nsf 2011 nsec grantees conference...nanoscale science & engineering center for integrated...
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International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
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NSF 2011 NSEC Grantees ConferenceNanoscale Science & Engineering Center for Integrated
Nanopatterning and Detection Technologies
Chad A. Mirkin, Director
Milan Mrksich, Associate Director
Northwestern University
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Center Vision
NSEC for Integrated
Nanopatterning and
Detection Technologies
New Educational Paradigms
Integrated Research
Nanostructure
Characterization
Knowledge Creation
Design & Fabrication of
Soft NanostructuresNanoscale Experiments,
Theory and Engineering
New Detection Technologies
Unique Sub-100 nm Surface
Patterning Capabilities
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Synergistic Team 10 mi
UIUC
80 mi
NU
UCANL
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Mission
To advance discovery and knowledge within the field of
nanotechnology through focused and collaborative research leading
to the development of powerful new biological and chemical
detection systems that have the potential to revolutionize many
diverse fields.
This research forms the foundation for, and is effectively integrated
with, innovative and diverse educational outreach programs that seek
to inform, engage, and inspire people of all ages and broaden the
participation of underrepresented minorities.
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Participating PIs by Department
ChemistryFranz Geiger
Mark Hersam, JABrian Hoffman, JA
Joseph HuppMercouri Kanatzidis
Thomas MeadeChad Mirkin
Milan Mrksich, UCSonBinh Nguyen
Teri OdomMonica Olvera de la Cruz, JA
George SchatzTamar Seideman
Stephen Sligar, UIUC, JAJ. Fraser StoddartSamuel Stupp, JA
Richard Van Duyne
Materials Science and EngineeringMichael BedzykVinayak DravidMark HersamJiaxing HuangLincoln LauhonChad Mirkin, JATeri Odom, JA
Monica Olvera de la CruzDavid SeidmanSamuel Stupp
MedicineThomas Meade, JA
Chad Mirkin, JAStephen Sligar, UIUC-JA
Samuel Stupp, JA
Electrical Engineering and Computer Science
Matthew GraysonChang Liu, JA
Mechanical EngineeringCate Brinson
Horacio EspinosaChang Liu, JAWing Kam Liu
Jane Wang
Neurobiology and PhysiologyWilliam Klein
Thomas Meade, JA
Kellogg School of MgmtBarry Merkin
Physics and AstronomyMichael Bedzyk, JA
Donald EllisJohn Ketterson
Weinberg College Writing ProgramJohn Anderson
BiochemistryStephen Sligar, UIUC-JA
Thomas Meade, JA
Biomedical EngineeringChad Mirkin, JA
Chemical and Biological Engineering
Chad A. Mirkin, JAJustin Notestein
Monica Olvera de la Cruz, JA
Civil and Environmental EngineeringKimberly Gray
Physical ScienceMichael Davis, HWC
Medical Humanities and EthicsLaurie Zoloth
Medicine – Infectious Diseases
Steven Wolinsky
Medicine - Urology
C. Shad Thaxton
181 FTE graduate students
53 graduate student fellowships
114 FTE postdocs
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Research Objectives
Develop a suite of high throughput, parallel
nanolithography tools with soft matter compatibility for
patterning materials on surfaces with sub-100 nm
spatial resolution and evaluate their potential for building
the targeted devices.
Develop detection systems with novel receptors and
signal transduction methods made possible through the
development of these novel lithographic tools and
related nanostructures.
