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September 29-30, 2018 Loews Santa Monica Beach Hotel 1700 Ocean Avenue, Santa Monica, CA 90401 www.usc.edu/cme Optimizing Multimodality Management of Brain and Spine Tumors 2018: 20 th Annual Brain Tumor Update and 9 th Annual Symposium on Brain and Spine Metastases In Joint Providership, Present the This meeting is supported in part by the Henry L. Jaffe, MD Annual Oration in Therapeutic Radiology, a generous gift of the Peggy Bernstein Trust

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Page 1: Optimizing Multimodality Managementmanagement of patients with brain metastases. • Describe the latest available treatments for spinal tumors. • Interpret the role of stereotactic

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September 29-30, 2018

Loews Santa Monica Beach Hotel 1700 Ocean Avenue, Santa Monica, CA 90401

www.usc.edu/cme

Saturday, September 29, 20188:00 am Registration and Continental Breakfast 8:30 am Welcome and Introductions

Gene H. Barnett, MD, MBA and Steven L. Giannotta, MD

Spinal Tumors and MetastasesModerator: Ajit Krishnaney, MD

8:40 am Update on Imaging for Tumors of the Spinal Axis Wende Gibbs, MD9:00 am Vertebral Augmentation and Quality of Life Ajit Krishnaney, MD9:20 am Innovations in Spinal Oncologic Neurosurgery Patrick C. Hsieh, MD9:40 am Single vs. Hypo-Fractionation Outcomes for Spine Tumors Eric L. Chang, MD, FASTRO10:00 am Break10:20 am Building a Spine Radiosurgery Program Lilyana Angelov, MD10:40 am Minimally Invasive Spinal Surgery for Tumors John C. Liu, MD11:00 am Debate: Surgery vs. Radiosurgery for Spine Tumors Patrick C. Hsieh, MD vs. Lilyana Angelov, MD

11:30 am Lunch

Brain MetastasesModerator: Samuel Chao, MD

12:30 pm Pre-Op vs. Post-Op SRS for Brain Metastasis Ehsan H. Balagamwala, MD 12:50 pm Brain Metastases: Growth Signaling and the Microenvironment Josh Neman-Ebrahim, PhD1:10 pm Parafascicular Surgery for Brain Metastases Gabriel Zada, MD, MS1:30 pm Diagnosis and Treatment of Cerebral Radiation Necrosis Samuel Chao, MD1:50 pm LITT in Management of Brain Metastases Gene H. Barnett, MD, MBA 2:10 pm Break2:30 pm Immunotherapy and Targeted Therapy in Brain Metastases - Ready for Prime Time Manmeet S. Ahluwalia, MD2:50 pm Gamma Knife Radiosurgery for Brain Metastases Jason C. Ye, MD 3:10 pm Staged and Adaptive Radiosurgery Lilyana Angelov, MD3:30 pm Debate: Brain Metastases (5 or more) Radiosurgery vs. Radiotherapy Moderator: Samuel Chao, MD Eric L. Chang, MD, FASTRO vs. John Suh, MD, FASTRO4:00 pm Adjourn6:00 pm Poster Walk and Reception until 8:00 pm

Optimizing Multimodality Management of Brain and Spine Tumors 2018:

20th Annual Brain Tumor Update and 9th Annual Symposium on

Brain and Spine Metastases

In Joint Providership, Present the

PROGRAM

The 2nd annual joint USC/CCF symposium, Optimizing Multi-Modality

Management of Brain and Spine Tumors in 2018 is an advanced

multidisciplinary conference led by expert faculty from USC and the

Cleveland Clinic, with additional guest faculty from major national academic

institutions. The meeting covers the latest treatment strategies for the most

commonly occurring brain and spine tumors, including spinal metastases,

brain metastatses, gliomas, and meningiomas (a special topic this year).

Disciplines involved include Oncology, Radiation Oncology, Neurology,

Neurosurgery, Pathology, Medicine, and Radiology, among others. The

meeting is similar to the one held in October 2017 in Las Vegas, which

was a highly successful conference with solid attendance. This two-day

conference is in Santa Monica, California, a popular and family-friendly

tourist destination, and of major interest to a variety of practitioners,

including physicians, nurses, residents and fellows, and other physician

extenders.

COURSE DESCRIPTION

By the end of the course, participants will be able to:

• Incorporate evidence-based data to improve diagnostic and therapeutic

management of patients with brain metastases.

• Describe the latest available treatments for spinal tumors.

• Interpret the role of stereotactic radiosurgery in the treatment of brain

metastases patients.

• Identify the latest multimodality treatments and clinical trials for gliomas.

EDUCATIONAL OBJECTIVES

This CME conference has been designed to target neurosurgeons, neuro-

oncologists, radiation oncologists, radiologists, residents, medical students,

nurses, nurse practitioners, physician assistants and allied health professionals.

TARGET AUDIENCE

This meeting is supported in part by the Henry L. Jaffe, MD Annual Oration in

Therapeutic Radiology, a generous gift of the Peggy Bernstein Trust

This activity has been planned and implemented in accordance with the

accreditation requirements and policies of the Accreditation Council for

Continuing Medical Education (ACCME) through the joint providership of

Keck School of Medicine of USC, Cleveland Clinic Foundation Center for

Continuing Education and American Brain Tumor Association. The Keck

School of Medicine of USC for Continuing Medical Education is accredited

by the ACCME to provide continuing medical education for physicians.

ACCREDITATION STATEMENT

The Keck School of Medicine of USC designates this live activity for a

maximum of 12.5 AMA PRA Category 1 Credits™. Physicians should claim only

the credit commensurate with the extent of their participation in the activity.

CREDIT DESIGNATION

Page 2: Optimizing Multimodality Managementmanagement of patients with brain metastases. • Describe the latest available treatments for spinal tumors. • Interpret the role of stereotactic

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September 29-30, 2018

Loews Santa Monica Beach Hotel 1700 Ocean Avenue, Santa Monica, CA 90401

www.usc.edu/cme

Saturday, September 29, 20188:00 am Registration and Continental Breakfast 8:30 am Welcome and Introductions

Gene H. Barnett, MD, MBA and Steven L. Giannotta, MD

Spinal Tumors and MetastasesModerator: Ajit Krishnaney, MD

8:40 am Update on Imaging for Tumors of the Spinal Axis Wende Gibbs, MD9:00 am Vertebral Augmentation and Quality of Life Ajit Krishnaney, MD9:20 am Innovations in Spinal Oncologic Neurosurgery Patrick C. Hsieh, MD9:40 am Single vs. Hypo-Fractionation Outcomes for Spine Tumors Eric L. Chang, MD, FASTRO10:00 am Break10:20 am Building a Spine Radiosurgery Program Lilyana Angelov, MD10:40 am Minimally Invasive Spinal Surgery for Tumors John C. Liu, MD11:00 am Debate: Surgery vs. Radiosurgery for Spine Tumors Patrick C. Hsieh, MD vs. Lilyana Angelov, MD

11:30 am Lunch

Brain MetastasesModerator: Samuel Chao, MD

12:30 pm Pre-Op vs. Post-Op SRS for Brain Metastasis Ehsan H. Balagamwala, MD 12:50 pm Brain Metastases: Growth Signaling and the Microenvironment Josh Neman-Ebrahim, PhD1:10 pm Parafascicular Surgery for Brain Metastases Gabriel Zada, MD, MS1:30 pm Diagnosis and Treatment of Cerebral Radiation Necrosis Samuel Chao, MD1:50 pm LITT in Management of Brain Metastases Gene H. Barnett, MD, MBA 2:10 pm Break2:30 pm Immunotherapy and Targeted Therapy in Brain Metastases - Ready for Prime Time Manmeet S. Ahluwalia, MD2:50 pm Gamma Knife Radiosurgery for Brain Metastases Jason C. Ye, MD 3:10 pm Staged and Adaptive Radiosurgery Lilyana Angelov, MD3:30 pm Debate: Brain Metastases (5 or more) Radiosurgery vs. Radiotherapy Moderator: Samuel Chao, MD Eric L. Chang, MD, FASTRO vs. John Suh, MD, FASTRO4:00 pm Adjourn6:00 pm Poster Walk and Reception until 8:00 pm

