Open Drug Discovery Teams

(ODDT)http://slidesha.re/xzGhFH

A New Challenge

Mid January Pistoia Alliance ask for volunteers to present in a Dragon’s Den scenario Feb 8th at the RSC

Ideas that will transform Pharma R&D in 2014 So my natural response was :

“If I am going to take part I want to create something real”

http://pistoiaalliance.org/

http://bit.ly/wImJtH

Could an app transform R&D ?

Tuberculosis Kills 1.6-1.7m/yr (~1 every 8 seconds) equivalent to malaria No new drugs in over 40 yrs Pipeline is thin and weak BMGF & NIH do not coordinate TB efforts, not

mandating open data.

> 7000 rare diseases e.g. Jill Wood started a foundation, raises money, awareness, funds

ground breaking research happening globally.

She is in a race against time – what can we do to translate ideas from bench to patient faster?

How can we help parents and families ?

Inspiration There are many 1000s of diseases and few with cures

Science Online 2012 on open notebooks and data overload

Flipboard

Could we create an app for science like Flipboard?

http://slidesha.re/why7gg

Within about 10 days Alex Clark Created ODDT to present at the Pistoia meeting

Focused on Tuberculosis, Malaria, HIV/AIDS, Huntington’s Disease, Sanfilippo Syndrome, and Green Chemistry as topics in version 1

We did not win the competition but had useful feedback – the need to articulate the value proposition

http://slidesha.re/GzVSPr

The Value Proposition The project is intended to bring together open data in a single aggregated

collection, and then facilitate forming open research teams around this data

Disseminate important information to a highly relevant target audience

Network and discover other researchers with complementary interests, and opportunities to collaborate

Team members will be able to borrow and reuse a growing collection of existing Open data.

The community as a whole can debate, contest or endorse data based on its quality.

The app could also be used as a type of “lab notebook” whereby individual researchers share links (URLs) to content and the app aggregates these.

http://slidesha.re/weDFLg

Latest Layout

9 Panels includes one on ODDT information

Can use multiple Twitter accounts Here is my icon

Stats summary

About App

Tap on a panel and look at Incoming contents

Click here to endorse or disapprove

Click here to follow hyperlink

Incoming is sorted by time of creation

Browse through multiple pages of tweets

Endorse, Disapprove and Comment

Recent contents

Click on image to open it

Recent isfactoids with a vote count of +1 or better

Content

Ranked content

Click on image to open it

Content is currently anything with a votecount of +1 or better, sorted by most popular first

Tap on a link or image

Be able to download content

Look at your own statistics

Exposing rare diseases – creating communities of researchers and sparking

discussion

My tweets on recent analyses and ideas

My Retweets

Coming Soon

Rewards – badges Beta version More ideas that may need funding to cover server

etc - Would you fund us if we posted ODDT on

Kickstarter or Petridish.org or IndieGoGo?? Are there sponsors for specific pages or content?

From idea to appstore in ~2 months Available on appstore since April 12 Future versions will allow user to specify topics Presented at ACS Submitted business plan to ACS GCI

Thank you Alpha testers

Antony J. Williams Hans De Winter Chris Swain Andrew Lang Carlo Yuvienco Paul Reinheimer Michael S. Lajiness Nancy Connell Greta Beekhuis Joe Hupcey III Freundlich, Joel Tanya Parrish Peter Olinga Peter Caduff

ODDTPhoto for San Fillipo Syndrome courtesy of Jill Wood www.jonahsjustbegun.org

More Information Please contact us for further details or suggestions at:

aclark@molmatinf.com and ekinssean@yahoo.com

You can learn more about the ODDT app at: http://www.scimobileapps.com/index.php?title=Open_Drug_Discovery_Teams

And frequent blogs at http://www.collabchem.com and http://cheminf20.org/

User guide now available at SlideShare http://slidesha.re/JcDTOsand FigShare http://bit.ly/IjR52V