organic chemistry faculty research interests. prof. deb dillner overview: nmr spectroscopy and...
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Organic Chemistry
Faculty Research Interests
Prof. Deb Dillner
Overview:NMR Spectroscopy and Collaboration with Professor Rehill (biology) on a project to isolate and identify tannins from oak leaves.
Continuing projects:1. Isolation and identification of tannins from Oak leaves (Midn. J. Mohamed) – Combines chromatography and NMR spectroscopy.
Prof. Deb Dillner
Overview:NMR Spectroscopy and Collaboration with Professor Rehill (biology) on a project to isolate and identify tannins from oak leaves.
Continuing projects:2. Using NMR spectroscopy and Computational Modeling to Investigate Conformation and Chemical Shifts for Bicyclic Compounds.
H2 H3
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Prof. Jeff FitzgeraldOverview:
Synthesis and understanding of nonlinear optical materials.
Continuing projects: Tetraazaporphyrin / phthalocyanine hybrids for optical limiting. - Optical limiters are materials which transmit ambient light but are opaque to laser light.- Some Pb phthalocyanine complexes show good limiting but the analogous tetraazaporphyrin complexes are disappointing.
Prof. Jeff FitzgeraldOverview:
Synthesis and understanding of nonlinear optical materials.
Continuing projects: Tetraazaporphyrin / phthalocyanine hybrids for optical limiting. - Optical limiters are materials which transmit ambient light but are opaque to laser light.- Some Pb phthalocyanine complexes show good limiting but the analogous tetraazaporphyrin complexes are disappointing.
Prof. Jeff FitzgeraldOverview:
Synthesis and understanding of nonlinear optical materials.
Continuing projects: Tetraazaporphyrin / phthalocyanine hybrids for optical limiting. - Optical limiters are materials which transmit ambient light but are opaque to laser light.- Some Pb phthalocyanine complexes show good limiting but the analogous tetraazaporphyrin complexes are disappointing.
- Alex Kriegel, ‘12, found a way to make and separate four hybrids of phthalocyanine and tetraazaporphyrins.
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MgN
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Mg
Bz3TAP cis-Bz2TAP trans-Bz2TAP BzTAP- I would like to study the optical limiting behavior of Alex’s hybrids in order to understand the structure required for effective optical limiting.
Assoc. Prof. Shirley LinOverview:My background is in organometallic and supramolecular chemistry
with a focus on polymers.My research interests are:A) developing new catalytic transformations (with Prof MacArthur
and CDR Brown, USNA)B) synthesis of new functional materialsC) chemical education (with Prof. Hartman, USNA)
Project : tandem catalytic synthetic methodologies (fulfills biochemistry concentration)
Hydrodehalogenation of ArCl and ArBr Cyanation of ArCl
ClR + KCN
1.2 eq.
NHMe
NHMe40 mol %
20 mol % CuI
MeCNw, 200 oC
CNR + KCl
IR
XR + NaI
2 eq.
NHMe
NHMe1.5 equiv
20 mol % CuI
MeCNw, 200 oC
HR + NaX
IR
X = Cl, Br
K. A. Cannon, M. E. Geuther, C. K. Kelly, S. Lin, and A. H. R. MacArthur Organometallics 2011 30 (15), 4067-4073M. M. Coughlin, C. K. Kelly, S. Lin, and A. H. R. MacArthur Organometallics 2013 32(12), 3537-3543
Prof. Joe Urban
Overview:Computational chemistry/molecular modeling of organic and bioorganic compounds
Projects: Molecular Modeling Studies of Model Peptide MimicsComputational chemistry techniques are being used to investigate the conformational properties of modified peptide compounds. The work involves using molecular modeling software (ex: Spartan) on local computers as well as remote DoD supercomputers.
Current students: 1/C Mac Hastings
I am taking new research students. Please contact me if you are interested. ([email protected])
Peptide Mimics by Modification of Peptides
NH
R1
F R2
O
mimic
NH
R1
CF3 R2
O
NH
NHR1
R2
O
CF3
mimic mimic
peptide
NH
NH
R1
O R2
O
NH
NHR1
O
O
NH
NH
R1O O
NH
NH
R1O O
F
Peptide Bond Modifications Amino Acid Modifications
peptide mimic
mimic
• The mimics we study come from the modification of either the peptide bond that links amino acids in a natural peptide, or the amino acids themselves.
• We use molecular modeling to investigate how these modifications impact the structure and properties of the mimics in comparison to their natural peptide counterparts.
Professor Craig WhitakerOverview:
My research areas focus on materials and polymer chemistry.
Project:Smart hydrogels incorporating chemical agent markers and dye sensor molecules are being synthesized and characterized. The novel polymeric materials will use a chemical reaction to detect and destroy organophosphorus nerve agents (Sarin gas). The stimuli-responsive hydrogels will act as sensors when immersed in water supplies, used as filtering materials or as boundary layers in surgical masks.
Current students: Ashley Gilliard (‘14), Allison Reitmayer (‘14) and Elaine Zhong (‘14)