Optimizing Multimodality Management of Brain and Spine Tumors 2018:

20th Annual Brain Tumor Update and 9th Annual Symposium on

Brain and Spine Metastases

In Joint Providership, Present the

PROGRAM

The 2nd annual joint USC/CCF symposium, Optimizing Multi-Modality

Management of Brain and Spine Tumors in 2018 is an advanced

multidisciplinary conference led by expert faculty from USC and the

Cleveland Clinic, with additional guest faculty from major national academic

institutions. The meeting covers the latest treatment strategies for the most

commonly occurring brain and spine tumors, including spinal metastases,

brain metastatses, gliomas, and meningiomas (a special topic this year).

Disciplines involved include Oncology, Radiation Oncology, Neurology,

Neurosurgery, Pathology, Medicine, and Radiology, among others. The

meeting is similar to the one held in October 2017 in Las Vegas, which

was a highly successful conference with solid attendance. This two-day

conference is in Santa Monica, California, a popular and family-friendly

tourist destination, and of major interest to a variety of practitioners,

including physicians, nurses, residents and fellows, and other physician

extenders.

COURSE DESCRIPTION

By the end of the course, participants will be able to:

• Incorporate evidence-based data to improve diagnostic and therapeutic

management of patients with brain metastases.

• Describe the latest available treatments for spinal tumors.

• Interpret the role of stereotactic radiosurgery in the treatment of brain

metastases patients.

• Identify the latest multimodality treatments and clinical trials for gliomas.

EDUCATIONAL OBJECTIVES

This CME conference has been designed to target neurosurgeons, neuro-

oncologists, radiation oncologists, radiologists, residents, medical students,

nurses, nurse practitioners, physician assistants and allied health professionals.

TARGET AUDIENCE

This meeting is supported in part by the Henry L. Jaffe, MD Annual Oration in

Therapeutic Radiology, a generous gift of the Peggy Bernstein Trust

This activity has been planned and implemented in accordance with the

accreditation requirements and policies of the Accreditation Council for

Continuing Medical Education (ACCME) through the joint providership of

Keck School of Medicine of USC, Cleveland Clinic Foundation Center for

Continuing Education and American Brain Tumor Association. The Keck

School of Medicine of USC for Continuing Medical Education is accredited

by the ACCME to provide continuing medical education for physicians.

ACCREDITATION STATEMENT

The Keck School of Medicine of USC designates this live activity for a

maximum of 12.5 AMA PRA Category 1 Credits™. Physicians should claim only

the credit commensurate with the extent of their participation in the activity.

CREDIT DESIGNATION

Page 3: Optimizing Multimodality Managementmanagement of patients with brain metastases. • Describe the latest available treatments for spinal tumors. • Interpret the role of stereotactic

REGISTRATION FORM

Optimizing Multimodality Management of Brain and Spine Tumors 2018: 20th Annual Brain Tumor Update and

9th Annual Symposium on Brain and Spine MetastasesSeptember 29-30, 2018

Loews Santa Monica Beach Hotel, Santa Monica, CA

1700 Ocean Avenue, Santa Monica, CA 90401

(PRINT)NAME__________________________________________________________________________ FIRST LAST

MEDICAL LICENSE NUMBER_________________DEGREE_____________________________

TELEPHONE ________________________________ FAX ______________________________

EMAIL ADDRESS* ______________________________________________________________

ADDRESS_____________________________________________________________________ STREET

CITY _______________________________________ STATE _____________ ZIP___________

SPECIALTY____________________________________________________________________*COMFIRMATION COMFIRMED BY EMAIL.

METHOD OF PAYMENTCheck (Payable to USC) • Credit Card (Visa, Mastercard or American Express) • No cash payment accepted.

CARD NUMBER________________________________________________________________

EXPIRATON DATE________________________ SECURITY CODE______________________

AUTHORIZED SIGNER__________________________________________________________

AMOUNT $___________________________________________________________________COURSES ARE SUBJECT TO CANCELLATION. USC WILL NOT REFUND TRAVEL COSTS FOR CANCELLED COURSES.

EARLY BIRD REGISTRATION Closes September 25, 2018, noon, PDT

❏ $495 for MDs

❏ $195 for RN/Allied Health Professionals

❏ $95 Students/Residents/Fellows (Letter needed from program director for students/residents/fellows)

AFTER SEPTEMBER 25, 2018, NOON, PDTRegister on site on September 29, 2018

❏ $545 for MDs

❏ $225 for RN/Allied Health Professionals

❏ $105 Students/Residents/Fellows (Letter needed from program director for students/residents/fellows)

To register by mail or fax, please fill out the following form. To register online, visit www.usc.edu/cme.

Saturday, September 29, 20182018 Brain Tumor ‘Partners in Care’ Conference8:00 am Registration/Continental Breakfast8:30 am Welcome and ABTA Overview Emily Lippert8:40 am Patient Advocacy Michele Rakoff

9:20 am Translational Research Overview on Breast to Brain Metastases: Wolf in Sheep’s Clothing Josh Neman-Ebrahim, PhD10:00 am Break10:20 am Neuroscience Functions: Brain Functions and How They Interact With Tumors Sean A. Grimm, MD10:55 am Brain Tumors: Treatment, Symptoms, and Late Effects Sean A. Grimm, MD11:30 am Lunch12:30 pm Targeted Therapies: Meningioma and Brain Metastases Priscilla K. Brastianos, MD1:20 pm Optimizing Supportive Care from Diagnosis to End of Life Cheryl Fogel, MSW, LCSW, ACHP-SW, OSW-C and Arlene Johnson, RN, CCM2:10 pm Break2:30 pm Caring for the Caregiver: Self Care for the Healthcare Professional Margaretta S. Page, RN, MS3:15 pm Financial & Legal Resources for Brain Tumor Patients and Families Craig Pressley, MSW, LICSW, OSW-C4:00 pm Evaluation and Adjourn

Sunday, September 30, 20188:00 am Registration and Continental Breakfast

Meningiomas: State of the Art Multimodal and Emerging TherapiesModerator: Gabriel Zada, MD, MS

8:30 am Surgical Management of Meningioma: Dealing with Recurrence Steven L. Giannotta, MD8:50 am Endoscopic Skull Base Surgery for Meningiomas Pablo Recinos, MD9:10 am Stereotactic Radiosurgery for Meningiomas John Suh, MD, FASTRO9:30 am Chemotherapy Options for Refractory Meningiomas David Peereboom, MD9:50 am Towards Precision Medicine for Meningiomas and Craniopharyngiomas Priscilla K. Brastianos, MD10:10 am Debate: Best Management Strategy Moderator: Gabriel Zada, MD, MS Pablo Recinos, MD-Surgery vs. Samuel Chao, MD-Radiosurgery10:30 am Break

GliomasModerator: Manmeet S. Ahluwalia, MD

10:50 am Radiomics and Advanced Neuroimaging of Brain Tumors: Implications for Diagnosis and Prognosticating Outcomes for Brain Tumors TBD11:10 am Medical Treatment for Glioblastoma Naveed A. Wagle, MD11:30 am Update on LITT for Gliomas Alireza Mohammadi, MD11:50 am Lunch

