now is the time · web view1983 william n. creasy visiting professor of clinical pharmacology,...

Henry R Bourne Curriculum vitae and bibliography 1

Name Henry R Bourne Date 14 June 2012

Born ` March 1, 1940

Education AB 1960, Harvard College, Cambridge, Massachusetts

MD 1965, Johns Hopkins University, Baltimore, Maryland

Postgraduate training1965-1966 Internship in Internal Medicine, Columbia Presbyterian

Medical Center, New York, NY1966-1968 Research Associate in Pharmacology, Laboratory of

Chemical Pharmacology, National Heart Institute1968-1969 Residency in Internal Medicine, Columbia Presbyterian

Medical Center, New York, NY1969-1971 Fellow, Division of Clinical Pharmacology,

Department of Medicine, UCSF

Career experience1971-1972 Instructor in Medicine, UCSF1972-1975 Assistant Professor, Medicine and Pharmacology, UCSF1975-1981 Associate Professor, Medicine and Pharmacology, UCSF1980-1983 Chief, Division of Clinical Pharmacology, Department of

Medicine, UCSF1980-present Senior Staff, Cardiovascular Research Institute, UCSF1981-present Professor, Medicine and Pharmacology, UCSF1983-1991 Professor and Chair, Department of Pharmacology, UCSF1993-1994 Acting Chair, Department of Pharmacology, UCSF2005-present Professor Emeritus, Cellular and Molecular

Pharmacology, UCSF

Honors1957 Harvard National Scholarship (Honorary) 1965 Phi Beta Kappa, Johns Hopkins University1965 Alpha Omega Alpha, Johns Hopkins University1971-76 Established Investigatorship, American Heart

Association1982-84 Burroughs Wellcome Scholar in Clinical Pharmacology1983 William N. Creasy Visiting Professor of Clinical

Pharmacology, Washington University, School of Medicine

1984 Rawls-Palmer Award for Progress in Medicine, American Society for Clinical Pharmacology and Therapeutics


1985 Vice-Chairman, Gordon Conference on Molecular Pharmacology

1987 Chairman, Gordon Conference on Molecular Pharmacology

1988 Summary Lecturer, Cold Spring Harbor Symposium on Molecular Biology of Signal Transduction

1990 Merit Award, National Institutes of Health1991 Faculty Research Lecturer, UCSF1991 Keynote Lecturer, Annual Meeting, American Society for

Cell Biology1992 American Academy of Arts and Sciences1994 National Academy of Sciences1996 Fellow, American Association for the Advancement of

Science2003 Institute of Medicine, National Academy of Sciences

Bibliography

Scientific Reports1. HR Bourne, HN Wagner Jr, M Iio, JR Jude, & GG Knickerbocker:

Cerebral blood flow during external cardiac massage. J Nucl Med 5:738-745, 1964.

2. HR Bourne, WE Bunney Jr, JM Davis, JN Davis, DM Shaw, & A Coppen: Noradrenaline, 5-hydroxytryptamine, and 5-hydroxyindolacetic acid in hindbrains of suicidal patients. Lancet II:805-808, 1968.

3. P Schonhofer, IF Skidmore, HR Bourne, GK Krishna, & BB Brodie: Influence of adrenal cortical hormones on the norepinephrine-induced lipolysis. Arzneimittel-Forschung 18:1540-1541, 1968.

4. RL Miller, C McCord, M Sanda, HR Bourne, & KL Melmon: Application of the enzymatic double isotope dilution assay for the study of histamine in plasma. J Pharmacol Exp Ther 175:228-234, 1970.

5. HR Bourne, RI Lehrer, MJ Cline, & KL Melmon: Cyclic 3´,5´-adenosine monophosphate in the human leukocyte: Synthesis, degradation, and effects on neutrophil candidacidal activity. J Clin Invest 50:920-929, 1971.

6. HR Bourne, KL Melmon, & LM Lichtenstein: Histamine augments leukocyte adenosine 3´,5´-monophosphate and blocks antigenic histamine release. Science 175:743-745, 1971.

7. HR Bourne & KL Melmon: Adenyl cyclase in human leukocytes: Evidence for activation by separate -adrenergic and prostaglandin receptors. J Pharmacol Exp Ther 178:1-7, 1971.


8. DS Robinson, A Nies, JM Davis, WE Bunney, JN Davis, RW Colburn, HR Bourne, DM Shaw, & AJ Coppen: Ageing, monoamines and monoamine-oxidase levels. Lancet I:290-291, 1972.

9. HR Bourne, LM Lichtenstein, & KL Melmon: Pharmacologic control of allergic histamine release in vitro: Evidence for an inhibitory role of 3´,5´-adenosine monophosphate in human leukocytes. J Immunol 108:695-705, 1972.

10. CS Henney, HR Bourne, & LM Lichtenstein: The role of cyclic 3´,5´-adenosine monophosphate in the specific cytolytic activity of lymphocytes. J Immunol 108:1525-1534, 1972.

11. KL Melmon, HR Bourne, Y Weinstein, & M Sela: Receptors for histamine can be detected on the surface of selected leukocytes. Science 177:707-709, 1971.

12. P Schonhofer, IF Skidmore, HR Bourne, & GK Krishna: Cyclic 3´,5´-AMP phosphodiesterase in isolated fat cells: Simple and sensitive methods for the assay of phosphodiesterase activity in fat cells and studies of the enzyme inhibition by theophylline. Pharmacology 7:65-67, 1972.

13. LM Lichtenstein, E Gillespie, HR Bourne, & C Henney: The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity. Prostaglandins 2:519-528, 1972.

14. HR Bourne: Cholera enterotoxin: Failure of anti-inflammatory agents to prevent cyclic AMP accumulation. Nature 241:399, 1973.

15. LM Lichtenstein, CS Henney, HR Bourne, & WB Greenough: Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity: Further evidence for the role of cyclic adenosine 3´,5´-monophosphate. J Clin Invest 52:691-697, 1973.

16. HR Bourne, RI Lehrer, LM Lichtenstein, G Weissman, & R Zurier: Effects of cholera enterotoxin on adenosine 3´,5´-monophosphate and neutrophil function: Comparison with other compounds which stimulate leukocyte adenyl cyclase. J Clin Invest 52:698-708, 1973.

17. Y Weinstein, KL Melmon, HR Bourne & M Sela: Specific leukocyte receptors for small endogenous hormones: Detection by cell binding to insolubilized hormone preparations. J Clin Invest 52:1349-1361, 1973.

18. V Daniel, HR Bourne & GM Tomkins: Altered metabolism and endogenous cyclic AMP in cultured cells deficient in cyclic AMP-binding proteins. Nature (New Biology) 224:167-169, 1973.

19. HR Bourne, GM Tomkins & S Dion: Regulation of phosphodiesterase synthesis: Requirement for cyclic adenosine monophosphate-dependent protein kinase. Science 181:952-954, 1973.


20. IF Skidmore, PS Schonhofer, HR Bourne & G Krishna: Effect of adrenalectomy and cortisone replacement on the lipolysis in fat tissue and fat cells. Naunyn-Schmiedeberg's Arch Pharmakol 274:113-124, 1972.

21. E Mozes, GM Shearer, KL Melmon & HR Bourne: In vitro correction of antigen-induced immune suppression: Effects of poly(A)-poly(U) and prostaglandin E1. Cell Immunol 9:226-233, 1973.

22. KL Melmon, Y Weinstein, GM Shearer, HR Bourne & S Bauminger: Separation of specific antibody-forming mouse cells by their adherence to insolubilized endogenous hormones. J Clin Invest 53:22-30, 1974.

