Greetings from the President

AIST's Vision and Fundamental Policies for the Fourth Medium- to Long-term Plan

Organization Chart

Department of Energy and EnvironmentDepartment of Life Science and BiotechnologyDepartment of Information Technology and Human FactorsDepartment of Materials and ChemistryDepartment of Electronics and ManufacturingGeological Survey of JapanNational Metrology Institute of Japan

Fukushima Renewable Energy Institute, AIST (FREA)TIAAIST Tokyo Waterfront, Bio and IT Fusion Research Base

Open Innovation LaboratoriesCooperative Research Laboratories

Regional Research Bases and Roles

Commercialization Support and International CollaborationHuman Resources Development

Highlights of Research AchievementsDirectory

［ Seven Domains ］

［ Open Innovation Platforms ］

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The National Institute of Advanced Industr ial

Science and Technology (AIST) was designated as a

designated national research and development institute

under a Special Measures Act last October. We take this

designation as signifying strong Japanese government

expectations for us, and we will continue to take a

leadership role in Japan’s research and development

(R&D), to contribute to industry and society. To meet

these expectations, AIST must maintain R&D levels

befitting a world-class research institute. Gaining an

international reputation will enable us to enhance

interaction and collaboration with research institutes

and universities around the world, creating a virtuous

circle for research enrichment and development.

As a public research institute, AIST has a mission to

provide research results to industry, and return them to

Japanese society. We therefore need not only to enrich

basic and applied research, but also to conduct R&D

activities with clearly defined goals.

AIST is pursuing activities focusing on the bridging

of technology under the Fourth Medium- to Long-

term Plan. At AIST’s research sites, we are promoting

the establishment of cooperative research laboratories,

bearing partner company names. Collaboration between

AIST’s researchers and companies’ engineers will

promote effective and efficient R&D, responding to

social needs. AIST has already established cooperative

research laboratories with seven companies, and begun

collaborative research.

At the same time, over the last fiscal year, AIST has

begun to establish open innovation laboratories (OILs)

on university campuses, collaborative research hubs

between AIST and universities. OILs will integrate the

strengths of both AIST and the universities, with basic

and applied research, development, and demonstration

continuously conducted to accelerate research. AIST

has thus far established OILs at seven universities, and

commenced related activities.

In parallel with strengthening our collaboration

with outside partners, AIST is considerably expanding

the number of its innovation coordinators, full-

time personnel who play a role in the bridging of

technology. We recruit a variety of human resources

from companies and public prefectural research

organizations, and approach industry with marketing

ideas not found in conventional public research

institutes.

AIST has activity bases throughout Japan, because

one of its important roles is to contribute to local

industries and economies. Many technologies have

been developed through collaborative development, and

commercialized by local companies. Such technologies

have created new industries and services; therefore, we

must ensure a more stable flow of development. AIST is

not only increasing the number of points of contact for

companies, but also actively advancing collaboration

with public research organizations and universities in

each region, to enhance contact with industry. In the

last fiscal year, we established new collaboration sites

in Ishikawa and Fukui Prefectures, to develop a system

to provide more detailed responses to industry needs.

Please feel free to consult with a nearby AIST regional

research base. We also provide telephone and email

consultations. Our staff will make every effort to solve

your problems.

We look forward to your continued understanding

and support.

President,National Institute of Advanced Industrial

Science and Technology (AIST)

Ryoji Chubachi

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AIST’s Vision and Fundamental Policiesfor the Fourth Medium- to Long-term Plan

In order to build a sustainable society, we are called to deliver solutions to 21st century issues, such as global warming, the energy problem, and a rapidly aging society. AIST conducts research in line with its principle of “Technology to Society.” During the Fourth Medium- to Long-term Plan (duration of 5 years) which started in April 2015, AIST aims to realize the principle by enforcing the three pillars of its activities. Specifically, we strengthen goal-oriented basic research which forms the basis of innovation, bridge its outcomes and industry, and utilize and nurture human resources who will create future innovation.AIST’s subject of research is wide covering almost all industrial technologies of Japan. In order for the state of the art research outcomes to be widely used, we realigned our research organization into seven domains for the fourth period. We are aiming for maximum results by setting research institutes and research centers in each domain. The research institutes undertake goal-oriented basic research and applied research to practical research to bridge the gap between research and industry in an integrated manner. The research centers focus on practical, commercialization research in response to the needs of industry and society. Moreover, we are actively tackling close collaboration with small and medium-sized enterprises with our 7 regional research bases. We are also establishing a system by which TIA, Fukushima Renewable Energy

Institute, and even AIST Tokyo Waterfront can be used by universities, other research institutes, and private companies as open innovation platforms. Thus, we will make the platforms places for international research and development.From fiscal 2016, we are establishing AIST labs (open innovation laboratories) on university campuses, to conduct end-to-end research from basic, applied, to demonstration and practical research through collaboration with universities and industry. We are also establishing cooperative research laboratories bearing partner companies’ names within AIST to promote closer collaboration with companies committed to commercialization of research results.In addition, we have established a technology marketing section and will significantly increase the number of innovation coordinators to fundamentally strengthen our bridging function of technology. We will support the development of innovative products and production processes of regional companies by closely collaborating with the public research organizations of the regions.AIST has been specif ied as a designated national research and development institute from October 2016. We will tackle world class research and development and human resource development suitable of such an institute, in order to respond to expectations as a core institute that powerfully drives the national innovation system.

Technology to society

AIST labs on campus (open innovation laboratories (OILs))

Building a sustainable society

Green Technology for a rich and

eco-friendly society

Information Technology fora super smart society

Life Technology for healthy, safe, and secure living

Close collaboration with small and medium-sized enterprises of regionsAIST seven regional research bases

An open innovation hub for semiconductors and nanotechnology

(TIA)

Energy and Environment

Creation, storage and conservation of energy

Life Science and Biotechnology

Drug discovery and health care Bioproduction

Information Technology and Human Factors

Artificial intelligence Robotics

A base for integrated research in IT and life sciences (AIST Tokyo Waterfront)

Innovative manufacturingInternet of Things

Electronics and Manufacturing

Earthquake, volcano and natural resource surveys

Geological SurveyMaterials and

Chemistry

Chemicals and processesNew materials

Measurement standardsAdvanced measurements

Metrology Standards

An international research and development base for renewable

energy (Fukushima Renewable Energy Institute (FREA))

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Organization ChartAs of April 1, 2017

President Management Steering Committee Auditor

Board

Human Resource Committee Committee of Research and Cooperation Strategies

Compliance Headquarters

Audit Office

Evaluation DepartmentTIA Central Office

■ Planning Headquarters

■ Research and Innovation Promotion Headquarters

■ Environment and Safety Headquarters

■ General Affairs Headquarters

■ AIST Tokyo Headquarters

■ AIST Tsukuba

■ Fukushima Renewable Energy Institute, AIST

■ AIST Tokyo Waterfront

■ AIST Hokkaido

■ AIST Tohoku

■ AIST Chubu

■ AIST Kansai

■ AIST Chugoku

■ AIST Shikoku

■ AIST Kyushu

Department of Energy and Environment● Research Center for Photovoltaics● Renewable Energy Research Center● Advanced Power Electronics Research Center

● Research Institute of Energy Frontier● Research Institute of Electrochemical Energy● Research Institute for Energy Conservation● Environmental Management Research Institute● Research Institute of Science for Safety and Sustainability

Department of Life Science and Biotechnology● Biotechnology Research Institute for Drug Discovery● Biomedical Research Institute● Health Research Institute● Bioproduction Research Institute

● Molecular Profiling Research Center for Drug Discovery

Department of Information Technology and Human Factors● Automotive Human Factors Research Center● Robot Innovation Research Center● Artificial Intelligence Research Center

● Information Technology Research Institute● Human Informatics Research Institute● Intelligent Systems Research Institute

Department of Materials and Chemistry● Interdisciplinary Research Center for Catalytic

Chemistry● CNT-Application Research Center● Research Center for Computational Design of

Advanced Functional Materials● Magnetic Powder Metallurgy Research Center

● Research Institute for Sustainable Chemistry● Research Institute for Chemical Process Technology● Nanomaterials Research Institute● Inorganic Functional Materials Research Institute● Structural Materials Research Institute

Department of Electronics and Manufacturing● Spintronics Research Center● Flexible Electronics Research Center● Advanced Coating Technology Reserch Center● Research Center for Ubiquitous MEMS and

Micro Engineering

● Nanoelectronics Research Institute● Electronics and Photonics Research Institute● Advanced Manufacturing Research Institute

Geological Survey of Japan● Research Institute of Earthquake and Volcano Geology● Research Institute for Geo-Resources and Environment● Research Institute of Geology and Geoinformation● Geoinformation Service Center

National Metrology Institute of Japan● Research Institute for Engineering Measurement● Research Institute for Physical Measurement● Research Institute for Material and Chemical Measurement● Research Institute for Measurement and Analytical Instrumentation● Center for Quality Management of Metrology

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Department of Energy and EnvironmentIn order to promote green innovations toward solutions to energy and environmental issues growing on a global scale, the Department of Energy and Environment pursues the following development: 1) Technology to accelerate introduction of new energy, including renewable energy, to enable reduced greenhouse gas emissions, 2) Technology to store energy in high density, 3) Technology to convert and exploit energy efficiently and achieve an energy-conserving society, 4) Technology to use new energy resources such as methane hydrate effectively, and 5) Technology to evaluate and reduce environmental risks in order to achieve a society where industry and environment coexist.