FACULTY

FACULTYPROGRAM PROGRAM

Keck School of Medicine of USC Co-DirectorsEric L. Chang, MD, FASTROChair and Professor of Radiation Oncology

Steven L. Giannotta, MDChair and Professor of Neurological Surgery

Gabriel Zada, MD, MS, FAANS, FACSAssociate Professor of Neurosurgery, Otolaryngology and Internal Medicine

Cleveland Clinic Co-DirectorsManmeet Ahluwalia, MD, FACP Director, Brain Metastasis Research ProgramRose Ella Burkhardt Brain Tumor and Neuro-Oncology

Gene H. Barnett, MD, MBA Director, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center

Pablo Recinos, MD Section Head, Skull Base Surgery Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center

John Suh, MD, FASTRO Chairman, Radiation Oncology

American Brain Tumor Association Co-DirectorsLeticia J. Terry, MSDirector, Programs and Outreach

Emily LippertProgram Manager

Guest FacultyPriscilla K. Brastianos, MDHarvard University and Massachusetts General Hospital

Lilyana Angelov, MDCleveland Clinic

Frank Attenello, MD, MSKeck School of Medicine of USC

Ehsan Balagamwala, MDCleveland Clinic

Samuel Chao, MDCleveland Clinic

Thomas C. Chen, MD, PhD Keck School of Medicine of USC

Cheryl W. Fogel, MSW, LCSW, ACHP-SW, OSW-CSharp Memorial Hospital

Wende Gibbs, MD Keck School of Medicine of USC

Sean A. Grimm, MD Northwestern Medicine Regional Medical Group

Patrick C. Hsieh, MDKeck School of Medicine of USC

Kyle M. Hurth, MD, PhDKeck School of Medicine of USC

Arlene Johnson, RN, CCMSharp Memorial Hospital

Ajit Krishnaney, MDCleveland Clinic

Emily LippertThe American Brain Tumor Association

John C. Liu, MDKeck School of Medicine of USC

Alireza Mohammadi, MDCleveland Clinic

Erin Murphy, MDCleveland Clinic

Josh Neman-Ebrahim, PhDKeck School of Medicine of USC

Margaretta S. Page, RN, MSUniversity of California, San Francisco

David Peereboom, MDCleveland Clinic

Craig Pressley, MSW, LICSW, OSW-CBeth Israel Deaconess Medical Center

Michele RakoffBreast Cancer Care & Research Fund

Michael A. Vogelbaum, MD, PhDCleveland Clinic

Naveed A. Wagle, MDKeck School of Medicine of USC

Jason C. Ye, MDKeck School of Medicine of USC

Jennifer Yu, MD, PhDCleveland Clinic

MAIL: Office of CME

1540 Alcazar Street, CHP 223 Los Angeles, CA 90033

ONLINE: www.usc.edu/cme, go to

“Quick Links,” and click on Conference Calendar

PHONE: 1 (323) 442-2555

FAX: 1 (888) 665-8650

EMAIL: [email protected]

ONSITE: Loews Santa Monica Beach Hotel on September 29-30, 2018 at 8:00 am.

PARKING:Overnight valet parking is $45.

Daytime parking is $18. Subject to change.

CANCELLATION FEE:There is a cancellation fee of $50. All requests

must be received by fax or email only by September 25, 2018, noon, PDT, for a refund of tuition to be issued. No cancellations after

September 25, 2018, noon, PDT.

CANCELLATION POLICY:In the event of course cancellation by conference

organizers, all registration fees only will be fully refunded. Travel costs incurred

will not be refunded.

Loews Santa Monica Beach HotelRoom Block Rate: $319, for Single or Double, City or Oceanfront King Suite

Courtesy rate is provided based on availability until September 7, 2018.Please call the hotel directly to reserve a room:

1 (888) 332-0160

Abstracts will be solicited for poster presentations. Posters will be on display in the exhibit hall on Saturday, September 29, from 8:00 am-8:00 pm.

The poster walk and reception is scheduled for September 29 from 6:00 pm-8:00 pm. Poster participants will be notified of acceptance as well as poster format and content

requirements on or before August 17, 2018. A total of two resident prizes will be offered, (1) radiation oncology and (1) neurosurgery. Each winner is awarded a

$1500 travel grant.

HOTEL INFORMATION

Sunday, September 30, 2018Moderator: Gene H. Barnett, MD, MBA

12:50 pm Surveying the Genomic Landscape of High-Grade Glioma Frank Attenello, MD, MS1:10 pm New WHO Classification of Gliomas Kyle M. Hurth, MD, PhD1:30 pm Radiotherapy for Low Grade Glioma Erin Murphy, MD1:50 pm Break2:10 pm Intraoperative MRI for Glioma Resection Michael A. Vogelbaum, MD, PhD 2:30 pm Emerging Therapy for Gliomas Based on Glioma Stem Cells Jennifer Yu, MD, PhD2:50 pm Novel Methods for Drug Delivery to the Brain Thomas C. Chen, MD, PhD3:10 pm Concluding Remarks Eric L. Chang, MD, FASTRO, Gabriel Zada, MD, MS and John Suh, MD, FASTRO3:15 pm Adjournment

CALL FOR RESIDENT ABSTRACT SUBMISSIONS

ABSTRACT REQUIREMENTS• Deadline Date: July 30, 2018. One entry per presenter. • Only residents and fellows may be the lead author on an abstract submission. • Submit your abstract as a word document to Gabriel Zada, MD: [email protected].• 300 word limit

Page 4: Optimizing Multimodality Managementmanagement of patients with brain metastases. • Describe the latest available treatments for spinal tumors. • Interpret the role of stereotactic

REGISTRATION FORM

Optimizing Multimodality Management of Brain and Spine Tumors 2018: 20th Annual Brain Tumor Update and

9th Annual Symposium on Brain and Spine MetastasesSeptember 29-30, 2018

Loews Santa Monica Beach Hotel, Santa Monica, CA

1700 Ocean Avenue, Santa Monica, CA 90401

(PRINT)NAME__________________________________________________________________________ FIRST LAST

MEDICAL LICENSE NUMBER_________________DEGREE_____________________________

TELEPHONE ________________________________ FAX ______________________________

EMAIL ADDRESS* ______________________________________________________________

ADDRESS_____________________________________________________________________ STREET

CITY _______________________________________ STATE _____________ ZIP___________

SPECIALTY____________________________________________________________________*COMFIRMATION COMFIRMED BY EMAIL.

METHOD OF PAYMENTCheck (Payable to USC) • Credit Card (Visa, Mastercard or American Express) • No cash payment accepted.

CARD NUMBER________________________________________________________________

EXPIRATON DATE________________________ SECURITY CODE______________________

AUTHORIZED SIGNER__________________________________________________________

AMOUNT $___________________________________________________________________COURSES ARE SUBJECT TO CANCELLATION. USC WILL NOT REFUND TRAVEL COSTS FOR CANCELLED COURSES.

EARLY BIRD REGISTRATION Closes September 25, 2018, noon, PDT

❏ $495 for MDs

❏ $195 for RN/Allied Health Professionals

❏ $95 Students/Residents/Fellows (Letter needed from program director for students/residents/fellows)

AFTER SEPTEMBER 25, 2018, NOON, PDTRegister on site on September 29, 2018

❏ $545 for MDs

❏ $225 for RN/Allied Health Professionals

❏ $105 Students/Residents/Fellows (Letter needed from program director for students/residents/fellows)

To register by mail or fax, please fill out the following form. To register online, visit www.usc.edu/cme.