23. KL Melmon, HR Bourne, Y Weinstein, GM Shearer, J Kram & S. Bauminger: Hemolytic plaque formation by leukocytes in vitro: Control by vasoactive hormones. J Clin Invest 53:13-21, l974.

24. E Mozes, Y Weinstein, HR Bourne, KL Melmon & GM Shearer: In vitro correction of antigen-induced immune suppression: Effects of histamine, dibutyryl cyclic AMP and cholera enterotoxin. Cell Immunol 11:57-63, 1974.

25. DR Webb, HR Bourne & WL Levinson: A new phosphodiesterase inhibitor in human lymphocytes: N-methyl-isatin--thiosemicarbazone. Biochem Pharmacol 23:1663-1667, 1974.

26. Y Weinstein, DA Chambers, HR Bourne & KL Melmon: Cyclic GMP stimulates lymphocyte nucleic acid synthesis. Nature 251:352-353, 1974.

27. HR Bourne, P Coffino & GM Tomkins: Selection of a variant lymphoma cell deficient in adenylate cyclase. Science 187:750-752, 1975.

28. HR Bourne, P Coffino & GM Tomkins: Somatic genetic analysis of cyclic AMP action: Characterization of unresponsive mutants. J Cell Physiol 85:611-619, 1975.

29. P Coffino, HR Bourne & GM Tomkins: Somatic genetic analysis of cyclic AMP action: Selection of unresponsive mutants. J Cell Physiol 85:603-609, 1975.

30. PA Insel, HR Bourne, P Coffino & GM Tomkins: Cyclic AMP-dependent protein kinase: Pivotal role in regulation of enzyme induction and growth. Science 190:896-898, 1975.

31. J Hochman, PA Insel, HR Bourne, P Coffino & GM Tomkins: A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proc Natl Acad Sci USA 72:5051-5055, 1975.

32. JA Kram, HR Bourne, HI Maibach & KL Melmon: Cutaneous immediate hypersensitivity in man: Effects of systemically administered adrenergic drugs. J Allergy Clin Immunol 56:387-392, 1975.

33. LB Epstein & HR Bourne: Interferon production by mitogen stimulated lymphocytes: Cyclic AMP-mediated inhibition by


cholera toxin. IN Mitogens in Immunobiology, D Rosenstreich & J Oppenheim (eds.), Academic Press, New York, pp. 453-462, 1976.

34. KL Melmon, Y Weinstein, HR Bourne, T Poon, GM Shearer & N Castagnoli: The pharmacological effects of conjugates of pharmacologically active amines to complex or simple carriers: A new class of drug. Mol Pharmacol 12:701-710, 1976.

35. PA Insel, M Maguire, AC Gilman, HR Bourne, P. Coffino & KL Melmon: Beta adrenergic receptors and adenylate cyclase: Products of separate genes? Mol Pharmacol 12:1062-1069, 1976.

36. HR Bourne & E Rozengurt: An 18,000 molecular weight polypeptide induces early events and stimulates DNA synthesis in cultured cells. Proc Natl Acad Sci USA 73:4555-4559, 1976.

37. J Hochman, HR Bourne, P Coffino, PA Insel, L Krasny & KL Melmon: Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. Proc Natl Acad Sci USA 74:1167-1171, 1977.

38. NM Wigglesworth, A Mastro, HR Bourne & E Rozengurt: Cyclic AMP-binding proteins in normal and virus-transformed fibroblasts. Arch Biochem Biophys 180:258-263, 1977.

39. GL Johnson & HR Bourne: Influence of cholera toxin on the regulation of adenylate cyclase by GTP. Biochem Biophys Res Commun 78:792-797, 1977.

40. WM Gold, GL Meyers, DS Dain, RL Miller & HR Bourne: Changes in airway mast cells and histamine caused by antigen aerosol in allergic dogs. J Appl Physiol 43:271-275, 1977.

41. GL Johnson, HR Kaslow & HR Bourne: Reconstitution of cholera toxin-activated adenylate cyclase. Proc Natl Acad Sci USA 75:3113-3117, 1978.

42. J Naya-Vigne, GL Johnson, HR Bourne & P Coffino: Complementation analysis of hormone-sensitive adenylate cyclase. Nature 272:720-722, 1978.

43. GL Johnson, HR Bourne, MK Gleason, P Coffino, PA Insel & KL Melmon: Isolation and characterization of S49 lymphoma cells deficient in -adrenergic receptors: Relation of receptor number to activation of adenylate cyclase. Mol Pharmacol 15:16-27, 1979.

44. DB Barnett, SE Chesrown, AF Zbinden, M Nisam, BR Reed, HR Bourne, KL Melmon & WM Gold: Cyclic AMP and cyclic GMP in canine peripheral lung: Regulation in vivo. Am Review Resp Dis 118:723-733, 1978.

45. GL Johnson, HR Kaslow & HR Bourne: Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase. J Biol Chem 253:7120-7123, 1978.


46. N Kaiser, HR Bourne, PA Insel & P Coffino: Regulation of phosphodiesterase and ornithine decarboxylase by cAMP is cell cycle independent. J Cell Physiol 101:369-374, 1979.

47. HR Kaslow, Z Farfel, GL Johnson & HR Bourne: Adenylate cyclase assembled in vitro: Cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5´-triphosphate. Mol Pharmacol 15:472-483, 1979.

48. HR Kaslow, GL Johnson VM Brothers & HR Bourne: A regulatory component of adenylate cyclase from human erythrocyte membranes. J Biol Chem 255:3736-3741, 1980.

49. Z Farfel, HR Kaslow & HR Bourne: A regulatory component of adenylate cyclase is located on the inner surface of human erythrocyte membranes. Biochem Biophys Res Commun 90:1237-1241, 1979.

50. Z Farfel, AS Brickman, HR Kaslow, VM Brothers & HR Bourne: Defect of receptor-cyclase coupling protein in pseudohypoparathyroidism. N Engl J Med 303:237-242, 1980.

51. MR Salomon & HR Bourne: Novel S49 lymphoma variants with aberrant cyclic AMP metabolism. Mol Pharmacol 19:109-116, 1981.

52. Z Farfel & HR Bourne: Deficient activity of receptor-cyclase coupling protein in platelets of patients with pseudohypoparathyroidism. J Clin Endocrinol Metab 51:1202-1204, 1980.

53. Z Farfel, VM Brothers, AS Brickman, F Conte, R Neer & HR Bourne: Pseudohypoparathyroidism: Inheritance of deficient receptor-cyclase coupling activity. Proc Natl Acad Sci USA 78:3098-3102, 1981.

54. HR Kaslow, D Cox, VE Groppi & HR Bourne: An Mr=52,000 peptide can mediate effects of cholera toxin on adenylate cyclase in intact cells. Mol Pharmacol 19:406-410, 1981.

55. HR Bourne, HR Kaslow, AS Brickman & Z Farfel: Fibroblast defect in pseudohypoparathyroidism, type I: Reduced activity of receptor-cyclase coupling protein. J Clin Endocrinol Metab 53:636-640, 1981.

56. HR Bourne, D Kaslow, HR Kaslow, MR Salomon & V Licko: Hormone-sensitive adenylate cyclase: Mutant phenotype with normally regulated -adrenergic receptors uncoupled from catalytic adenylate cyclase. Mol Pharmacol 20:435-441, 1981.

57. HR Kaslow, VE Groppi, ME Abood & HR Bourne: Cholera toxin can ADP-ribosylate cytoskeletal proteins. J Cell Biol 91:410-413, 1981.

