By Leaps and By Leaps and BoundsBounds

What’s happening in medicine today can only be described a miraculous!

Information technologies and ‘instant communication’ capabilities

have enabled sharing and processing of vast amounts of information.

Our bodiesOur bodies ‘know’ what to do ‘know’ what to do

Amazing as artificial intelligence and computers may be, our bodies are the most complex

and finely tuned creations of all.

Billions of bits of information are being processed and acted upon all at the same

time.

One is Influenced One is Influenced by the Many . . . by the Many . . .

and in turn the Many are and in turn the Many are Influenced by the One!Influenced by the One!

We have just begun to scratch the surface of the enormity and complexity of it all.

During our road trip During our road trip through life . . .through life . . .

maintenance and repair takes place every second, of every minute of every

day.

And when we stray from the normal path, experience fender-benders,

or just the day to day wear and tear catches up . . .

. . . the time comes for a. . . the time comes for a tune up or repair. tune up or repair.

We are learning. We are learning.

Our cells, tissues, and organs have a built in road map and GPS system.

When we get off course and need help, we hope to find the ‘RIGHT STUFF’ to get back on track!

The TerrainThe TerrainThe pursuit of cures

for complex health problems has lead investigators

in pursuit of Regenerative Medicine.

Stem Cells Growth FactorsLaser Therapy

Nutrients

Now that you get the conceptNow that you get the conceptits time to turn to the its time to turn to the

mechanicsmechanicsCompassionate Understanding Knowledge - to get the right diagnosisExperience - to perform at the leading edge Fair Price – for the latest technological

advances

OroGen OroGen Biosciences Biosciences A forward thinking wound care and

regenerative medicine company

simplifying the complex . . . safely, economically and resourcefully.

Formed in April 2008,

OROGEN BIOSCIENCES

specializing in Tissue Regenerative Biomatrix

OROGEN OROGEN technologytechnology

Over 50,000 patients have benefited from this technology at the hands of the founders of OroGen without any evidence of cancer.

The unique proprietary processes discovered at OroGen intensify your own (autologous) tissue regenerative factors, preserving their function.

Advances have led to expanding the use of limited donor (allogeneic) resources through

preservation. (With even greater safety in use then provided

by blood banks! )

Animal & Human Animal & Human CasesCases

The following cases are examples of the the use of

OroGen’s CanineTissue Regenerative Biomatrix

in supporting wound care and regenerative processes.

Equine and human cases provide further support of the technology.

Canine Femoral Fracture 8/24/09 – Surgery Repair

10-22-09 8 weeks post op x-rays: non union with pin migration10-27-11 T(rf) injected at fracture site

Post T(rf)) Injection 21 days 34 days

11-17-09 12-1-09

Upper photos- 7 days after injury, T(rf) applied; lower left – 7 days ; lower left - 14 days

HBC 1-12-11. Initial assessment HBC 1-12-11. Initial assessment pending a request for euthanasia. pending a request for euthanasia.

The client agreed to the terms of the clinical trial of The client agreed to the terms of the clinical trial of TT(rf))(rf))..

1/19/11 One week after initial T 1/19/11 One week after initial T (rf) (rf) treatment and treatment and second application of T second application of T (rf) (rf) applied “SQ” to applied “SQ” to

‘devitalized’ areas and multiple ‘5/100 unit’ ‘devitalized’ areas and multiple ‘5/100 unit’ injections where no skin cover was present on distal injections where no skin cover was present on distal

leg.leg.

3-29-11 3-29-11 Patient has full use Patient has full use of leg. Very active. of leg. Very active.

Any attempts to Any attempts to photograph medial photograph medial aspect of leg was aspect of leg was

unsuccessful due to unsuccessful due to motion blurring.motion blurring.

No complications No complications were noted from were noted from

JanuaryJanuary through March. through March.

Pelvic fractures Pelvic fractures stabilized with stabilized with

normal capacity to normal capacity to eliminate .eliminate .

Current case- unresponsiveto standard therapies. One application of Trf.

Current Case

Toe to be amputated following a year of unsuccessful attempts to stabilize.

T(rf) has mostly been used with owners permission on a variety of patients including rescue cases that would have otherwise been euthanized including:

long bone fractures general soft tissue surgeries; severe bite wounds with extensive soft tissue trauma post Sx and no Sx stifle instability (especially geriatric cases); degenerative joint

disease comminuted mandibular fractures with concurrent oral disease; dentals performed and

fx sites injected, tape stabilization utilized chemo-extravascular injection necrosis elbow hygroma Chronic humeral-scapular joint tear with 30 degree range of motion -3 month duration,

poor response to NSAIDS and steroid injection : significant improvement followed by recurrence with unregulated exercise.

Severely Proliferative Cherry Eye in Bull Dogs with uncomplicated post op recovery and minimal to no swelling within 24 hr post Sx

KCS , one 5 day course of topical application - reduced the frequency of ophthalmic ointments for several months (client comments on phone follow up). Second case, stopped due to sting. Third case lost to follow up.

Personal observation: T(rf is a valuable addition/alternative to offer clients with limited options; as an adjunct therapy to common challenges; and for compromising surgeries. The full potential of this product will require more extensive and controlled studies. Until further studies are performed avoid using the product in the presence of neoplasia.

Dr Gary H Nelson, Viscaya Prado Veterinary Hospital, Cape Coral, FL

OROGEN OROGEN BIOSCIENCESBIOSCIENCES

5602 Marquesas Circle, Suite 214

Sarasota, FL 34233

Ph: 941-923-0009

www.orogen.net

OROGEN OROGEN BIOSCIENCESBIOSCIENCES