❶ CIGS solar cells, composed of copper (Cu), indium (In), gallium (Ga), and selenium (Se) , have attracted attention as lightweight and flexible solar

cells with high conversion efficiency.

❷ We are developing technology to produce natural gas economically from methane hydrate, which is widely distributed offshore of Japan, and which

is expected to be a new energy resource.

❸ Technology development that enhances recovery rates of rare metals collected from electrical and electronic hardware wastes (urban mine). In the

future, the technology is expected to boost economic growth and preservation of the earth’s environment.

Tackling energy and environmental issues

❶ Flexible CIGS solar cells

❸ High-purity recovery and recycling technology for rare metals❷ Methane hydrate core sample

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The field of storage batteries for electric vehicles is pursuing the

development of secondary batteries which have higher capacity and safety compared to lithium ion batteries (LIBs) currently in use. In addition to being non-flammable, all-solid-state batteries using solid electrolytes are expected to have a high voltage reaching 5 V; a voltage level which is difficult to achieve with the current organic solvents. AIST has engaged in the development of all-solid-state LIBs using sulf ide solid electrolytes, and has succeeded in the operation of a prototype laminate-type battery (see photo). Furthermore, with the discovery of metal polysulfide cathode mater ials that show high capacities― an achievement in materials development― we are working on the development of an all-solid-state battery employing a highly-safe oxide

solid electrolyte. Material synthesis, elect rode fabr icat ion and bat ter y fabrication technologies constitute the initiatives for device development. R&D

efforts will aim for the early practical implementation of high performance all-solid-state LIBs that are highly safe.

We promote technology development that br ings innovation to the

future of power electronics, utilizing new semiconductors that are superior in material characteristics, such as silicon carbide (SiC). Tsukuba Power Electronics Constellations (TPEC), a new-type joint research alliance utilizing the vitality of the private sector, was organized in collaboration with many companies and universities at TIA, our open innovation plat form of indust r ial technology development. It pursues manufacturing at practical mass-production levels for successive fabrication processes f rom wafers to devices, modules, and systems. Participating members encompass a wide range of industry segments: mater ial manufacturers, electronics manufacturers, apparatus manufacturers, and applied systems companies, and TPEC supports mutual

collaborations. A scheme for f lexible use of intellectual property (IP) and know-how is in place, so IP and know-

how developed individually at TIA can be used among participating members at no charge.

■ Technology Development and Practical Implementation that Bring Innovation to Power Electronics

■ Development of Practically-Usable All-Solid-State Lithium Secondary Batteries

How to reach us Research Promotion Division of Energy and Environment

+81-29-862-6033 envene-liaison-ml@aist.go.jp http://www.aist.go.jp/aist_e/dept/en_denvene.html

Laminate-type all-solid-state battery (The laminate-type battery operates as a battery and lights the LED, thanks to the good interface formed between the electrode and electrolyte.)

Cleanroom for TPEC SiC device prototyping

SiC ingot

Device chips (transistors, diodes)

SiC inverter

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Department of Life Science and BiotechnologyDepartment of Life Science and Biotechnology implements advanced research that contributes to Life Innovation and Green Innovation for healthy longevity in society through a healthy and secure daily life, and for a sustainable society that minimizes the burden to the environment. Specific efforts include the following: 1) Fundamental drug discovery technologies that enable rapid, highly successful and cost effective ways; 2) Health care technologies ranging from stem-cell treatments for regenerative medicine to bio-devices for handy and precise measurement of health conditions; 3) Bioproduction to efficiently produce useful substances like starting materials for pharmaceuticals by enhancing substance productivity of microorganisms, plants and animals, with transgenic technology.

❶ World’s first closed-type transgenic plant factory developed at AIST, where the transgenic strawberries for canine gingivitis were developed (left).

The animal drug made from the strawberries was approved and is now commercially available as veterinary pharmaceuticals (right).

❷ Electron microscopy image of a living bacteria at 30,000X magnification captured using the “TRANSEM” technology developed at AIST, which

enables observation of living cells and other particles in liquid suspension at resolutions up to 10nm without staining, freezing or slicing.

❸ World’s first early diagnosis of hepatic cancer by a blood test using a sugar-chain biomarker, which can reduce processing time and burdens on

patients in comparison to conventional biopsy methods.

Realizing a healthy, active, aged society and creating a sustainable society

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❷ Electron microscopy image of a living bacteria in liquid suspension ❸ Early diagnosis of hepatic cancer using a biomarker for hepatic fibrosis

❶ Transgenic strawberries for animal medicine grown in closed-type transgenic plant factory

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In the context of reduction of genome sequencing cost, rapid development

of IT technologies, and availability of convenient genome manipulation techniques, AIST is working on full ut il izat ion of animals, plants, and microorganisms’ potential by designing and modify ing thei r genomes for addit ional funct ions and mater ial production at low environmental cost.

We implemented a genome editing technology to chicken for the f irst time, which can be applied to mass production of valuable proteins in eggs. For plants, we are working on developing “super plants,” including those which contribute to the fixation of CO2 or can survive under harsh environments, by manipulating transcription factors and other genes. Moreover, to draw out

the vast and wide ranges of potential of microbial species, technologies to treat and analyze masses of biological omics data, including transcriptomes, proteomes and metabolomes, are being developed, which can allow to design and modify metabolic pathways in the species for high production of materials and so on.

Fo r r e a l i z a t io n of h e a l t h a n d well-being, we are developing

technologies to dynamically reduce the drug discovery processes and to readily evaluate health conditions, such as the handy fast qPCR equipment for detection of various pathogens causing such conditions as viral infection and

food poisoning, and the humanoid robot “Mahoro” for reliable operations of biotechnological experiments. These technologies realize more efficient and convenient processes in drug discoveries, medical services and diagnosis. The s tea lth R NA vector developed at AIST enables us to introduce multiple

object ive genes into cells without damage of chromosomes, which can largely contribute to safe and effective preparation of iPS cells in clinical use.

■ Innovative Technologies Implementation for Medical Care and Human Health

■ Efficient Material Production and Organisms’ High Functionalization by Genome Design

Genetically modified drought-tolerant Arabidopsis thaliana (right)

Humanoid robot for drug discoveries and biotechnologies, Mahoro (Robotic Biology Institute Inc.)

Rhodococcus species bacteria for material production

iPS cells created using the stealth RNA vector

Genetically modified chickens by genome editing

Handy fast qPCR equipment (co-developed with Nippon Sheet Glass Company, Ltd.)

How to reach us Research Promotion Division of Life Science and Biotechnology

+81-29-862-6032 life-liaison-ml@aist.go.jp https://unit.aist.go.jp/lsbt/rp-lsbt/english.html

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Department of Information Technology and Human Factors

Robots, artificial intelligence: information technology prospering alongside people

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Cyber [information] space

❸ Cyber-physical system

❶ We perform measurement and evaluation of various human activities including the state of driving an automobile in order to elucidate

human physiological, cognitive, and physical functions, and achieve safe and comfortable living in society.

❷ Technology development pursues practical application of robots in various industries such as caregiving, mobility assistance, and

manufacturing. The photo shows a two-armed robot lining up parts.

❸ We aim to build systems that contribute to advancement of industry and social systems by integrating information gathered from

people, things, and services.

Reflect to real space activities

Acquisition of big data and information distribution

Living (Smart House)Services (Smart City)

Analysis/interpretation of big data

Production (Industry 4.0)

Transport, traffic, logistics

Network security

Electricity/energy (Smart Grid)

Cloud computingSensors (Internet of Things)

Open data

❶ Human measurement and evaluation technology ❷ Robot technology

Physical [real] space

In the Department of Information Technology and Human Factors, R&D concentrates on interactions between information science and ergonomics, and aims for enhanced industrial competitiveness and a plentiful and comfortable society. Development efforts include the following: 1) Artificial intelligence technology that creates value from big data, 2) Cloud technology that creates new value from people, things, and services and security technology for safe Internet use, 3) Measurement and evaluation technology of human activities, like driving an automobile, that elucidates human factors such as physiological, cognitive, and physical functions, and 4) Practical implementation technology for robots used in various fields such as caregiving, daily-life assistance, and manufacturing lines, and fundamental technology for autonomous work of robots that withstand environmental changes.

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Department of Information Technology and Human Factors I n order to solve issues by people working together with ar tif icial

intelligence, it is necessary to have artificial intelligence with a high affinity to human intelligence. AIST conducts research focused on the following two areas. 1) Research of brain-like artificial intelligence: Bringing forth a computer system that performs flexible and agile information processing, like neural circuits and neurons of the brain process information, through engineering studies of the mechanism of expressing human intelligence by the human brain. 2) Research of data/knowledge integration-type artificial intelligence: Complex decisions and explanations of decision processes are made possible by natural integration of machine learning technology that lea r ns reg ula r it y f rom vast data , semantic comprehension technology for

understanding knowledge accumulated by human society, and inferent ial technology that applies knowledge. For these fundamental research themes,

we set specific, clear applications in real society, and promote continuing research.