58. VM Brothers, N Walker & HR Bourne: Increased cyclic nucleotide phosphodiesterase activity in a mutant S49 lymphoma cell: Characterization and comparison with wild type enzyme activity. J Biol Chem 257:9349-9355, 1982.


59. Z Farfel ME Abood, AS Brickman & HR Bourne: Deficient activity of receptor-cyclase coupling protein in transformed lymphoblasts of patients with pseudohypoparathyroidism, Type I. J Clin Endocrinol Metab 55:113-117, 1982.

60. HR Bourne, B Beiderman, F Steinberg & VM Brothers: Three adenylate cyclase phenotypes in S49 lymphoma cells produced by mutations of one gene. Mol Pharmacol 22:204-210, 1982.

61. HJ Motulsky, RJ Hughes, AS Brickman, Z Farfel, HR Bourne & PA Insel: Platelets of pseudohypoparathyroidism patients: Evidence that distinct receptor-cyclase coupling proteins mediate stimulation and inhibition of adenylate cyclase. Proc Natl Acad Sci USA 79:4193-4197, 1982.

62. ME Abood, JB Hurley, M-C Pappone, HR Bourne & L Stryer: Functional homology between signal-coupling proteins: Cholera toxin inactivates the GTPase activity of transducin. J Biol Chem 257:10540-10543, 1982.

63. HR Bourne, F Steinberg, MS Golbus & Z Farfel: A convenient method for measuring receptor-cyclase coupling activity in whole blood: Application to Duchenne muscular dystrophy. Am J Med Genet 15:469-474, 1983.

64. JA Fischer, MA Dambacher, F Tschopp, C Nagant de Deuxchaisnes, R De Meyer, J-P Devogelaer, HR Bourne & E Werder: Pseudohypoparathyroidism: Inheritance and expression of deficient receptor-cyclase coupling protein activity. Clin Endocrinol 19:747-754, 1983.

65. VE Groppi, F Steinberg, H Kaslow, N Walker & HR Bourne: Identification by direct photoaffinity labelling of an altered phosphodiesterase in a mutant S49 lymphoma cell. J Biol Chem 258:9717-9723, 1983.

66. GF Casperson, N Walker, AR Brasier & HR Bourne: A guanine nucleotide sensitive adenylate cyclase in the yeast Saccharomyces cerevisiae. J Biol Chem 258:7911-7914, 1983.

67. C Van Dop, G Yamanaka, F Steinberg, RD Sekura, CR Manclark, L Stryer & HR Bourne: ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal phosphodiesterase in retinal photoreceptors. J Biol Chem 259:23-26, 1984.

68. C Van Dop, M Tsubokawa, HR Bourne & J Ramachandran: Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin. J Biol Chem 259:696-698, 1984.

69. MJ Frey, SE Chesrown, BR Reed, LW Greenspan, RL Shields, HR Bourne, JK Brown & WM Gold: Immunological release of histamine from dog lung: Comparison of in vivo and in vitro responses in the same animal. J Allergy Clin Immunol 74:728-737, 1984.


70. C Van Dop, D Medynski, K Sullivan, AM Wu, BK-K Fung & HR Bourne: Partial cDNA sequence of the gamma subunit of transducin. Biochem Biophys Res Commun 124:250-255, 1984.

71. C Van Dop, HR Bourne & RM Neer: Father to son transmission of decreased Ns activity in pseudohypoparathyroidism Type Ia. J Clin Endocrinol Metab 59:825-828, 1984.

72. DC Medynski, K Sullivan, D Smith, C Van Dop, F-H Chang, B K-K Fung, PH Seeburg & HR Bourne: Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci USA 82:4311-4315, 1985.

73. DW Goldman, F-H Chang, LA Gifford, EJ Goetzl & HR Bourne: Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. J Exp Med 162:145-156, 1985.

74. GF Casperson, N Walker & HR Bourne: Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 82:5060-5063, 1985.

75. KA Sullivan, Y-C Liao, A Alborzi, B Beiderman, F-H Chang, SB Masters, AD Levinson & HR Bourne: The inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the chains. Proc Natl Acad Sci USA 83:6687-6691, 1986.

76. SB Masters, RM Stroud & HR Bourne: Family of G protein chains: Amphipathic analysis and predicted structure of functional domains. Protein Engineering 1:47-54, 1986.

77. W Heideman, GF Casperson & HR Bourne: Adenylyl cyclase in yeast: Hydrodynamic properties and activation by trypsin. J Biol Chem 262:7087-7091, 1987.

78. F-H Chang & HR Bourne: Dexamethasone increases adenylyl cyclase activity and expression of the subunit of Gs in GH3 cells. Endocrinology 121:1711-1715, 1987.

79. KA Sullivan, RT Miller, SB Masters, B Beiderman, W Heideman & HR Bourne: Identification of receptor contact site involved in receptor-G protein coupling. Nature 330:758-760, 1987.

80. MA Levine, TG Ahn, SF Klupt, KD Kaufman, PM Smallwood, HR Bourne, KA Sullivan & C Van Dop: Genetic deficiency of the -subunit of Gs as the molecular basis for Albright's hereditary osteodystrophy. Proc Natl Acad Sci USA 85:617-621, 1988.

81. PL Ashley, J Ellison, KA Sullivan, HR Bourne & DR Cox: Chromosomal assignment of the murine Gi and Gs genes: Implications for the obese mouse. J Biol Chem 262:15299-15301, 1987.

82. SB Masters, KA Sullivan, RT Miller, B Beiderman, NG Lopez, J Ramachandran & HR Bourne: Carboxy terminal domain of Gs specifies coupling of receptors to stimulation of adenylyl cyclase. Science 241:448-451, 1988.


83. RT Miller, SB Masters, KA Sullivan, B Beiderman & HR Bourne: A mutation that prevents GTP-dependent activation of the chain of Gs. Nature 334:712-715, 1988.

84. VC Yu, G Hochhaus, F-H Chang, ML Richards, HR Bourne & W Sadee: Differentiation of human neuroblastoma cells: Marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid. J Neurochem 51:1892-1899, 1988.

85. F-H Chang & HR Bourne: Cholera toxin induces cAMP-independent degradation of Gs. J Biol Chem 264:5352-5357, 1989.

86. SB Masters, RT Miller, MH Chi, F-H Chang, B Beiderman, NG Lopez, & HR Bourne: Mutations in the GTP binding site of Gs alter stimulation of adenylyl cyclase. J Biol Chem 264:15467-15474, 1989.

87. CA Landis, SB Masters, A Spada, AM Pace, HR Bourne & L Vallar: GTPase inhibiting mutations activate the chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340:692-696, 1989.

88. W Heideman, GF Casperson & HR Bourne: Adenylyl Cyclase in Yeast: Antibodies and mutations identify a regulatory domain. J Cell Biochem 42:229-242, 1990.

89. DT Jones, SB Masters, HR Bourne & RR Reed: Biochemical characterization of three stimulatory GTP-binding proteins: The large and small forms of Gs and the olfactory specific G-protein, Golf. J Biol Chem 265:2671-2676, 1989.

90. I Zachary, SB Masters & HR Bourne: Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs. Biochem Biophys Res Communic 168:1184-1193, 1990.

91. J Lyons, CA Landis, G Harsh, L Vallar, K Grünewald, H Feichtinger, Q-Y Duh, OH Clark, E Kawasaki, HR Bourne & F McCormick: Two G protein oncogenes in human endocrine tumors. Science 249:655-659, 1990.

