organocatálisis asimétrica (hoca)...organocatalysis (ed. p. dalko) wiley, 2013, 1359;...
TRANSCRIPT
Organocatálisis asimétrica (HOCA)
Contact: [email protected], [email protected]
https://hoca.unizar.es
Raquel P. Herrera (Head of the group), Eugenia Marqués-López,Juan V. Alegre-Requena, Isaac G. Sonsona, Fernando Auria-Luna,
Rosa Ortiz, Sara Graus, Alberto Valero
About us
Research
Collaborations
organocatalytic methodologies, providing environmentally friendly access to biologically active targets, including drugs and natural products. Its research covers both the design and synthesis of novel catalytic systems and the search of new applications, related with the organocatalysts and the final products of the explored reactions.
Other collaborators: Dr. Santiago Uriel Rubio (Organic chemistry department, Universidad de Zaragoza); Prof. Dr. Carmen Berné (Marketing andmarket research department, Universidad de Zaragoza) and Prof. Dr. Gabriela Guillena (Organic chemistry department, Universidad de Alicante).
H–OCA group (Herrera-OrganoCatálisis Asimétrica) is a young research team dedicated to develop new
(thio)ureas and squaramides. We also work with other different organocatalyst families, such as proline derivatives, cinchona alkaloids and phase transfer catalysts.
Our goals could be summarized as follows:
Developing new organocatalysts through a proper design.
Exploring novel and more efficient reactions based on DOS.
Synthesizing highly enantiopure functionalized compounds, with special interest in a variety of heterocycles.
Testing the biological properties and other possible applications such as the capacity of gel formation of the resulting compounds.
Studying the mechanism of action and the role of the organocatalysts in the explored reactions and processes.
Innovating and transferring the obtained knowledge, processes and synthesized products is other of our main aims regarding our research overall strategy.
Asymmetric organocatalysis appeared in the early 21st century as a complementary discipline to the metal and enzymatic catalysis. We have invested most efforts in the hydrogen bond based catalysts area, such as
Dr. Gemma Triola(IQAC-CISC, Barcelona)Biomedicinal chemistry department. Chemical biology
biological activity
Med. Chem. Commun. 2016, 7, 550.
Prof. Dr. David Díaz Díaz(Universität Regensburg)Organic chemistry institute. Germany
gel formation
Chem. Eur. J. 2014, 20, 10720.CrystEngComm 2016, DOI: 10.1039/C5CE02526E.Soft Matter 2016, DOI: 10.1039/C5SM02997J.
Org. Biomol. Chem. 2014, 12, 1258.
Dr. Pablo J. Sanz Miguel (ISQCH-CSIC, Zaragoza)Catalysis and catalytic processes department
structural analysis
Prof. Dr. M. Concepción Gimeno(ISQCH-CSIC, Zaragoza)Chemistry of the organometallic compounds department
fluorescence and cell imaging studies
Beilstein J. Org. Chem. 2014, 10, 2206.Dalton Trans. 2015, 44, 9052.RSC Adv. 2016, 6, 14171.
For recent publications of our original research, see: Org. Biomol. Chem. 2014, 12, 4503; RSC Adv. 2014, 4, 9856; Asian J. Org. Chem. 2015, 4, 884; Molecules 2015, 20, 15807; RSC Adv. 2015, 5, 33450;Adv. Synth. Catal. 2016, DOI: 10.1002/adsc.201600046. For some of our relevant compilation works, see: An. Quím. 2009, 105, 5; Nat. Prod. Rep. 2010, 27, 1138; Hydrogen bonds as an alternativeactivation in New Strategies in Chemical Synthesis and Catalysis (Ed. B. Pignataro) Wiley, 2012, 175; Asymmetric organocatalysis in total synthesis in Comprehensive EnantioselectiveOrganocatalysis (Ed. P. Dalko) Wiley, 2013, 1359; Multicomponent Reactions. Concepts and Applications for Design and Synthesis (Eds. R. P. Herrera and E. Marqués-López) Wiley, 2015.