Real i z i ng i n novat ion t h roug h robotic technology means that

development of the robot alone is insuff icient. Upst ream processes, such as analysis of the target work, determination of service to provide in order to improve operations, and the estimation of investment efficiency, are important. For that, we establish the analysis method for the target work of

robotic technology and the calculation method of investment ef f iciency, benefit and safety evaluation protocols supporting design specif ications of the robot, and acquisition and analysis technology of log data in order to evaluate operational benefit. Building on these, we aim to spur innovation in relevant indust r ies th rough the realization in society of robot services

that implement the following: provide support to those receiving care; reduce the burden of care givers; suppor t independent mobility of the elderly both indoors and outdoors; apply emerging AI technologies to industrial robots and manufacturing processes; and support new transportation systems revitalizing regional areas based on autonomous driving technologies.

■ Realizing Industrial Innovation Using Robotic Technology

■ Research of Artificial Intelligence with High Affinity to Human Intelligence

Safety tests of robotic care devices Manufacturing by intelligent industrial robots

3-D map building for autonomous mobile robots

Conceptual diagram of brain-like artificial intelligence

How to reach us Research Promotion Division of Information Technology and Human Factors

+81-29-862-6028 ith-contact-ml@aist.go.jp http://www.aist.go.jp/aist_e/dept/en_dithf.html

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Department of Materials and ChemistryIn the Department of Materials and Chemistry, we aim to provide technology to create innovative components and primary materials, keys to product competitiveness, by synergy of materials and chemistry research fields. We promote green sustainable chemistry and chemical process innovation, and we develop nano-materials such as nano-carbon materials as well as their application technologies. The development of inorganic functional materials is also our focus to drive manufacturing technology and advanced structural materials contributing to establishment of energy-conserving technology. The efforts provide opportunities to create new added value for the materials and chemical industries.

Enhancement of added value to functional chemicals and implementation of the realized new materials

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❶ Organic-electroluminescence element using graphene astransparent electrodes

❷ Cellulose nano-fibers towards high-performance materials through composite processes

❸ Computer simulation of electrochemical reactions ❹ High-performance magnetic materials without rare earth elements

❶ Development of high-speed-fabrication technique for large-area films of nano-carbon materials such as graphene, which has high

electrical and thermal conductivity, and search for their potential applications towards various optical and electrical devices

❷ Development of technique for compositing of cellulose nano-fibers, a new lightweight material with high strength and low expansion

coefficient made from woody biomass, with versatile materials such as resin and rubber (the inset figure: a prototype of an instrument

panel of cars for audio equipment)

❸ Development of high-performance devices through various simulation technologies for electrochemical interfaces, which are

developed and used at research sites of industry, academia, and government

❹ Development of high-performance magnets which do not need rare metal (dysprosium: Dy) and are riskless from issues of significant

price escalation and unsecured supply

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High-f unct ional organosi l icon components are expected to be

materials that can be utilized widely: next-generation LED sealants, organic EL sealants, and solar cells, and wind-power generat ion components, for instance.A I S T d e v e l o p s t e c h n o l o g y t o manufacture organosilicon intermediate materials of these components through an energy-saving process from sand, which has few resource constraints.F u r t h e r m o r e , A I S T c o n d u c t s development of processes using non-metallic catalysts as substitutes for precious met a l ca t a lys t s such a s platinum with limited reserves. We are also aiming to develop new processes that can manufacture high functional c o m p o n e n t s f r o m i n t e r m e d i a t e materials.This effor t aims to solve issues on

natural resources and environment while ensuring competitive advantages

of catalyst technology of Japan.

Our aim is commercializing highly crystalline, long single-walled

CNTs, which were originally discovered in Japan, and expanding their use in the market. For this purpose we are developing low-cost mass production technology targeting yields greater than 10 times those obtained previously by applying the super growth method that boasts the world’s highest efficiency for synthesis.In addition, following the development of fundamental synthetic technology of CNTs, which surpass metal and carbon fibers in dynamic, electrical, and thermal properties, we develop technology to create composite material of C N Ts w i t h va r iou s m at e r i a l s by ut i l iz ing coat ing, l ithographic processing, and printing technologies. We aim for application to LSI writing and parts in automobiles and motors.

Single-walled CNTs obtained from the super growth method are expected to be applied in new functional materials and next-generat ion dev ices . We

are pursuing development of mass-production technology and composite technology as industrial use approaches.

■ Mass-production and Composite Technologies for Single-walled Carbon Nanotubes (CNTs)

■ Development of Manufacturing Process for Organosilicon Functional Chemicals

Key raw material of silicon chemical industry made from sand

Production example at CNT demonstration plant using super growth method (50 cm × 50 cm)

How to reach us Research Promotion Division of Materials and Chemistry

+81-29-862-6031 mc-liaison-ml@aist.go.jp http://www.aist.go.jp/aist_e/dept/en_dmc.html

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Department of Electronics and ManufacturingIn the Department of Electronics and Manufacturing, AIST engages in development of devices that possess world-class performance for enabling both considerable energy-saving and high performance in IT equipment, and targets development of innovative manufacturing technology to achieve industrial activities that save energy, resources and money. Eyeing the arrival of the Internet of Things (IoT) connecting appliances other than information devices to the Internet, we develop super-efficient manufacturing systems and contribute to reinforcement of Japan’s industrial competitiveness by tying advanced sensing technology to acquire information from “things” together with innovative manufacturing technology.

Innovative technology that leads to change in electronics and manufacturing

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❶ Ultraviolet excitation V-trench biosensor ❷ Electrochemical-based sensor for hormones in blood of livestock

❸ 512-pixel superconducting tunnel junction array detector module ❹ “Minimal Fab,” a novel integrated circuit manufacturing system

❶ A V-trench biosensor that uses a sensor chip having a V-shaped microfluidic channel coated with an aluminum layer for surface plasmon resonance

excitation. The sensor can detect fluorescent-labeled biological substances with high sensitivity.

❷ An Electrochemical-based sensor, equipped with micro-structures of pyramid-shaped electrode arrays, enables efficient reproduction and breeding

of livestock through accurate detection of hormone molecules in blood.

❸ Superconducting tunnel junction array soft X-ray detectors exhibit a high energy resolution of 5-10 eV in full width at half maximum, which is

exceedingly better than that of conventional semiconductor detectors. Analytical instruments equipped with the superconducting tunnel junction

array soft X-ray detector can obtain unrevealed material information.

❹ Meeting high-mix, low-volume production by using an innovative semiconductor manufacturing system with half-inch wafers as the manufacture

substrate unit

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We have been studying topological p r o p e r t i e s e me rg i ng f r om

c h a l c o g e n i d e m a t e r i a l s a n d i t s superlattices. Among them, we have developed a low dimensional electron control technique by external electric f ields at room temperature, using Ge2Te2/Sb2Te3 chalcogenide superlattices. We are going to apply the technology with multi functionalities to ultra-low e ne rg y nonvola t i l e me mor ie s , a universal memory equipped with spin p rope r t ie s , r econ f ig u r able log ic switches, neural networking circuits, and a THz-optical switch controlling open/close of a band gap due to a Dirac cone.

■ Innovation Technology for Two Dimensional Multiferroic Functional Devices using Chalcogenide Superlattices with Topological Phase Transition

Currentheating

Current heating

Currentheating

Crystal Amorphous (high resistance > 1 MΩ)

Voltage applied

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Ge electric field motion

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Conventional type(heating/cooling cycle)

(low resistance 〜1 KΩ)

(low resistance 〜10 KΩ) (high resistance > 1 MΩ)

Cooling (slow)

Cooling (rapid)

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Sb2Te3

Sb2Te3

Sb2Te3

Sb2Te3

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Differences in the switching mechanism between a conventional phase change memory and a superlattice phase change memory

A HAADF-TEM image of the cross section of the Ge2Te2/Sb2Te3 superlatticeA Dirac cone band is generated in Ge2Te2 layers (left), and each Sb2Te3 (5-atomic) layer is weakly connected by van der Waals forces.

The aerosol deposition (AD) method i s a new coa t i ng t ech nolog y

developed by AIST, which can produce a robust ceramic film simply by spraying powder without sintering. The ceramic film is formed on a metal or resin base material not having heat resistance by the impact of the collision of blowing the mixtures of fine particles and gas at room temperature. The film is not only very ultra hard but also chemically stable. Therefore, the AD method has already been commercialized for parts of semiconductor manufacturing e q u i p m e n t , a n d s u p p o r t s t h e manufacture of semiconductor chips in the world. Also, the ceramic coating by the AD method can impart various surface functions to the member surface such as electrical, optical, abrasion

resistance, corrosion resistance and heat resistance. It is expected to expand applications in a wide range of fields

■ Room Temperature Ceramic Coating by the Aerosol Deposition Method

such as electronics, automobiles and aircraft, energy and medical related members.

Basic configuration of an AD apparatus and an example of room temperature coating

Directionof filmgrowth

Substrate

Highly dense ceramic film

Ceramics powder

Carrier gas

Room temperature impactconsolidation phenomenon

Nozzle

Colored hard coating

Plasma-resistant coating for semiconductor industry

Mask

How to reach us Research Promotion Division of Electronics and Manufacturing

+81-29-862-6592 rpd-eleman-ml@aist.go.jp http://www.aist.go.jp/aist_e/dept/en_delma.html

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Geological Survey of JapanGeological knowledge is considered to be “information with a time axis,” crucial in predicting the future of the earth by understanding its history. It is fundamental knowledge for building a safe and secure society particularly in Japan, which sits on a tectonically active belt. With an abundance of knowledge in geology, the Geological Survey of Japan (GSJ) pursues technology development to solve various issues related to mitigation of geological disaster, environmental protection and others. In addition, through resource potential assessment and the studies and surveys on the usage and maintenance of geo-environment to facilitate resource and energy policy planning and sustainable industrial development, we contribute to the advancement of a geo-friendly and sustainable society that uses resources and energy effectively.