92. CA Landis, G Harsh, J Lyons, RL Davis, F McCormick & HR Bourne: Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein. J Clin Endocrinol Metab 71:1416-1420, 1990.

93. YH Wong, A Federman, AM Pace, I Zachary, T Evans, J Pouysségur & HR Bourne: Mutant subunits of Gi2 inhibit cyclic AMP accumulation. Nature 351:63-65, 1991.

94. AM Pace, YH Wong & HR Bourne: A mutant subunit of Gi2 induces neoplastic transformation of Rat-1 cells. Proc Natl Acad Sci USA 88:7031-7035, 1991.

95. YH Wong, BR Conklin & HR Bourne: Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science 255:339-342, 1992.


96. BR Conklin, O Chabre, YH Wong, AD Federman & HR Bourne: Recombinant Gq. Mutational activation and coupling to receptors and phospholipase C. J Biol Chem 267:31-34, 1992.

97. AD Federman, BR Conklin, KA Schrader, RR Reed & HR Bourne: Hormonal stimulation of adenylyl cyclase via Gi protein subunits. Nature 356:159-161, 1992.

98. CH Berlot & HR Bourne: Identification of effector-activating residues of Gs. Cell 68:911-922, 1992.

99. O Chabre, BR Conklin, HY Lin, HF Lodish, E Wilson, HE Ives, L Catanzariti, BA Hemmings & HR Bourne: A recombinant calcitonin receptor independently stimulates cAMP and Ca2+/inositol phosphate signaling pathways. Mol Endocrinol 6:551-556, 1992.

100. MJ Levis & HR Bourne: Activation of the subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity. J Cell Biol 119:1297-1307, 1992.

101. BR Conklin, Z Farfel, KD Lustig, D Julius & HR Bourne: Substitution of three amino acids switches receptor specificity of Gq to that of Gi. Nature 363:274-276, 1993.

102. KD Lustig, BR Conklin, P Herzmark, R Taussig & HR Bourne: Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. J Biol Chem 268:13900-13905, 1993.

103. YH Ma, C Landis, N Tchao, J Wang, G Rodd, D Hanahan, HR Bourne & GM Grodsky: Constitutively active stimulatory G-protein s in -cells of transgenic mice causes counterregulation of the increased adenosine 3,5-monophosphate and insulin secretion. Endocrinology 134:42-47, 1994.

104. PB Wedegaertner, DH Chu, PT Wilson, MJ Levis & HR Bourne: Palmitoylation is required for signaling functions and membrane attachment of Gq and Gs. J Biol Chem 268:25001-25008, 1993.

105. DW Markby, R Onrust & HR Bourne: Separate GTP binding and GTPase activating domains of a G subunit. Science 262:1895-1901, 1993.

106. T Voyno-Yasenetskaya, BR Conklin, RL Gilbert, R Hooley, HR Bourne & DL Barber: G13 stimulates Na-H exchange. J Biol. Chem. 269:4721-4724, 1994.

107. O Chabre, BR Conklin, S Brandon, HR Bourne & LE Limbird: Coupling of the 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system. J. Biol. Chem. 269:5730-5734, 1994.

108. M Faure, TA Voyno-Yasenetskaya & HR Bourne: cAMP and subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J. Biol. Chem. 269:7851-7854, 1994.


109. TA Voyno-Yasenetskaya, AM Pace & HR Bourne: Mutant subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts. Oncogene 9:2559-2565, 1994.

110. E Reuveny, PA Slesinger, J Inglese, JM Morales, JA Iñiguez-Lluhi, RJ Lefkowitz, HR Bourne, YN Jan & LY Jan: Activation of the cloned muscarinic potassium channel by G protein subunits. Nature 370:143-146, 1994.

111. PB Wedegaertner & HR Bourne: Activation and depalmitoylation of Gs. Cell 77:1063-1070, 1994.

112. T Iiri, P Herzmark, JM Nakamoto, C Van Dop & HR Bourne: Human Gs mutation accelerates GDP release, causing both gain and loss of endocrine function. Nature 371:164-168, 1994.

113. PT Wilson & HR Bourne: Fatty acylation of z: Effects of palmitoylation and myristoylation on z signaling. J. Biol. Chem. 270:9667-9675, 1995.

114. DR Benjamin, DW Markby, HR Bourne & ID Kuntz: Complete H-1, C-13, and N-15 assignments and secondary structure of the GTPase activating domain of G(s). Biochemistry 34:155-162, 1995.

115. T Iiri, Y Homma, Y Ohoka, JD Robishaw, T Katada & HR Bourne: Potentiation of Gi-mediated phospholipase C activation by retinoic acid in HL-60 cells. Possible role of G2. J. Biol. Chem. 270:5901-5908, 1995.

116. M Faure & HR Bourne: Differential effects of cAMP on the MAP kinase cascade: Evidence for a cAMP-insensitive step that can bypass Raf-1. Molec. Biol. Cell 6:1025-1035, 1995.

117. Y-H Wong, JSC Chan, LY Yung & HR Bourne: Mutant subunit of Gz transforms Swiss 3T3 cells. Oncogene 10:1927-1933, 1995.

118. PD Garcia, R Onrust, SM Bell, TP Sakmar & HR Bourne: Transducin- C-terminal mutations prevent activation by rhodopsin: A new assay using recombinant proteins expressed in cultured cells. EMBO J. 14:4460-4469, 1995.

119. AM Pace, M Faure & HR Bourne: Gi2-mediated activation of the MAP kinase cascade. Mol. Biol. Cell 6:1685-1695, 1995.

120. DR Benjamin, DW Markby, HR Bourne & ID Kuntz: Solution structure of the GTPase activating domain of s. J. Mol. Biol. 254:681-691, 1995.

121. O Lichtarge, HR Bourne & FE Cohen: An evolutionary trace method defines binding surfaces common to protein families. J. Mol. Biol. 257:342-358, 1996.

122. BR Conklin, P Herzmark, S Ishida, TA Voyno-Yasenetskaya, Y Sun, Z Farfel & HR Bourne: Carboxyl-terminal mutations of Gq and Gs that alter the fidelity of receptor activation. Mol Pharmacol 50:885-890, 1996.


123. PB Wedegaertner, HR Bourne & M von Zastrow: Activation-induced subcellular redistribution of Gs. Mol Biol Cell 7:1225-1233, 1996.

124. TA Voyno-Yasenetskaya, MP Faure, NG Ahn & HR Bourne: G12 and G13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. J Biol Chem 271:21081-21087, 1996.

125. O Lichtarge, HR Bourne & FE Cohen: Evolutionarily conserved G binding surfaces support a model of the G protein-receptor complex. Proc Natl Acad Sci USA 93:7507-7511, 1996.

126. Z Farfel, T Iiri, H Shapira, Z Roitman, M Mouallem & HR Bourne: Pseudohypoparathyroidism, a novel mutation in the -contact region of Gs impairs receptor stimulation. J Biol Chem 271:19653-19655, 1996.

127. SP Sheikh, TA Zvyaga, O Lichtarge, TP Sakmar & HR Bourne: Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 383:347-350, 1996.

128. T Iiri, PB Backlund, TLZ Jones, PB Wedegaertner & HR Bourne: Reciprocal regulation of Gs by palmitate and the subunit. Proc Natl Acad Sci USA 93:14592-14597, 1996.

129. R Onrust, P Herzmark, P Chi, PD Garcia, O Lichtarge, C Kingsley & HR Bourne: Receptor and binding sites in the subunit of the retinal G protein transducin. Science 275:381-384, 1996.

130. Y Yan, PP Chi & HR Bourne: RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis. J Biol Chem 272:11924-11927, 1997.