Saturday, September 29, 20182018 Brain Tumor ‘Partners in Care’ Conference8:00 am Registration/Continental Breakfast8:30 am Welcome and ABTA Overview Emily Lippert8:40 am Patient Advocacy Michele Rakoff

9:20 am Translational Research Overview on Breast to Brain Metastases: Wolf in Sheep’s Clothing Josh Neman-Ebrahim, PhD10:00 am Break10:20 am Neuroscience Functions: Brain Functions and How They Interact With Tumors Sean A. Grimm, MD10:55 am Brain Tumors: Treatment, Symptoms, and Late Effects Sean A. Grimm, MD11:30 am Lunch12:30 pm Targeted Therapies: Meningioma and Brain Metastases Priscilla K. Brastianos, MD1:20 pm Optimizing Supportive Care from Diagnosis to End of Life Cheryl Fogel, MSW, LCSW, ACHP-SW, OSW-C and Arlene Johnson, RN, CCM2:10 pm Break2:30 pm Caring for the Caregiver: Self Care for the Healthcare Professional Margaretta S. Page, RN, MS3:15 pm Financial & Legal Resources for Brain Tumor Patients and Families Craig Pressley, MSW, LICSW, OSW-C4:00 pm Evaluation and Adjourn

Sunday, September 30, 20188:00 am Registration and Continental Breakfast

Meningiomas: State of the Art Multimodal and Emerging TherapiesModerator: Gabriel Zada, MD, MS

8:30 am Surgical Management of Meningioma: Dealing with Recurrence Steven L. Giannotta, MD8:50 am Endoscopic Skull Base Surgery for Meningiomas Pablo Recinos, MD9:10 am Stereotactic Radiosurgery for Meningiomas John Suh, MD, FASTRO9:30 am Chemotherapy Options for Refractory Meningiomas David Peereboom, MD9:50 am Towards Precision Medicine for Meningiomas and Craniopharyngiomas Priscilla K. Brastianos, MD10:10 am Debate: Best Management Strategy Moderator: Gabriel Zada, MD, MS Pablo Recinos, MD-Surgery vs. Samuel Chao, MD-Radiosurgery10:30 am Break

GliomasModerator: Manmeet S. Ahluwalia, MD

10:50 am Radiomics and Advanced Neuroimaging of Brain Tumors: Implications for Diagnosis and Prognosticating Outcomes for Brain Tumors TBD11:10 am Medical Treatment for Glioblastoma Naveed A. Wagle, MD11:30 am Update on LITT for Gliomas Alireza Mohammadi, MD11:50 am Lunch

FACULTY

FACULTYPROGRAM PROGRAM

Keck School of Medicine of USC Co-DirectorsEric L. Chang, MD, FASTROChair and Professor of Radiation Oncology

Steven L. Giannotta, MDChair and Professor of Neurological Surgery

Gabriel Zada, MD, MS, FAANS, FACSAssociate Professor of Neurosurgery, Otolaryngology and Internal Medicine

Cleveland Clinic Co-DirectorsManmeet Ahluwalia, MD, FACP Director, Brain Metastasis Research ProgramRose Ella Burkhardt Brain Tumor and Neuro-Oncology

Gene H. Barnett, MD, MBA Director, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center

Pablo Recinos, MD Section Head, Skull Base Surgery Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center

John Suh, MD, FASTRO Chairman, Radiation Oncology

American Brain Tumor Association Co-DirectorsLeticia J. Terry, MSDirector, Programs and Outreach

Emily LippertProgram Manager

Guest FacultyPriscilla K. Brastianos, MDHarvard University and Massachusetts General Hospital

Lilyana Angelov, MDCleveland Clinic

Frank Attenello, MD, MSKeck School of Medicine of USC

Ehsan Balagamwala, MDCleveland Clinic

Samuel Chao, MDCleveland Clinic

Thomas C. Chen, MD, PhD Keck School of Medicine of USC

Cheryl W. Fogel, MSW, LCSW, ACHP-SW, OSW-CSharp Memorial Hospital

Wende Gibbs, MD Keck School of Medicine of USC

Sean A. Grimm, MD Northwestern Medicine Regional Medical Group

Patrick C. Hsieh, MDKeck School of Medicine of USC

Kyle M. Hurth, MD, PhDKeck School of Medicine of USC

Arlene Johnson, RN, CCMSharp Memorial Hospital

Ajit Krishnaney, MDCleveland Clinic

Emily LippertThe American Brain Tumor Association

John C. Liu, MDKeck School of Medicine of USC

Alireza Mohammadi, MDCleveland Clinic

Erin Murphy, MDCleveland Clinic

Josh Neman-Ebrahim, PhDKeck School of Medicine of USC

Margaretta S. Page, RN, MSUniversity of California, San Francisco

David Peereboom, MDCleveland Clinic

Craig Pressley, MSW, LICSW, OSW-CBeth Israel Deaconess Medical Center

Michele RakoffBreast Cancer Care & Research Fund

Michael A. Vogelbaum, MD, PhDCleveland Clinic

Naveed A. Wagle, MDKeck School of Medicine of USC

Jason C. Ye, MDKeck School of Medicine of USC

Jennifer Yu, MD, PhDCleveland Clinic

MAIL: Office of CME

1540 Alcazar Street, CHP 223 Los Angeles, CA 90033

ONLINE: www.usc.edu/cme, go to

“Quick Links,” and click on Conference Calendar

PHONE: 1 (323) 442-2555

FAX: 1 (888) 665-8650

EMAIL: [email protected]

ONSITE: Loews Santa Monica Beach Hotel on September 29-30, 2018 at 8:00 am.

PARKING:Overnight valet parking is $45.

Daytime parking is $18. Subject to change.

CANCELLATION FEE:There is a cancellation fee of $50. All requests

must be received by fax or email only by September 25, 2018, noon, PDT, for a refund of tuition to be issued. No cancellations after

September 25, 2018, noon, PDT.

CANCELLATION POLICY:In the event of course cancellation by conference

organizers, all registration fees only will be fully refunded. Travel costs incurred

will not be refunded.

Loews Santa Monica Beach HotelRoom Block Rate: $319, for Single or Double, City or Oceanfront King Suite

Courtesy rate is provided based on availability until September 7, 2018.Please call the hotel directly to reserve a room:

1 (888) 332-0160

Abstracts will be solicited for poster presentations. Posters will be on display in the exhibit hall on Saturday, September 29, from 8:00 am-8:00 pm.

The poster walk and reception is scheduled for September 29 from 6:00 pm-8:00 pm. Poster participants will be notified of acceptance as well as poster format and content

requirements on or before August 17, 2018. A total of two resident prizes will be offered, (1) radiation oncology and (1) neurosurgery. Each winner is awarded a

$1500 travel grant.

