THE BIG DATA

CHALLENGE

BRETT POWERS , DAVID SHRAYBER, CHRISTINA LAM

INTRODUCTION Hypoxia: Oxygen Concentration < 85%

Bradycardia: > 0.6 seconds/beat

Apnea: Breathing rate > 10 sec

1st HYPOTHESISThe QRS variability can be used as a marker to detect hypoxia.

- QRS complex

- Code

- Findings

- Machine Learning

QRS COMPLEX - ECG can measure apnea and

bradycardia through the R-R interval.

- QRS complex amplitude precursor

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831912/?report=printable

CODE

CODE

● Peak and Trough detection

● Interpolation

Chaotic Variability

Stable

Chaotic

Peak - Trough Distance

Stable

Amplitude

10 minutes - 15 minutes

10 minutes - 15 minutes

Stable2.25 minutes

2 hours 20 minutes - 2 hours 28 minutes

5 hours 37 minutes - 5 hours 43 minutes

15 hours 45 minutes - 15 hours 57 minutes

Whoa……..

Random blind test on a hypoxia showed similar precursors.

Blind Test 2

Nailed It!

Blind Test 2

Baby 1801 Test

MACHINE LEARNING

2nd Hypothesis Detecting the REM cycle by an ECG reading in conjunction with the abdominal movements, apnea can be predicted.

http://pediatrics.aappublications.org.sci-hub.ac/content/57/1/142?variant=short&sso=1&sso_redirect_count=1&nfstatus=401&nftoken=00000000-0000-0000-0000-000000000000&nfstatusdescription=ERROR%3a+No+local+token

REM sleep inhibits mechanisms that affect the respiratory system.

REM Sleep → Difficulties in breathing for preterm babies.

Ideas

RESEARCH Premature babies spend a lot of time in REM sleep.

Therefore, Apnea usually occurs during the REM cycle.

Arousal from REM sleep may trigger or precursor to apnea and hypoxia.

Since moter activities after being woken up are grouped together with laryngeal closure

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158333/pdf/431_2011_Article_1409.pdf

Taking EEG readings and correlating them with the ECG readings, we can find some markers before REM sleep.

Thank You For Being Awesome!

Dr. IndicDr. PaydarfarAlan Gee (Cal Tech Guy)Spon 1502Spon 1801Spon 1301

Questions