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Technology Base
Technology Integration
Lithography software development
Year 6 Year 7 Year 8 Year 9 Year 10
Knowledge Base
Development of routine chemistry and
methods for fabricating combinatorial
nanostructure libraries
Development of methods for structural and spectroscopic characterization
of lithographically generated nanostructures
Development of inks, low wear tip coatings,
and alignment strategies in the context of
multiple tip arrays
DPN probes with integrated Inking channels;
Integrated ink wells and stamp pads;
Multimode lithography
Nanolithography integration with
complementary fabrication techniques
1 million pen
passive writing
with multiplexed
Inking
Fabrication of
combinatorial
Polyvalent recog-
nition nanopatterns
Multi-valency site
recognition and assembly
1-dimensional passive and active probes
2-dimensional passive and active probes
Alignment sensors
On-chip DNA and
peptide synthesis
Versatile chemistry
& materials research
tool system
Coupled nanotechnology
research/manufacturing systems
Optimized active
probe actuation:
Pneumatics and
piezoelectrics
Integration of
nanolithography tool with
larger scale fabrication
techniques
1 million pen
active writing
with multiplexed
inking
Strategic Framework I – Versatile Parallel Nanolithography Tool
Multiplexed ink
deposition for DNA
and protein arrays
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Technology Base
Technology Integration
Year 6 Year 7 Year 8 Year 9 Year 10
Knowledge Base
• Dye-enhanced LSPR
• Plasmon-enhanced
diffraction
• Plasmon-enhanced
MALDI-TOF
• Multiplexing BCA
• Plasmon wire sensing
• Polymer-electro-
chemical probes
• Nanoporous materials
for small-molecule
sensing
• Plasmon-enhanced
SHG probes
• Detection of 10 different
targets with BCA
• Photonic arrays for
SERS
• Integrated photonic/
plasmonic sensors
• Single particle Raman
sensing
• Intracellular Raman
sensing
• Detection of 20+ different
targets with BCA sensor
• Semiconductor light
sources integrated with
metal plasmonics
Bio-barcode detection uses nanoparticle
enhanced equilibrium to beat conventional
sensing limits
Electrochemical detection uses polymer
amplification
Nanodisc receptors provide new
functionality to membrane bound proteins
Enhanced Raman sensing and allosteric
amplification enables molecule-specific
detection of small molecule targets
Quantification of photonic
sensors and barcode assays
Nanopatterning for electrical detection
Universal probe design
Single particle plasmonic sensors
Nanomaterials for amplificationIntegrated microfluidics and electrophoresis
“The breadboard”
Multiplexed HIV detection
using bio-barcodes in patient
samples
AD detection panel
assay based upon
LSPR and barcodes
Sepsis detection using bio-barcodes, with
onboard electrophoretic capabilities
Multiplexed protein,
DNA, and RNA detectionSmall molecule/Raman integrated detection
with onboard sample processing
Strategic Framework II – Integrated Point-of-Care Device
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Synergistic Research Groups
Nanopatterning SRG
Leader: Mark Hersam
Co-Leader: Teri Odom
Signal Transduction & Receptor Design SRG
Leader: Milan Mrksich
Co-Leader: George Schatz
Integrated Biodetection Chip SRG
Leader: Vinayak Dravid
Co-Leader: Chang Liu
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Notable Research AccomplishmentsFundamentals of Patterning in 2001
State-of-the-art available in 2001
Dip-pen Nanolithography (DPN)
Microcontact Printing (μCP)
Nanoimprint Lithography
Nanosphere Lithography (NSL)
Feedback Controlled Lithography (FCL)
Conventional (Photolithography, EBL)
Parallel DPN using two-pen