131. T Iiri, Z Farfel & HR Bourne: Conditional activation defect of a human Gs mutant. Proc Natl Acad Sci USA 94:5656-5661, 1997.

132. J Morales, CS Fishburn, PT Wilson & HR Bourne: Plasma membrane localization of Gz requires two signals. Mol Biol Cell 9:1-14, 1998.

133. ER Neptune & HR Bourne: Receptors induce chemotaxis by releasing the subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci USA 94:14489-14494, 1997.

134. DM Apanovitch, T Iiri, T Karasawa, HR Bourne & HG Dohlman: Second site suppressor mutations of a GTPase-deficient G-protein subunit: Selective inhibition of G-mediated signaling. J Biol Chem 273:28597-28602, 1998.

135. ER Neptune, T Iiri & HR Bourne: Gi is not required for chemotaxis mediated by Gi-coupled receptors. J Biol Chem 274:2824-2828, 1999.

136. T Iiri, SM Bell, TJ Baranski, T Fujita & HR Bourne: A Gs mutant designed to inhibit receptor signaling through Gs. Proc Natl Acad Sci U S A 96:499-504, 1999.


137. G Servant, OD Weiner, ER Neptune, JW Sedat & HR Bourne: Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10:1163-1178, 1999.

138. TJ Baranski, P Herzmark, O Lichtarge, BO Gerber, J Trueheart, EC Meng, T Iiri, SP Sheikh & HR Bourne: C5a receptor activation: Genetic identification of critical residues in four transmembrane helices. J Biol Chem 274:15757-15765, 1999.

139. SP Sheikh, J Villardarga, TJ Baranski, O Lichtarge, T Iiri, EC Meng, RA Nissenson & HR Bourne: Similar structures and shared switch mechanisms of the 2 adrenoceptor and the parathyroid hormone receptor: Zn(II) bridges between helices III and VI block activation. J Biol Chem 274:17033-17041, 1999.

140. CS Fishburn, P Herzmark, J Morales & HR Bourne: G and palmitate target newly synthesized Gz to the plasma membrane. J Biol Chem 274:18793-18800, 1999.

141. OD Weiner, G Servant, MD Welch, TJ Mitchison, JW Sedat & HR Bourne: Spatial control of actin polymerization during neutrophil chemotaxis. Nature Cell Biology 1:75-81, 1999.

142. CS Fishburn, SK Pollitt & HR Bourne: Localization of a peripheral membrane protein: G targets Gz. Proc Natl Acad Sci USA 97:1085-1090, 2000.

143. G Servant, OD Weiner, P Herzmark, T Balla, JW Sedat & HR Bourne: Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287:1037-1040, 2000.

BO Gerber, EC Meng, V Dötsch, TJ Baranski & HR Bourne: An activation switch in the ligand binding pocket of the C5a receptor. J Biol Chem 276:3394-3400, 2001.

P Rondard, T Iiri, S. Srinivasan, E Meng, T Fujita, HR Bourne: Mutant G protein subunit activated by G: a model for receptor activation? Proc Natl Acad Sci 98:6150-6155, 2001.

OD Weiner, PO Neilsen, GD Prestwich, MW Kirschner, LC Cantley and HR Bourne. A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nature Cell Biology 4:509-512, 2002.

F Wang, P Herzmark, OD Weiner, S Srinivasan, G Servant and HR Bourne. Lipid products of phosphoinositide 3-kinases maintain persistent cell polarity and directed motility in neutrophils. Nature Cell Biology 4:513-518, 2002.

JL Whistler, BO Gerber, EC Meng, TJ Baranski, M Von Zastrow and HR Bourne. Constitutive Activation and Endocytosis of the Complement Factor 5a Receptor: Evidence for Multiple Activated Conformations of a G protein-Coupled Receptor. Traffic 3:866, 2002.

W Yu, LE O'Brien, F Wang, HR Bourne, KE Mostov, K. E., and M Zegers. Hepatocyte Growth factor switches orientation of polarity and


mode of motility during morphogenesis of multicellular epithelial structures. Mol Biol Cell, 14:748-763, 2003.

S Srinivasan, F Wang, S Glavas, A Ott, F Hofmann, K Aktories, D Kalman, and HR Bourne. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol 160:375-385, 2003.

J Xu, F Wang, A Van Keymeulen, P Herzmark, A Straight, K Kelly, Y Takuwa, N Sugimoto, T Mitchison, and HR Bourne. Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils. Cell 114:201-214, 2003.

152. E Buck, HR Bourne, and JA Wells. Site-specific Disulfide Capture of Agonist and Antagonist Peptides on the C5a Receptor. J Biol Chem 280: 4009-4012. 2005.

153. J Xu, F Wang, A Van Keymeulen, M Rentel, and HR Bourne. Neutrophil microtubules suppress polarity and enhance directional migration. Proc Natl Acad Sci U S A 102: 6884-6889, 2005.

154. OD Weiner, MC Rentel, A Ott, GE Brown, M Jedrychowski, MB Yaffe, SP Gygi, LC Cantley, HR Bourne and MW Kirschner. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biology 4: e38, 2006.

155. A Van Keymeulen, K Wong, ZA Knight, C Govaerts, KM Hahn, KM Shokat, HR Bourne. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol 174: 437-45, 2006.

156. K Wong, O Pertz, K Hahn, and H Bourne. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc Natl Acad Sci U S A 103: 3639-3644, 2006.

157. P Herzmark, K Campbell, F Wang, K Wong, H El-Samad, A Groisman, and HR Bourne. Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proc Natl Acad Sci U S A 104: 13349-13354, 2007.

158. K Wong, A Van Keymeulen, and HR Bourne. PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. J Cell Biol 179: 1141-1148, 2007.

159. J Xu, A Van Keymeulen, NM Wakida, P Carlton, MW Berns, and HR Bourne. Polarity reveals intrinsic cell chirality. Proc Natl Acad Sci U S A 104: 9296-9300, 2007.

Refereed reviews1. HR Bourne, DA Sanders & F McCormick: The GTPase superfamily:

A conserved switch for diverse cell functions. Nature 348:125-132, 1990.


2. HR Bourne, DA Sanders & F McCormick: The GTPase superfamily: Conserved structure and molecular mechanism. Nature 349:117-127, 1991.

3. HR Bourne & RA Nicoll: Molecular machines integrate coincident synaptic signals. Cell 72/Neuron 10 (Suppl.):65-75, 1993.

4. BR Conklin & HR Bourne: Structural elements of G subunits that interact with G, receptors, and effectors. Cell 73:631-641, 1993.

5. PB Wedegaertner, PT Wilson & HR Bourne: Lipid modifications of trimeric G proteins. J. Biol. Chem. 270:503-506, 1995.

6. T Iiri, Z Farfel & HR Bourne: G-protein diseases furnish a model for the turn-on switch. Nature 394:35-38, 1998.

7. Z Farfel, HR Bourne & T Iiri: Mechanisms of disease: The expanding spectrum of G protein diseases. N Engl J Med 340:1012-1020, 1999.

8 P Rickert, OD Weiner, F Wang, HR Bourne & G Servant: Leukocytes navigate by compass: roles of PI3K and its lipid products. Trends in Cell Biol 10:466-473, 2000.

9. HR Bourne & EK O’Shea: Editors of Cell regulation issue. Current Opinion in Cell Biology v.14 no. 2, 2002.

10. GR Sambrano, G Chandy, S Choi, D Decamp, R Hsueh, KM Lin, D Mock, N O'Rourke, T Roach, H Shu, B Sinkovits, M Verghese, H Bourne: Unravelling the signal-transduction network in B lymphocytes. Nature 420:708-10, 2002.