Geological information supporting a safe and comfortable society

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❶ East-southeastern view of Nishinoshima

Continental shelf extension

Ocean area applied for, left for future decision

❷ Providing scientific evidence relating to continental shelf extension

❸ Geological map viewer showing the Kumamoto region❹ Peeled sample of tsunami deposit of the Jogan Earthquake

❶ Nishinoshima in the Ogasawara (Bonin) Islands (June 2014). Eruption began in 2013, paused in 2016, and resumed from April 2017. AIST offers

information for the assessment and prediction of its volcanic activity based on field study and analyses of volcanic products.

❷ In 2012, the United Nations recommended the extension of Japan’s continental shelf limits. AIST assumed the central role in the marine geological

survey, and contributed to the filing of the application to the UN and handling of the review together with other related organizations.

❸ AIST promotes the online distribution of its geological research outcomes as open data. The portal map viewer can display many geologic maps

and data overlaying each other. The figure represents the epicenters of aftershocks of the Kumamoto Earthquake and active faults, shown with the

geologic maps.

❹ Peeled sample of tsunami deposits. An AIST study used geological evidence of unusually large tsunamis to estimate the recurrence intervals and

inundation extent of past tsunamis in an effort to better prepare the Japanese coastline for future events.

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Diversification of energy resources is one of the most important and

urgent issues for Japan in the days when unpredictable international situations and energy and environmental issues need t o be con side red . Met ha ne hydrates beneath the seaf loor around Japan are expected to be a new energy resource.AIST has conducted geological surveys usi ng va r ious methods to a ssess the distribution and characteristics of shal low-t y pe methane hyd rate under consignment of the national government, and has estimated the resource amount in some areas off the Joetsu region. Responding to the result, the government has started the research on collecting the shallow-type methane hydrate.AIST also promotes basic research and development on geo-environmental ut il izat ion and protect ion, as well as t ranslat ional research th rough

collaboration especially with various indust r ies and others. One of the recent hot topics is the first discovery of an underground microorganism

(methanogen) which can produce methane directly from methoxylated aromatic compounds in a variety of coal types.

Towa rd t he u t i l i z a t ion of t he offshore around Japan, AIST has

discovered several active hydrothermal areas on the seafloor taking advantage of its experience and earth scientific k nowledge. The “United Nat ions Convention on the Law of the Sea” recognizes the sovereign r ights of coastal countries to explore and exploit natural resources in its continental shelf zone. Substantial resources such as rare metals and unknown resources are expected to exist within the exclusive economic zone (EEZ) of Japan. Marine geological survey is very important to accurately identify the distribution of these resources and to determine potential areas of mineral deposits.I n a dd i t ion , A IST p romot e s t he research and development of efficient exploration techniques for inactive hydrothermal deposits. AIST is also

engaged in the development of survey methods conducted with the private sector, the transfer of exploration and analysis technologies to the private

sector to enhance commercialization, and the support of human resource development.

■ Survey on Potential of Submarine Mineral Resources

■ Research on Methane Gas and Methane Hydrates

The active hydrothermal area on the seafloor discovered by AIST. Unique organisms, such as bathymodiolus, lamellibrachia, and alvinocarididae, are densely inhabiting around hydrothermal vents.

Mound

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5 cm

200 m

Surveys to assess the amount of shallow-type methane hydrate (Top-left: Seafloor topography of the target area. Top-right: Geological survey by an autonomous underwater vehicle. Bottom: Mined samples of methane hydrate)

How to reach us Research Promotion Division for Geological Survey of Japan

+81-29-861-3540 gweb@gsj.jp http://www.aist.go.jp/aist_e/dept/en_gsj.html

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National Metrology Institute of JapanDevelopment of the measurement standards such as length, time, and mass is a vital mission of AIST. The National Metrology Institute of Japan (NMIJ) develops and maintains measurement standards of physical quantities for seven base units and numerous combinations of those base units, and disseminate these standards to society. NMIJ advances the development of measurement technologies associated with the measurement standards, and undertakes the development of infrastructure underpinning cutting-edge manufacturing as well as the safety and security of our society. Four Research Institutes and the Center for Quality Management of Metrology are organically connected and cooperate closely to disseminate measurement standards, conduct legal metrology services, and enhance personnel training.

Measurement standards support the spectrum from daily life to advanced industry

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❶ The one and only torque standard machine in the world using electromagnetic force

❷ The world’s first standard LED covering the full visible light

❸ Dissemination of certified reference materials for chemical measurements

❹ Nondestructive vacancy-inspection system for characterizing steel materials

❶ The world's first torque standard machine based on the watt balance method was developed, in which the torque is generated using electromagnetic

force and is traceable to the International System of Units (SI). The standard machine is expected to be used for microscopic torque measurements

that are difficult to be realized by torque standard machines based on a moment arm deadweight system using gravity.

❷ The world’s first standard LED covering the full visible light, which is indispensable for the quality evaluation of LED products, was developed in

collaboration with an LED manufacturer so as to improve the quality and the consumer confidence regarding LED products.

❸ Certified reference materials, which are necessary for calibrating analytical instruments and evaluating analytical methods, are widely disseminated

domestically and internationally.

❹ In collaboration with a private enterprise, we developed a commercial desktop-type vacancy-inspection system for characterizing atomic vacancies

inducing metal fatigue of structural materials such as the frame of automobiles. This system, based on the positron annihilation lifetime technique,

allows nonexperts to measure materials nondestructively as well as easily.18

Among the base units of the SI which are widely used as units to

express physical quantities, worldwide preparat ions for the shif t towards the new definitions planning in 2018 are underway for mass, temperature, e le c t r ic c u r r e n t , a nd a mou nt of substance.AIST participates in the International

Avogadro Coordination project aiming to redefine the kilogram, and is also developing new realization methods based on the elementary charge and Boltzmann constant for electric current and temperature, respectively. Moreover, the development is proceeding for an optical lattice clock that may realize ult ra-precision of the order of 10 -18

(a deviat ion of one second every 13.7 bi l l ion years) and leads to a new definition of the second in the future. Those research approaches here are also expected to be applied to new measurement technologies such as micromass and microcurrent measurements.

Since many infrastructures in Japan were built more than 50 years ago,

we have to develop techniques for securing their structural integrity. NMIJ has been developing non-destructive inspection techniques for maintaining these aging structures. For example, we have developed a novel digital

image processing technique with Moiré fringes to evaluate the def lection of bridges in service. Moreover, we have developed a battery-driven compact high energy X-ray source that is capable of inspecting corrosion in chemical plant pipelines by being installed in an inspection robot. NMIJ’s specialists

on measurement and instrumentation help r e solve t e ch n ica l p roblem s confronting companies and universities through cooperative schemes such as collaborative research and technical consulting.

■ Development of Infrastructure Diagnosis Techniques for Safety and Security of Our Society

An X-ray photoelectron spectroscopy (XPS) system which can analyze the surface layers of a 1 kg single-crystal silicon sphere with sub-nanometer depth resolution (The Avogadro constant can be accurately determined with the aid of the surface analysis of the Si sphere.)

A verification test on deflection measurement of a bridge using a digital moiré technique

A 5-axis manipulator system to thoroughly analyze a Si sphere surface by its rotation (installed into the XPS system shown in the left picture)

An X-ray inspection machine mounted on an automatic plant pipe inspection robot

■ Development of New Measurement Technology Based on the Redefinition of the SI (International System of Units)

How to reach us NMIJ Public Relations Office, Center for Quality Management of Metrology

+81-29-861-4346 https://www.nmij.jp /english/inquiry/form/ http://www.aist.go.jp/aist_e/dept/en_nmij.html

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Demonstration Field

① Energy management demonstration: solar and wind power generation facility

⑤ Crystalline silicon cell by standard FREA process

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International cooperationCollaboration with universities, etc.

Fukushima Renewable Energy Institute, AIST (FREA)

Towards early introduction of renewable energy at scale

From Fukushima, we promote renewable energy R&D and deployment internationally, and contribute to the activation of the area affected by the disaster through developing new industrial clusters.

After receiving the government's “Basic Guidelines for Reconstruction in response to the Great East Japan

Earthquake” (issued in July 2011), AIST established the Fukushima Renewable Energy Institute, AIST (FREA) in Koriyama, Fukushima Pref. in April 2014. FREA has two missions: the promotion of R&D of renewable energy internationally, and the contribution to reconstruction through developing new industrial clusters in this area.In order to introduce renewable energy on a large scale, it is necessary to solve issues that include large f luctuations and high costs in power generation, and selection of appropriate technologies by location.Thus, in collaboration with domestic and foreign research organizations, universities, and companies, FREA promotes innovative technology development and its demonstration and commercialization and also contributes to development of regional industry and human resource development.