cantilever and single feedback
Nanosphere Lithography (NSL)
93 nm
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Multi-Step FCL
Notable Research AccomplishmentsFundamentals of Patterning in 2010
Dip-pen Nanolithography
Microcontact Printing
Nanoimprint Lithography
Nanosphere Lithography
Feedback Controlled Lithography
Photolithography
Polymer Pen Lithography
Electrochemical DPN
Liquid Phase Nanolithography
Field Induced Oxidation
Soft Interference Lithography
Cathodic Electrografting
Laser-assisted Embossing
Soft E-Beam Lithography
PEEL (Phase-shifting photolithography, Etching,
Electron-beam deposition, Lift-off)
New Techniques and Advanced Fabrication Methods
Liquid Phase
Nanolithography
1.3 Million Probe 2-D Passive Array
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Notable Research AccomplishmentsFundamentals of Patterning in 2010
Conducting Polymers
290 nm
55 nm
65 nm
Silicon Nanostructures
Sol Gel Templates290 nm
New Substrates, Surface Chemistries, and Materials
100 nm
4mm
DNA and Protein Nanoarrays
1 mm
Single Nanoparticles
PZT
500 nm
Multifunctional Oxides
Polymer Brushes
500 nm
40nm
Complex ShapesssDNA-CNT on Si(111):H
Cylindrical Nanostructures
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
1 nm
Feedback Controlled Lithography(10,000,000,000 Dots/200 × 200 µm2)
Notable Research AccomplishmentsFundamentals of Patterning in 2010Higher Density, Higher Throughput, & Improved Spatial Resolution
single atom precision
Polymer Pen Array3-inch wafer
with 11 million pens
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Notable Research AccomplishmentsSignal Transduction and Receptors in 2010
Mechanisms of selective target detection
– Polyvalent molecular recognition
– Biomimetic molecules for protein recognition
– Small molecule recognition with genetically engineered proteins
– Non biological receptors via supramolecular chemistry capable allosteric amplification
Nanostructure assembly to transduce target recognition into signals
– Surface-directed assembly
– Receptor-functionalized polymeric linkers
– Film formation and nanostructure assembly
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Notable Research AccomplishmentsSignal Transduction and Receptors
Microfluidic bio-barcode assays
Novel Receptors and High-throughput Methods
Multiplexed detection
PSA
mAb
HCG
mAb
100 aM sensitivity,
a standing record
Supramolecular structuresNanodics Nanoflares
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Notable Research AccomplishmentsAdvanced Sensing Capabilities
Detection of:
Alzheimer’s
HIV
Cancer markers
Influenza
PSA
Sepsis
Cholera
Biowarfare agents
Carbohydrates
Calmodulin
Human Cyt P450
Outlet
Chip
Inlet
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Notable Research AccomplishmentsOther Advanced Capabilities
Targeted injection for therapeutics at the single cell level
Multiplexed gas sensing at ppm sensitivity
Room temperature
multiplexed gas sensor
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Major NU-NSEC Outputs
Over 700 total publications
– Highly cited, 59 with >100 citations, 26 with >200,
18 with >300
1177 citations – Mirkin, et al. “Photoinduced conversion of
silver nanospheres to nanoprisms,” Science, 2001, 294, 1901.
936 citations – Mirkin, et al. “Nanoparticles with Raman
spectroscopic fingerprints for DNA and RNA detection,”
Science, 2003, 297, 1536.
613 citations – Van Duyne, et al. “A nanoscale optical
biosensor: Sensitivity and selectivity of an approach based on
the LSPR spectroscopy of triangular silver nanoparticles ,”
JACS, 2002, 124, 10596.
473 citations – Schatz, et al. “Controlling anisotropic
nanoparticle growth through plasmon excitation,” Nature, 2003,
425, 487.