11. HR Bourne. G-proteins and GPCrs: from the beginning. Ernst Schering Found Symp Proc: 1-21, 2006.

12. HR Bourne. Ambition, surprise and delight: necessary lessons. Nat Cell Biol 11: 1046, 2009.

Clinical1. E Leifer, DJ Gocke & HR Bourne: Lassa fever, a new virus disease

of man from West Africa: II. Report of a laboratory-acquired infection treated with plasma from a person recently recovered from the disease. Am J Tropical Med and Hyg 19:677-679, 1970.

2. HR Bourne, PD Thompson & KL Melmon: Diagnosis and treatment of -adrenergic receptor hyperresponsiveness: A critical appraisal. Arch Internal Med 125:1063-1066, 1970.

3. HR Bourne & KL Melmon: Guides to the pharmacologic management of essential hypertension. Pharmacol Physicians 5:1-6, 1971.

4. HR Bourne: Unrecognized therapeutic measures, including placebo. IN Clinical Pharmacology: Basic Principles in Therapeutics, KL Melmon & HF Morrelli (eds.), MacMillan, New York, pp. 549-567, 1972.


5. HR Bourne: The placebo — a poorly understood and neglected therapeutic agent. Rational Drug Therapy 5:1-6, 1971.

6. HR Bourne: Tolbutamide — therapeutic trials and clinical practice. California Medicine 117:45-52, 1972.

7. HR Bourne: Rational use of placebo. IN Clinical Pharmacology: Basic Principles in Therapeutics, 2nd ed., KL Melmon & HF Morrelli (eds.), MacMillan, New York, pp. 1052-1062, 1978.

Reviews, chapters in books1. LM Lichtenstein & HR Bourne: Inhibition of allergic histamine

release by histamine and other agents which stimulate adenylate cyclase. IN Biochemistry of the Acute Allergic Reactions: 2nd International Symposium, KF Austen & EL Becker (eds.), Blackwell Scientific, Oxford, pp. 161-174, 1971.

2. HR Bourne: Leukocyte cyclic AMP: Pharmacologic regulation and possible physiologic implications. IN Prostaglandins in Cellular Biology, PW Ramwell & BB Pharris (eds.), Plenum, New York, pp. 111-149, 1972.

3. LM Lichtenstein, E Gillespie & HR Bourne: Studies on the biochemical mechanisms of IgE-mediated histamine release. IN Biological Role of Immunoglobulin E System, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 1973.

4. HR Bourne, LM Lichtenstein, KL Melmon, CS Henney, Y Weinstein & GM Shearer: Modulation of inflammation and immunity by cyclic AMP. Science 184:19-28, 1974.

5. KL Melmon, Y Weinstein, GM Shearer & HR Bourne: Leukocyte separation on the basis of their receptors for biogenic amines and prostaglandins: Relation of the receptor to antibody formation. IN Cyclic Nucleotides, Immune Response and Tumor Growth, W Braun, CW Parker & LM Lichenstein (eds.), Academic Press, New York, pp. 114-139, 1974.

6. HR Bourne, KL Melmon, Y Weinstein & GM Shearer: Pharmacologic regulation of antibody release in vitro: Effects of vasoactive amines and cyclic AMP. IN Cyclic Nucleotides, Immune Response and Tumor Growth, W Braun, CW Parker & LM Lichtenstein (eds.), Academic Press, New York, pp. 99-113, 1974.

7. GM Shearer, Y Weinstein, KL Melmon & HR Bourne: Separation of leukocytes by their amine receptors: Subsequent immunologic functions. IN Cyclic Nucleotides, Immune Response and Tumor Growth, W Braun, CW Parker & LM Lichtenstein (eds.), Academic Press, New York, pp. 135-146, 1974.

8. C Sibley, U Gehring HR Bourne & GM Tomkins: Hormonal control of cellular growth. IN Control of Proliferation in Animal Cells, B


Clarkson & R Baserga (eds.), Cold Spring Harbor Laboratories, New York, pp. 115-124, 1974.

9. HR Bourne: Immunology. IN Prostaglandins, 2nd Edition, P Ramwell (ed.), Plenum, New York, pp. 277-291, 1974.

10. KL Melmon & HR Bourne: Mechanisms of inflammation. Clin Pharmacol Ther 16:886-891, 1974.

11. HR Bourne, P Coffino, KL Melmon, GM Tomkins & Y Weinstein: Genetic analysis of cyclic AMP in a mammalian cell. IN Adv Cyclic Nucl Res 5, GI Drummond, P Greengard & GA Robison (eds.), Raven, New York, pp. 771-786, 1975.

12. P Coffino, HR Bourne & GM Tomkins: Mechanisms of lymphoma cell death induced by cyclic AMP. Am J Pathol 81:199-204, 1975.

13. HR Bourne, P Coffino, J Hochman, P Insel, P Jones, KL Melmon & GM Tomkins: Genetic and functional studies of the cyclic AMP receptor in a cultured mammalian cell. IN Proceedings of the Sixth International Congress of Pharmacology, Vol 1: Receptors and Cellular Pharmacology, Pergamon, New York, pp. 223-232, 1976.

14. P Coffino, HR Bourne, J Hochman, P Insel, KL Melmon & GM Tomkins: Hormone-mediated lymphoma cell death: Mechanisms of glucocorticoid and cyclic AMP action. J Invest Derm 67:648-649, 1976.

15. P Coffino, HR Bourne, U Friedrich, J Hochman, PA Insel, I Lemaire, KL Melmon & GM Tomkins: Molecular mechanisms of cyclic AMP action: A genetic approach. Rec Prog Horm Res 32:669-684, 1976.

16. KL Melmon, Y Weinstein, T Poon, HR Bourne, GM Shearer, P Coffino & PA Insel: Receptors for low molecular weight hormones in lymphocytes. IN Comprehensive Immunopharmacology, JW Hadden, F Spreafica & RC Coffey (eds.), Plenum, New York, pp. 331-356, 1977.

17. KL Melmon, Y Weinstein, HR Bourne, GM Shearer, T Poon, L Krasny & S Segal: Isolation of cells with specific receptors for amines: Opportunities and problems. IN Cell Membrane Receptors for Viruses, Antigens and Antibodies, Polypeptide Hormones, and Small Molecules, FF Beers Jr & EG Bassett (eds.), Raven, New York, pp. 117-133, 1976.

18. P Coffino, HR Bourne, PA Insel, KL Melmon, G Johnson & J Naya-Vigne: Studies of cyclic AMP action using mutant tissue culture cells. In Vitro 14:140-145, 1978.

19. GL Johnson, P Coffino & HR Bourne: Somatic genetic analysis of hormone action. IN Membrane Receptors: Methods for Purification and Characterization, Receptors and Recognition series, S Jacobs & P Cuatrecasas (eds.), Chapman and Hall, London, pp. 171-201, 1981.


20. GL Johnson, HR Kaslow, Z Farfel & HR Bourne: Genetic analysis of hormone-sensitive adenylate cyclase. IN Adv Cyclic Nucl Res 13, P Greengard & GA Robison (eds.), Raven, New York, pp. 1-38, 1980.

21. Z Farfel, M Salomon & HR Bourne: Genetic studies of adenylate cyclase in mouse and man. IN Ann Rev Pharmacol Toxicol 2l, R George & R Okun (eds.), Annual Reviews, Palo Alto, pp. 251-264, 1981.

