nutrition controversies - memberclicks controversies... · 2016 nutrition today survey: many...
TRANSCRIPT
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NUTRITION CONTROVERSIES
How to Handle the Tough Questions & Separate Fact From Emotion
Keith Thomas Ayoob, EdD, RDN, FADN
Associate Professor Emeritus of Pediatrics
Albert Einstein College of Medicine
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Disclosures
Services
• Consultation
• Counsel
• Speaking
• Writing
• Development of
education materials
Clients
• Ajinomoto
• Florida Department of Citrus
• National Dairy Council/American
Dairy Association Northeast
• National Cattlemen’s Beef
Association
• Calorie Control Council
• Glutamate Association
• McCormick Science
Institute
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“THE GUESTS THAT NEVER LEAVE”
PESTICIDES & GLYPHOSATE
GMOs
SUGAR
SUGAR SUBSTITUTES
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WHAT MOST DIETS ARE MISSING
FRUITS
VEGETABLES
LOW-FAT DAIRY
WHOLE GRAINS
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2016 Nutrition Today Survey:Many consumers fear conventional produce
Overall preference for
organic, but cost was a
factor
Information about
“organic” & “conventional”
did not increase
likelihood of buying more
fruits & vegetables
Those hearing messages about
pesticide residues on
produce were less likely to buy ANY type of fruits and vegetables
Huang, Y, Nutrition Today, doi: 10.1097/NT.0000000000000176
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EVALUATING SAFETY OF PESTICIDES
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WHO’S IN CHARGE?
• Food & Insecticide Regulation Act (FIFRA)
• Food Quality Protection Act (FQPA)
EPA Regulates pesticides
• Sets standards for levels on & in crops
• Operates Pesticide Data Program (PDP)
FDA & USDA
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ENFORCEMENT of STANDARDS: USDA’s PESTICIDE DATA PROGRAM
20 years
Rotating tests
Numerous samples: domestic & imported produce
457 pesticides, 22 environmental contaminants
https://www.ams.usda.gov/sites/default/files/media/2015PDPAnnualSummary.pdf
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PDP: TESTING METHODOLOGY
Samples from distribution centers, minimum 600 samples per commodity
Sampled as consumer would eat them: wash & drain, peel if appropriate
>99.9% of commodities have consistently tested well below acceptable levels
VAST majority do not come close to limits
https://www.ams.usda.gov/sites/default/files/media/2015PDPAnnualSummary.pdf
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SETTING THE BAR: DEFINING NOAEL, ADI, & RfD
• Maximum DAILY dose for a lifetime at which there is no biological/statistical toxic effect
No Observable Adverse Effect Level (NOAEL):
• 100th or 1000th of the maximum dose at which there was no adverse effect
Acceptable Daily Intake (ADI):
• Context: Like ADI but focused on pesticides
• Safety factor of 103 or 104Reference Dose (RfD):
https://www.epa.gov/iris/reference-dose-rfd-description-and-use-health-risk-assessments
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LEVEL OF EXPOSURE
Only 1 commodity >1% of the RfD (bell peppers at 2%)
7 foods were >0.1% of RfD
75% of foods were <0.01% of RfD
41% of foods were <0.001% of RfD
NOTE: RfD includes 1000-fold cushion of safety
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GOT GLYPHOSATE? Got Confusion.
• As seen on TV: “Used Roundup? Got cancer (any type)? You may be entitled to compensation. Call 800-555-1212 and get money!”
• “I just don’t want to be giving my kids weed killer in their oatmeal.”
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GOT GLYPHOSATE?
• Glyphosate classified as “probably carcinogenic to humans”
International Agency for Research on
Carcinogens (IARC 2015):
• “Glyphosate is unlikely to pose a carcinogenic threat to humans from exposure through diet”
Joint Meeting on Pesticide Residues
(JMPR 2016):
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GLYPHOSATE SAFETY:GLOBAL REGULATORY BODIES WEIGH IN
• “. . . a comprehensive and scientifically sound consideration of the data and arguments that led to the IARC conclusion is simply not possible . . .”
(03/15) Federal Institute for Risk
Assessment (Germany)
• “. . . glyphosate is unlikely to pose a carcinogenic threat to humans. . .”
(11/15) European Food Safety Authority
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GLYPHOSATE SAFETY:GLOBAL REGULATORY BODIES WEIGH IN
• “…products containing glyphosate do not present unacceptable risks to human health when used according to the label directions…”
(04/15) Pest Management Regulatory
Authority (Canada)
• Concluded that “…glyphosate does not pose a cancer risk to humans…”
(12/15) Australian Pesticides & Veterinary
Medicines Authority
• “…glyphosate is not likely carcinogenic to humans at doses relevant to human health risk assessment… ”
(09/16) EPA FIFRA Science Advisory Panel
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Reuters investigation, October 19, 2017
• “In glyphosate review, WHO cancer agency edited out “non-carcinogenic” findings”
• “…significant changes were made between a draft of its report and the published version. The agency won't say who made the changes or why.”
https://www.reuters.com/investigates/special-report/who-iarc-glyphosate/
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PERSPECTIVE IS EVERYTHING
IARC classifies glyphosate in the same category as:
• The occupational exposure experienced as a barber and a fry cook.
