid beta Precursor Protein• BACE1• BDNF• beta Amyloid• c-FOS• Gamma-secretase• GNAT• Histone H3

• Histone H3 [Monomethyl Lys9]

• Histone H3 [Trimethyl Lys9]• Histone H4• Huntingtin• MeCP2• NFkB• NRSF• p21• REST• SETDB1• SMCX

Related Antibodies

Histone H3 [Dimethyl Lys9] Antibody NB21-1072

Western blot analysis of H3K9me2 in C. elegans embryo lysate usingNB21-1072.

Species: Hu, Mu, Rt, Ce, MaApplications: WB, ChIP, DB, ICC, IF

Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Antibody NB21-1202

Chromatin from one million formaldehyde cross-linked Hela cells was used with 2 ug of NB21-1202.

Species: Hu, Mu, CeApplications: WB, ChIP, DB, ICC, IF

beta Amyloid (MOAB-2) Antibody NBP2-13075

Western blot analysis of betaAmyloid inHEK-APP SWE/BACE1 cellsusing NBP2-13075.

Species: Hu, MuApplications: WB, ELISA, ICC, IF, IHC-P, IP

Customer Reviews

FOS Antibody (NB100-91772)Application: IHCSample Tested: MouseSample Pretreatment: Citrate bufferSpecies: Mouse

p21 Antibody (WA-1) (NB500-303)Application: Western blotSample Tested: Horse skinSample Pretreatment: 100 ugSpecies: Equine

Histone H3 Antibody (NB500-267)Application: Western blotSample Tested: HeLa cell lysatesSample Pretreatment: 50 ugSpecies: Rat

MeCP2 Antibody (NB600-1101)Application: Western blotSample Tested: iPS (Induced Pluripotent stem cells derived from AFMSC)Sample Pretreatment: Lysis bufferSpecies: Human

Histone Acetyltransferase Antibodies

• AIB1

• CLOCK

• ELP3

• KAT1

• KAT2A

• KAT3A/CBP

• KAT3B/p300

• KAT6B-MORF

• MYST1

• MYST3

• NCOA2

• PCAF

• SRC1

• TAF1

• TIP60

KAT3B/p300 (RW128) Antibody NB100-507

Western blot analysis of p300in a HeLa nuclearexctract usingNB100-507.

Species: Hu, Mu, Rt, MkApplications: WB, IF, IP

KAT3A/CBP Antibody (NB100-381)Application: IPSample Tested: HeLa cell lysatesSpecies: Human

Customer Review

TIP60 Antibody NBP1-61537

Immuno-histochemical analysis of human liver carcinoma tissue usingNBP1-61537.

Species: Hu, MuApplications: ELISA, IF, IHC

CLOCK AntibodyNB100-126

Western blotanalysis of alpha CLOCK immunoprecipitated DNA using NB100-126.

Species: Hu, MuApplications: WB, ChIP


Histone H3 [Dimethyl Lys9] Antibody NB21-1072

Western blot analysis of H3K9me2 in C. elegans embryo lysate usingNB21-1072.

Species: Hu, Mu, Rt, Ce, MaApplications: WB, ChIP, DB, ICC, IF

KAT3A/CBP Antibody (NB100-381)Application: IPSample Tested: HeLa cell lysatesSpecies: Human

TIP60 Antibody NBP1-61537

Immuno-histochemical analysis of human liver carcinoma tissue usingNBP1-61537.

Species: Hu, MuApplications: ELISA, IF, IHC

Histone Deacetylase Antibodies

• HDAC1

• HDAC2

• HDAC3

• HDAC4

• HDAC5

• HDAC6

• HDAC7

• HDAC8

• HDAC9

• HDAC10

• HDAC11

• Sir2.1

• SIRT1

• SIRT2

• SIRT3

• SIRT4

• SIRT5

• SIRT6

• SIRT7

SIRT6 Antibody NB100-2522

Species: MuApplications: IHC-P, WB

Immuno-histochemical analysis of human testes tissue using NB100-2522.

HDAC6 Antibody NBP1-78981

Species: HuApplications: IF, ICC

Immuno-cytochemicalanalysis in HeLa cells with FITC (green) using NBP1-78981.

SIRT1 Antibody NBP1-49540

Species: HuApplications: IHC, WB

Immuno- histochemical analysis in human renal cell carcinoma using NBP1-49540.

[alpha-Synuclein (24.8) [Nitrate Tyr123, Nitrate Tyr133] Antibody NBP1-26380] Huang Z, Xu Z, Wu Y, Zhou Y. Determining nuclear localization of alpha-synuclein in mouse brains. Neuroscience. 2011 Oct 19. [PMID: 22033456][BACE1 NB120-2077] Chang W, Barnes AM, Cabral WA, et al. Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complex. Hum Mol Genet. 2010 Jan 15;19(2):223-34. [PMID: 19846465]

[CLOCK Antibody NB100-126] Xu CX, Krager SL, Liao DF, et al. Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene. Toxicol Sci. 2010 May;115(1):98-108. [PMID: 20106950][Histone H3 Antibody NB500-171] Liu R, Lei JX, Luo C, et al. Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer’s disease. Neurobiology of Disease. 2012 45(3):902-912. [PMID: 22186421][Histone H3 [Asym-dimethyl Arg8] Antibody NB21-1062] Blythe SA, et al. beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev Cell. 2010 Aug 17;19(2):220-31. [PMID: 20708585][Histone H3 [Dimethyl Lys36] Antibody NB21-1252] Hsia DA, et al. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9671-6. [PMID: 20457893][Histone H3 [p Thr3, Monomethyl Lys4] Antibody NB21-1012] Metzger E. et al, Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature. 2010 Apr 1;464(7289):792-6. [PMID:20228790][KAT3B/p300 Antibody NB500-161] Luo W, Hu H, Chang R, et al. Pyruvate Kinase M2 is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1. Cell. 2011 May 27;145(5):732-44. [PMID: 21620138][p21 (WA-1) Antibody NB500-303] Deschene K, Céleste C, Boerboom D, Theoret CL. Constitutive expression of hypoxia-inducible factor-1 a in keratinocytes during the repair of skin wounds in horses. Wound Repair Regen. 2011 Mar-Apr;19(2):250-9. [PMID: 21362093][SETDB1 Antibody NBP1-84790] Ceol CJ, et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 2011 Mar 24;471(7339):513-7. [PMID: 21430779][SMCX Antibody NB100-55328] M. L. C. Powell, J. A. Smith, M. E. Sowa, et al. NCoR1 Mediates Papillomavirus E8^E2C Transcriptional Repression. J. Virol. 2010 84 (9): 4451-4460. [PMID: 20181716]

Product Citations

Novus offers our Epi-Plus™ antibodies for modified histones. All Epi-Plus™ antibodies are multi-assay validated, including testing by dot blots using modified peptide arrays, western blots, and chromatin immunoprecipitation (ChIP). Learn more at www.novusbio.com/epi-plus.html

Epi-Plus®

HDAC2 Antibody NBP1-87109


Immuno-fluorescentanalysis showingpositivity in nucleiusing NBP1-87109.