22. L Lichtenstein, HR Bourne, C Cochrane, C Cohen, C Henney, K Ishizaka, DG Marsh, R Orange, S Ruddy & P Ware: Basic Mechanisms. IN Asthma and the Other Allergic Diseases, NIAID Task Force Report, National Institutes of Health, Bethesda, pp. 35-86, 1979.

23. HR Bourne, Z Farfel, AS Brickman, HR Kaslow & VM Brothers: Human mutations affecting hormone-sensitive adenylate cyclase. Prog Clin and Biolog Res 63:433-437, 1981.

24. HR Bourne, Z Farfel & AS Brickman: Pseudohypoparathyroidism, a mutation of adenylate cyclase. IN Adv Cyclic Nucl Res 14, JE Dumont, P Greengard & GA Robison (eds.), Raven, New York, pp. 43-50, 1981.

25. HR Bourne, AS Brickman & Z Farfel: Molecular basis of pseudohypoparathyroidism. IN Hormonal Control of Calcium Metabolism, DV Cohn, RV Talmage & JL Matthews (eds.), Excerpta Medica, Amsterdam, pp. 102-108, 1981.

26. WH Daughaday, HR Bourne, J Fried, F Murad, P Needleman, LG Raisz & R Volpe: Hormones in pharmacology and therapeutics. IN An Evaluation of Research Needs in Endocrinology and Metabolic Diseases 5, Task Force Report, National Institutes of Health, Bethesda, pp. 637-661, 1981.

27. HR Bourne: The adenylate cyclase system, chapter 86, IN Harrison's Principles of Internal Medicine, RG Petersdorf, RD Adams, E Braunwald, KJ Isselbacher, JB Martin & JD Wilson (eds.), McGraw-Hill, New York, pp. 478-482, 1982.

28. Z Farfel & HR Bourne: Pseudohypoparathyroidism: Mutation affecting adenylate cyclase. Mineral and Electrolyte Metabolism 8:227-236, 1982.

29. HR Bourne & JM Roberts: Drug receptors and pharmacodynamics. IN Basic and Clinical Pharmacology, BG Katzung (ed.), Appleton & Lange, Norwalk, pp. 10-34, 1992.

30. NL Benowitz & HR Bourne: Antihypertensive agents. IN Basic and Clinical Pharmacology, BG Katzung (ed.), Lange Medical, Los Altos, pp. 119-139, 1989.

31. HR Bourne: Introduction to endocrine pharmacology. IN Basic and Clinical Pharmacology, BG Katzung (ed.), Lange Medical, Los Altos, pp. 414-422, 1987.


32. HR Bourne, VM Brothers, HR Kaslow, V Groppi, N Walker & F Steinberg: Genetic analysis of cyclic nucleotide phosphodiesterase in S49 mouse lymphoma cells. IN Adv Cycl Res 16, P Greengard & GA Robison (eds.), Raven Press, New York, pp. 185-194, 1984.

33. HR Bourne: A human mutation affecting hormone-sensitive adenylate cyclase. IN Cell Surface Receptors, PG Strange (ed.), Ellis Horwood, Chichester, pp. 240-248, 1983.

34. C Van Dop & HR Bourne: Pseudohypoparathyroidism. Ann Rev Med 34, pp. 259-66, 1983.

35. C Van Dop & HR Bourne: Molecular basis of pseudohypoparathyroidism. IN Clinical Disorders of Bone and Mineral Metabolism, B Frame & JT Potts Jr (eds.), Excerpta Medica, Amsterdam, pp. 453-458, 1983.

36. HR Bourne, GF Casperson, C Van Dop, ME Abood, B Beiderman, F Steinberg & N Walker: Mutations of adenylate cyclase in yeast, mouse and man. IN Advances in Cyclic Nucleotide Research, P Greengard & GA Robison (eds.), Raven Press, New York, pp. 199-205, 1983.

37. HR Bourne, C Van Dop & GF Casperson: Genetic and functional studies of guanine nucleotide-binding regulatory protein. IN Neurotransmitter Receptors: Mechanisms of Action and Regulation, S Kito, T Segawa, K Kuriyama, HI Yamamura & RW Olsen (eds.), Plenum Press, New York, pp. 85-98, 1984.

38. HR Bourne: Inheritance of deficient Ns activity and pseudohypoparathyroidism, type I. IN Endocrinology (Proc 7th International Congress), F Labrie & L Proulx (eds.), Elsevier, Amsterdam, pp. 281-283, 1984.

39. HR Bourne, GF Casperson, N Walker, K Sullivan & DC Medynski: Adenylate cyclase and GTP-binding proteins in yeast and vertebrate cells. IN Yeast Cell Biology (Proceedings of 1985 UCLA Symposium), Vol. 33, J. Hicks (ed.), Alan R. Liss Publishers, New York, pp. 81-100, 1986.

40. HR Bourne: Transducing proteins. Yeast RAS and Tweedledee's Logic. Nature 317:16-17, 1985.

41. HR Bourne, D Medynski, C Van Dop, K Sullivan & F-H Chang: Genetic and functional studies of pertussis toxin substrates. IN Pertussis Toxin, RD Sekura, J Moss & M Vaughan (eds.), Academic Press, New York, pp. 167-184, 1985.

42. HR Bourne & KA Sullivan: Mammalian G proteins: Models for ras proteins in transmembrane signaling? Cancer Surveys, 5:257-274, 1986.

43. L Stryer & HR Bourne: G Proteins: A family of signal transducers. IN Ann Rev Cell Biol 2, GE Palade, BM Alberts & JA Spudich (eds.), Annual Reviews, Palo Alto, pp. 391-419, 1986.


44. SB Masters & HR Bourne: Role of G proteins in transmembrane signaling: Possible functional homology with the ras proteins. IN Oncogenes and Growth Control, T Graf & P Kahn (eds.), Springer-Verlag, Heidelberg, pp. 184-191, 1986.

45. HR Bourne: GTP-binding proteins: One molecular machine can transduce diverse signals. Nature 321:814-816, 1986.

46. GF Casperson & HR Bourne: Biochemical and molecular genetic analysis of hormone-sensitive adenylyl cyclase. Ann Rev Pharmacol Toxicol 27:371-384, 1987.

47. HR Bourne, SB Masters & KA Sullivan: Mammalian G proteins: Structure and function. Biochem Soc Trans 15:35-38, 1987.

48. HR Bourne: The adenylate cyclase system, chapter 67, IN Harrison's Principles of Internal Medicine, E Braunwald, KJ Isselbacher, RG Petersdorf, JD Wilson, JB Martin & AS Fauci (eds.), Mc-Graw Hill, New York, pp. 370-374, 1986.

49. HR Bourne: Preliminary structural model of the G protein chain. Advances in Second Messenger and Phosphoprotein Research, Vol 21, RS Adelstein, CB Klee, M Rodbell (eds.). Raven Press, New York, pp. 33-38, 1988.

50. HR Bourne: G proteins. “Wrong” subunit regulates cardiac potassium channels. Nature 325:296-297, 1987.

51. HR Bourne: A certain style: “Apprentice to Genius — The Making of a Scientific Dynasty” [review of book by Robert Kanigel]. Trends in Pharmacol Sci 8:362-363, 1987.

52. HR Bourne: G proteins and cAMP. Discovery of a new oncogene in pituitary tumours? Nature 330:517-518, 1987.

53. HR Bourne: Do GTPases direct membrane traffic in secretion? Cell 53:669-671, 1988.

54. W Heideman & HR Bourne: Structure and function of G protein chains. IN G Proteins, L Birnbaumer, R Iyengar (eds.). Academic Press, San Diego, pp. 17-40, 1990.

