organ on a chipcc.ee.ntu.edu.tw/~ultrasound/belab/midterm_oral... · organ on a chip don ingber,...
TRANSCRIPT
Organ on a chip
Don Ingber, MD, PhD Founding Director, Wyss Institute at Harvard
Reportors: W.-C. Wang, T.-W. Chiang, M.-J. Yang
Group 4, Biomedical Engineering Lab
Department of Electrical Engineering
National Taiwan University
Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
Manufacturing
Process
- poly(dimethylsiloxane) (PDMS)
- tetrabutylammonium fluoride
- introduce
alveolarepithelial cells and
microvascular endothelial cells
into their respective channels
Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
Advantage • Observing information immediately
• Real time
• Whole procedure is viewable
• Allow to do Mechanical and Quantitative Analysis • Change the concentration of drugs instantaneously
• In drug testing, this chip shows us • Drug Toxicity
• Human Disease Model
• Drug Efficacy.
Replace current drug development model
Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
Future : Human body on a chip