Neurogeneisis is the formation of new neuronal cells. Once thought only to occur in developing organisms, recent studies have shown that neurogeneis occurs through an organism’s lifespan and plays a crucial role in neuron plasticity. Gliogeneisis is the formation of non-neuronal glia population. Glia cells function to support neural cells by providing physical structure and insulation, supplying nutrients and destroying pathogens. The Notch signaling pathway plays a major regulatory role in both events which are also affected by the Wnt and SHH pathways. Disruption of these processes has been implicated in several neurodegenerative diseases including Parkinson’s and Multiple Sclerosis.

Neurogenesis and Gliogenesis

Related Antibodies

• AKT

• alpha Catenin

• Axin 1, 2

• beta Catenin

• CCL12

• CCL2

• CNTF

• CSPG4P5

• Delta 1, 3, 4

• Dishevelled

• EGF

• Eotaxin

• FGF

• GABA

• gamma-Secretase

• GFAP

• Glutamate Receptor 5

• HIP1

• IGF1

• IGF1 Receptor

• Jagged 1, 2

• JAK 1, 2, 3

• LRP2

• LRP5/6

• MASH1

• Neurogenin 1

• NMDA

• Notch1

• NRG1

• NUMB

• OLIG2

• PACAP Receptor

• Sonic Hedgehog

• SS18L1

• Stat 1–6

• TGF alpha

• VIP

• Wnt

Customer Reviews

PPAR delta Antibody (NB600-637)Application: IHC-P Sample Tested: Gerbil stomachSpecies: Gerbil

AKT1 Antibody (NB600-467)Application: Western blotSample Tested: Mouse spleen lysateSpecies: Mouse

FGFR1 Antibody (M19B2) (NB600-1287)Application: FACSSample Tested: Transfected cell lineSpecies: Rat

Delta 1, 3, 4

Jagged 1, 2

Notch 1, 2, 3, 4

NICD

γ-Secretase

HDACCoR

CSL

MAML

CSL

NICD

p300

X

CoA

Overview of the Notch Signaling Pathway

11

Notch 1 Antibody NBP1-78292

Immuno-histochemicalanalysis in humankidney usingNBP1-78292.

Species: Hu, MuApplications: WB, IHC-P


Western blot analysis in 1. HepG2, 2. MCF7, and 3. Cos7 whole cell lysates using NBP1-54467.

beta Catenin Antibody (12F7) Antibody NBP1-54467

NUMB Antibody NB500-178

Western blot analysis of isoforms 1 and 2 in A431 whole cell lysate using NB500-178.

IGF1 Receptor Antibody NBP1-77679

Immuno-cytochemicalanalysis in A431 cells with FITC (green) using NBP1-77679.

Jagged1 Antibody NB600-1161

Immuno-fluorescentanalysis ofhuman corneal epithelial cellsusing NB600-1161.

Neurogenin 1 (3F9) Antibody NBP1-47871

Immuno-histochemicalanalysisof prostate tissueusing NBP1-47871.

Species: Hu, Mu, Rt, Ch, MkApplications: WB, ICC, IF, IHC-P, IP

Species: Hu, Mu, Rt, ChApplications: WB

Species: Hu, Mu, Rt, MkApplications: WB, ICC, IF, IHC-P

Species: Hu, Mu, RtApplications: WB, ELISA, IF, IHC-P


[AKT2 Antibody NBP1-26594] Lin HP, Jiang SS, Chuu CP. Caffeic Acid Phenethyl Ester Causes p21 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells. PLoS One. 2012;7(2). [PMID: 22347457][EGFR Antibody (29.1) NB120-10414] Kondratov, K.A., et al., Termination Of Tyrphostin AG1478 Application Results In Different Recovery Of EGF Receptor Tyrosine Residues 1045 And 1173 Phosphorylation In A431 Cells. Cell Biol. Int. 2010 34:81-87. [PMID: 19947936][GABA A Receptor gamma 2 Antibody NBP1-52033] You IJ, Jung YH, Kim MJ, et al. Alterations in the emo-tional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT1A, GABA(A), and NMDA receptors. Neuropharmacology. 2012 Feb;62(2):1034-43. [PMID: 22074644][GABA B Receptor 1 Antibody NB300-160] Luo C, Rajput AH, Robinson CA, Rajput A. Gamma- aminobutyric acid (GABA)-B receptor 1 in cerebellar cortex of essential tremor. J Clin Neurosci. 2012 Feb 7. [PMID: 22321358][GABARAP Antibody NB300-158] Diaz MR, Christian DT, Anderson NJ, McCool BA. Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses. J. Pharmacol. Exp. Ther. 2011 Apr;337(1):162-170. [PMID: 21209156][GFAP Antibody NB300-141] O’Donnell LA, Conway S, Rose RW, et al. STAT1-Independent Control of a Neurotropic Measles Virus Challenge in Primary Neurons and Infected Mice. J Immunol. 2012 Feb 15;188(4):1915-23. [PMID: 22246627][HIP1 (1B11) Antibody NB300-204] Datta M, Bhattacharyya NP. Regulation of RE1 Protein Silencing Transcription Factor (REST) Expression by HIP1 Protein Interactor (HIPPI). J Biol Chem. 2011 Sep 30;286(39). [PMID: 21832040] [Notch1 Antibody NB300-251] Sciacca S, Pilato M, Mazzoccoli G, Pazienza V, Vinciguerra M. Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease. Heart Vessels. 2012 Feb 28. [PMID: 22370592][PKC delta (K15-K) Antibody NBP1-30125] Ku CS, Park Y, Coleman SL, Lee J. Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. The Journal of Nutritional Biochemistry. 2011 Dec 29. [PMID: 22209005]

Product Citations

HIP1 (4B10) Antibody NB300-203

Western blot on HeLa whole cell extractsusing NB300-203.

Species: HuApplications: WB

Sonic Hedgehog Antibody NBP1-69270

Immuno-histochemicalanalysis ofchicken embryosusing NBP1-69270.

Species: Hu, Mu, Rt, Ca, Ch, Xp, ZeApplications: WB, IHC-P

Wnt1 (10C8) Antibody NBP1-51575

Immuno-fluorescentanalysis of 3T3-L1 cells usingNBP1-51575.

Species: Hu, MuApplications: WB, ELISA, FACS, IF, IHC-P

Immuno-histochemicalanalysis ofhuman braintissue usingNBP1-68600.