HOTEL INFORMATION

Sunday, September 30, 2018Moderator: Gene H. Barnett, MD, MBA

12:50 pm Surveying the Genomic Landscape of High-Grade Glioma Frank Attenello, MD, MS1:10 pm New WHO Classification of Gliomas Kyle M. Hurth, MD, PhD1:30 pm Radiotherapy for Low Grade Glioma Erin Murphy, MD1:50 pm Break2:10 pm Intraoperative MRI for Glioma Resection Michael A. Vogelbaum, MD, PhD 2:30 pm Emerging Therapy for Gliomas Based on Glioma Stem Cells Jennifer Yu, MD, PhD2:50 pm Novel Methods for Drug Delivery to the Brain Thomas C. Chen, MD, PhD3:10 pm Concluding Remarks Eric L. Chang, MD, FASTRO, Gabriel Zada, MD, MS and John Suh, MD, FASTRO3:15 pm Adjournment

CALL FOR RESIDENT ABSTRACT SUBMISSIONS

ABSTRACT REQUIREMENTS• Deadline Date: July 30, 2018. One entry per presenter. • Only residents and fellows may be the lead author on an abstract submission. • Submit your abstract as a word document to Gabriel Zada, MD: [email protected].• 300 word limit

Page 5: Optimizing Multimodality Managementmanagement of patients with brain metastases. • Describe the latest available treatments for spinal tumors. • Interpret the role of stereotactic

REGISTRATION FORM

Optimizing Multimodality Management of Brain and Spine Tumors 2018: 20th Annual Brain Tumor Update and

9th Annual Symposium on Brain and Spine MetastasesSeptember 29-30, 2018

Loews Santa Monica Beach Hotel, Santa Monica, CA

1700 Ocean Avenue, Santa Monica, CA 90401

(PRINT)NAME__________________________________________________________________________ FIRST LAST

MEDICAL LICENSE NUMBER_________________DEGREE_____________________________

TELEPHONE ________________________________ FAX ______________________________

EMAIL ADDRESS* ______________________________________________________________

ADDRESS_____________________________________________________________________ STREET

CITY _______________________________________ STATE _____________ ZIP___________

SPECIALTY____________________________________________________________________*COMFIRMATION COMFIRMED BY EMAIL.

METHOD OF PAYMENTCheck (Payable to USC) • Credit Card (Visa, Mastercard or American Express) • No cash payment accepted.

CARD NUMBER________________________________________________________________

EXPIRATON DATE________________________ SECURITY CODE______________________

AUTHORIZED SIGNER__________________________________________________________

AMOUNT $___________________________________________________________________COURSES ARE SUBJECT TO CANCELLATION. USC WILL NOT REFUND TRAVEL COSTS FOR CANCELLED COURSES.

EARLY BIRD REGISTRATION Closes September 25, 2018, noon, PDT

❏ $495 for MDs

❏ $195 for RN/Allied Health Professionals

❏ $95 Students/Residents/Fellows (Letter needed from program director for students/residents/fellows)

AFTER SEPTEMBER 25, 2018, NOON, PDTRegister on site on September 29, 2018

❏ $545 for MDs

❏ $225 for RN/Allied Health Professionals

❏ $105 Students/Residents/Fellows (Letter needed from program director for students/residents/fellows)

To register by mail or fax, please fill out the following form. To register online, visit www.usc.edu/cme.

Saturday, September 29, 20182018 Brain Tumor ‘Partners in Care’ Conference8:00 am Registration/Continental Breakfast8:30 am Welcome and ABTA Overview Emily Lippert8:40 am Patient Advocacy Michele Rakoff

9:20 am Translational Research Overview on Breast to Brain Metastases: Wolf in Sheep’s Clothing Josh Neman-Ebrahim, PhD10:00 am Break10:20 am Neuroscience Functions: Brain Functions and How They Interact With Tumors Sean A. Grimm, MD10:55 am Brain Tumors: Treatment, Symptoms, and Late Effects Sean A. Grimm, MD11:30 am Lunch12:30 pm Targeted Therapies: Meningioma and Brain Metastases Priscilla K. Brastianos, MD1:20 pm Optimizing Supportive Care from Diagnosis to End of Life Cheryl Fogel, MSW, LCSW, ACHP-SW, OSW-C and Arlene Johnson, RN, CCM2:10 pm Break2:30 pm Caring for the Caregiver: Self Care for the Healthcare Professional Margaretta S. Page, RN, MS3:15 pm Financial & Legal Resources for Brain Tumor Patients and Families Craig Pressley, MSW, LICSW, OSW-C4:00 pm Evaluation and Adjourn

Sunday, September 30, 20188:00 am Registration and Continental Breakfast

Meningiomas: State of the Art Multimodal and Emerging TherapiesModerator: Gabriel Zada, MD, MS

8:30 am Surgical Management of Meningioma: Dealing with Recurrence Steven L. Giannotta, MD8:50 am Endoscopic Skull Base Surgery for Meningiomas Pablo Recinos, MD9:10 am Stereotactic Radiosurgery for Meningiomas John Suh, MD, FASTRO9:30 am Chemotherapy Options for Refractory Meningiomas David Peereboom, MD9:50 am Towards Precision Medicine for Meningiomas and Craniopharyngiomas Priscilla K. Brastianos, MD10:10 am Debate: Best Management Strategy Moderator: Gabriel Zada, MD, MS Pablo Recinos, MD-Surgery vs. Samuel Chao, MD-Radiosurgery10:30 am Break

GliomasModerator: Manmeet S. Ahluwalia, MD

10:50 am Radiomics and Advanced Neuroimaging of Brain Tumors: Implications for Diagnosis and Prognosticating Outcomes for Brain Tumors TBD11:10 am Medical Treatment for Glioblastoma Naveed A. Wagle, MD11:30 am Update on LITT for Gliomas Alireza Mohammadi, MD11:50 am Lunch

FACULTY

FACULTYPROGRAM PROGRAM

Keck School of Medicine of USC Co-DirectorsEric L. Chang, MD, FASTROChair and Professor of Radiation Oncology

Steven L. Giannotta, MDChair and Professor of Neurological Surgery

Gabriel Zada, MD, MS, FAANS, FACSAssociate Professor of Neurosurgery, Otolaryngology and Internal Medicine

Cleveland Clinic Co-DirectorsManmeet Ahluwalia, MD, FACP Director, Brain Metastasis Research ProgramRose Ella Burkhardt Brain Tumor and Neuro-Oncology

Gene H. Barnett, MD, MBA Director, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center

Pablo Recinos, MD Section Head, Skull Base Surgery Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center

John Suh, MD, FASTRO Chairman, Radiation Oncology

American Brain Tumor Association Co-DirectorsLeticia J. Terry, MSDirector, Programs and Outreach

Emily LippertProgram Manager

Guest FacultyPriscilla K. Brastianos, MDHarvard University and Massachusetts General Hospital

Lilyana Angelov, MDCleveland Clinic

Frank Attenello, MD, MSKeck School of Medicine of USC

Ehsan Balagamwala, MDCleveland Clinic

Samuel Chao, MDCleveland Clinic

Thomas C. Chen, MD, PhD Keck School of Medicine of USC

Cheryl W. Fogel, MSW, LCSW, ACHP-SW, OSW-CSharp Memorial Hospital

Wende Gibbs, MD Keck School of Medicine of USC

Sean A. Grimm, MD Northwestern Medicine Regional Medical Group

Patrick C. Hsieh, MDKeck School of Medicine of USC

Kyle M. Hurth, MD, PhDKeck School of Medicine of USC

Arlene Johnson, RN, CCMSharp Memorial Hospital

Ajit Krishnaney, MDCleveland Clinic

Emily LippertThe American Brain Tumor Association

John C. Liu, MDKeck School of Medicine of USC

Alireza Mohammadi, MDCleveland Clinic

Erin Murphy, MDCleveland Clinic

Josh Neman-Ebrahim, PhDKeck School of Medicine of USC

Margaretta S. Page, RN, MSUniversity of California, San Francisco

David Peereboom, MDCleveland Clinic

Craig Pressley, MSW, LICSW, OSW-CBeth Israel Deaconess Medical Center

Michele RakoffBreast Cancer Care & Research Fund

Michael A. Vogelbaum, MD, PhDCleveland Clinic

Naveed A. Wagle, MDKeck School of Medicine of USC

Jason C. Ye, MDKeck School of Medicine of USC

Jennifer Yu, MD, PhDCleveland Clinic

MAIL: Office of CME

1540 Alcazar Street, CHP 223 Los Angeles, CA 90033

ONLINE: www.usc.edu/cme, go to

“Quick Links,” and click on Conference Calendar

PHONE: 1 (323) 442-2555

FAX: 1 (888) 665-8650

EMAIL: [email protected]

ONSITE: Loews Santa Monica Beach Hotel on September 29-30, 2018 at 8:00 am.

