organic synthesis reverse synthesis. always begin with the desired compound deconstruct your desired...
DESCRIPTION
Synthesis FlowchartTRANSCRIPT
Organic Synthesis
Reverse Synthesis
Reverse Synthesis
• Always begin with the desired compound• Deconstruct your desired compound using the
organic synthesis flowchart• Begin by using a word analysis of the reverse
synthesis• Above each word of the word analysis draw a
structure that matches the words • Complete each structure such that they
correspond the previous compounds structure
Synthesis Flowchart
ExampleShow one synthesis pathway that will produce ethanoic acid
beginning with an alkene or alkyl halide
Step 1: Draw structure of product and identify the functional groups present.
carboxylic acidOH
O
Step 2: Prepare a word analysis by asking: “What comes before the current functional group on the synthesis flow chart.
Carboxylic AcidAldehyde1o AlcoholAlkene
Step 3: Draw the correct structures above each word in the word analysis.
Carboxylic AcidAldehyde1o AlcoholAlkene
OH
OOOH
CH2 CH2CH3 CH2OH
CH3 CH
O
CH3 C
O
OH
Step 4: Complete the synthesis by adding reagents/conditions and name compounds.
OH
OOOH+
H2O
[O*] [O*]
ethanoic acidethanalethanolethene
How does the synthesis differ if it begins with an alkyl halide?
ExamplePropose a synthesis pathway for the production of hexanamide.
amide
O
NH2
carboxylic acidaldehydealcoholalkyl halide
amine
+
O
NH2
O
OH
OOH
NH3
Br
H2O+
[O*] [O*]