Dishevelled 3 Antibody NBP1-68660

Species: Hu, MuApplications: ELISA, IHC


Axons are the part of a neuronal cell that carries signals away from the soma. For a given neuronal cell type, axons may vary greatly and undergo extensive branching. Axonal growth is stimulated by a variety of neutrophic growth factors (NTFs) and also regulated by Src family kinases (SFKs). [PMID: 17646673] Guidepost cells assist in axon growth and play a role in neuroregeneration, in which damaged axons regenerate synaptic connections with other neurons. Under normal physiological conditions, “axon-pruning” occurs as a mechanism to maintain connectivity and plasticity and also to repair damaged axons. [PMID: 16022592] Axon loss contributes to neurological symptoms in disorders including multiple sclerosis, stroke and chronic neurode-generative diseases. [PMID: 12220882]

Axon Function and Structure

Related Antibodies

• alpha 2 Mannosidase 2A

• BDNF

• BLK

• ChABC

• F-actin

• FGR

• FRK

• Fyn

• GDNF

• GFAP

• Gigaxonin

• GNB5

• Hck

• Laminin

• Lck

• Lyn

• Mitofusin 1, 2

• Myelin Protein Zero

• Netrin 1

• Netrin-G1 Ligand

• Neurotrophin 3

• Neurotrophin 4

• Neurturin

• NGF

• p75NTR

• PMP22

• Src

• TDP1

• TNF alpha

• TrkA

• TrkB

• TrkC

• Yes1

Immuno-cytochemical analysis in Hela cells (green)using NB300-144.

Laminin Antibody NB300-144

PMP22 (Hu1) Antibody NB110-59086

Immuno-histochemicalanalysis in dorsal root ganglion and spinal roots in 20 week fetal spinal cord usingNB110-59086.

Western blot analysis ofChondroitinaseABC usingNBP1-96141.

ChABC (6A12) Antibody NBP1-96141

Src [p Tyr418] Antibody NBP1-60970

Immuno-histochemicalanalysis human colonusing NBP1-60970.

Species: Hu, Mu, RtApplications: WB, ICC, IHC-Fr, IHC-P

Mitofusin-1 Antibody NBP1-51841

Immuno-histochemicalanalysis ofmouse intestineusing NBP1-51841.

Species: Hu, MuApplications: ICC, IF, IHC-P

Species: Hu, MkApplications: IHC-P

Species: NAApplications: WB, ELISA

Species: Hu, Mu, RtApplications: WB, WB, ELISA, IHC-P

GFAP Antibody NB300-141

Immuno-fluorescentanalysis of mixedneuron glial culturesusing NB300-141.

Species: Hu, Mu, Rt, Bv, Fe, PoApplications: WB, ICC, IF, IHC-Fr, IHC-P

Dendrite

Cell body

Myelin sheath(Schwann cell)

Node of Ranvier

Axon

Axon terminals

Customer Reviews

BLK Antibody (7A12) (H00000640-M02)Application: Western blotSample Tested: Recombinant (r) BLK, Ramos whole cell lysate, Jurkat whole cell lysateSpecies: Human

Laminin Antibody (NB300-144)Application: IHC-FrSample Tested: RatSample Pretreatment: DoxorubicinSpecies: Rat

Src [p Tyr418] Antibody (NB100-92633)Application: IFSample Tested: RatSpecies: Rat


Species: Hu, Mu, RtApplications: WB, ICC, IHC-Fr, IHC-P

Species: Hu, Mu, RtApplications: WB, WB, ELISA, IHC-P

AuditoryHearing is a complex interaction between many structures of the ear that amplify sound vibrations, convert vibrations into electrical signals, and then carry those signals to the brain. Neurotransmitters convey signals from the hair cells of the inner ear to auditory neurons. The encoded message travels through multiple areas of the brain until it is relayed to the primary auditory cortex via the temporal lobe. Defects in certain hearing related proteins have been associated with hearing loss; these proteins include Tubby, Myosin 1C and proteins associated with Waardenburg syndrome (PAX3, MITF, EDNRB, EDN3 and SOX10.)

Related Antibodies

• ARC

• Connexin 26

• Endothelin

• Endothelin 3

• MiTF

• Myosin 1C

• PAX3

• Tubby

• TULP1

• TULP2

• TULP3

• TULP4

Tubby Antibody NB100-1922

Western blotanalysis of tub-1 (GFP complex) using NB100-1922.

Myosin 1C Antibody NBP1-87745

Immuno-histochemicalanalysis ofhuman gallbladder usingNBP1-87745.

Species: CeApplications: WB, IHC-P, IP


OlfactoryThe initial olfactory signal is initiated when an odorant molecule binds to an olfactory receptor which triggers the activation of a G-protein signal cascade. Olfactory receptors are GPCRs similar to those known to be important in neurotransmission and photoreception; there are as many as 1,000 genes for ORs in the mammalian genome. [PMID: 17903277]

Related Antibodies

• Adenylyl Cyclase 3

• Cyclic AMP

• F-Actin

• GABA A Receptor alpha 1

• MAP2

• NKCC1

• Phospholipase C beta 2

• TRPC6 Novus offers hundreds of antibodies for ORs. Visit www.novusbio.com and search on your gene of interest to find related products.

MAP2 Antibody NB300-213

Immuno-cytochemicalanalysis ofmixed neuron/glialcultures using NB300-213.

Adenylate Cyclase 3 Antibody NBP1-92683

Immuno-fluorecentanalysis ofMixed neuron-glial cultures usingNBP1-92683.

Species: Hu, Mu, Rt, BvApplications: WB, IF, IHC-Fr

Species: Hu, RtApplications: WB, IF

[Endothelin A Receptor Antibody NB600-836] Marroquin Belaunzaran O, Cordero MI, Setola V, Bianchi S, Galli C, Bouche N, Mlynarik V, Gruetter R, Sandi C, Bensadoun JC, Molinari M, Aebischer P. Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool. PLoS One. 2011 Apr 20;6(4):e18268. [PMID: 21533130][MAP2 Antibody NB300-213] Schätzle P, Wuttke R, Ziegler U, Sonderegger P. Automated quantification of synapses by fluorescence microscopy. Journal of Neuroscience Methods. 2011 Nov 11204(1):144-149. [PMID: 22108140]

[MAP2 Antibody NB300-213] Sur S, Pashuck ET, Guler MO, et al. A hybrid nanofiber matrix to control the survival and maturation of brain neurons. Biomaterials. 2011 Oct 19. [PMID: 22018390]

Product Citations

Sensory Systems: Auditory & Olfactory


VisionVision is a complex process involving interactions between the surface and lens of the eye, the retina and neural receptors and the processing by the brain of information collected from the eyes. Because there are many processes involved in eyesight, a wide range of genes are involved in the processes of collecting, relaying, and processing visual signals. Likewise, mutations to any of these genes can cause problems in a variety of areas including ocular development, retinal development or degeneration, or signal transmission to the brain.