PARKING:Overnight valet parking is $45.

Daytime parking is $18. Subject to change.

CANCELLATION FEE:There is a cancellation fee of $50. All requests

must be received by fax or email only by September 25, 2018, noon, PDT, for a refund of tuition to be issued. No cancellations after

September 25, 2018, noon, PDT.

CANCELLATION POLICY:In the event of course cancellation by conference

organizers, all registration fees only will be fully refunded. Travel costs incurred

will not be refunded.

Loews Santa Monica Beach HotelRoom Block Rate: $319, for Single or Double, City or Oceanfront King Suite

Courtesy rate is provided based on availability until September 7, 2018.Please call the hotel directly to reserve a room:

1 (888) 332-0160

Abstracts will be solicited for poster presentations. Posters will be on display in the exhibit hall on Saturday, September 29, from 8:00 am-8:00 pm.

The poster walk and reception is scheduled for September 29 from 6:00 pm-8:00 pm. Poster participants will be notified of acceptance as well as poster format and content

requirements on or before August 17, 2018. A total of two resident prizes will be offered, (1) radiation oncology and (1) neurosurgery. Each winner is awarded a

$1500 travel grant.

HOTEL INFORMATION

Sunday, September 30, 2018Moderator: Gene H. Barnett, MD, MBA

12:50 pm Surveying the Genomic Landscape of High-Grade Glioma Frank Attenello, MD, MS1:10 pm New WHO Classification of Gliomas Kyle M. Hurth, MD, PhD1:30 pm Radiotherapy for Low Grade Glioma Erin Murphy, MD1:50 pm Break2:10 pm Intraoperative MRI for Glioma Resection Michael A. Vogelbaum, MD, PhD 2:30 pm Emerging Therapy for Gliomas Based on Glioma Stem Cells Jennifer Yu, MD, PhD2:50 pm Novel Methods for Drug Delivery to the Brain Thomas C. Chen, MD, PhD3:10 pm Concluding Remarks Eric L. Chang, MD, FASTRO, Gabriel Zada, MD, MS and John Suh, MD, FASTRO3:15 pm Adjournment

CALL FOR RESIDENT ABSTRACT SUBMISSIONS

ABSTRACT REQUIREMENTS• Deadline Date: July 30, 2018. One entry per presenter. • Only residents and fellows may be the lead author on an abstract submission. • Submit your abstract as a word document to Gabriel Zada, MD: [email protected].• 300 word limit

Page 6: Optimizing Multimodality Managementmanagement of patients with brain metastases. • Describe the latest available treatments for spinal tumors. • Interpret the role of stereotactic

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September 29-30, 2018

Loews Santa Monica Beach Hotel 1700 Ocean Avenue, Santa Monica, CA 90401

www.usc.edu/cme

Saturday, September 29, 20188:00 am Registration and Continental Breakfast 8:30 am Welcome and Introductions

Gene H. Barnett, MD, MBA and Steven L. Giannotta, MD

Spinal Tumors and MetastasesModerator: Ajit Krishnaney, MD

8:40 am Update on Imaging for Tumors of the Spinal Axis Wende Gibbs, MD9:00 am Vertebral Augmentation and Quality of Life Ajit Krishnaney, MD9:20 am Innovations in Spinal Oncologic Neurosurgery Patrick C. Hsieh, MD9:40 am Single vs. Hypo-Fractionation Outcomes for Spine Tumors Eric L. Chang, MD, FASTRO10:00 am Break10:20 am Building a Spine Radiosurgery Program Lilyana Angelov, MD10:40 am Minimally Invasive Spinal Surgery for Tumors John C. Liu, MD11:00 am Debate: Surgery vs. Radiosurgery for Spine Tumors Patrick C. Hsieh, MD vs. Lilyana Angelov, MD

11:30 am Lunch

Brain MetastasesModerator: Samuel Chao, MD

12:30 pm Pre-Op vs. Post-Op SRS for Brain Metastasis Ehsan H. Balagamwala, MD 12:50 pm Brain Metastases: Growth Signaling and the Microenvironment Josh Neman-Ebrahim, PhD1:10 pm Parafascicular Surgery for Brain Metastases Gabriel Zada, MD, MS1:30 pm Diagnosis and Treatment of Cerebral Radiation Necrosis Samuel Chao, MD1:50 pm LITT in Management of Brain Metastases Gene H. Barnett, MD, MBA 2:10 pm Break2:30 pm Immunotherapy and Targeted Therapy in Brain Metastases - Ready for Prime Time Manmeet S. Ahluwalia, MD2:50 pm Gamma Knife Radiosurgery for Brain Metastases Jason C. Ye, MD 3:10 pm Staged and Adaptive Radiosurgery Lilyana Angelov, MD3:30 pm Debate: Brain Metastases (5 or more) Radiosurgery vs. Radiotherapy Moderator: Samuel Chao, MD Eric L. Chang, MD, FASTRO vs. John Suh, MD, FASTRO4:00 pm Adjourn6:00 pm Poster Walk and Reception until 8:00 pm

Optimizing Multimodality Management of Brain and Spine Tumors 2018:

20th Annual Brain Tumor Update and 9th Annual Symposium on

Brain and Spine Metastases

In Joint Providership, Present the

PROGRAM

The 2nd annual joint USC/CCF symposium, Optimizing Multi-Modality

Management of Brain and Spine Tumors in 2018 is an advanced

multidisciplinary conference led by expert faculty from USC and the

Cleveland Clinic, with additional guest faculty from major national academic

institutions. The meeting covers the latest treatment strategies for the most

commonly occurring brain and spine tumors, including spinal metastases,

brain metastatses, gliomas, and meningiomas (a special topic this year).

Disciplines involved include Oncology, Radiation Oncology, Neurology,

Neurosurgery, Pathology, Medicine, and Radiology, among others. The

meeting is similar to the one held in October 2017 in Las Vegas, which

was a highly successful conference with solid attendance. This two-day

conference is in Santa Monica, California, a popular and family-friendly

tourist destination, and of major interest to a variety of practitioners,

including physicians, nurses, residents and fellows, and other physician

extenders.

COURSE DESCRIPTION

By the end of the course, participants will be able to:

• Incorporate evidence-based data to improve diagnostic and therapeutic

management of patients with brain metastases.

• Describe the latest available treatments for spinal tumors.

• Interpret the role of stereotactic radiosurgery in the treatment of brain

metastases patients.

• Identify the latest multimodality treatments and clinical trials for gliomas.

EDUCATIONAL OBJECTIVES

This CME conference has been designed to target neurosurgeons, neuro-

oncologists, radiation oncologists, radiologists, residents, medical students,

nurses, nurse practitioners, physician assistants and allied health professionals.

TARGET AUDIENCE

This meeting is supported in part by the Henry L. Jaffe, MD Annual Oration in

Therapeutic Radiology, a generous gift of the Peggy Bernstein Trust

This activity has been planned and implemented in accordance with the

accreditation requirements and policies of the Accreditation Council for

Continuing Medical Education (ACCME) through the joint providership of

Keck School of Medicine of USC, Cleveland Clinic Foundation Center for

Continuing Education and American Brain Tumor Association. The Keck

School of Medicine of USC for Continuing Medical Education is accredited

by the ACCME to provide continuing medical education for physicians.

ACCREDITATION STATEMENT

The Keck School of Medicine of USC designates this live activity for a

maximum of 12.5 AMA PRA Category 1 Credits™. Physicians should claim only

the credit commensurate with the extent of their participation in the activity.