11 publications
13 publications
15 publications
37 publications
22 publications
Fundamental insight into design, fabrication, and engineering of
nanomaterials
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Major NU-NSEC Outputs
Nanosphere Verigene
Nanostructures that optimize and amplify detection events in
the context of many important chemical, biological, and
medical analytes
Flexible, massively parallel nanofabrication system now used
in 23 countries
First nanotechnology based point-of-care medical diagnostic
system, now with 5 FDA-approved assays
NanoInk NscriptorNanointegris SWCNT
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Domestic Collaborations
Academic
Industrial
36 Academic Institutions 6 National Labs 70 Industrial Partners
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
International Collaborations
Collaborations in 19 Countries
Active exchange programs with Tel-Aviv University and NTU in Singapore
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Research & Knowledge Transfer
Metrics To Date
702 publications
65 patents
144 inventions disclosures
Findings presented at seminars
& colloquia
– 1,419 domestic
– 71 international
163 workshops and short
courses given by NSEC
researchers to industry/others
16 spin-off companies launched– >$500M venture investment realized
Nanotechnology Corporate Partners– $620K in unrestricted funds to date
The journal Small launched in 2005– Partnership with Wiley Publishing
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Electron ProbeInstrumentationCenter (EPIC)
Keck Interdisciplinary Surface Science Center
Nanoscale Imaging, Fabrication, Testing & Instrumentation(NIFTI)
Advanced Photon Source (ANL)
Integrated Molecular Structure Eduand Research Center
(IMSERC)
J.B. Cohen X-Ray Diffraction Facility
NSEC Secured $7M in State Funding to Provide
Instrumentation for Centralized Facilities
Biological ImagingFacility
NSEC
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Special Events Organized/Sponsored
104 Frontiers in Nanotechnology Seminars held (~10,000 total attendees)
8 IIN Symposiums (>4760 total attendees)
5 Summer Institutes on Nano Mechanics & Materials
Swiss Nanotechnology Road Show
Singapore Econ Dev Workshop on Nanotechnology
2 ASME Nano Training Boot Camps
International Symposium on the Relations between Homogeneous and Heterogeneous Catalysis
Gateway to the Future of Nanotechnology
Symposium on Electronic Processes and Molecular Properties at the Nanoscale
SERS-Ablation Conference
Pan-American Advanced Studies Institute
Program (PASI) on Nano and Biotechnology,
Argentina
Workshop on New Advances in AFM and Optical
MEMS Measurement
Nanotechnology Frontiers Workshop I, DC
Productive Nanosystems: Launching the
Technology Roadmap
NSF-MEXT Young Scientists Exchange Program
& Symposium, US/Japan
Nanotechnology Frontiers Workshop II, DC
Illinois Biotechnology Index Event
Summer Institute on Energy Challenges &
Nanotechnology
US-India-Israel Workshop on Nanoscale
Phenomena in Soft & Hybrid Materials
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Educational Program Achievements
Nanotechnology Museum Exhibit
– Partnership with the Museum of Science & Industry, Chicago
– Set to open in 2013
– 2,000,000 potential visitors per year
All Scout Nano Day
– Annually since 2003
– 715 pre-college children to date
– One of first participants is now an engineering graduate student at Northwestern
Research Experience for Teachers
– 88 teachers supported and 88 curriculum projects developed
– ~11,000 students impacted @ 125 students per teacher
Research Experience for Undergraduates
– 255 undergraduates supported
– 94% of recent participants indicated that the
program had positively influenced their decision to
go to graduate school
Nanoscape Undergrad Journal
– 8 issues published, on-line & print
– Mailed to >1,000 academic libraries
Nanoscience Module
– Developed for pre-college classrooms
– Being disseminated nationwide by the Materials
World Modules (MWM) program
DiscoverNANO
– Educational website
– ~1,000,000 visitors a year
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
NU-NSEC Diversity Program Achievements
Source: NSF Division of Science Resource Statistics, 2006
0%
5%
10%
15%
20%
25%
Year 10 Ctr Faculty National Averages
Women Minorities
0%
5%
10%
15%
20%
25%
30%
35%
Year 10 Ctr Graduate Students National Averages
Women Minorities
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
Year 10 Ctr Undergrads National Averages
Women Minorities
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
$95M Leveraged by NU-NSEC
Some Samples of NU-NSEC leveraged grants:
Center of Cancer Nanotechnology Excellence$ 31,817,440
REU Site $ 697,994
Programs organized by request of the National Nanotechnology Initiative
(US-MEXT Young Researchers Exchange, Frontier Nano 1.0 and 2.0)$ 151,100
NCP Program $ 688,750
State of Illinois $ 12,000,000
Specific Detection of HIV Targets by Gold Nanoparticle Probes $ 376,659
AFOSR Bio-Mechanical Interfaces for Cell-Based Microsystems $ 659,387
HSARPA-Bioinformatics and Assays Development Program $ 1,461,025
International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University
Cd-SnO2
Zn-SnO2
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Cd-SnO2
Zn-SnO2
5 µm
A
Cd-SnO2
Zn-SnO2
5 µm
A
+
+
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