Risk vs: Hazard
• EVERYTHING is a potential hazard
• Risk: the potential for a hazard to cause harm.
Hint: Water is a hazard.
The dose makes the poison: AND ALSO BRINGS THE BENEFIT
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GMNO?
“All our food has GMOs now”
“We still don’t know what they could do to us 20 years from now.”
It’s hard to find a food that’s not a GMO.”
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HOW MANY GMO CROPS ARE THERE?
• Soybeans
• Corn
• Cotton
• Canola
• Summer squash
• Sugar beets
• Papaya
• Alfalfa
• Potatoes
• Apples
www.GMOanswers.com
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JUST SO THERE’S NO CONFUSION…
• GMO technology has no impact on nutrient content
• “GMO” refers only to the method of production, not to the resulting food
• Consumers should be assured:
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NOT A HEALTH CLAIM!
• Olive oil
• Wheat
• Oats
• Broccoli
• Salt
• Water
Source: https://www.flickr.com/photos/44126314@N07/15535539877
https://creativecommons.org/licenses/by-nd/2.0/
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PUTTING SCIENCE BEFORE PHILOSOPHY ANYMORE?
>130 NOBEL PRIZE-WINNING SCIENTISTS signed a letter to Greenpeace, in FAVOR of GMO technology.
GEOGRAPHICALLY- AND SPECIALTY-DIVERSE
NONE affiliated with Monsanto
http://supportprecisionagriculture.org/nobel-laureate-gmo-letter_rjr.html
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SUGAR
SUGAR
SUGAR
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THE BUZZ
Sugar gets kids hyperactive
Sugar makes kids overweigh
School Meals make kids overweight!
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YOU CAN’T GET OBESE BYEATING AGE-APPROPRIATE CALORIES!!!
GRADES BREAKFAST LUNCH
K-5: 350-500 calories 550-650 calories
6-8: 400-500 600-700
9-12: 450-600 750-850
Source: USDA Healthy Hunger-Free Kids Act, www.schoolnutrition.org
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HOW MUCH SUGAR DO WE EAT?
107.7
97
77
1999 2007 2016
lb. sugar/yr
LESS THAN WE DID 20 YEARS AGO!
Total added sugars eaten, per capita1:
• 1999: 107.7 lb. (133 gm/day)
• 2007: 97.0 lb. (120 gm/day)
• 2016: 77.0 lb. (95 gm/day)2
1 - ers.usda.gov, accessed 9/21/09
2 - https://www.sugar.org/diet/intake/
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THE DUMBEST FIGHT IN SCHOOL
CHOCOLATE MILK
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“New York City proposes ban on chocolate milk in schools. State officials are unhappy”
Dr. Keith Ayoob@DrKeithAyoob
Sep 16
“This is the DUMBEST FIGHT IN
SCHOOL. W/ a measly 8 grams of added
sugar & tons of nutrition it’s STILL one
of the best & most nutrient rich drinks.
The NYC Dept. of Ed. needs to deal w/
facts not ideology & stop using this as a
distraction from their failed education
policies.”
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Food Sources of Added SugarsAges 2 Years and Older, 2015 Dietary Guidelines
Data Source: What We Eat in America (WWEIA) Food Category analyses
for the 2015 Dietary Guidelines Advisory Committee
Dairy
4%
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AAP Policy Statement: Prevention of pediatric overweight & obesity
“Dietary practices should be fostered that encourage moderation rather than overconsumption, emphasizing healthful choices rather than restrictive eating patterns.”
TRANSLATION: Avoid “OCD”
(Overachievement of Consumption Directives)
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Empty-calorie DrinksWhere They Get Them, Where They Drink Them
Source: NCHS Data Brief No. 71, Figure 6. August 2011
1.4
Drink at Home (53%) Drink Away from Home (47%)
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Sugar, HFCS, and obesity? Evidence suggests otherwise
• IOM report (2002):• Higher intakes of sugar are associated
with lower rates of obesity
• “No clear and consistent association between increased intake of added
sugars and BMI.”
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SUGAR AND BEHAVIOR
Negative associations generally dismissed by the scientific community1
Perception of sugar by parents and consumers continues to defy years of sound science and logic.
Some evidence that behavior is positively affected by sugar.