CREDIT DESIGNATION

Page 7: Optimizing Multimodality Managementmanagement of patients with brain metastases. • Describe the latest available treatments for spinal tumors. • Interpret the role of stereotactic

REGISTRATION FORM

Optimizing Multimodality Management of Brain and Spine Tumors 2018: 20th Annual Brain Tumor Update and

9th Annual Symposium on Brain and Spine MetastasesSeptember 29-30, 2018

Loews Santa Monica Beach Hotel, Santa Monica, CA

1700 Ocean Avenue, Santa Monica, CA 90401

(PRINT)NAME__________________________________________________________________________ FIRST LAST

MEDICAL LICENSE NUMBER_________________DEGREE_____________________________

TELEPHONE ________________________________ FAX ______________________________

EMAIL ADDRESS* ______________________________________________________________

ADDRESS_____________________________________________________________________ STREET

CITY _______________________________________ STATE _____________ ZIP___________

SPECIALTY____________________________________________________________________*COMFIRMATION COMFIRMED BY EMAIL.

METHOD OF PAYMENTCheck (Payable to USC) • Credit Card (Visa, Mastercard or American Express) • No cash payment accepted.

CARD NUMBER________________________________________________________________

EXPIRATON DATE________________________ SECURITY CODE______________________

AUTHORIZED SIGNER__________________________________________________________

AMOUNT $___________________________________________________________________COURSES ARE SUBJECT TO CANCELLATION. USC WILL NOT REFUND TRAVEL COSTS FOR CANCELLED COURSES.

EARLY BIRD REGISTRATION Closes September 25, 2018, noon, PDT

❏ $495 for MDs

❏ $195 for RN/Allied Health Professionals

❏ $95 Students/Residents/Fellows (Letter needed from program director for students/residents/fellows)

AFTER SEPTEMBER 25, 2018, NOON, PDTRegister on site on September 29, 2018

❏ $545 for MDs

❏ $225 for RN/Allied Health Professionals

❏ $105 Students/Residents/Fellows (Letter needed from program director for students/residents/fellows)

To register by mail or fax, please fill out the following form. To register online, visit www.usc.edu/cme.

Saturday, September 29, 20182018 Brain Tumor ‘Partners in Care’ Conference8:00 am Registration/Continental Breakfast8:30 am Welcome and ABTA Overview Emily Lippert8:40 am Patient Advocacy Michele Rakoff

9:20 am Translational Research Overview on Breast to Brain Metastases: Wolf in Sheep’s Clothing Josh Neman-Ebrahim, PhD10:00 am Break10:20 am Neuroscience Functions: Brain Functions and How They Interact With Tumors Sean A. Grimm, MD10:55 am Brain Tumors: Treatment, Symptoms, and Late Effects Sean A. Grimm, MD11:30 am Lunch12:30 pm Targeted Therapies: Meningioma and Brain Metastases Priscilla K. Brastianos, MD1:20 pm Optimizing Supportive Care from Diagnosis to End of Life Cheryl Fogel, MSW, LCSW, ACHP-SW, OSW-C and Arlene Johnson, RN, CCM2:10 pm Break2:30 pm Caring for the Caregiver: Self Care for the Healthcare Professional Margaretta S. Page, RN, MS3:15 pm Financial & Legal Resources for Brain Tumor Patients and Families Craig Pressley, MSW, LICSW, OSW-C4:00 pm Evaluation and Adjourn

Sunday, September 30, 20188:00 am Registration and Continental Breakfast

Meningiomas: State of the Art Multimodal and Emerging TherapiesModerator: Gabriel Zada, MD, MS

8:30 am Surgical Management of Meningioma: Dealing with Recurrence Steven L. Giannotta, MD8:50 am Endoscopic Skull Base Surgery for Meningiomas Pablo Recinos, MD9:10 am Stereotactic Radiosurgery for Meningiomas John Suh, MD, FASTRO9:30 am Chemotherapy Options for Refractory Meningiomas David Peereboom, MD9:50 am Towards Precision Medicine for Meningiomas and Craniopharyngiomas Priscilla K. Brastianos, MD10:10 am Debate: Best Management Strategy Moderator: Gabriel Zada, MD, MS Pablo Recinos, MD-Surgery vs. Samuel Chao, MD-Radiosurgery10:30 am Break

GliomasModerator: Manmeet S. Ahluwalia, MD

10:50 am Radiomics and Advanced Neuroimaging of Brain Tumors: Implications for Diagnosis and Prognosticating Outcomes for Brain Tumors TBD11:10 am Medical Treatment for Glioblastoma Naveed A. Wagle, MD11:30 am Update on LITT for Gliomas Alireza Mohammadi, MD11:50 am Lunch

FACULTY

FACULTYPROGRAM PROGRAM

Keck School of Medicine of USC Co-DirectorsEric L. Chang, MD, FASTROChair and Professor of Radiation Oncology

Steven L. Giannotta, MDChair and Professor of Neurological Surgery

Gabriel Zada, MD, MS, FAANS, FACSAssociate Professor of Neurosurgery, Otolaryngology and Internal Medicine

Cleveland Clinic Co-DirectorsManmeet Ahluwalia, MD, FACP Director, Brain Metastasis Research ProgramRose Ella Burkhardt Brain Tumor and Neuro-Oncology

Gene H. Barnett, MD, MBA Director, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center

Pablo Recinos, MD Section Head, Skull Base Surgery Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center

John Suh, MD, FASTRO Chairman, Radiation Oncology

American Brain Tumor Association Co-DirectorsLeticia J. Terry, MSDirector, Programs and Outreach

Emily LippertProgram Manager

Guest FacultyPriscilla K. Brastianos, MDHarvard University and Massachusetts General Hospital

Lilyana Angelov, MDCleveland Clinic

Frank Attenello, MD, MSKeck School of Medicine of USC

Ehsan Balagamwala, MDCleveland Clinic

Samuel Chao, MDCleveland Clinic

Thomas C. Chen, MD, PhD Keck School of Medicine of USC

Cheryl W. Fogel, MSW, LCSW, ACHP-SW, OSW-CSharp Memorial Hospital

Wende Gibbs, MD Keck School of Medicine of USC

Sean A. Grimm, MD Northwestern Medicine Regional Medical Group

Patrick C. Hsieh, MDKeck School of Medicine of USC

Kyle M. Hurth, MD, PhDKeck School of Medicine of USC

Arlene Johnson, RN, CCMSharp Memorial Hospital

Ajit Krishnaney, MDCleveland Clinic

Emily LippertThe American Brain Tumor Association

John C. Liu, MDKeck School of Medicine of USC

Alireza Mohammadi, MDCleveland Clinic

Erin Murphy, MDCleveland Clinic

Josh Neman-Ebrahim, PhDKeck School of Medicine of USC

Margaretta S. Page, RN, MSUniversity of California, San Francisco

David Peereboom, MDCleveland Clinic

Craig Pressley, MSW, LICSW, OSW-CBeth Israel Deaconess Medical Center

Michele RakoffBreast Cancer Care & Research Fund

Michael A. Vogelbaum, MD, PhDCleveland Clinic

Naveed A. Wagle, MDKeck School of Medicine of USC

Jason C. Ye, MDKeck School of Medicine of USC

Jennifer Yu, MD, PhDCleveland Clinic

MAIL: Office of CME

1540 Alcazar Street, CHP 223 Los Angeles, CA 90033

ONLINE: www.usc.edu/cme, go to

“Quick Links,” and click on Conference Calendar

PHONE: 1 (323) 442-2555

FAX: 1 (888) 665-8650

EMAIL: [email protected]

ONSITE: Loews Santa Monica Beach Hotel on September 29-30, 2018 at 8:00 am.