Sensory Systems: Vision

Related Antibodies

• 3-OHKYN


• Adenylate Cyclase 6

• ALDH1A3

• APXL

• Arrestin 3 Retinal

• BBS10

• Bestrophin

• betaTrCP

• BMAL1

• CACNA2D4

• Calnexin

• CaMK1

• Cannabinoid Receptor II

• CD147

• CEP290

• Ceramide Kinase Like

• CHX10

• clarin 1

• CLOCK

• CNNM4

• Crystallin AB

• Cytokeratin 3/12

• Dock5

• EFEMP1

• ELAVL2

• EYA3

• EYA4

• FOXE3

• GDF6

• Glutamate Receptor 1

• Glutamate receptor 2

• Glutamate receptor 2/3

• Glutamine Synthetase

• Homeobox protein SIX6

• IMPG2

• LRP5/6

• Melanopsin

• MERTK

• Metabotropic Glutamate Receptor

• mGluR1

• mGluR6/7

• Mucolipin 1

• Ndufs1

• NIR2

• OPA1

• Opsin 1 (Medium Wave)

• Opsin 3

• Otx2

• OTX3

• PAX6

• PDE6A

• PER1

• Peropsin

• PROX1

• PRPF3

• PRPF8

• Retinoic Acid Receptor alpha

• Retinoic Acid Receptor beta

• RGR

• Rhodopsin

• RIT1

• RPE65

• S Opsin

• S-arrestin

• SHH

• SNAP25

• SOX2

• Syntrophin

• Syntrophin alpha 1

• Transducin alpha

• Transducin beta

• TULP1

• WDR36

• WFS1

Customer Reviews

Mucolipin 1 Antibody (NB110-82375)Application: Western blotSample Tested: HEK lysate overexpressing mcoln1

OPA1 Antibody (NB110-55290)Application: Western blotSample Tested: COS-1 cell

SOX2 Antibody (NB110-37235)Application: Western blotSample Tested: Oral cancer cell lineSpecies: Human


Western blotanalysis in A549 cell lysate using NB100-2911.

Ceramide Kinase Antibody NB100-2911

Cytokeratin 19 Antibody NBP1-78278

Immuno-histochemicalanalysis human kidney carcinoma using NBP1-78278.

Metabotropic Glutamate Receptor 6 Antibody NB300-189

Immuno-fluorecentanalysis in trapezoid body in mouse brain using NB300-189.


Species: Hu, Mu, Rt, MkApplications: WB, ICC, IF, IHC-P

Species: Mu, RtApplications: WB, IF

Western blotanalysis in in mouse brainlysates usingNB110-82375.

Mucolipin 1 Antibody NB110-82375

OPA1 Antibody NB110-55290

Immuno-histochemicalanalysis inprostatic smoothmuscle usingNB110-55290.

RPE65 (401.8B11.3D9) Antibody NB100-355

Immuno-histochemicalanalysis in mouse retina tissue using NB100-355.

Species: Hu, Mu, RtApplications: WB

Species: Hu, Mu, Rt, Ch, Mk, ZeApplications: WB, IHC

Species: Hu, Mu, Bv, PoApplications: WB, ICC, IF, IHC, IHC-Fr

[Adenylate Cyclase 3 Antibody NBP1-92683] Louvi A and Grove EA. Cilia in the CNS: the quiet organelle claims center stage. Neuron 2011 69:1046-1060. [PMID: 21435552][Crystallin AB (1B6.1-3G4) Antibody NBP1-97494] Schwirtlich M, Kwakowsky A, Emri Z, et al. GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation. Cell Calcium. 2011 Aug 3. [PMID: 21820173][Calnexin (1D4) Antibody H00000821-M08] Teoh KT, Siu YL, Chan WL et al. The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis. Mol Biol Cell. 2010 Nov;21(22):3838-52. [PMID: 20861307] [Cannabinoid Receptor II Antibody NB300-606] Patsenker E, Stoll M, Millonig G, et al. Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis. Mol Med. 2011 Aug 19. [PMID: 21863215][CEP290 Antibody NB100-86991] Hopp K, Heyer CM, Hommerding CJ, et al. B9D1 is revealed as a novel Meckel syndrome (MKS) gene by targeted exon-enriched next-generation sequencing and deletion analysis. Hum Mol Genet. 2011 Apr 14. [PMID: 21493627][ELAVL2 Antibody NB110-10865 ] Hayakawa H, Fujikane A, Ito R, et al. Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress. Biochem Biophys Res Commun. 2010 Nov 10. [PMID: 21073862]

[OPA1 Antibody NB110-55290] Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, et al. Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer’s Disease. PLoS ONE. 2012 7(2). [PMID: 22393443][Rhodopsin (4D2) Antibody NBP1-48334] Matsuyama T, Yamashita T, Imai H, Shichida Y. Covalent bond between ligand and receptor required for efficient activation in rhodopsin. J Biol Chem. 2010 Mar 12;285(11):8114-21. [PMID: 20042594]

Product Citations

Western blotanalysis in modified BSAusing NB100-597.

3-OHKYN (P3UI) Antibody NB100-597

Crystallin AB Antibody NB100-2520

Western blotof Lane 1: human skeletal muscle and Lane 2: mouse skeletal muscle proteins using NB100-2520.

Calnexin Antibody NB100-1974

Immuno-histochemicalanalysis inmouse bladderusing NB100-1974.

Species: Hu, AllApplications: WB, ICC

Species: Hu, MuApplications: WB

Species: Hu, MuApplications: WB, ICC, IF, IHC-P, IP

16


CNS Control of MetabolismCircadian RhythmsSleep cycles are regulated through both circadian and homeostatic processes. The biological clock genes are well conserved across species. Circadian rhythms are thought to be controlled by the interactions of a relatively small set of proteins. Gene variations and genetic defects in these proteins can lead to sleep disorders and poor adaptations to the light-dark cycle. [PMID: 17299246]

Related Antibodies

• BMAL1

• Casein Kinase 1 delta

• CLOCK

• Cryptochrome I

• CRY2

• PER2

• PER3

• Timeless

CRY2 Antibody NBP1-86273

Immuno-fluorscentanalysis showingpositivity in nuclues& cytoplasm usingNBP1-86273.

Timeless Antibody NB100-40853

Immuno-histochemicalanalysis ofbreast carcinomausing NBP1-31401.


Species: Hu, MuApplications: WB, IF, IHC-P, IP

Food IntakeFood intake is controlled by a highly complex process. Compounds that affect food intake and that are critical for normal energy homeostasis are termed adiposity signaling molecules. Several neuropeptide and neurotransmitters have been identified as molecules that act through intermediaries as adiposity signals including Leptin, Insulin, Neuropeptide Y, Melanocortins, Noradrenaline, Dopamine, Serotonin. [PMID: 10766253]

Related Antibodies

• AGRP

• Alpha-MSH

• CARTPT

• Corticotropin Releasing Factor

• CRHBP

• Galanin

• GALP

• GalR1, 2, 3

• GLP1R

• IL1 beta

• Insulin

• Insulin Receptor

• Insulin Receptor beta

• IR-related receptor

• Leptin

• Leptin Receptor

• MCHR

• MCHR1

• MCHR2

• MRAP2

• Neuropeptide Y

• Neurotensin

• Neurotensin Receptors 1, 2

• Noradrenaline transporter

• NPY1R

• NPY2R

• NPY4R

• NPY5R

• Orexin

• Orexin A

• Orexin Receptors 1, 1/2, 2

• Oxytocin

• Oxytocin Receptor

• Serotonin

• Thyrotropin Releasing Hormone

• Urocortin

Immuno-histochemicalanalysis inmouse pancreasusing NBP1-97308.

