Vitamin C can be a main stream dermatologic drug if topically delivered to the Dermis

Outstanding Benefits of Vitabrid C12

Vitamin C

Whitening, Photo-Damage

Recovery by decreasingmelanin

formation

Hair-GrowthPromotion

by inducing growth factors: IGF-1, etc.

Anti-Oxidant Efficacy

scavenging free radicals

Anti-Wrinkle,Healthier Skin

by collagen synthesis promotion

Anti-Hair Lossby collagen synthesis promotion

Anti-Inflammatory, Anti-Histamine, Wound Healing

Pumori Saokar Telang, Vitamin C in dermatology,

Indian Dermatology Online Journal, 2013 Apr-Jun; 4(2): 143-146

(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673383/)

Vitabrid C12 – Brand New Vitamin C

LDH Technology – Problem Solved!

Easily oxidized once exposed to air, sun or moisture and loses its “antioxi-dant” properties. Due to its water-soluble nature, hard to penetrate through lipid membrane

Quickly oxidized once topically appliedVery limited and ineffective permeabilityIrritation and pain due to acidity of vitamin C

Vitabrid CG, the main ingredient of Vitabrid C12 products, stores and preserves active Vitamin C within skin-friendly mineral layers; once it is applied to the skin, it releases active vitamin C continuously for over 12 hours permeating through the skin layers down to dermis.

Vitamin C

Excellent skin efficacy,but highly unstable

compounds

Mineral

Bio-compatible andskin-friendly mineral

Vitabrid CG

Stabilization, effective skin delivery,

sustained release, excellent efficacy

Time (Hour)

LDH-Vitamin C powder

100

80

60

40

20

02 4 6 8 10 12

Accu

mul

ated

relea

se am

ount

rate

of vi

tamin

C (%

)

Accumulated Amount of Vitamin C Released

Unstable Vitamin C

LDH Technology

Weakness of existing topical Vitamin C products

Limitations of Vitamin C

Basic Technology of Vitabrid C12

12-hour Transdermal Vitamin C

Vitamin C Absorption Via Ion-Exchange Mechanism

Vitabrid CG POWDER

Vitabrid CG POWDER

STRATUMCORNEUM

VITAMIN C

EPIDERMIS

DERMIS

SKIN WASTES VITAMIN C SWEAT CO2

Joint Research Institute of New Materials, Seoul National University

1hr 2hr 4hr 24hr Magnified image

LDH Technology

0 week 1%

1 week 4%

4 weeks 9%

6 weeks 10%

8 weeks 12%

Participants: 22 females with age between 18-52Evaluation Method: Measuring melanin index and its color after UV-induced pigmentationTesting Agency: DermaPro Corp / Skin Science Institute

Vitabrid CG inhibited 80% of UV-induced melanin formation in HMV-II cell at 43% or 10% lower concentration than APPS

or vitamin C, respectively.Nobuhiko MIWA, Emeritus Prof. Pref. Univ. Hiroshima

Conc. (mg/L)

Inhi

bitio

n(%

)

9876543210

65

67

69

71

73

75

77

79

81

83

85Vitabrid CG

APPS

12% reduction in melanin within 8 weeks of use in comparison to the controlled group.

DermaPro Corp / Skin Science Institute

Vitabrid C12 FACE SolutionBrand new introduction of the revolutionized Vitamin C

Vitabrid C12 Skin Brightening EffectMelanin Inhibition by Vitabrid CG

0 week 0.55

4 weeks 0.47

12 weeks 0.42

8 weeks 0.45

Participants : 22 females with age over 30Evaluation Method : Measuring wrinkle improvement by using skin visiometerTesting Agency : DermaPro Corp / Skin Science Institute

Vitabrid CG had an antioxidant capacity that was 200 times higher compared to AA2G (Vitamin C Derivative) and over 13 times more than

VC-100 (Vitamin C Derivative) in RAW 264.7 cell.Hoseo Toxicoligical Research Center

24% reduction in skin roughness within 12 weeks of use.

DermaPro Corp / Skin Science Institute

61.6

0.3

4.8

Antioxidant capacity

Vitabrid CG

VC-100

AA2G

Inhibition (%)

Vitabrid C12 FACE Solution

Vitabrid C12 Anti-wrinkle EffectAntioxidant Effect of Vitabrid CG

Vitabrid C12 FACE Solution

Direct Correlation between Increase in Collagen Levels vs. Increase in Vitabrid CG Concentration in Human Dermal Fibroblasts

Korea Institute of Permatological Seciences

It was confirmed that CO-

L1A1 mRNA expression was

increased after treatment of

human dermal fibroblasts with

Vitabrid CG. Especially, at 100

ppm treatment, about 2 times

increase compared with Con-

trol. (*P < 0.05)

The expression of COL3A1

mRNA was increased after

treatment with Vitabrid CG in

human dermal fibroblasts. Es-

pecially, at 100 ppm treatment,

about 3 times increase com-

pared with Control. (*P < 0.05)

**

400

350

300

250

200

150

100

50

00 10 50 100

Relat

ive ex

pres

sion

level

ofCO

L1A1

mRN

A

Vitabrid CG (ppm)

Relat

ive ex

pres

sion

level

ofCO

L3A1

mRN

A

Vitabrid CG (ppm)

350

300

250

200

150

100

50

00 10 50 100

*

***

400

350

300

250

200

150

100

50

00 10 50 100

Relat

ive ex

pres

sion

level

ofCO

L1A1

mRN

A

Vitabrid CG (ppm)

Relat

ive ex

pres

sion

level

ofCO

L3A1

mRN

A

Vitabrid CG (ppm)

350

300

250

200

150

100

50

00 10 50 100

*

*

Vitabrid C¹² FACE

Transdermal vitamin C powder for anti-aging and skin rejuvenation. Highly potent Vitamin C compound helps brighten the skin and minimize fine lines and wrinkles through collagen synthesis, making your skin bright, nour-ished and glowing with natural radiance.

1. Key Benefits- Skin brightening- Improves skin tone / texture- Skin rejuvenation - Reduce fine lines / wrinkles

2. Main Features- Strong anti-oxidation benefit - Vitamin C makes skin healthy and radiant by neutralizing the damaging effects of free radical activity from sun, stress, and pollution helping prevent and repair visible signs of aging.- Skin rejuvenation and anti-aging - Vitamin C is one of the most essential substances to promote collagen production, helping maintain vibrant and firm skin texture.- Skin brightening - Vitamin C, a powerful brightening ingredient with antioxidant benefits that reduces the look of melanin for a perfectly bright and even complexion.

3. How to Use1. Shake before using to loosen the powder.2. Mix an appropriate amount of the powder (equivalent of 2 spoonfuls) with daily skin care product of choice (serum or moisturizer) in the palm of the hand.3. Smooth the mixture onto clean face and neck. For best results, apply twice a day (morning and evening).

4. Ingredients- Vitabrid CG - ascorbic acid, zinc oxide, glyceryl monostearate- niacindamide - Help to brighten the appearance of discoloration- allantoin - Helps soothe, hydrate and calm the skin. - adenosine - helps prevent skin damage from UV-B and promotes collagen synthesis, improving visible signs of aging- hydrolyzed collagen - Helps improve skin tone, thickness and moisturization

* Trusted quality vitamin C from the U.K. Quality raw materials are essential for quality skin care. Vitabrid C12 values skin by using Vitamin C imported from the U.K. supplier.

Vitabrid C12

FACE BRIGHTENING PowderState-of-the art 12-hour transdermal Vitamin C powder for your face!