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Top cell

Crystalline silicon solar cell

50 nm

100 nm

500 nm

② Hydrogenation/dehydrogenation reaction apparatus

③ Windmill and search device for acoustic source ④ Next-generation type multi-junction solar cell “smart stack technology”

⑥ Micro-earthquake data integration and visualization system (monitoring the behavior of the injected water)

⑦ Suitability assessment of ground-source heat pump system ⑧ Smart System Research Facility ⑨ Electromagnetic wave anechoic chamber

●Experiment Building This single-story building with blocks of large space can be arranged

flexibly depending on usage, and is currently used for research and development of high-performance thin-wafer based crystalline silicon solar cells and hydrogen carriers.

●Demonstration Field Equipped with solar power generation, wind power generation,

storage battery, hydrogen carrier production/storage/utilization systems, and the energy management system that controls these, the field demonstrates the integration of large-scale power generation, energy storage and ut il izat ion technologies and is used for performance evaluations.

●Smart System Research Facility (started operations in April 2016) (Photos ⑧ ⑨)

This facility offers the world’s top level in testing and R&D of advanced power electronics equipment, such as a full-size power conditioner (PCS) that is indispensable for renewable energy and storage battery installations.

■ Main Research Themes ■ Collaboration Activities

■ Research Facilities and Open Innovation Platform

●Research and verification of advanced integration of renewable energy source (Photo ①)

In order to develop and demonstrate a system that can use renewable energy maximally, we engage in R&D of energy management and peripheral technology that make full use of storage and control technology.

●Production and utilization technology of hydrogen energy carrier (Photo ②)

We engage in R&D of hydrogen energy carrier production and application to store and transport large amount of fluctuating renewable energy.

●Advanced technology for wind power generation (Photo ③) We develop sophisticated wind-condition forecast technology, and

apply it to improve windmill efficiency and lifetime.●High-performance PV modules with crystalline silicon solar cells

(Photos ④ ⑤) We are continuing R&D of thin-wafer based crystalline silicon solar

cells to reduce cost through high efficiency and high reliability. Smart stack technology is also being developed to achieve ultra-high efficiency at low cost.

●Technologies for the effective and sustainable use of geothermal resources (Photo ⑥)

We engage in R&D to overcome problems such as subsurface uncertainty, cost effectiveness, co-existence with hot spring spas, and sustainability, and to advance proper geothermal resource development and utilization that meet the underground conditions and demand.

●Suitability assessment of ground-source heat pump system and its system optimization technology (Photo ⑦)

In order to promote ground-source heat pump systems, we develop suitability maps that reflect hydrogeological data of the region, and are pursuing R&D for high performance and cost-effective systems to be used according to hydrogeological conditions.

●Support of the industry in the disaster area We support commercialization of technologies and know-how related

to renewable energy held by companies located in the three prefectures of Fukushima, Miyagi, and Iwate affected by the Great East Japan Earthquake (82 cases as of end of March 2017).

●Human resource development in renewable energy fields We accept students from local universities, and train them through joint

research with universities as future human resource in renewable energy fields.

●Active alliances with domestic and international organizations We are actively working on strategic alliances with local universities,

domestic and foreign research organizations in technology development, human resource development, and international standardization.

How to reach us Fukushima Renewable Energy Institute, AIST

+81-24-963-0813 frea-info-ml@aist.go.jp http://www.aist.go.jp/fukushima/en/

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① Three-dimensional packaging technology using through-silicon vias (TSVs)

⑤ Device mass-production prototypes (3-inch wafers)

⑨ O-rings fabricated from the CNT-rubber composites

SCR Building (Left) / TIA Collaboration Building (Right)

We disclose the results of our cutting-edge research, provide R&D facilities and equipment for open use, and promote open innovation.

TIA

Expanding from Tsukuba city, to Tokyo, TIA, is Japan's largest center for open innovation operated by five public

research organizations* with the support of the Japan Business Federation (Keidanren).Since establishment in 2009, TIA has been creating various core technologies, including SiC power devices, single-walled carbon nanotubes (the super growth method) and composite materials, and super-low power consumption wireless sensor terminals, some of which have already reached mass-production and commercialization.In phase 2 (FY 2015-2019), TIA improves user convenience with one-stop services in collaboration contracts, open access of facilities, and human resource development, undertakes project planning and marketing in collaboration with public investors, and establishes a global brand with international alliances.

TIA

Five organizations creating a platform for open innovation

Tsukuba

KashiwaTokyo

*Five core organizations that constitute TIA:● National Institute of Advanced Industrial Science and Technology (AIST)● National Institute for Materials Science (NIMS)● University of Tsukuba● High Energy Accelerator Research Organization (KEK)● The University of Tokyo

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⑦ Ultra-thin PZT/Si strain sensor sheet

③ Next-generation low power device using atom transfer switches

⑥ SiC pre-production line ⑧ MEMS foundry

⑩ IBEC (Innovation Booting Equipment Common) ⑪ Helium ion microscope ⑫ TIA graduate summer school

●Nanoelectronics: Various R&D projects related to silicon (Si) devices and photonic devices are conducted using the Super Cleanroom (Photo ①②③④)

●Power electronics: R&D of silicon carbide (SiC) power electronics and super conduct iv ity is conducted by joint projects and consortiums. (Photo ⑤⑥)

●MEMS (micro electronic mechanical system): Using micro-fabrication and measurement facilities, R&D projects are conducted for devices and systems such as sensor networks. (Photo ⑦⑧)

●Carbon nanotubes (CNTs): Development of composite materials and safety research of CNTs are conducted. (Photo ⑨)

●Nanotechnology facilities belonging to the five core organizations are available to external users. We provide them with one-stop services through accessible tools such as the database for open research facilities in Tsukuba.

●AIST offers three open platforms to external users and accepts applications: the Super Cleanroom, MEMS foundry, and IBEC for advanced processing and measurement. (photo ⑩⑪)

●Nanotech Career Up Alliance (Nanotech CUPAL) (see page 34).●As part of lectures and summer schools that use advanced facilities

of TIA led by the University of Tsukuba, AIST offers classes and short courses in nanoelectronics, power electronics, and MEMS. (photo ⑫)

●Under the guidance of AIST staff, internships offer experience in practical research together with corporate researchers. With the support of private companies, endowed courses on power electronics are held at the University of Tsukuba.

■ R&D in Various Fields

■ TIA Collaborative Research Program “Kakehashi”

■ Open Use of Facilities

■ Human Resource Development Using the Facilities

●The program, started in FY2016, is a collaborative framework for researchers among the five core organizations to explore research themes with potential to spark innovation in various fields such as biotechnology, computational materials science, big data analysis, and IoT.

② ArF immersion lithography in the Super Cleanroom ④ 32x32 optical switch device

How to reach us TIA Central Office

+81-29-862-6122 tiaco-soukatsu-ml@aist.go.jp https://unit.aist.go.jp/tia-co/index_en.html

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We promote open innovation toward the attainment of a super smart society, and healthy and safe living afforded by information and life technologies

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●Identification of targets of lead compounds (Photo ①) Using ultra-sensitive mass spectrometry and a robotic

sampling system with high reproducibility, we analyze interactions of lead compounds and intracellular proteins. These results will be used for analysis of drug efficacy and side effect mechanisms, and linked to clinical research.

●Natural product library (Photo ②) Using the world’s largest library of natural products of

approximately 270,000 samples, we support the actualization of efficient, effective drug discovery by screening that targets various diseases, including tumors and central nervous system diseases.

●Kids design industry support based on injury prevention engineering (Photo ③)

We are developing injury prevention engineering, including databases of physical and behavioral characteristics of children and injury simulation technology for children, in order to reduce injuries and fatal accidents of children, and are creating an infrastructure of kids design industry based on data.

●Cryptography with advanced functionality (Photo ④) We are developing h igh-per for mance cr yptographic

technology to meet sophisticated needs, including data processing of encrypted data, simple setting of users that are allowed to decrypt each encrypted document, and user verification enabling privacy protection of users.

●Digital human model for product design (Photo ⑤) To design industrial products with more ease of use and safety,

we are developing technologies to measure body geometry and motion, technologies to create digital human models with individual differences after analyzing measured data statistically and mechanically, and technology to evaluate compatibility of human models and products by computing interaction.

●Artificial intelligence (AI) (Photo ⑥) In cooperation with universities and private enterprises, we

conduct large-scale basic research and R&D of advanced core-AI technology modules, and construct devise technical foundations as Japan’s largest AI research platform. In addition, we return research results to society through human resource development and technology transfer.

AIST Tokyo WaterfrontBio and IT Fusion Research Base

Becoming an open innovation platform through integration of bio and IT

■ Main Research Themes

As a base of integrated bio and IT research, AIST Tokyo Waterfront engages principally in research

associated with the departments of Life Science and Biotechnology, and Information Technology and Human Factors, and intends to become an open innovation platform of this integrated research.Specifically, we promote cutting-edge R&D with an emphasis on integrated bio and IT: for instance, the medical application of genomic data, optimization of drug discovery by robotics and mathematical analysis technology, drug discovery screening by creating a library of natural products, measurement and digital modeling of human functions and behaviors, artificial intelligence technology that creates value from big data, and advanced cryptography to handle information safely.

