oral pathology - disease of-jaw-bone
TRANSCRIPT
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DISEASES OF JAW BONE
Dr : Tareq al_shawabkeh
BY
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Inherited and developmental Diseases of bone:
Osteogenesis Imperfecta (brittle bone syndrome)
Osteopetrosis-marble bone disease
Achondroplasia Cleidocranial dysplasia
Cherubism
Achodroplasia Fibro-osseous lesions
Fibrous dysplasia of bone
Cemento-osseous dysplasia
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Osteogenesis Imperfecta(brittle bone disease)
Hereditary diseases Caused by mutations in type-1 collagenFour main types:
.Type I: autosomal dominant, blue sclera, premature deafness ,with or without dentinogensis imperfecta
autsomal dominant.: Type II autsomal dominant ,severe osteoporotic bone: Type
III Type IV :similar to type I but more severe
Other abnormatities, joint hypermobility, thin translucent skin ,heart valve defects ,
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Osteopetrosis-(marble bone disease)
Rare diseaseExcessive density of all bones
2nd anaemia Weak bone fractures are common Delayed eruption of teeth Osteomyelitis common complication after tooth extraction Radiographicaly
bone densityRoots of the teeth invisible on RG Mandible more affected than maxilla
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A chondroplasia
An autosomal dominant traitIt is the most common form of dwarfism Abnormality in endochondral ossification The trunk and head are of normal size but the limbs are excessively short The middle third of the face is retrusive Malocclusion is common No effective treatment
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Cleidocranial dysplasia An autosomal dominant trait Abnormalities of the skull,jaws &clavical Dental anamoles are common
Delayed closure of frontale
Nasal bridge is also depressed Partial or complete absence of the clavicles
Dental manifestation Narrow high arched palate
Many or most permanent teeth typically remain embedded in the jaw Many additional unerupted teeth also present Sometimes many dentigerous cysts
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cherubismAn autosomal dominant trait
Males are affected about twice as frequently as females But there is reduction in deformity of puberty 2-4 age
Symmetrical swelling ,mandible bilateral ,may affect maxilla
the eye appear upturned to heaven Dental aspect Premature loss of deciduous teeth
Lack of eruption , failure of development of many permanent teeth
Radio graphically Maltilocular radiolucencies with expansion
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Fibro-osseous lesions
Characterized by the replacement of normal bone by fibrous tissueA . Osseous dysplasiaFibrous dysplasia
_ monostotic _ polyostotic
Cemento-osseous dysplasia B .Benign neoplasiaOssifying fibroma /cemento-ossifing fibroma
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Fibrous dysplasia of bone Monostotic fibrous dysplasia:
More common than polyststic
Affect limb,rib ,skull bone &jaw Maxilla >mandible
Present in achildhood or adolescent but diagnosis at adult life
Painless swelling –fusiform expansion-When max. affected prominence of cheek&buccal expansion Mand. Molar-premolar region
depth of the jaw Tipping, displacement of teeth Radiographically Ground-glass or orange-peel
Treatment: Cosmetic contouring when growing completed
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Polystotic fibrous dysplasia
Two to three times are common in females as males
Affecting bones of one limb,especially the lower but the skull,vertebrae,ribs &pelvis
Usually associated with other systems involvement (Albright’s syndrome)Café au lait spotsPrecocious puberty in femaleEndocrine abnormalitiesN.B Margins of lesion merge with surrounding normal boneFew cases of malignant transformation to fibrosarcomaMajority of cases are treated by conservative surgical removal of the lesion
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Cemento-osseous dysplasia
More in women than men Occurs predominantly in the mandible
>30 yrs of age Clinically May be multiple and small <1cm diameterLesions are multiple,large &involve one or more quadrants
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Alveolar osteitis (dry socket)
A localized inflammation of the bone following either the failure of a blood clot to form in the socket ,or premature loss or disintegration of the clot Occurs mainly in the mandible Severe pain few days after extraction ,foul taste
Predisposing factor:Paget diseaseAfter radiotherapy Excessive use of V.CExcessive mouth rinsing
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Focal sclerosing (condensing) oseitis
Periapical inflammation Result from low-grade irritation &or high tissue resistanceSeen at the apex of the a tooth, most commonly 1st Per MolarAsymptomatic
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Suppurative osteomyelitis
Divided clinically into acute & chronic types Anaerobic organisms predominateMandible >maxilla Clinically acute suppurative present with Pain, swelling ,pyrexia &malaise ,trismus ,paraesthesia of the lip &mobility of teeth Chronic present with chronic suppuration &discharge of pus through one or More intraoral or extraoral sinuses
radiograph Moth _eaten radiolucency
OSTEOMYLITIS
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Sclerosing osteomyelitis
Is a controversial condition Localized lesions are identical to focal
sclerosing osteitis Diffuse lesion are complication of low grade infection
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Chronic osteomyelitis with proliferative periostitis (garres osteomyelitis periostitis ossificans)
Seen almost in the mand in children &young adultsBony hard swelling on the
outer surface of the mandShow a focal subperiosteal overgrowth of bone with asmooth surface on the outer cortical plate
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Chronic periostitis associated with hyaline bodies (pulse granuloma,vegetable granuloma)
An unusual form of chronic periositis Histologically With hyaline ring-shaped bodies accompanied by foreign-body ,giant-cell reaction
associated with fibrous thickening of the periosteum ,periostitis, chronic suppurationThe vegetable material access to the tissues via a tooth socket, surgical flap, open root canal ,or through other breach in the mucosa such as Traumatic ulceration associated with ill-fitting