GLP1R Antibody NBP1-97308

Neuropeptide Y Antibody NBP1-78352

Immuno-histochemicalanalysis inthe rat centralnervous systemusing NBP1-78352.

Species: Hu, MuApplications: WB, ICC, IF, IHC-P

Species: Hu, Mu, Rt, Am, Av, Fe, Fi, GP, Other, ZeApplications: ICC, IHC-Fr, IHC-P

Immuno-histochemicalanalysis inhuman breastcarcinoma tissueusing NBP1-51404.

Insulin Receptor [p Tyr1361] Antibody NBP1-51404

Species: Hu, Mu, RtApplications: WB, IHC-P

17


Alzheimer’s DiseaseAlzheimer’s Disease (AD) is a progressive neurodegenerative condition that affects mental capacity, especially memory and behavior. AD is characterized by two key abnormalities: amyloid plaques and neurofibrillary tangles. Apolipoprotein E (ApoE) is a lipid transport protein that plays a central role in the pathogenesis of neurodegeneration in Alzheimer’s disease. [PMID: 14657206] There is also evidence linking Reelin with neurodegeneration through binding of ApoE receptors and as a mediator of Tau hyperphosphorylation. [PMID: 15583703]

Related Antibodies

• 160kDa Neurofilament Medium

• Amyloid beta precursor protein

• ApoE

• ApoE4

• ApoER2

• Presenilin 1

• Presenilin 2

• Reelin

• Tau

ApoER2 Antibody NB100-2216

Western blotanalysis on mouse brain membrane using NB100-2216.

ApoE4 (4E4) Antibody NBP1-49529

Western blotanalysis in concentrated supernatants of CHO cells usingNBP1-49529.

Species: Hu, Mu, ChApplications: WB

Species: HuApplications: WB, ELISA, IP

Immuno-fluorescentanalysis of adultneural cells usingNB300-134.

160kDa Neurofilament Medium (3H11) Antibody NB300-134

Species: Hu, Mu, Av, MaApplications: WB, IF, IHC-P

GAPDH (2D4A7) Antibody NB300-328

Immuno-cytochemicalanalysis inHeLa cells usingNB300-328.

Species: Hu, MuApplications: WB, ELISA, ICC, IF, IHC-P

Customer Reviews

GAPDH Antibody (1D4) NB300-221Application: Western blotSample Tested: Human Hepatoblastoma Species: Human Additional Comments: The cultured cells were harvested, washed and lysed. Extracts were stored at -20C prior to analysis

GAPDH Antibody (2D4A7) NB300-328Application: Western blotSample Tested: HaCaT whole cell lysate Sample Pretreatment: UV exposure Species: Human

GAPDH Antibody (NB300-322)Application: Western blotSample Tested: PC3 Whole Cell Lysate (Human prostate cancer cell) Species: Human

[160kDa Neurofilament Medium Antibody NB300-133] Ziv-Polat O, Skaat H, Shahar A, Margel S. Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering. Int J Nanomedicine. 2012;7:1259-74. [PMID: 22419873][ApoE Antibody NB100-2040] Terwel D, Steffensen KR, Verghese PB, et al. Critical Role of Astroglial Apolipoprotein E and Liver X Receptor alpha Expression for Microglial Abeta Phagocytosis. J Neurosci. 2011 May 11;31(19):7049-59. [PMID: 21562267][ApoE (WUE-4) Antibody NB110-60531] Lee CY, Tse W, Smith JD, Landreth GE. Apolipoprotein E Promotes ß-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels. J Biol Chem. 2012 Jan 13;287(3):2032-44. Epub 2011 Nov 30. PubMed [PMID: 22130662].[GAPDH (1D4) Antibody NB300-221] Hoeffer CA, Sanchez E, Hagerman RJ, Mu Y, Nguyen DV, Wong H, Whelan AM, Zukin RS, Klann E, Tassone F. Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome. Genes Brain Behav. 2012 Jan 23. [PMID: 22268788][GAPDH Antibody NB300-327] Wang M-E, Chen Y-C, Chen I-S, et al. Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. The Journal of Nutritional Biochemistry. 2012 Jan 3. [PMID: 22221674]

Product Citations

18


Parkinson’s disease is a motor system disorder that results from a loss of dopamine-producing neurons. Protein aggregates called Lewy bodies develop inside neural cells and displace other cellular contents. Symptoms of the disorder include trembling of the extremities and face, stiffness of movement and impaired balance and coordination. Several genes have been implicated in Parkinson’s disease. These include PARK2, PARK7, PINK1, LRRK2, SNCA, GBA, SNCAIP, and UCHL1. Mutations these genes have been linked to increased incidence of the disorder.

Parkinson’s Disease

Related Antibodies

• alpha-Synuclein

• CASK

• Caspase 1

• Caspase 8

• CD73

• Cullin 1

• Cyclin E

• DARPP32

• DORFIN

• Drebrin

• GBA

• Glutamate Dehydrogenase

• GNB3

• Hsp70

• LRRK2

• Park7(DJ-1)

• Parkin

• PINK1

• Proteasome 26S S5

• Rhodopsin

• Septin-5

• SIAH1

• SIAH1/2

• SIAH2

• Synphilin-1

• Tubulin alpha

• Tubulin beta

• Ube2G2

• Ube2L3

• Ube2L6

• UCHL1

Western blotanalysis ofHEK293 cell extract using NB500-208

Caspase 8 (FLICE 4-1-20) Antibody NB500-208


Hsp70 Antibody NBP1-77455

Immuno-histochemicalanalysis in humanxenograft kidney cancer usingNBP1-77455.

Species: HuApplications: ICC, IF, IHC-P

LRRK2 Antibody NB300-268

Immuno-histochemicalanalysis ofbrain using NB300-268.

Park7(DJ-1) Antibody NB300-270

Immuno-cytochemicalanalysis inhuman cortexusing NB300-270.

Species: Hu, Mu, BvApplications: WB, ICC, IF, IHC-P, IP

Species: Hu, Mu, Rt, Bv, Ch, SyHa, ZeApplications: WB, ICC, IF, In vitro, IP

UCHL1 Antibody NB300-675

Immuno-histochemicalanalysis ofneurons and theircell processes using NB300-675.

Species: Hu, Mu, Rt, Bv, Eq, GP, Mk, PoApplications: WB, IHC-P

alpha-Synuclein (24.8) [Nitrate Tyr123, Nitrate Tyr133] Antibody NBP1-26380

Western blot analysis of (A) Nitrated alpha-Synuclein protein and (B) non-nitrated alpha-Synuclein protein using NBP1-26380.

SIAH2 (24E6H3) Antibody NB110-88113

Immuno-fluorescentanalysis in ovarian carcinoma (OVCR3) cells using NB110-88113.


Species: Hu, Dr, PoApplications: FACS, ICC, IF, IHC-Fr, IHC-P

Tubulin (YL1/2) Antibody NB600-506

Immuno-histochemicalanalysis on human breast cancer using NB600-506.