In addition, by taking advantage of the convenient location of the research base at Tokyo Waterfront, AIST drives activities such as technology transfer, personnel exchange, and human resource development through joint research and collaboration among companies and universities, development of next-generation human resources, and public exhibitions of research results.

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Experts of measurement technologies

New devices for measurements concerning health

Professionals of clinical trials

New healthcare service

New evidence

Needs from industries

Open innovation through the consortium as a hub

④ Cryptography with advanced functionality

Functional encryption key

Homomorphic encryption key

Decrypt

Forum for government, industry and academia association in Tokyo Waterfront area

⑤ Digital human modeling ⑥ Conceptual diagram of brain-like AI

① Humanoid robot Mahoro ② Natural product library

③ Kids design industry support

●International collaboration As an international collaboration hub for bio and IT, the research

base collaborates with China, India, Singapore, Finland, the U.K., Germany, the Netherlands, and the U.S., and engages in personnel exchanges.

●Consortium for Evidence-based Health & Wellness Service “Consortium for Evidence-based Health & Wellness Service” was

established to implement seeds of healthcare service in the industry to public use. For promotion of evidence-based healthcare business, we will develop new measurement technologies for effective healthcare by conducting the following: promotion of standard creation, development of new effective measurement procedures, planning for appropriate substantiative experiments, differentiation of services in the market and promotion of international standardization. To facilitate evidence-based healthcare businesses in affiliated companies, we produce associated projects through conducting the following: disclosed or member-limited lecture meetings, tours of inspection on job-sites and survey studies.

●Hub function of AI research We gather domestic and foreign talents engaged in ar tif icial

intelligence (AI) research, engage in AI from basic research to practical application, and serve as a hub for AI research and as a platform.

●Forum for government, industry and academia association in Tokyo Waterfront area

We produce an association forum gathering people who work in government, industry and academia in the Tokyo Waterfront area (Daiba, Aomi, Ariake and Toyosu) to promote interactive connections of people working in universities, companies and public research institutes. This association is hosted by AIST Tokyo Waterfront, Tokyo Metropolitan Industrial Technology Research Institute and Asia Startup Office MONO. We aim at creating open innovation to contribute to 2020 Tokyo Olympics and Paralympics by further promoting our collaboration.

■ Open Innovation Platform

How to reach us AIST Tokyo Waterfront

+81-3-3599-8001 sgk-wf-ml@aist.go.jp http://www.aist.go.jp/waterfront/index_en.html

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Open Innovation Laboratories

Since FY 2016, as a part of the “Open Innovation Arena concept” promoted by the Ministry of Economy, Trade and Industry (METI), AIST has created the concept of “open innovation laboratories” (OILs), collaborative research bases located on university campuses, and has been engaged in their provision. We are planning to establish more than ten OILs by FY 2020.

〈Objectives of establishing OILs〉① Carrying out successive research and development from

basic research to demonstration in a seamless manner.② Accelerating research with a cross-appointment

system, in which professors of the universities can also work as AIST researchers.

③ Developing doctoral researchers with open-minded and practical visions, capable of playing active roles in industries.

AIST will merge the basic research carried out at universities, etc. with AISTʼs goal-oriented basic research and applied technology development, and will promote bridging research and development and industry by the establishment of OILs.

Initiative for strengthening our bridging function―Cooperation with universities

AIST-NU GaN Advanced Device Open Innovation Laboratory（GaN-OIL） Based on the technology of blue LED which Japan realized first in the world, we aim at early practical application of power semiconductors using GaN (gallium nitride).

AIST-UTokyo Advanced Operando-Measurement Technology Open Innovation Laboratory（OPERANDO-OIL） Operando-measurement technology will lead to elucidation of functional mechanisms and visualization of manufacture processes. The acceleration of development of materials, devices is expected.

AIST-TohokuU Mathematics for Advanced Materials Open Innovation Laboratory（MathAM-OIL） We will systemize technology for materials modeling research by means of mathematical science, such as discrete geometric analysis, and computational materials science. We will clarify the principle of correlation among the structures, functions, and processes of materials, and will accelerate materials development.

AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory（CBBD-OIL） We are aiming at elucidating life phenomena and mechanisms of diseases and the creation of innovative drugs and supplements, by integrating biological big data and information infrastructure technology with technology for life information analysis.

AIST-Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory（PhotoBIO-OIL） We will conduct research and development of biosensing technology to elucidate mechanisms of organisms and to realize epoch-making drug creation, drug effect, toxicity evaluation, and infectious disease diagnosis, by integrating nanophotonics technology and biodevice technology.

AIST- Tokyo Tech Real World Big-Data Computation Open Innovation Laboratory（RWBC-OIL） Our mission is to advance the high-end processing and applications of big data in the real world, utilizing high performance, scalable computing as well as AI-based analysis technologies on world-leading computing infrastructures.

AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory（ChEM-OIL） By creating innovative materials based on new concepts and developing them into chemical energy devices, we will contribute to realizing a low carbon society by 2050 that is aimed at in the Energy and Environment Innovation Strategy.

"Comprehensive strategy for town, people, creation" projectAIST-Kyushu University Hydrogen Materials Laboratory（HydroMate） By developing materials for safe and economical utilization of hydrogen, we aim to expand utilization and application technology of hydrogen.

〈Actual cases〉

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Open innovation laboratoriesCross-appointment / Research Assistant

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In order to conduct research and development more closely related to strategies of companies, we have established collaborative research laboratories, bearing partner company names.Partner companies provide their researchers and funding, and AIST provides research resources, such as its researchers, research facilities, and intellectual property. The loaned researchers of companies and AIST researchers jointly conduct research and development.

〈Actual cases〉◇NEC–AIST AI Cooperative Research Laboratory◇ SEI–AIST Cyber Security Cooperative

Research Laboratory◇ Zeon–AIST Nanotube Industrialization

Cooperative Research Laboratory◇ TICO‒AIST Cooperative Research Laboratory

for Advanced Logistics◇ Panasonic–AIST Advanced AI Cooperative

Research Laboratory◇ NGK SPARK PLUG–AIST Healthcare・

Materials Cooperative Research Laboratory◇ TEL–AIST Cooperative Research Laboratory

for Advanced Materials and Processes

Cooperative Research Laboratories

Initiative for strengthening our bridging function―Cooperation with partner companies

■ Collaborative research with private companies

Based on the individual needs of private companies, AIST transfers technology.

● How to reach us

Planning Headquarters General Planning Office +81-3-5501-0901 pl-inquiry-ml@aist.go.jp

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Research fundingRegistered loaned employees

First class researcherPrivileged measures forintellectual properties

Companies

Commercialization

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Regional Research Bases and Roles

AIST united as a whole supports regional industry

■ Research Bases of AIST around Japan

Development of hydroponic cultivationCompletely-controlled plant factory

The shipment value for the agricultural, fishery, and livestock industries of Hokkaido is the highest among prefectures in Japan, and the associated food industry is an important industry base. For further development of the food industry, AIST Hokkaido is promoting research and development of new substance production technology using biotechnology, as represented by the closed-type transgenic plant factory using artificial lamps only. Through this research and development, we contribute to efficient production of pharmaceuticals, and high added value to agricultural and marine products and food.

■ AIST Hokkaido Emphasized research theme: Bio-manufacturing

Tamamushi lacquerware with nanocomposite coating (The technique of Claist(R) developed at AIST Tohoku is applied to the nanocomposite coating) Photo courtesy of Tohoku Kogei Co., Ltd.

Coating apparatus emitting reduced volatile organic compounds (VOCs) by using supercritical carbon dioxide

AIST Tohoku merges technologies of chemical reaction, processes, and materials, and promotes research and development of chemical manufacturing that leads to innovation for chemical processes and materials. Through transfers of research achievements to industry, we aim for environmental load reduction in the chemical manufacturing industry and high added value for regional resources. At the same time, we contribute to the construction of a new industry base, reinforcement of international competitiveness, and recovery from the Great East Japan Earthquake.

■ AIST Tohoku Emphasized research theme: Chemical-manufacturingR

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To support competitiveness of a regional economy, we promote emphasized research according to the respective region’s industrial structure, available technological seeds, and needs, and advance the dissemination of achievements.

Aligning closely with public research institutions of the region, we provide technical advice services, develop human resources, provide equipment and research facilities, and implement joint proposals for public funds and various joint activities, and thus support regional companies

■ Research and development — Creating unique regional strength

■ Promoting collaboration — Responding to regional needs

● To contact for collaboration

+81-11-857-8406hokkaido-counselors-ml@aist.go.jp

● To contact for collaboration

+81-22-237-0936tohoku-counselors-ml@aist.go.jp

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● To contact for collaboration

+81-72-751-9606kansai-counselors-ml@aist.go.jp

Fukui Site

+81-776-55-0152http://www.aist.go.jp/kansai/ja/fukui/index.html

Test field that enables mounting of new building materials for environmental performance testing

Portable solid oxide fuel cell (SOFC) power generating system for disaster and emergency response that employs commercially available LPG cartridges

The Chubu region is an industrial hub for the automotive, aircraft, and machine tools industries. Targeting mainly inorganic new materials, such as ceramics and metals relating to these industry clusters, AIST Chubu promotes research and development of various industrial components with outstanding environmental resistance and reliability, structural members contributing to lightweight transportation equipment, and thermal control structural materials suitable for various usage environments. Through these efforts, we contribute to the enhancement of international competitiveness in the field of materials.

