outline - lorentz center · - basal ganglia oscillations in ocd ... outline - short description...
TRANSCRIPT
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‘Brainwaves’ in the human basal ganglia
L.J. Bour Department of Neurology/Clinical Neurophysiology, Academic
Medical Center, University of Amsterdam,Amsterdam
Brainwaves meeting Leiden, 25 june 2009
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Outline
- Short description stereotactic
procedure for DBS
- Targets for DBS in the basal ganglia
- Model(s) of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Parkinson’s Disease and Essential Tremor
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
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Outline
- Short description stereotactic
procedure for DBS
- Targets for DBS in the basal ganglia
- Model(s) of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Parkinson’s Disease and Essential Tremor
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
![Page 4: Outline - Lorentz Center · - Basal ganglia oscillations in OCD ... Outline - Short description stereotactic procedure for DBS - Targets for DBS in the basal ganglia - Model(s) of](https://reader031.vdocuments.net/reader031/viewer/2022011803/5b923e7209d3f215288d6fdd/html5/thumbnails/4.jpg)
DBS-neurosurgery
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DBS-neurosurgery
• Movement Disorders– Parkinson’s Disease (STN,GPi)– Dystonia (GPi)– Essential Tremor (VIM)– Gilles de la Tourette (GPi, Thal)
• Psychiatric Disorders – OCD (Nucleus Accumbens..)– Depression
• Alzheimer (?)• Epilepsy
– Hippocampus (?)
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3D Imaging and planning
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Surgical Procedure
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Effect of Unilateral DBS turned off and on in PD patient
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Outline
- Short description stereotactic
procedure for DBS
- Targets for DBS in the basal ganglia
- Model(s) of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Parkinson’s disease
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
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Sagital View Basal Ganglia
Globus
Pallidus
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Sagital View Basal Ganglia
Globus
Pallidus
Subthalamic
Nucleus
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Sagital View Basal Ganglia
Globus
Pallidus
Subthalamic
Nucleus
Substantia
Nigra
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Sagital View Basal Ganglia
Globus
Pallidus
Subthalamic
Nucleus
Substantia
Nigra
Thalamus
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Sagital View Basal Ganglia
Globus
Pallidus
Subthalamic
Nucleus
Substantia
Nigra
Thalamus
VIM
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Sagital View Basal Ganglia
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Sagital View Basal GangliaDopamine Pathways
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Sagital View Basal GangliaDopamine Pathways Serotonin Pathways
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Outline
- Short description stereotactic
procedure for DBS
- Indicate targets for DBS in the basal ganglia
- Models of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Parkinson’s disease
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
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Model
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Model
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Outline
- Short description stereotactic
procedure for DBS
- Indicate targets for DBS in the basal ganglia
- Model(s) of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Parkinson’s disease
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
![Page 22: Outline - Lorentz Center · - Basal ganglia oscillations in OCD ... Outline - Short description stereotactic procedure for DBS - Targets for DBS in the basal ganglia - Model(s) of](https://reader031.vdocuments.net/reader031/viewer/2022011803/5b923e7209d3f215288d6fdd/html5/thumbnails/22.jpg)
Needle for MER/test stimulation/LFP
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Electrode Array
CentralLateral Medial
Anterior
Posterior
4 mm
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Implanted electode in STNSagital view: 13.0 mm lateral
Anterior
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Implanted electode in GPSagital view: 20.0 mm lateral
Anterior
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Outline
- Short description stereotactic
procedure for DBS
- Indicate targets for DBS in the basal ganglia
- Model(s) of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Essential Tremor and Parkinson’s Disease
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
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Parkinson Patient spike trains and power spectra of rectified MER activity in the STN
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Parkinson Patient Oscillatory Beta Activity (12-22 Hz) in the dorsal part of the STN
Power spectrum MER activity Power spectrum LFP activity
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Parkinson Patient Spike detection and spike clustering in STN
0 1000 2000 3000 4000 5000 6000 7000 8000 9000 10000-0.1
-0.05
0
0.05
0.1
time (ms)
Volta
ge
00.05
0.10.15 0 0.01
0.020.03
0
0.02
0.04
0.060.08
coeff 24
Best projection of the wavelet coefficients
coeff 2
coef
f 12
-0.2 -0.1 0 0.1