1 – IOM, Dietary carb, 2002
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SUGAR CAN EVEN IMPROVE BEHAVIOR AND PERFORMANCE
Decrease in activity after sucrose1 or glucose2
Sugar-containing snack can enhance ability to stay on task3
Glucose enhances long-term verbal and spatial memory4
1 – Behar et al (1994); 2- Saravis et al (1990)
3 – Busch et al (2002); 4- Sunram-Lea et al (2001)
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SUGAR: Bottom line
It’s not “angel food” but not “devil’s food” either.
Spend WISELY: Drive consumption of needed foods!
Quantity matters, frequency matters. TYPE of sugar doesn’t matter.
WON’T make kids hyperactive!
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SS “OK” PER IOM REPORT ON SCHOOL MEALS
Safe for all ages
One of the most rigorously tested ingredients in the U.S. food supply
Can’t use it until high school
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THE ALLEGATIONS
“Causes formaldehyde
In our blood”
Brain tumors
Cancer
Glucose intolerance
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WHERE WE’RE GETTING SUGAR SUBSTITUTES
% Total by Wt
Beverages
Tabletop
Pers care
Food
Other
Based on low calorie sweetener sales to the processed food and beverage industry.
SRI Consulting Chemical Handbook. 2007
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AAP POLICY STATEMENT: Soft drinks in schools
• Each 12-oz sugared soft drink consumed daily has been associated with a 0.18-point increase in a child’s BMI and a 60% increase in risk of obesity, associations not found with "diet" (sugar-free) soft drinks. Sugar-free soft drinks constitute only 14% of the adolescent soft drink market.
American Academy of Pediatrics, 2004
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ASPARTAME: Some safety concerns from the Internet
“Possibility” of toxicity from methanol
“Possible” plasma level elevations of phenylalanine and aspartic acid (altering brain function!)
Postulated link with:
• Epilepsy
• Brain tumors
• Ailments from infertility to baldness
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ASPARTAME & “The Ramazzini Study”
Largest (and worst) animal study ever done on Aspartame.
1,800 (male and female) 8 wk old rats
Very low to very high concentrations:
“Statistically significant dose-related increase in lymphomas and leukemias in females”; No significant increase in brain tumors
Soffriti et al. Eur. J. Oncology, 10(2) 107-116.
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The Ramazzini Study:International Response
• Not a single regulatory body endorsed findings; cite large database of credible evidence showing absence of a carcinogenic effect
• Design and execution did not follow international protocol for animal carcinogenicity studies (or that of the National Toxicology Program)
• No access allowed outside pathologists to analyze all of the tissue samples where cancerous tumors were found (standard practice)
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ASPARTAME: Absorption & Metabolism
• Aspartic acid
• Phenylalanine
• Methanol
ASPARTAME is metabolized to 3
(and ONLY 3) dietary components:
• *Stegink et al. The Clinical Evaluation of a Food Additive. New York, NY. CRC Press; 1996.
Absorption and metabolism of
constituents the same whether derived from
aspartame or other food products*
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Methanol in Aspartame-sweetenedBeverage vs. Common Foods (mg)
0
20
40
60
80
100
120
Aspartame-sweetened beverage (12 oz)
Banana (1)
Orange juice (12 oz)
Apple juice (12 oz)
Red grape juice (12 oz)
Tomato juice (12 oz)
1821 23
29
65
107
(Wucherphennig et al. Flussuges Obst. 348-354, 1983).
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PHE Content of Aspartame-Sweetened Beverage Compared with Common Foods
(in mg)
0
200
400
600
800
1000
1200
Aspartame sweetened beverage (12 0z)
Nonfat milk (12 oz)
Chicken breast (3 0z)
Boiled egg (1)
Ground beef (3 oz)
(Pennington and Douglass, Bowes & Church, FOOD VALUES OF PORTIONS COMMONLY USED. 18th ed., Lippencott Williams & Wilkins, 2005)
90
606
1059
332
934
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2006 NIH/NCI Research Results
Conducted independently of any funding or ties to industry groups
Subjects included 556,990 men and women
PROSPECTIVE study, 5 years of follow up -1995-2005
RESULTS:
• Increasing consumption NOT ASSOCIATED with any cancer risk, including cancers reported in the Ramazzini study
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Highlights of GlobalSafety Confirmation
Over 500 toxicological and clinical studies conducted over 30 years confirm safety
Regulatory authorities in more than 100 countries have approved aspartame for use:
• European Food Safety Authority (EFSA) Re-Confirms Safety of Aspartame (May 2006)
• Scientific Committee on Food (SCF) of European Commission Reconfirms Aspartame’s Clean Bill of Health-(December 2002)
• U.K. Food Standards Agency supports conclusions of SCF- (December 2002)
• French Food Safety Agency Supports Safety of Aspartame-(May 2002)
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Suez, et al: Sugar Substitutes & Glucose intolerance
Studied: Saccharin, Aspartame, Sucralose
“…consumption of (SS) drives the development of glucose intolerance through induction of compositional and functional alterations in to the intestinal microbiota.”
https://www.nature.com/nature/journal/v514/n7521/pdf/nature13793.pdf
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Suez, et al: Sugar Substitutes & Glucose intolerance
“…findings suggest that (SS) may have directly contributed to enhancing the exact epidemic (obesity) that they themselves were intended to fight.”