PARKING:Overnight valet parking is $45.

Daytime parking is $18. Subject to change.

CANCELLATION FEE:There is a cancellation fee of $50. All requests

must be received by fax or email only by September 25, 2018, noon, PDT, for a refund of tuition to be issued. No cancellations after

September 25, 2018, noon, PDT.

CANCELLATION POLICY:In the event of course cancellation by conference

organizers, all registration fees only will be fully refunded. Travel costs incurred

will not be refunded.

Loews Santa Monica Beach HotelRoom Block Rate: $319, for Single or Double, City or Oceanfront King Suite

Courtesy rate is provided based on availability until September 7, 2018.Please call the hotel directly to reserve a room:

1 (888) 332-0160

Abstracts will be solicited for poster presentations. Posters will be on display in the exhibit hall on Saturday, September 29, from 8:00 am-8:00 pm.

The poster walk and reception is scheduled for September 29 from 6:00 pm-8:00 pm. Poster participants will be notified of acceptance as well as poster format and content

requirements on or before August 17, 2018. A total of two resident prizes will be offered, (1) radiation oncology and (1) neurosurgery. Each winner is awarded a

$1500 travel grant.

HOTEL INFORMATION

Sunday, September 30, 2018Moderator: Gene H. Barnett, MD, MBA

12:50 pm Surveying the Genomic Landscape of High-Grade Glioma Frank Attenello, MD, MS1:10 pm New WHO Classification of Gliomas Kyle M. Hurth, MD, PhD1:30 pm Radiotherapy for Low Grade Glioma Erin Murphy, MD1:50 pm Break2:10 pm Intraoperative MRI for Glioma Resection Michael A. Vogelbaum, MD, PhD 2:30 pm Emerging Therapy for Gliomas Based on Glioma Stem Cells Jennifer Yu, MD, PhD2:50 pm Novel Methods for Drug Delivery to the Brain Thomas C. Chen, MD, PhD3:10 pm Concluding Remarks Eric L. Chang, MD, FASTRO, Gabriel Zada, MD, MS and John Suh, MD, FASTRO3:15 pm Adjournment

CALL FOR RESIDENT ABSTRACT SUBMISSIONS

ABSTRACT REQUIREMENTS• Deadline Date: July 30, 2018. One entry per presenter. • Only residents and fellows may be the lead author on an abstract submission. • Submit your abstract as a word document to Gabriel Zada, MD: [email protected].• 300 word limit

Page 8: Optimizing Multimodality Managementmanagement of patients with brain metastases. • Describe the latest available treatments for spinal tumors. • Interpret the role of stereotactic

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September 29-30, 2018

Loews Santa Monica Beach Hotel 1700 Ocean Avenue, Santa Monica, CA 90401

www.usc.edu/cme

Saturday, September 29, 20188:00 am Registration and Continental Breakfast 8:30 am Welcome and Introductions

Gene H. Barnett, MD, MBA and Steven L. Giannotta, MD

Spinal Tumors and MetastasesModerator: Ajit Krishnaney, MD

8:40 am Update on Imaging for Tumors of the Spinal Axis Wende Gibbs, MD9:00 am Vertebral Augmentation and Quality of Life Ajit Krishnaney, MD9:20 am Innovations in Spinal Oncologic Neurosurgery Patrick C. Hsieh, MD9:40 am Single vs. Hypo-Fractionation Outcomes for Spine Tumors Eric L. Chang, MD, FASTRO10:00 am Break10:20 am Building a Spine Radiosurgery Program Lilyana Angelov, MD10:40 am Minimally Invasive Spinal Surgery for Tumors John C. Liu, MD11:00 am Debate: Surgery vs. Radiosurgery for Spine Tumors Patrick C. Hsieh, MD vs. Lilyana Angelov, MD

11:30 am Lunch

Brain MetastasesModerator: Samuel Chao, MD

12:30 pm Pre-Op vs. Post-Op SRS for Brain Metastasis Ehsan H. Balagamwala, MD 12:50 pm Brain Metastases: Growth Signaling and the Microenvironment Josh Neman-Ebrahim, PhD1:10 pm Parafascicular Surgery for Brain Metastases Gabriel Zada, MD, MS1:30 pm Diagnosis and Treatment of Cerebral Radiation Necrosis Samuel Chao, MD1:50 pm LITT in Management of Brain Metastases Gene H. Barnett, MD, MBA 2:10 pm Break2:30 pm Immunotherapy and Targeted Therapy in Brain Metastases - Ready for Prime Time Manmeet S. Ahluwalia, MD2:50 pm Gamma Knife Radiosurgery for Brain Metastases Jason C. Ye, MD 3:10 pm Staged and Adaptive Radiosurgery Lilyana Angelov, MD3:30 pm Debate: Brain Metastases (5 or more) Radiosurgery vs. Radiotherapy Moderator: Samuel Chao, MD Eric L. Chang, MD, FASTRO vs. John Suh, MD, FASTRO4:00 pm Adjourn6:00 pm Poster Walk and Reception until 8:00 pm

Optimizing Multimodality Management of Brain and Spine Tumors 2018:

20th Annual Brain Tumor Update and 9th Annual Symposium on

Brain and Spine Metastases

In Joint Providership, Present the

PROGRAM

The 2nd annual joint USC/CCF symposium, Optimizing Multi-Modality

Management of Brain and Spine Tumors in 2018 is an advanced

multidisciplinary conference led by expert faculty from USC and the

Cleveland Clinic, with additional guest faculty from major national academic

institutions. The meeting covers the latest treatment strategies for the most

commonly occurring brain and spine tumors, including spinal metastases,

brain metastatses, gliomas, and meningiomas (a special topic this year).

Disciplines involved include Oncology, Radiation Oncology, Neurology,

Neurosurgery, Pathology, Medicine, and Radiology, among others. The

meeting is similar to the one held in October 2017 in Las Vegas, which

was a highly successful conference with solid attendance. This two-day

conference is in Santa Monica, California, a popular and family-friendly

tourist destination, and of major interest to a variety of practitioners,

including physicians, nurses, residents and fellows, and other physician

extenders.

COURSE DESCRIPTION

By the end of the course, participants will be able to:

• Incorporate evidence-based data to improve diagnostic and therapeutic

management of patients with brain metastases.

• Describe the latest available treatments for spinal tumors.

• Interpret the role of stereotactic radiosurgery in the treatment of brain

metastases patients.

• Identify the latest multimodality treatments and clinical trials for gliomas.

EDUCATIONAL OBJECTIVES

This CME conference has been designed to target neurosurgeons, neuro-

oncologists, radiation oncologists, radiologists, residents, medical students,

nurses, nurse practitioners, physician assistants and allied health professionals.

TARGET AUDIENCE

This meeting is supported in part by the Henry L. Jaffe, MD Annual Oration in

Therapeutic Radiology, a generous gift of the Peggy Bernstein Trust

This activity has been planned and implemented in accordance with the

accreditation requirements and policies of the Accreditation Council for

Continuing Medical Education (ACCME) through the joint providership of

Keck School of Medicine of USC, Cleveland Clinic Foundation Center for

Continuing Education and American Brain Tumor Association. The Keck

School of Medicine of USC for Continuing Medical Education is accredited

by the ACCME to provide continuing medical education for physicians.

ACCREDITATION STATEMENT

The Keck School of Medicine of USC designates this live activity for a

maximum of 12.5 AMA PRA Category 1 Credits™. Physicians should claim only

the credit commensurate with the extent of their participation in the activity.

CREDIT DESIGNATION