-0.10
0.10.2
-0.04
-0.02
0
0.02
pc1
Scores pc1 vs. pc2 vs. pc3
pc2
pc3
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Parkinson Patient Synchronous Beta Activity (17-20 Hz) in the dorsal part of the STN
Coherence spectrum of spike activity of two single units measured at the same microneedle
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Parkinson Patient Disappearance of Beta Activity (15-30 Hz) in the STN with DBS
From Hammond, Bergman and Brown, Brain 2008
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Effect of pallidotomy on STN Beta activity
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Effect of pallidotomy on STN Beta activity
pallidotomy patients n=7; no pallidotomy n=35
100
150
200
250
300
3-8Hz 8-12Hz 12-20Hz 20-30Hz 30-60Hz 60-100Hz
Pallidotomy Contralateral Control
Absolute spectral power* * * *
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Essential Tremor Patient MER activity in Thalamus (VIM) and EMG FEDC muscle
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Essential Tremor Patient MER ~ 6 Hz activity in Thalamus (VIM) ; bistability
5 sec ->
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Outline
- Short description stereotactic
procedure for DBS
- Indicate targets for DBS in the basal ganglia
- Model(s) of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Parkinson’s disease
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
![Page 37: Outline - Lorentz Center · - Basal ganglia oscillations in OCD ... Outline - Short description stereotactic procedure for DBS - Targets for DBS in the basal ganglia - Model(s) of](https://reader031.vdocuments.net/reader031/viewer/2022011803/5b923e7209d3f215288d6fdd/html5/thumbnails/37.jpg)
Dystonia Patient Myoclonus and Dystonia
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Dystonia Patient MER activity in the GP
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Coherence Analysis between LFP of the GPi
and EMG Activity of Two Skeletal Muscles
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Coherence Analysis between LFP of the GPi
and EMG Activity of Two Skeletal Muscles
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5 sec
Warning cue Imperative Cue
GO
NOGO
Warning cue Imperative Cue
Flash
LED
LED
Event Related Spectral Pertubation of LFP (De)synchronization in GPi with Go/Nogo Paradigm
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Event Related Spectral Pertubation of LFP (De)synchronization in GPi with Go/Nogo Paradigm
Go NoGo
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Outline
- Short description stereotactic
procedure for DBS
- Indicate targets for DBS in the basal ganglia
- Model(s) of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Parkinson’s disease
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
![Page 44: Outline - Lorentz Center · - Basal ganglia oscillations in OCD ... Outline - Short description stereotactic procedure for DBS - Targets for DBS in the basal ganglia - Model(s) of](https://reader031.vdocuments.net/reader031/viewer/2022011803/5b923e7209d3f215288d6fdd/html5/thumbnails/44.jpg)
OCD Patient
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Delta power increase with exposure (increase of anxiety)
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Event Related Spectral Pertubation of LFP (De)synchronization in Accumbens with Go Nogo
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Event Related Spectral Pertubation of LFP (De)synchronization in Accumbens with Go Nogo
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Event Related Spectral Pertubation of LFP (De)synchronization in Nucleus Accumbens with Reward Paradigm
3/4/5 sec
Warning Cue
Money
No Money
Push
Symbol O
1 sec
Reward
Symbol 5
Symbol 5
Total Amount
Total Amount
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Event Related Spectral Pertubation of LFP (De)synchronization in Nucleus Accumbens with Reward Paradigm
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Event Related Spectral Pertubation of LFP (De)synchronization in Nucleus Accumbens with Reward Paradigm
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Outline
- Short description stereotactic
procedure for DBS
- Indicate targets for DBS in the basal ganglia
- Model(s) of the network of cortex, basal ganglia and thalamus
- Micro electrode recording (MER) and local field potentials (LFP)
- Basal ganglia oscillations in Parkinson’s disease
- Basal ganglia oscillations in Dystonia
- Basal ganglia oscillations in OCD
- What does oscillatory activity in the brain mean?
![Page 52: Outline - Lorentz Center · - Basal ganglia oscillations in OCD ... Outline - Short description stereotactic procedure for DBS - Targets for DBS in the basal ganglia - Model(s) of](https://reader031.vdocuments.net/reader031/viewer/2022011803/5b923e7209d3f215288d6fdd/html5/thumbnails/52.jpg)
Brainwaves in the Basal Ganglia1) Pathological ongoing synchronous firing of neuronal populations
PD/Essential Tremor: 3-7 Hz
Beta activity in PD:
15-30 Hz
Abnormal cortical drive in Dystonia: 3-10 Hz
Increase in sub-delta power in OCD: < 2 Hz
2) (De)Synchronizations
of different frequencies in relation to:
Events:
2-20 Hz
Movement:
30 and 60 Hz
Emotion (?):
20-30 Hz
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Thank you for your attention
With many thanks to: M.F. Contarino, R.A.M. De Bie, M.A.J. De Koning Tijssen, D. Denys, E.M. Foncke, P. van den Munckhof, P.R. Schuurman, J.D. Speelman, A.F. Van Rootselaar.