Widely quoted, frequently cited
https://www.nature.com/nature/journal/v514/n7521/pdf/nature13793.pdf
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Suez, et al: Weaknesses/Limitations
Contradicts years of significant human clinical studies that address SS and glycemic response.
“Causative” of obesity? Saccharin is rarely used in countries with the highest incidence of obesity & diabetes.
Animal evidence of gut microbiota changes with high doses of saccharin in animals, the effect is probiotic.
http://caloriecontrol.org/council-spokesperson-berna-magnuson-reviews-nature-study-on-low-calorie-
sweeteners/
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Suez, et al: Weaknesses/Limitations
Contradicts years of significant human clinical studies that address SS and glycemic response.
“Causative” of obesity? Saccharin is rarely used in countries with the highest incidence of obesity & diabetes.
Animal evidence of gut microbiota changes with high doses of saccharin in animals, the effect is probiotic.
Lacks a plausible mechanism!http://caloriecontrol.org/council-spokesperson-berna-magnuson-reviews-nature-study-on-low-calorie-
sweeteners/
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Ramazzini Institute Sucralose Studies:NO CREDIBILITY.
“EPA has decided not to rely on data from the RI on lymphomas and leukemias in these…assessments.”
Safety of sucralose supported by ALL major international regulatory authorities
National Cancer Institute:
• “100 safety studies…showed no evidence that these sweeteners cause cancer or pose any other threat to human health.”
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SAFETY:It’s EVERYTHING…
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MUST be Assessed & Vetted Across Many Subgroups
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GLOBAL CONFIRMATION OF SAFETY:ALL MAJOR REGULATORY AUTHORITIES
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Sugar Substitutes:Support of Major Health Authorities
American Diabetes Association
American Dental Association
AND Position Paper, “Use of Nutritive and Non-Nutritive Sweeteners”
American Medical Association Council on Scientific Affairs
American Academy of Pediatrics, Committee on Nutrition
American Cancer Society
….And ALL major international health organizations
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Non-nutritive Sweeteners: Acceptable Daily Intake (ADI)
• ADI: weight of sweetener/kg bw that a person can safely consume every day over a lifetime without risk…
…divided by 100
• ADI is a conservative estimate:• Approximately1/100 of maximum level that produces no adverse effects
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SUCRALOSE & STEVIA:Metabolism & Absorption
• 95% Excreted intactSUCRALOSE
• Broken apart by gut bacteria
• Metabolized in liver
• Metabolites excreted by kidneysSTEVIA
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“Reported Use of Reduced-Sugar Foods and Beverages Reflects High-Quality Diets”
“Reduced-sugar food users” consistently reported significantly higher intakes of fruit, similar or higher micronutrient intakes, lower energy intakes and lower intake of discretionary fat and added sugars.
J Food Sci. Vol. 70, Nr.1, 2005, S42-S46.
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Do Diet Beverages Affect Dietary Consumption Patterns?
• Choose Healthy Options Consciously EverydayC.H.Oi.C.E. STUDY
• Water (n=106)
• Diet beverages (n=104)
SS randomized to replace sugar-sweetened drinks
for 6 months
• DB group: in most caloric drinks
• more desserts than the water group
• NO EVIDENCE DBs INCREASE PREFERENCE FOR SWEET FOODS/BEVERAGES
RESULTS:
Piernas et al. Am J Clin Nutr. 2013 Mar;97(3):604-11. doi: 10.3945/ajcn.112.048405.
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STEVIA – Sweet & Sustainable
• 1/5th of the land
• Only a fraction of the water
• Preserves rainforest land
To get the same sweetness as sugar cane, stevia uses:
• Needs less pesticide/herbicide
• Produces several crops per yearHas few predators
• Good for smaller plots of land
• Ideal for both small, independent farms & large farms
Hardy crop
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TALKING ABOUT HIGH-EMOTION TOPICS
1st priority: SOUND, SCIENCE-BASED FACTS
USE THE TOTAL BODY OF SCIENCE, NOT “CHERRY-PICKED” STUDIES
Distinguish “opinion” from “facts”
Always remember: FACTS first, THEN opinions
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THANK YOU! QUESTIONS?
WWW.CUTTOTHECHASENUTRITION.COM
@DrKeithAyoob
FB: KEITH AYOOB
FB: cuttothechasenutrition
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www.cuttothechasenutrition.com
@DrKeithAyoob
FB: KEITH AYOOB
FB: cuttothechasenutrition