Original phantom

Tianfang Li

Quantitative Reconstruction for Brain SPECT with Fan-Beam Collimators

Nov. 24th, 2003

• Developing a fast and accurate reconstruction algorithm for single photon emission computed tomography (SPECT)

• Compensates for Poisson noise, Compton scatter, collimator/detector response, and attenuation effects

• Quantitative analysis with regional bias-variance plot, receiver operating characteristic (ROC) study, and Hotelling trace calculation

• Verified with Monte Carlo simulations and compared with the widely used ordered-subset expectation maximization (OSEM) algorithm. Similar image quality is achieved with computational cost improved about 48 times.

SPECT system:

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Non-uniform attenuation

Detector response orpoint spread function (PSF)

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Scatter

Poisson noise

Filtered backprojection (FBP) reconstruction

Reconstruction with proposed method

OSEM reconstruction