■ AIST Chubu Emphasized research theme: Functional materials

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Hydrothermal processing apparatus that facilitates biomass decomposition

AIST Chugoku conducts research and development toward a sustainable society, with an emphasis on the chemical, bio- and material technologies to produce fundamental and functional chemicals with high efficiency and low environmental load from wood-based biomass resources abundant in the Chugoku region. We have been working toward innovation to activate regional industries in cooperation with METI Chugoku and public research institutions in the Chugoku region, and constructing the network between companies in the region.

■ AIST Chugoku Emphasized research theme: Biomass conversion technology

Lithium ion battery prototypes Chicks modified by "Genome editing"

In order to meet the needs of the manufacturing industries such as batteries and medical equipment concentrated in the Kansai region, AIST Kansai puts emphasis on both advanced battery and medical technology that enable us to live a healthy and safe life. For the sake of supporting these two technologies, AIST Kansai is promoting research and development of material and information technologies. By creating technology that can solve problems of energy which is vital for industry and people's lives, and biotechnology that invents the future, AIST Kansai contributes to the realization of a new system of living.

■ AIST Kansai Emphasized research themes: Battery technology/Medical technology

Fluorescent image

Bright-field image

A wild-type chick⬇ EGFP expressing chick

⬇

● To contact for collaboration

+81-52-736-7370chubu-counselors-ml@aist.go.jp

Ishikawa Site

+81-76-268-3383ishikawa-site-ics-ml@aist.go.jp

Nano-cellulose fiber observed by electron microscope

200 nm

x 60,000

Width: approx. 20 nm

● To contact for collaboration

+81-82-420-8245c-ic-ml@aist.go.jp

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■ AIST Shikoku Emphasized research theme: Health care

Collaboration with Sanyu Co., Ltd. (Ibaraki)

The Kyushu region has a concentration of automobile-related and semiconductor-related plants. To contribute to productivity improvement at sites of industrial production, AIST Kyushu is promoting research and development for upgrading production technology and driving maintenance efficiency, new sensing technology, sensor network technology, and application technology for collected data. While “bridging” research and development achievements and companies, we contribute widely to industry through measurement and diagnostic system research councils to solve common challenges faced by regional companies.

■ AIST Kyushu Emphasized research theme: Manufacturing plant diagnosis

The Shikoku region faces relatively high rates of life-style diseases, such as diabetes, and looks toward technology development that will lead to disease prevention and early diagnosis. AIST Shikoku is pursuing research and development for disease-predictive diagnosis that measures health conditions in people, and research and development for the removal and detoxification of health risk factors in living environments. Through the integration of advanced biotechnology and nanotechnology with technology for materials and systems, we contribute to healthy and comfortable daily life in our rapidly aging society.

■ Examples of “Bridging” Technology (Technology Transfer) to Regional Small and Medium-sized Enterprises

AIST supports new product development using its technological seeds

AIST's novel evaluation technologiesdistinguish newly developed products from their competitors.

AIST provides technological supportto regional companies in collaborationwith municipal research institutes.

Collaboration with TAKAGI KOGYO CO., Ltd. (Kagawa), and Kagawa Prefectural Industrial Technology Research Center

▶ Development of evaluation technology for static electricity free rope

▶ Quantitative measurement apparatus for gas volume in ultra-high vacuum

▶ LSI internal wiring uncovered by suction-type micro plasma etcher; no residue remains

AIST satisfies extensive needs of regional businesses by its technological seeds and nationwide network.

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Electric discharge condition observed by a high sensitive camera

Spherical shape electrode and earth (left) and a high sensitive camera(right)

Immobilized antibody

Multi-antigen-antibody reaction chip

● To contact for collaboration

+81-87-869-3530Camera

Auto stage

Illumination

Design and manufacture equipment for microchips used in health and medical diagnosis

Injector mount

shikoku-counselors-ml@aist.go.jp

Plasma etching apparatus for semiconductors that can reproduce mass production process

Plant diagnosis employing high heat-resistant acoustic emission (AE) sensors

● To contact for collaboration

+81-942-81-3606q-sangakukan1-ml@aist.go.jpConventional

AE sensor

Thin AE sensor

12 mm

Collaboration with PURERON JAPAN CO.,LTD. (Fukushima), and ULVAC, Inc. (Kanagawa)

Standard conductance element

Molecular flow controller

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Commercialization Support and International Collaboration

Creating and fostering technological seeds, “bridging” them and society

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Through research at the highest global standards based on societal and industrial needs and “bridging” the achieved results and industry, AIST fulfills a central role in innovation and contributes to the attainment of a sustainable society.

In order to upgrade our capability of "bridging" technology and industry, AIST has assigned innovation coordinators (including personnel who formerly worked at private companies and public research institutions) to its research bases around Japan. The coordinators are ready to respond to various needs of industry, society and their regions under the dictum to “Meet frequently, listen carefully, act promptly.” In addition, diverse solutions across planning, development, demonstration, and commercialization are available through technology consulting that leverages knowledge obtained from cutting-edge research and development.

■ Reinforcement of Technology Marketing Function

● How to reach us

Technology Marketing OfficeResearch and Innovation Promotion Headquarters

+81-29-862-6026ic-contact-ml@aist.go.jp

AIST engages in creating start-ups and suppor t ing business ventures that create new markets and industries utilizing research achievements of AIST. In addition to AIST technological seeds, start-ups can be launched through incor porat ing tech nolog ical seeds from universities or private companies.

■ Creation of AIST Start-ups

MIRAISENS,Inc.With 3D haptic technology which represents operational feelings such as tactile sensation and response by digitalizing them, we launch many digital products with bodily sensation and build markets for digital bodily sensation business.

TOKIWA-Bio Inc.We developed technology and equipment for automated generation of safe and stable iPS cells (photo on the left) by using the stealth RNA vector which delivers therapeutic genes into cytoplasm. We will contribute to gene therapy worldwide.

● How to reach us

Innovation Center for Technology Transfer and StartupsResearch and Innovation Promotion Headquarters

+81-29-862-6655dsu-koho-ml@aist.go.jp

● How to reach us

Innovation Center for Technology Transfer and StartupsResearch and Innovation Promotion Headquarters

Since 2014, following the amendment of the Act for the Reinforcement of Research and Development Capability, AIST has been able to provide in-kind investment to venture companies that leverage AIST research achievements. By investing facilities, equipment, and intellectual property rights held by AIST, we can aid in the enhancement of the business foundation and credibility of venture companies.

■ Investment of IP and Facilities for Venture Companies

+81-29-862-6655dsu-koho-ml@aist.go.jp

Wit h r e s p e c t t o f u n d a m e n t a l r e s e a r c h achievements, AIST is promoting wide utilization of our intellectual property including jointly owned IP, in many domains and companies. On the other hand, regarding the applicable research results achieved through collaboration with companies, we make IP available in accordance with the intent of collaborating companies.

● How to reach us

Intellectual Property and Standardization Promotion DivisionResearch and Innovation Promotion Headquarters

■ IP that Companies can Flexibly Utilize

+81-29-862-6153chizai-hyoujun-pl-ml@aist.go.jpRobotic seal “Paro,” recognized for its

highest therapeutic effect in the world (Certified 2002 Guinness World Record) *Case study of research achievement transferred to industry

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When the research achievements of AIST are utilized, companies can use the state-of-the-art research facilities of AIST to produce and sell samples of their own products. Companies can reach commercialization seamlessly from the research stage in a shorter period of time.

Ref lecting the characteristics of each partner organization or country, AIST develops strategic approaches toward international cooperation. The international activities include implementation of cutting-edge research in a joint laboratory, utilization of overseas resources, contribution to global issues, and promotion of measurement standards.

● How to reach us

● How to reach us

Research and Innovation Promotion Planning OfficeResearch and Innovation Promotion Headquarters

Collaboration Promotion and International Affairs DivisionResearch and Innovation Promotion Headquarters

■ Accessibility to AIST Facilities and Equipment

■ Promotion of Strategic International Collaboration

+81-29-862-6144

+81-29-862-6040raiso-general-ml@aist.go.jp

cpiad-ml@aist.go.jp

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Nano-carbon polymer actuator

Malaria detection by cell chipField test and international collaboration

Auto-mini pipette using nano-carbon polymer actuator

Malaria-infected red blood cell (white arrow)

DNA micro array scanner

Evaluation and improvement of diagnostic device using blood of malaria patients at Lacor Hospital of Gulu University

Quantitative single-layered array of red blood cells is possible

Joint research agreement signing ceremony (DBT Secretary and AIST President Chubachi)

Chemical metrology seminar

Joint experiment with DBT researchers at joint laboratory within AIST

A joint laboratory was established in the premises of AIST in cooperation with the Fraunhofer Institute for Manufacturing, Engineering and Automation (IPA) of Germany. The lab works on development and mass-production of such devices as medical pipettes using AIST’s polymer actuator technology.

A joint laboratory (DAILAB) was established with the Department of Biotechnology (DBT), Ministry of Science and Technology of India, within AIST, and is working on joint research toward development of anti-cancer drug reagents based on screening and imaging technology of AIST and India’s bio-resources. DAILAB actively hosts periodic seminars and personnel exchanges. In total, six DAILABs have been established in India and Sri Lanka.