denture
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Radiation injury & osteoradionecrosis
Radiation affects the vascularity of the bone Causing a proliferation of the blood vesselsInfection may spread resulting in extensive osteomyelitis &painful necrosis of the boneSloughing of the overlying oral &occasionally soft tissues
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Metabolic and endocrine disorders of bone
OsteoporosisPrimary hyperparathyroidismsecondary hyperparathyroidismRickets and osteomalaciaAcromegaly
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osteoporosisResult either when the bone loss is excessive or opposition of bone is reduced
In postmenopausal women
Female more than male
Is accentuated in several other diseases cushing syndrome, thyrotoxicosis & primary hyperparathyroidism
Normal composition but it is reduced in quantity, radiolucency of bone ,
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Primary hyperparathyroidismCommon disease
Seen in middle aged women Results from excessive parathormone secretionExcess secretion of the hormone results in hypercalcaemia &hypercalciuria Histologically
Osteoclastic activity ,focal areas of bone resorption result in the formation brown tumours
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Secondary hyperparathyroidism
Occurs in response to chronic hypocalcaemiaAs a result of chronic renal failureThe bone changes are complex and are mixture of those associated with osteomalacia & hyperparathyroidism
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Rickets and osteomalacia
Rickets and osteomalacia are due to deficiency \resistance to the action of vit D Lack of exposure to sunlight or dietary causesThe bone present is normally mineralizedDental abnormalities include Enamel hypoplasia
width of the predentine Large amounts of interglobular dentine
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acromegaly
Excessive secretion of growth hormone After fusion of epiphysisEnlarged jaw and protrusiveSpaced teeth & macroglossiaLips ,,nose ) ) Enlarged soft tissue
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Pagets disease of boneA etiology involves genetic & environmental factors, paramyxovirus infection
Affect old ages >40 yrs Can be divided into three phases:
1-an initial predominantly osteolytic phase
2-an active stage of mixed osteolysis &osteogenesis 3-apredominantly osteoblastic or sclerotic phase clinically:
Cranial nerve compression
Enlarge of the maxilla
In dentate pts derangement of the occlusion ,spacing of the teeth
Hypercementosis Difficulty in extraction , postextraction haemorrhage Highly vascular marrow ,bone pain
N.B blood chemistry ALK- phosphatase Radio graphically appear as cotton-wool appearance
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Central giant cell granuloma F >M In the second and third decadesMandible more than maxillaSwelling of the bone , growth may sometimes be rapid Radiograhically Apprear as a well-defined radiolucent area
,perforation of the cortexInvolved teeth may be displaced
,roots show resorptionHistologically Showing collections of multinucleated osteoclast-like giant cells in a vascular spindle cell stroma
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Torus palatinus ,torus mandibularis, & other exostoses
Bony outgrowths Unknown etiologyOccurs at either midline of the palate(torus palatinus),or on the lingual surface of the mandible in the PM region (torus mandibularisMand. Tori are bilateral Palatal tori > mand. Tori
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Dense bone island
Localized area of sclerotic boneIn the premolar-molar region of the mandible Radiographically Well-defined , denseNot surrounded by radiolucent space
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Tumours of boneBone-forming tumours
(a)Benign osteoma
osteoblastoma
(b)Malignant osteosarcoma
Cartilage-forming tumours
(a)Benign chondroma
(b)Malignant chondrosarcoma
Marrow tumours
(a)Myeloma
(b)Other types
Fibrous tumours
Benign ossifying (cemento-ossifying) fibroma
Tumours -like lesions in the bone
(a )Langerhans cell histiocytosis
(b )Haemangioma of bone
Metastatic tumours
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Osteoma &osteoblastoma OsteomaBenign-slow growing of boneMandible>maxilla Histologically : can be divided into compact and cancellous types Solitary , multiple osteomas occur as afeature of Gardner syndromeOsteoblastomaRare tumour in the jawsHistologically &radiographically it reembles the cementoblastoma but it is not related to the root of the teeth
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osteosarcoma
Commonest malignant tumor of the boneAround 30 years of age RadiographicallyAppear as a radiolucent
,radiopaqe or mixed lesion
Histologically Formation of abnormal osteoid or bone by malignant osteoblasts
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Chondroma & chondrosarcomaRare tumours Ant part of the max &post part of the mandOriginate in the condylar processesChondroma is a benign tumour characterized by formation of mature cartilagePrognosis for chondrosarcoma is better for mand compared to max
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Myeloma
Neoplasm composed of plasma cellMultiple myeloma or Solitary myeloma
50- 70 yrsAffect the skull ,, vertebra ribs and pelvic Radiographically Punched out RL
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Ossifying (cemento-ossifying) fibroma
Benign neoplasm Consist of fibrous tissue containing varying amounts of bony trabeculae &rounded calcified bodies Clinically Most often in the PM-molar region of the mandibleRadiologicallyWell-demarcated radiolucent area as the lesion matures
,varying amounts of calcified tissue are deposited
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Langerhans cell histiocytosisMale more than female Under 20 yrs old It presents in one of three main ways:As a solitary lesion in the bone
Multifocal eosinophilic (hand schuller – christion syndrome )
(3)As disseminated multiorgan disease
Radiographs Show either a solitary or multiple osteolytic lesions Teeth may appear to be floating in air
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Haemangioma of bone
Rare lesion Mandible>maxillaRadiographicallyMultilocular honey-comb appearance Aspiration will reveal fresh blood
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