Species: Hu, Mu, Rt, Av, Ma, YeApplications: WB, ELISA, ICC, IF, IHC-Fr, IHC-P, IP, RIA

19


alpha-Synuclein (24.8) [Nitrate Tyr123, Nitrate Tyr133] Antibody NBP1-26380

Customer Reviews

alpha Tubulin (DM1A) Antibody (100-690)Application: Western blot Sample Tested: Mouse lung tissueSample Pretreatment: 95 C boilingSpecies: Mouse

GBA Antibody (H00002629-B01P)Application: IPSample Tested: Cell lysate Species: Human

Hsp70 Antibody (13D3) (NB120-2788)Application: Western blotSample Tested: HEK293 cell lysate Sample Pretreatment: 20 ug

Park7(DJ-1) Antibody (NB300-270)Application: Western blotSample Tested: HeLa whole cell lysate, mouse brain Species: Human Other Species: MousePub Med ID: 21645620

PINK1 Antibody (BC100-494)Application: Western blotSample Tested: HeLa whole cell, mito extract Sample Pretreatment: 20 ug Sample Pretreatment: CCCPSpecies: Human

alpha Tubulin (DM1A) Antibody (100-690)Application: Western blotSample Tested: Cell lysateSpecies: Mouse

Beta Tubulin Antibody (NB600-936)Application: IHCSample Tested: Hippocampal Primary Culture Species: Mouse

Beta Tubulin Antibody (NB600-936)Application: Western blotSample Tested: Chicken cell line Species: Chicken

UCHL1 Antibody (NB100-65827)Application: Immunohistochemistry-Paraffin Sample Tested: Brain tissue Species: Human

[alpha-Synuclein (24.8) [Nitrate Tyr123, Nitrate Tyr133] Antibody NBP1-26380] Huang Z, Xu Z, Wu Y, Zhou Y. Determining nuclear localization of alpha-synuclein in mouse brains. Neuroscience. 2011 Oct 19. [PMID: 22033456][alpha Tubulin (DM1A) Antibody NB100-690] Kadiu I, Gendelman HE. Human Immunodeficiency Virus type 1 Endocytic Trafficking Through Macrophage Bridging Conduits Facilitates Spread of Infection. J Neuroimmune Pharmacol. 2011 Jul 26. [PMID: 21789505][Caspase 8 Antibody NB110-56116] Harcourt JL, Caidi H, Anderson LJ, Haynes LM. Evaluation of the Calu-3 cell line as a model of in vitro respiratory syncytial virus infection. J Virol Methods. 2011 Jun;174(1-2):144-9. Epub 2011 Mar 31. [DARPP32 [p Thr34] Antibody NBP1-60812] Sarantis K, Antoniou K, Matsokis N, Angelatou F. Exposure to novel environment is characterized by an interaction of D1/NMDA receptors underlined by phosphorylation of the NMDA and AMPA receptor subunits and activation of ERK1/2 signaling, leading to epigenetic changes and gene expression in rat hippocampus. Neurochemistry International. 2011 Nov 7. [PMID: 22080157][Drebrin (M2F6) Antibody NB100-1951] Chen Q, Prior M, Dargusch R, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer’s disease. PLoS ONE. 2011 6(12). [PMID: 22194796][Hsp70 interacting protein HIP (2G6) Antibody NB120-2813] Barker BL, Benovic JL. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Biochemistry. 2011 Aug 16;50(32):6933-41. [PMID: 21728385][LRRK2 Antibody NB300-954] Sharma S, Bandopadhyay R, Lashley T, et al. LRRK2 expression in idiopathic and G2019S positive Parkinson’s disease subjects: A morphological and quantitative study. Neuropathol Appl Neurobiol. 2011 Jun 23. [PMID: 21696411][Park7 (DJ-1) Antibody NB300-270] Usami Y, Hatano T, Imai S, et al. DJ-1 associates with synaptic membranes. Neurobiol Dis. 2011 May 30. [PMID: 21645620][PINK1 Antibody BC100-494] Meissner C, Lorenz H, Weihofen A, et al. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J. Neurochem. 2011 Jun; 117(5):856-67. [PMID 21426348][PINK1 Antibody BC100-494] Qi Z, Yang W, Liu Y, Cui T, Gao H, Duan C, Lu L, Zhao C, Zhao H, Yang H. Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Neurochem Int. 2011 Oct;59(5):572-81. [PMID: 21672589][UCHL1 (BH7) Antibody NB110-58869] Zhang M, Deng Y, Luo Y, et al. Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1. Journal of Neurochemistry. 2011 Dec 30. [PMID: 22212137]

Product Citations

20


Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. The HD gene product is widely expressed in human tissues, with the highest level of expression in the brain.

Huntington’s Disease

Related Antibodies

• BDNF

• Caspase 3

• Choline Acetyltransferase

• GM-CSF

• HIP1

• HOXA13

• Huntingtin

• LAMC2

• Somatostatin

Caspase 3 (CPP32 4-1-18) Antibody NB500-210

Immuno-histochemicalanalysis ofepithelial cells of the tongue base usingNB500-210.

Species: Hu, RtApplications: WB, IHC

Huntingtin Antibody NBP1-03377

Immuno-fluorescentanalysis on 1day old mousecortical cell using NBP1-03377.

Species: Mu, RtApplications: WB, IF, IHC-Fr, IHC-P

Customer Reviews

Caspase 3 Antibody (CPP32 4-1-18) (NB500-210)Application: Western Blot Sample Tested: Human Hepatoblastoma Additional comments: The cultured cells were harvested, washed and lysed. Extracts were stored at -20C prior to analysis Species: Human

Caspase 3 Antibody (CPP32 4-1-18) (NB500-210) Application: Western blotSample Tested: Human Species: Human

Choline Acetyltransferase Antibody (NB100-1615)Application: Immunohistochemistry-Paraffin Sample Tested: Mouse brainSpecies: MouseAdditional comments: : I recommend this product for any IHC-related stains.

[Active Cleaved Caspase 3 Antibody NB600-1235] Jee D, Lee WK. Inhibitory Effect of intravitreal Injection of Bevacizumab on Nerve Growth Factor. Current Eye Research. 2011 Oct 31. [PMID: 22040304][Caspase 3 (CPP32 4-1-18) Antibody NB500-210] Fuzio P, Ditonno P, Rutigliano M, et al. Regulation of TGF-1 expression by Androgen Deprivation Therapy of prostate cancer. Cancer Letters. 2012 28;318(2):135-144. [PMID: 22269108][Caspase 3 (CPP32 4-1-18) Antibody NB500-210] Hsu L-C, Hsu Y-W, Liang Y-H, et al. Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568. Molecules. 2012 17(1):664-673. [PMID: 22237681][Choline Acetyltransferase Antibody NBP1-30052] Sciamanna G, Tassone A, Martella G, et al. Developmental Profile of the Aberrant Dopamine D2 Receptor Response in Striatal Cholinergic Interneurons in DYT1 Dystonia. PLoS ONE. 2011 6(9). [PMID: 21912682][Somatostatin Receptor 2 Antibody NB300-157] Li F, Ryu BY, Krueger RL, et al. Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to wild type viral glycoproteins. Journal of Virology. 2011 Oct 19. [PMID: 22013043]

Product Citations

Huntingtin Antibody NBP1-89710

Immuno-fluorescentanalysis of humancell line U-2 OSshowing positivity innucleus usingNBP1-89710.