Through seminars and trainings, AIST promotes Japanese measurement standards toward ASEAN countries and works on human resource development for local companies in such countries, starting with Thailand. These efforts are aimed at the entry of Japanese companies into ASEAN markets.

With the purpose to enable early diagnosis of malaria, which is one of the world’s three major infectious diseases, AIST independently developed a test apparatus using a cell chip. With this device, AIST has been conducting field tests together with overseas research organizations. AIST strives to gain the use of the device in malaria-infected areas in Africa and other regions in the future in cooperation with international organizations such as WHO.

Collaboration with Fraunhofer Collaboration with India

Standards (metrology hub in ASEAN countries)Malaria diagnosis technology

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Human Resources Development

AIST actively brings together diverse, superb technological seeds and human resources from domestic and foreign universities and regional public research organizations and companies. Our role of bridging becomes smoother through enhanced career mobility for advanced research personnel and higher AIST research potential.Richly varied curricula foster and form human resources who will lead the formulation of innovation in the future.

Development and succession of human resources that create innovation

As a core institution of “bridging” research and industry, AIST has established the cross-appointment system for researchers, who can have appointments at multiple institutions and take an active role as formal staff in any institution, in order to build a research structure that extends beyond the boundaries of an organization.Based on this system, advanced research personnel have an expanded area in which to take active roles. The increased mobility of human resources, and selection of superior technological seeds born from fundamental research at universities lead to expectations of an organization structured for bridging research and industry for commercialization.

■ Deployment of the Cross-appointment System

Other institution

University Public corporation

Technological seeds

Reinforcement of research structure

Core institution of bridging research and industry

Bridging of research

achievements for commercialization

AIST

※Example of engagement share

60%※ 40%※

Sharing and development of

technological seeds

Work engagement at both institutions in

specific proportions

Improvement of human resource mobility

● How to reach us

Human Resources DivisionGeneral Affairs Headquarters

+81-29-862-6282hrd-keikaku-ml@aist.go.jp

Company Company Company Company

Employment contract Employment contract

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AIST accepts students, as well as researchers and engineers from companies, for certain periods. The program offers opportunities for technology trainees to learn cutting-edge testing and analysis technology at AIST. Such opportunities encourage those human resources to challenge themselves in new research and technology fields.AIST has a program to hire graduate students as AIST Research Assistants. Graduate students hired under this program can concentrate on research activities without financial difficulties, and can participate in R&D projects implemented by AIST to gain practical research experience. They come to develop skills to carry out sophisticated research and improve research plans, and progressively apply research achievements to their degree theses.

■ Technical Training/Research Assistant Program

● How to reach us

Collaboration Promotion and International Affairs DivisionResearch and Innovation Promotion Headquarters

+81-29-862-6144 aist-ra-ml@aist.go.jp

Nanotech Career-up Alliance (Nanotech CUPAL) was established based on the subsidized project by MEXT “The Consortium Structuring Project to Foster Science and Technology Personnel” in FY 2014. To enhance the careers of nanotech researchers in Japan and to improve their career mobility, Nanotech CUPAL has enlisted TIA, a center for open innovation, and Kyoto University's Nanotechnology Hub, which are at the heart of developing the Nanotech Research Professional (NRP) and the Nanotech Innovation Professional (NIP) .

■ Nanotech CUPAL

● How to reach us

TIA Central OfficeNanotech CUPAL Secretariat

+81-29-862-6123 nanotech-cupal-ml@aist.go.jp

With the aim of developing doctoral talent that can perform across a broad range of fields in society, AIST hosts the Innovation School for postdoctoral researchers and PhD students with a curriculum to encourage broader perspective and reform of awareness.Lectures and seminars bring instructors active in a variety of fields, and practical research work at AIST research sites and corporate internship programs (OJT) aim to develop human resources fit and ready for work. The teaching encompasses a synthetic research methodology that lets students consider research scenarios from an all-encompassing perspective, realize what skills they must acquire for the future, and work to develop communication skills.Over 270 trainees have completed the Innovation School curriculum since its opening in 2008, with a growing human network. Many alumni work daily at the frontline of innovative development in companies, universities, and public research institutions today.

■ Innovation School

● How to reach us

Innovation SchoolGeneral Affairs Headquarters

+81-29-849-1600 school-jimukyoku-ml@aist.go.jp

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Highlights of Research AchievementsStarting as the Geological Survey of Japan in 1882, followed by the era of its forerunner, the Agency of Industrial Science and Technology, and up until now, AIST has achieved numerous instances of breakthrough research and development that have left their mark in the annals of science history. We introduce here prime achievements spanning nearly 130 years from the 1880s until today.

Geological map of Japan (1 : 3,000,000) TIEL method of ammonia synthesis

The first complete geological map of Japan was published in 1889, a mere seven years after founding of the Geological Survey of Japan. Its history is closely linked to the development of geology, industry and mining in Japan, which began with instruction by foreign nationals at the beginning of the Meiji Period.

The Provisional Laboratory of Nitrogen developed the first national ammonia synthesis technology using its original robust catalyst. It is the result of Japan's first large-scale project and is recognized worldwide as the “TIEL method of ammonia synthesis.”

1880s 1920s

Transistor computer MARK-IV PAN based carbon fiber

The Electrotechnical Laboratory completed Japan’s first transistor computer, the ETL Mark-Ⅲ, in 1956. It was then enhanced to create the Mark-Ⅳ and Mark-ⅣA, leading the way for commercialization of computers in Japan.

In 1959, the Government Indust r ial Research Institute, Osaka, was the first in the world to develop lightweight and high strength carbon fiber from polyacrylonitrile (PAN) fiber, which came to be used in clothing and other products. Research aimed at its practical application was launched in the 1960s, and the material is now widely used in a multitude of products from fishing rods to airplanes.

1950s 1950s

Production process for glucose isomerase used to make soft drink sweetener

Production method for transparent conductive film (ITO = indium tin oxide)

The Fermentation Research Institute developed a method for producing super sweet fructose by using glucose isomerase from glucose. It later signed license agreements with numerous companies in Japan, the US, and other countries, which resulted in its use all over the world.

The Government Industrial Research Institute, Osaka, was the first in the world to develop technology for industrial production of indium tin oxide (ITO) transparent conductive film, which is indispensable to liquid crystal displays and solar cells. This f ilm also aided in the industrialization of liquid crystal calculators and is now the source of a huge market.

1960s 1960s

Anode alloys as the foundation for nickel metal hydride batteries

Catalytic action of gold nanoparticles

Research on the nickel metal hydride batteries used in hybrid cars began at the Government Industrial Research Institute, Osaka, in the 1970s. Around 1990, the first nickel metal hydride battery that had the same performance as lead batteries at half the weight was created. It is also garnering interest for use as a large stationary battery.

Gold was considered to have no catalytic function, but in 1982 the Government Industrial Research Institute, Osaka discovered specifically high catalytic activity of gold nanoparticles (3–4 nm) carried on metal oxide surfaces. The activity was outstanding even at low temperatures, and opened doors to commercial applications like deodorizing catalysts, detoxification of carbon monoxide, and gas sensors.

1980s 1980s

A breakthrough in single-walled carbon nanotube synthesis

High-performance MTJ device for HDD magnetic heads

A revolutionary synthetic technology for single-walled carbon nanotubes (SWCNTs) called the "super growth method," was developed, and a synthetic efficiency 1,000 times higher than previous methods was realized. Furthermore, the synthesized SWCNTs possess various outstanding properties, such as high purity, compared to those synthesized by previous methods. Industrial mass production has been realized.

We develop e d h ig h - p e r fo r m a nce magnetic tunnel junction (MTJ) devices with c r ys t a l l i ne mag nesiu m ox ide (MgO) tunnel bar r ier for HDD read heads, which have more than doubled the recording density of HDD than before. Such high-performance MgO-TMR read heads are used in all HDDs manufactured today.

2000s 2000s

従来の数百倍将来大幅なコストダウンの可能性

高さで 500 倍時間効率で 3000 倍将来大量生産の可能性

触媒効率

　　　成長法 単層 CNT / 触媒 （重量比％）レーザーアブレーション 500％HiPCo 法 300％アルコール CVD 800％気相流動 100％

スーパーグロース 50000%

成長効率垂直配向単相ナノチューブ構造体高さ 2.5mm の成長時間：10 分

5 µm

10 nm

photo courtesy of Fujitsu Limited

ITO transparent conductive film

Glass substrate

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D i r e c t o r y

Research Bases Domains

O f f ic ia l Webs i te

2017.7©2017AIST

SearchAIST JAPAN

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AIST Tsukuba

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+81-87-869-3511 (main)

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AIST Kyushu

+81-942-81-3600 (main)

The latest research achievements, announcements, and various information for the general public, researchers and engineers, and industry associates can be found at these Internet sites.

https://www.aist.go.jp/aist_e/inquiry_e/form/inquiry_form.htmlGeneral inquiries

https://www.aist.go.jp/aist_e/inquiry_e/form/col_inquiry_form.htmlCollaboration and technical consultation ● Science Square Tsukuba

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http://www.aist.go.jp/aist_e/exhibitions/Facility tours

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+81-29-862-6032life-liaison-ml@aist.go.jp

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+81-29-862-6028ith-contact-ml@aist.go.jp

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+81-29-862-6031mc-liaison-ml@aist.go.jp

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