55. HR Bourne, SB Masters, RT Miller, KA Sullivan & W Heideman: Mutations probe structure and function of G protein chains. Cold Spring Harbor Symposium 53:221-228, 1988.

56. SB Masters, RT Miller, KA Sullivan & HR Bourne: Identification of functional domains in G protein chains. IN The Guanine-Nucleotide Binding Proteins: Common Structural and Functional Properties. L Bosch, B Kraal, A Parmeggiani (eds.), Plenum Press, New York, pp. 313-324, 1989.

57. HR Bourne: Summary: Signals past, present, and future. Cold Spring Harbor Symposium 53:1019-1031, 1988.

58. HR Bourne & AL DeFranco: Signal transduction and intracellular messengers. IN Oncogenes and the Molecular Origins of Cancer, R. Weinberg, M. Wigler (eds.). Cold Spring Harbor Press, Cold Spring Harbor, New York, pp. 97-124, 1989.


59. HR Bourne: G-protein subunits. Who carries what message? Nature 337:504-505, 1989.

60. HR Bourne, CA Landis & SB Masters: Hydrolysis of GTP by the chain of Gs and other GTP binding proteins. Proteins: Structure, Function, and Genetics 6:222-230, 1989.

61. SB Masters, CA Landis & HR Bourne: Mutational analysis of the structure and function of GTP-binding proteins. Adv Enzyme Reg 30:75-87, 1990.

62. HR Bourne: Diversity and differences. Nature 346:421, 1990.63. SB Masters, CA Landis & HR Bourne: GTPase-inhibiting mutations

in s. Advances in Second Messenger and Phosphoprotein Research, Vol 24: The Biology and Medicine of Signal Transduction, Y Nishizuka, M Endo & C Tanaka (eds.), Raven Press, New York, pp. 70-75, 1990.

64. HR Bourne: Toxins and Cellular Signals [review of book by J Moss & M Vaughan, eds.]. Science 250:841-842, 1990.

65. HR Bourne, L Wrischnik & C Kenyon: RAS proteins: Some signal developments. Nature 348:678-679, 1990.

66. HR Bourne: Colon cancer: Consider the coiled coil. Nature 351:188-190, 1991.

67. HR Bourne: G protein oncogenes. IN Cellular Regulation by Protein Phosphorylation (Proceedings of the NATO Advanced Study Institute on Cellular Regulation by Protein Phosphorylation). LMG Heilmeyer Jr., (ed.) Vol. 56, pp. 253-260, Springer-Verlag, Heidelberg, 1991.

68. HR Bourne: Colon cancer. Suppression with a difference. Nature 353:696-698, 1991.

69. HR Bourne, P Goretzki, C Landis, J Lyons, F McCormick, A Pace & YH Wong: G-protein oncogenes. IN Origins of Human Cancer. A Comprehensive Review. J Brugge, T Curran, E Harlow & F McCormick, (ed.). pp. 327-333, Cold Spring Harbor Press, Cold Spring Harbor, New York, 1991.

70. HR Bourne & L Stryer: The target sets the tempo. Nature 358:541-543, 1992.

71. HR Bourne: Channels of reception. Nature 359:443-444, 1992.72. HR Bourne: G proteins as signalling machines. IN Progress in

Endocrinology. Proceedings of the 9th International Congress of Endocrinology. R Mornex, C Jaffiol & J Leclère, (ed.). Vol. 3, pp. 698-704, Parthenon Publishing, Carnforth, Lancs, U.K., 1993.

73. HR Bourne, KD Lustig, YH Wong & BR Conklin: Detection of coincident signals by G proteins and adenylyl cyclase. Cold Spring Harbor Symposium 62:145-148, 1992.

74. PE Goretzki, J Lyons, PS Stacy, W Rosenau, M Demeure, OH Clark, F McCormick, HD Roher & HR Bourne: Mutational activation of


RAS and GSP oncogenes in differentiated thyroid cancer and their biological implications. World J Surg 16:576-581, 1992.

75. HR Bourne: GTPases everywhere! IN GTPases in Biology I, (Handbook of Experimental Pharmacology Vol. 108/I), BF Dickey, L Birnbaumer (eds.). Springer-Verlag, Berlin, Heidelberg, pp. 3-15, 1993.

76. HR Bourne: A turn-on and a surprise. Nature 366:628-629, 1993.77. BR Conklin & HR Bourne: Homeostatic Signals: Marriage of the

flytrap and the serpent. Nature 367:22, 1994.78. HR Bourne & LT Williams: Cell regulation. Editorial overview. IN

Current Opinion in Cell Biology. NB Gilula, M Kirschner & K Simons, (ed.). Vol. 6, pp. 161-162, 1994.

79. HR Bourne & HE Varmus: Oncogenes and cell proliferation. IN Current Opinion in Genetics and Development 2:1-3, 1992.

80. HR Bourne: The importance of being GTP. Nature 369:611-612, 1994.

81. HR Bourne: GTPases: A family of molecular switches and clocks. The Royal Society, London, Phil. Trans. R. Soc. Lond. B, 349:283-289, 1995.

82. HR Bourne: Team blue sees red. Nature 376:727-729, 1995.83. HR Bourne: Trimeric G proteins: Surprise witness tells a tale.

Science 270:933-934, 1995.84. HR Bourne, P Garcia, R Onrust, Y Yan, O Lichtarge & FE Cohen: G

protein activation by 7TM receptors—a progress report. Munksgaard, Copenhagen, Denmark, Structure and Function of 7TM Receptors. Alfred Benzon Symposium 39, 32-42, 1996.

85. HR Bourne: How receptors talk to trimeric G proteins. IN Current Opinion in Cell Biology. LC Cantley & SR Coughlin, (ed.). Vol. 9, No. 2, pp. 134-142, Current Biology, Ltd., London, 1997.

86. HR Bourne: The arginine finger strikes again. Nature 389:673-674, 1997.

87. HR Bourne: Drug Receptors & Pharmacodynamics (Chap. 2). IN Basic and Clinical Pharmacology, 7th Edition, BG Katzung (ed.), Appleton & Lange, Stamford, Connecticut, pp. 9-33, 1997.

88. T Iiri & HR Bourne: G proteins propel surprise. Nature Genetics 18:8-10, 1998.

89. HR Bourne: Pieces of the true grail: A G protein finds its target. Science 278:1898-1899, 1997.

90. HR Bourne: A necessary hero. Curr Biol 9:R870-R871, 1999. 91. OD Weiner, S Servant, CA Parent, PN Devreotes & HR Bourne: Cell

polarity in response to chemoattractants (Chap. 7). IN Cell Polarity, DG Drubin (ed.) Oxford U. Press, Oxford, pp. 201-239, 2000.

92. HR Bourne & EC Meng: Rhodopsin sees the light. Science 289: 733-734, 2000.


93. HR Bourne and OD Weiner: A chemical compass. Nature 419: 21, 2002.

94. HR Bourne: Q&A. Current Biology 13: R892-R893, 2003. 95. HR Bourne, Rac and cell migration: CDM proteins integrate

signals. Nat Cell Biol 7: 777-778, 2005.

BooksHR Bourne, Ambition and Delight, ExLibris (2009).HR Bourne, Paths to Innovation: Discovering Recombinant DNA,

Oncogenes, and Prions, in One Medical School, Over One Decade, University of California Medical Humanities Consortium, distributed by UC Press (2011).

now is the time · web view1983 william n. creasy visiting professor of clinical pharmacology,...

Documents