Somatostatin Antibody NBP1-78329

Immuno-fluorescentanalysis ofrat hypothalamususing NBP1-78329.

Species: HuApplications: IF, IHC-P

Species: Hu, Mu, Rt, Am, FiApplications: IF, IHC-Fr, IHC-P

21

HIP1 (1B11) Antibody NB300-204

Westernblot analysison HeLa whole cell extracts using NB300-204.

Species: Hu, MuApplications: WB, IP


Immuno-fluorescentanalysis ofrat hypothalamususing NBP1-78329.

Species: Hu, Mu, Rt, Am, FiApplications: IF, IHC-Fr, IHC-P

MS is an autoimmune disease caused by damage to the fatty myelin sheaths around the axons of the brain and spinal cord. Damage is caused by inflammation and results in nerve damage and slow or absent nerve signals. Susceptibility to MS is linked to genes in the Major Histocompatibility Complex and to T cell response. Disease activation biomarkers include interleukin-6, nitric oxide, nitric oxide synthase, osteopontin, and fetuin-A.

Multiple Sclerosis

Related Antibodies

• CCL3

• CCL4

• CCR1

• CCR5

• CXCL9

• CXCL10

• CXCL11

• CXCR3

• Fetuin

• HLA

• IL-6

• NOA1

• Osteopontin

• TNF alpha

• TNF betaOsteopontin (1B20) Antibody NB110-89062

Immuno-histochemicalanalysis on human lung adenocarcinomausing NB110-89062.

Species: Hu, Rt, RbApplications: WB, ICC, IHC-P, IP

IL6 (6D9A1,6C12B1) Antibody NBP1-47355

Immuno-histochemicalanalysis oflung cancer tumorusing NBP1-47355.

Species: HuApplications: WB, ELISA

Ischemic episodes, TBI and epilepsy typically result in necrotic cell death at the injury site as well as programmed cell death that is controlled via apoptotic cascades in the injured area. Specifically, the mitochondrial-mediated apoptotic pathways as well as the PI3K/AKT pathway been implicated in cell death after brain trauma. New research aims to reduce apoptosis of cells in the penumbral region after brain injury as means of preserving greater neuronal function. [PMIDs: 12684068 & 15662830]

Stroke, Epilepsy & Traumatic Brain Injury

• MEK2

• MEKK4

• MMP9

• RAIDD

• RIP1

• TNF-R1

• TRADD

• AIF

• CARD

• DEDD

• FADD

• Fas Ligand

• JNK

• MAPK

Related Antibodies CARD12 Antibody NBP1-78979

Immuno-cytochemicalanalysis in HepG2 cells with FITC (green) usingNBP1-78979.

Species: Hu, MuApplications: ICC, IF, IHC-P

JNK1 Antibody NB100-1925

Western blotanalysis in JNK-1 overexpression lysates usingNB100-1925.

Species: CeApplications: WB, ELISA, IHC-P

CCR1 Antibody NB100-702

Immuno-histochemicalanalysis ofhuman tonsilusing NB100-702.

Species: HuApplications: WB, ELISA, IHC-P

CCR5 Antibody NB100-531

Immuno-cytochemicalanalysis in HeLacells with FITC (green) usingNB100-531.

Species: Hu, MkApplications: ELISA, FACS, Func, ICC, In vitro

MAP2K1IP1/MAPKSP1 Antibody NBP1-50631

Immuno-histochemicalanalysis inmouse lungusing NBP1-50631.

Species: Hu, MuApplications: WB, ICC, IF, IHC-P

Fas Ligand (NOK-1) Antibody NB100-77833

Flow cytometricanalysis of transfected cells stained with purified NOK-1 using NB100-77833.

Species: HuApplications: FACS, ICC, IF, IP

22


Novus offers a complete line of neuronal marker antibodies that have been validated across multiple applica-tions and species.

Neuronal Markers

Astrocyte ABCA1

Astrocyte Actin Alpha 2 Smooth Muscle

Astrocyte GFAP

Astrocyte SLC1A3

Astrocytes Survivin

Glial Cells SOX2

Glial Cells Vimentin

Microglia CD11

Microglia Ferritin

Neural Stem Cells DACH1

Neural Stem Cells GFAP

Neural Stem Cells HES1

Neural Stem Cells ISL1

Neural Stem Cells Ki67

Neural Stem Cells Musashi-1

Neural Stem Cells Nestin

Neural Stem Cells Pax2



Neural Stem Cells PLAGL1

Neural Stem Cells PLZF

Neural Stem Cells REST

Neural Stem Cells SOX9

Neural Stem Cells Vimentin

Neurons Acetylcholinesterase

Neurons Bag 1

Neurons Bcl2

Neurons beta Tubulin

Neurons Calretinin

Neurons c-Fos

Neurons Choline Acetyltransferase

Neurons ELF

Neurons HSV1

Neurons MAP2

Neurons Nestin

Neurons Neurofilament Heavy

Neurons Neurofilament Light

Neurons Neurofilament Medium

Neurons NQO1

Neurons RBFOX3/NeuN

Neurons Synapsin

Neurons UCHL1

Oligodendrocytes CNPase

Oligodendrocytes MAP4

Oligodendrocytes MOG

Oligodendrocytes Nestin

Oligodendrocytes OLIG2

Schwann Cells Laminin

Schwann Cells Ran

ABCA1 Antibody (3A1.891.3) (NB400-164)Application: Western blotSample Tested: Brain microvessel total proteins Species: Mouse

Cell Type Antibody Cell Type Antibody

SLC1A3 Antibody (NBP1-20135)Application: Western blotSample Tested: RCC4 Whole cell lysate

Survivin Antibody (NB500-201)Application: Western blotSample Tested: Oswald 1771 Abrams D17 Cancer Cell Lines Sample Pretreatment: 7-15 ug

Survivin [p Thr34] Antibody(NB500-236)Application: Western blotSample Tested: Cancer cellsSpecies: Mouse

Ki67 Antibody (NB110-89717)Application: FACSSample Tested: Mouse bone marrow cells

Ki67 Antibody (NB500-170)Application: Western blotSample Tested: Whole cell lysate Species: Mouse

Tubulin Beta 3 Antibody (NB600-1018)Application: ICCSample Tested: Mouse Differentiated Neural Cell

23

ABCA1 Antibody (NB400-105)Application: Western bBlotSample Tested: MouseSpecies: Mouse

200 kDa Neurofilament Heavy Antibody NF-01 (NB500-416)Application: IFSample Tested: nerve tissue from mouse spinal cord

Customer Reviews

c-Fos Antibody (NB100-91772)Application: IHCSample Tested: MouseSample Pretreatment: Citrate buffer


ABCA1 Antibody NB400-105

Immuno-histochemicalanalysis in prostate epithelium using NB400-105.

