nps prohibited in sport: status and challenges...m1. manipulation of blood and blood components m2....
TRANSCRIPT
![Page 1: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/1.jpg)
NPS prohibited in sport: status and challenges13-14 November 2018, Novel Psychoactive Substances Symposium, Philadelphia, USA
Irene Mazzoni, Ph.D, Senior Manager, Sciences and Medicine Department
![Page 2: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/2.jpg)
• Identifies the substances and methods prohibited in sports
• The substances and methods on the List are classified by different categories.
• Updated on annual basis
• Year-long process; includes consultation with stakeholders
![Page 3: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/3.jpg)
▪ Categories of substances in the 2018 Prohibited List
Prohibited List
Substances prohibited at all times
S0. Non-approved substances-
S1. Anabolic androgenic steroids (AAS, exogenous, endogenous, other)
S2. Peptide hormones, growth factors, related substances and mimetics
S3. Beta-2 agonists
S4. Hormone and metabolic modulators
S5. Diuretics and masking agents
Substances prohibited in-competition only:
S6. Stimulants- psychoactive drugs
S7. Narcotics- psychoactive drugs
S8. Cannabinoids -psychoactive drugs
S9. Glucocorticoids
Substances prohibited in particular sports
P1. Beta-blockers
Methods (prohibited at all times)
M1. Manipulation of blood and blood components
M2. Chemical and Physical Manipulation
M3. Gene Doping
Concept of open list of examples :”substances with similar chemical structure or similar biological effects”
![Page 4: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/4.jpg)
Psychoactive drugs in Prohibited List 2018
S6-Stimulants: all stimulants (direct and indirect sympathomimetics)
are prohibited
➢ medicines (e.g. modafinil, pseudoephedrine)
➢ medicines & « recreational » use (e.g. amphetamine)
➢ designer drugs (e.g. mephedrone, MDMA)
➢ natural product (e.g. cathinone)
➢ discontinued and re-appeared in supplements under different name
(methylhexanamine)
Hallucinogens not prohibited
OPEN, NON-EXHAUSTIVE LIST
![Page 5: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/5.jpg)
S8: Cannabinoids:
• Natural cannabinoids, e.g. cannabis,
hashish and marijuana,
• Synthetic cannabinoids e.g. 9-
tetrahydrocannabinol (THC) and other
cannabimimetics.
▪ Except cannabidiol
Several WADA-sponsored grants to determine
metabolism and detection …….
Psychoactive drugs in Prohibited List 2018
……..but new compounds appear…..OPEN, NON-EXHAUSTIVE LIST
![Page 6: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/6.jpg)
▪ S7. NARCOTICS
▪ The following narcotics are
prohibited:
▪ Buprenorphine;
▪ dextromoramide;
▪ diamorphine (heroin);
▪ fentanyl and its derivatives;
▪ hydromorphone;
▪ methadone;
▪ morphine;
▪ nicomorphine;
▪ oxycodone;
▪ oxymorphone;
▪ pentazocine;
▪ pethidine.
Psychoactive drugs in Prohibited List 2018
CLOSED LIST, except for fentanyl derivatives
![Page 7: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/7.jpg)
▪ CHALLENGES
![Page 8: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/8.jpg)
Detection of NPS during doping control
Challenges-
1. Anti-doping detection based on:
▪ Chromatography/MS
✓ Need structure & Mass spectrum
2. Mostly urinary samples
▪ Metabolism unknown
3. Biologic effect/potency unknown
![Page 9: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/9.jpg)
Different Scenarios
1. Anti-doping lab detects new substance during
screening & identifies it; communicates to WADA.
2. Intelligence-based approach
a) Through AD labs/NADOs
b) Through WADA & collaborators
Detection/identification of NPS for doping control
![Page 10: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/10.jpg)
Detection of NPS during doping control
Different Scenarios
1. Intelligence-based approach
a) Through AD labs/NADOs:
i. working with Customs, analysis seized material
ii. information received by WADA from NADOs, sports
Federations, whistleblowers
![Page 11: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/11.jpg)
Detection of NPS during doping control
Different Scenarios
1. Intelligence-based approach
a) Through WADA & collaborators
i. Purchase of prohibited substances & analysis
ii. Partner with law-enforcement agencies
iii. Collaboration with governmental/NGO/academia
linked to drug abuse and control
iv. Collaboration with pharmaceutical industry
![Page 12: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/12.jpg)
Intelligence-based approach:Purchase of prohibited substances & analyze
➢ Search drugs in internet, field information, etc
➢ Buy
➢ Analyse product to e.g.:
✓ test if existing detection methods adequate
✓ detect contaminants
✓ identify chemical structure
✓ develop and validate detection method
✓ study metabolism (in vitro)
➢ Inform authorities of clandestine labs/stores
![Page 13: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/13.jpg)
Intelligence-based approach:Purchase of prohibited substances & analyze
![Page 14: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/14.jpg)
Intelligence-based approach:Collaboration with law-enforcement agencies
❖ 2,4 Dinitrophenol
▪ 1st ALERT JANUARY 2015 WADA
Australian Sports Drugs Testing Laboratory
▪ 2nd ALERT APRIL 2015 FRANCE
OCLAESP
▪ 3rd ALERT APRIL 2015 UK
Open-Sources
![Page 15: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/15.jpg)
❖ 2,4 Dinitrophenol
▪ INTERPOL Orange Notice
Issued 21/04/2015
Intelligence-based approach:Collaboration with law-enforcement agencies
![Page 16: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/16.jpg)
Nearly 300Underground
Laboratories
identified
More than 2millions of seized
products listed
in 2016
16 20Participating
countries Dozenof websites
regularly monitored
![Page 17: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/17.jpg)
Intelligence-based approach:Collaboration with governmental/NGO/academia
Information exchange
▪ UNODC
▪ EMCDDA
▪ University of Hertfordshire
▪ New……….
![Page 18: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/18.jpg)
Intelligence-based approach:Collaborations with Pharmaceuticals
➢ Collaborative agreements with pharmas
▪ Information on doping potential of new drugs in
clinical development.
▪ ADME/detection methods
▪ Reference Materials (Parent compound,
metabolites)
![Page 19: NPS prohibited in sport: status and challenges...M1. Manipulation of blood and blood components M2. Chemical and Physical Manipulation M3. Gene Doping Concept of open list of examples](https://reader036.vdocuments.net/reader036/viewer/2022070110/6047ef75c12adb46a42ad474/html5/thumbnails/19.jpg)
Thank you for your attention!