BIOCHEMISTRY 203.001: Fundamentals of Biochemistry

COURSE OUTLINE January 2014

Calendar Description

BIOC 203 - Fundamentals of Biochemistry (3 credits): Amino acids and proteins. Enzymes and enzymology. Human metabolic pathways. Structure, function and metabolism of carbohydrates including glycogen storage and gluconeogenesis. Restricted to students in Biochemistry specializations! Prerequisite: All of BIOL 200, CHEM 203; Co-reqs: CHEM 213.

Instructors:

Dr. Robert Maurus Office: 5458 Life Sciences Centre (2350 Health Sciences Mall)E-mail: maurus@mail.ubc.caLectures: January 7, 9, 14, 16, 21, 23, 28, 30; February 4, 6, 11, 13;Office hours: Tues & Thurs 9:30-12:00 am

Dr. Warren Williams (Course Administration)Office: COPP 4210E-mail: wwarren@mail.ubc.caPhone: 604 822 8729Lectures: February 27; March 4, 6, 11, 13, 18, 20, 25, 27; April 1, 3, 8;Office hours: Mon, Wed, Fri 2-3pm; Tues, Thur 11am-12pm

Lecture Schedule: Tues & Thurs from 8:00 – 9:20 am in IRC2

Dr. Maurus: January 7, 9, 14, 16, 21, 23, 28, 30; February 4, 6, 11, 13;Topics: Amino acids and proteins, protein structure and function, enzymes and enzymology.

Midterm: Tuesday Feb. 25 [In class – IRC2 - 40% for your final grade. This exam covers all material up to and including Feb. 13]

Dr. Williams: February 27; March 4, 6, 11, 13, 18, 20, 25, 27; April 1, 3, 8;Topics: Human metabolic pathways. Structure, function and metabolism of carbohydrates including glycogen storage and gluconeogenesis.

Final Exam: TBA [40% for your final grade. This exam that covers all material from Feb 27 to Apr 8]

Textbook: Required: Lehninger: Principles of Biochemistry (Sixth edition), Worth Publishers, 2013.

Grading:

The midterm exam will be worth 40% of the final grade and will cover the material on Amino acids and proteins, protein structure and function, enzymes and enzymology. (Dr. Maurus)

The final exam will be worth 40% of the final grade and will cover material on Human metabolic pathways. Structure, function and metabolism of carbohydrates including glycogen storage and gluconeogenesis. (Dr. Williams).

A written course project worth 20% of the final grade will be individually prepared by students. The due date of this course project is Monday Mar 31 at noon. NOTE: Late submissions of course projects will not be graded and will have a mark of zero recorded for the course project.

Tutorials: Tutorials will begin the second week of classes (week of January 13). Times and locations are as per students registration.

Teaching Assistant:

Alina Chan alinayujiachan@gmail.comRay Socha socharay@gmail.com

IMPORTANT NOTICE REGARDING EXAMINATIONS:

All prescribed examinations are mandatory. Students who miss an examination or are unable to complete other tests or graded work because of medical, emotional or other problems have to follow the procedures for requesting Academic Concession” [see UBC Calendar]. An inconvenient examination timetable is absolutely not grounds for deferring an examination in Biochemistry 203. Deferred examinations necessitated by health or other considerations that are completely out of the control of the student will be written on a date set by the instructor. The Department will not schedule make-up examinations for any student who does not notify his or her dean and does not provide appropriate documentation within 5 days of the exam in question. Students without appropriate medical excuses for missing a midterm or final examination will have zero recorded as their mark for that exam.

Final: Students should not book airline until the definitive final exam schedule has been posted, as preliminary schedules are often changed. April examinations are April 12-30 (inclusive). Note that Saturdays are included in the exam schedule.

Course Website: http://elearning.ubc.ca/connect/ gives the students access to all slides shown in class, lecture summaries and problem sets (voluntary). Note: The outline below is an approximate guide to lecture topics, and may be subject to change

Dr. Williams' Lecture schedule

Date Lecture Topics

Feb. 27th 1 Introduction. Metabolic pathways and thermodynamics

March 4th 2 ATPCarbohydrates

March 6th 3 Glycolysis: The 10 rxns

March 11th 4 Glycolysis: Redox & electron carrier molecules, fermentation, & regulation

March 13th 5 Pyruvate Dehydrogenase Complex: Cofactors, enzymes, and mechanism. Krebs cycle: 8 reactions

March 18th 6 Krebs cycle: 8 reactions, regulationOxidative phosphorylation: Intro, electron transfer, & thermodynamics

March 20th 7 Oxidative phosphorylation: The electron transport chain (ETC)

March 25th 8 Oxidative phosphorylation: ATP Synthase: Overview, F1, & F0

March 27th 9 Oxidative phosphorylation: Regulation, uncouplers, transportersGlycogen metabolism: Synthesis and breakdown

April 1st 10 Gluconeogenesis: Substrates, Bypass reactions, stoichiometry and regulation

April 3rd 11 Integration of carbohydrate metabolism: General concepts, hormones, fed/fast cycle

April 8th 12 Integration of carbohydrate metabolism: Glucose metabolism, Regulating glycogen metabolism, glycolysis vs. gluconeogenesis