Survivin Antibody NB500-201

Immuno-fluorescentanalysis of telophase in the midbodies of two daughter cells using NB500-201.

Species: Hu, Mu, Rt, HaApplications: WB, FACS, ICC, IF, IHC-P, IP

Species: Hu, Mu, Rt, Ca, FeApplications: WB, ChIP, ICC, IF, IHC-P, IP

CD11b Antibody NB110-89474

Immuno-histochemicalanalysis inin human renal cancer usingNB110-89474.

Species: Hu, Mu, RtApplications: WB, FACS, ICC, IF, IHC-P

Ki67 Antibody NB500-170

Immuno-histochemicalanalysis inhuman tonsil using NB500-170.

Species: Hu, Mu, PoApplications: ICC, IF, IHC-Fr, IHC-P

Nestin (10C2) Antibody NB300-266

Immuno-cytochemicalanalysis in PC-3 cells using NB300-266.

Species: HuApplications: WB, FACS, ICC, IF, IHC-Fr, IHC-P

beta Tubulin Antibody NB600-936

Immuno-cytochemicalanalysis ofHeLa cells usingNB600-936.

Species: Hu, Mu, Rt, Ch, Mk, Po, Xp, ZeApplications: WB, ICC, IF

68kDa Neurofilament Light (DA2) Antibody NB300-132

Immuno-fluorescentanalysis ofneurons in culture usingNB300-132.

Species: Hu, Av, MaApplications: WB, IF, IHC

ZNF643 Antibody NBP1-92639

Immuno-histochemicalanalysis ofhuman testis using NBP1-92639.


[68kDa Neurofilament Light Antibody NB300-131] Yokoyama K, Tezuka T, Kotani M, et al. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. The EMBO Journal. 2011 Sep 23. [PMID: 21946561][ABCA1 (HJ1) Antibody NB100-2068] de Souza Pinto R, Castilho G, Paim BA, et al. Inhibition of Macrophage Oxidative Stress Prevents the Reduction of ABCA-1 Transporter Induced by Advanced Glycated Albumin. Lipids. 2012 Jan 21. [PMID: 22271422][Actin Alpha 2 Smooth Muscle Antibody NB600-531] Saatchi S, Azuma J, Wanchoo N, et al. Three-dimensional microstructural changes in murine abdominal aortic aneurysms quantified using immunofluorescent array tomography. J Histochem Cytochem. 2012 Feb;60(2):97-109. [PMID: 22140132][CD11b Antibody NB110-89474] Jin H, Li YH, Xu JS, et al. Lipoxin A4 analog attenuates morphine antinociceptive tolerance, withdrawal-induced hyperalgesia, and glial reaction and cytokine expression in the spinal cord of rat. Neuroscience. April 19; 208;1-10. [PMID: 22366510][CD11c (AP-MAB0814) Antibody NBP1-06651] Dravis C, Henkemeyer M. Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues. Dev Biol. 2011 Jul 1;355(1):138-51. [PMID: 21539827][Ferritin Antibody NB600-920] Daba A, Koromilas AE, Pantopoulos K. Alternative ferritin mRNA translation via internal initiation. RNA. 2012 Mar;18(3):547-56. [PMID: 22271759][Ki67 Antibody NB500-170] McCaskey SJ, Rondini EA, Langohr IM, Fenton JI. Differential effects of energy balance on experimentally-induced colitis. World J Gastroenterol. 2012 Feb 21;18(7):627-36. [PMID: 22363133][SLC1A3 Antibody NB100-1869] Salvatore MF, Davis RW, Arnold JC, Chotibut T. Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser(19). Experimental Neurology. 2012 Jan 17. [PMID: 22285253][Survivin Antibody NB500-201] Francisco R, Pérez-Perarnau A, Cortés C, et al. Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. Cancer Letters. 2012 May 1: 318 (1) 42-52. [PMID: 22186300][Survivin Antibody (60.11) NB500-238] Schöneberger H, Weiss A, Brill B, et al. The integration of a Stat3 specific peptide aptamer into the thioredoxin scaffold protein strongly enhances its inhibitory potency. Hormone Molecular Biology and Clinical Investigation. 2011 Jun 135(1):1-9.

Product Citations

200kDa Neurofilament Heavy Antibody NB300-135

Immuno-fluorescentanalysis ofrat spinal cordusing NB300-135.

Species: Hu, Mu, Rt, Ma, MkApplications: WB, ELISA, IF, IHC-Fr, IHC-P


Antibody Support ProductsNovus offers a variety of products for use in conjunction with our Primary Antibodies. All support products are also of the highest quality and are backed by our Novus Guarantee, no hassles, no nonsense.

Secondary Antibodies, Lysates, Peptides, Proteins & RNAIs

Visit www.novusbio.com and select your primary antibody of interest to see all of the related

support products.

AbSelect Antibody Purification Kits

Commercially available antibodies often contain

substances (e.g. BSA, glycine, tris, azide) that interfere in

labeling reactions. The AbSelect Purification Kit quickly removes

these contaminants.

Lightning-Link Antibody Labeling Kits

Lightning-Link is the easiest and quickest method available for making antibody (protein) conjugates, requiring just 30

seconds hands-on time.

Epitope Tags Epitope tagging is a powerful

tool for the detection and purification of expressed

proteins, and Novus Biologicals offers a wide range of epitope tag specific antibodies for a

variety of immunologicalapplications.

Isotype Controls Identify any background signal in your FACS experiment with our extensive selection of top

quality isotype control antibodies. Now available for most species, isotypes, and

fluorescent conjugates.

ELISA Kits & Matched Antibody Pairs

Our complete ELISA kits contain all of the components & reagents for a successful ELISA. Plus, it has never been easier to find the right antibody pair for

your sandwich ELISA.

Contact us about a two week free trial.*

[email protected]*Applicable in the USA only

Realize the Many Advantages of PrecipitorTM

• IP in less than 30 minutes with no centrifugation or pipetting• Rapid, multi-step automation• 96 well plate format• Multiplex up to 16 samples• Reproducible and consistent results• No external device or PC required• Affordable Price

Precipitor™ High Throughput Immunoprecipitation and Purification SystemAutomated magnetic bead platform for high-throughput precipitation and purification of proteins.


Technical SupportNovus Biologicals stands behind all of our products 100%. We have a global team of specialists available to help you as well as detailed protocols, illustrated assay guides and video tutorials on our website. Our Techincal Support team can be reached at [email protected] and also on our live chat feature at www.novusbio.com.

Western Blot Protocol Immunocytochemistry Protocol

Chromatin Immunopreciptation Protocol

Novus Explorer This free bioinformatics tool is designed to facilitatescientific exploration of related genes, diseases and pathways based on co-citations. For moreinformation visit www.novusbio.com/explorer.

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