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American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Researcher Awards
• Professor Neal Chung, National University of Singapore
http://www.chbe.nus.edu.sg/faculty/chencts
• Professor En-Tang Kang, National University of Singapore
http://www.chbe.nus.edu.sg/faculty/cheket
• Professor Koon Gee Neoh, National University of Singapore
http://www.chbe.nus.edu.sg/faculty/chenkg
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Researcher Award
• Professor Neal Chung , National University of Singapore
http://www.chbe.nus.edu.sg/faculty/chencts
Prof. Chung is one of the World Leaders on Emerging Membrane Technologies for Water Reuse and Desalination
(a small MD pilot system at NUS )
1. Forward Osmosis 3. Membrane distillation 2. Biomimetic Membrane
aquaporin
Wang et al., Soft Matter 2011, Small 2012, JMS 2013 Zhong et al., JMS 2012, Duong et al JMS 2012 Sun et al., Colloids and Surfaces, 2011 and 2012 RSC Advances 2013
> 20 journal papers > 30 journal papers
What are the next clean energy sources? Prof. Chung is one of world leaders on membranes for blue (osmotic) energy,
biofuel separation, purification and separation of CH4 and H2, and CO2 capture
Natural Gas
Fuel cell
Bioenergy
Solar energy
Wind energy
Blue energy
Coal
CO2 capture technology
must also be developed
Hydrogen
Nuclear Energy
4
Battery
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Researcher Award
• Professor En-Tang Kang, National University of Singapore
http://www.chbe.nus.edu.sg/faculty/cheket
Copyright National University of Singapore 2012 6
Surface Functionalization via Molecular Design and Engineering
The highly robust and versatile controlled radical polymerization (CRP) techniques and click
chemistry are particularly suited for the preparation of multi-functional surfaces, including
antifouling, antibacterial, stimuli-responsive, biomolecule-coupled and micropatterned
surfaces. In addition to bioactive surfaces, CRP’s have also been widely used for the
preparation of well-structured functional membranes and biomaterials, such as micellar
delivery systems, hydrogels, cationic gene carriers and polymer–protein conjugates.
Prog. Polym. Sci. 2009, 34, 719
Biomacromolecules 2015, 16, 723
Copyright National University of Singapore 2012 7
Polymer/Organic Electronic Memories: Materials, Devices and Mechanisms
As an emerging area in organic electronics, polymer memories have become an active research
topic in recent years, because they are likely to be an alternative or supplementary technology
to the conventional memory technology facing the problems and challenges in miniaturizing from
microscale to nanoscale. Polymer/organic electronic memories draw the mechanistic analogy
between the polymer switching element and one of the three primary circuit elements, viz.,
capacitor, transistor and resistor.
Prog. Polym. Sci. 2008, 33, 917
Chem Soc. Rev. 2012, 41, 4688
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Researcher Award
• Professor Koon Gee Neoh, National University of Singapore
http://www.chbe.nus.edu.sg/faculty/chenkg
Department of Chemical & Biomolecular Engineering
Examples of Our Research (Orthopedic Implants)
9
Orthopedic Implants: race for the surface between bacteria & osteoblasts
Bacteria Osteoblasts
Orthopedic Implant
Conflicting requirements:
• Minimize adhesion of bacteria
but not osteoblasts
• Kill bacteria but not osteoblasts
Factor for osteoblast (peptide or protein)
Ti Substrate
Antimicrobial polymer
1 2
2-pronged strategy needed
Pristine Modified
Antimicrobial Polymer Antimicrobial Action Factors for Osteoblasts
Poly(methacrylic acid) Anti-adhesive Silk sericin
Carboxymethyl chitosan Bactericidal BMP-2, VEGF
Chitosan-hyaluronic acid Bactericidal and anti-adhesive
RGD
On modified Ti surface:
Bacterial colonization
reduced
Osteoblast attachment
promoted
Calcium deposition
promoted
Biomaterials 2010, 31, 8854
Biomaterials 2012, 33, 8082 Biomaterials 2008, 29, 4751 Biomaterials 2008, 29, 1412
Department of Chemical & Biomolecular Engineering
Examples of Our Research (Functionalized Nanoparticles)
(a) Stealth NPs: evading immune system &
selectively targeting cancer cells
(b) Magnetic-fluorescent NPs for stem cell
tracking: non-cytotoxic, high T2 relaxivity & uptake
MRI
signal Fluorescent
signal
(c) Mucoadhesive sustained drug
delivery system for bladder
cancer therapy
FITC DAPI Dox Merged
(a)
(b)
(c)
FITC DAPI DOX MERGED
(a)
(a) 2 h incubation, (b) 2 h followed by
rinsing with PBS and another 72 h
incubation in medium
(b)
Incubation of cancer cells with NPs
Langmuir 2014, 30, 6151
Eur J Pharm Sci. 2013, 48, 111 Biomaterials 2011, 32, 2166 Adv. Funct. Mater. 2009, 19, 2615 Adv. Funct. Mater. 2009, 19, 1158
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Researcher Awards
• Professor Neal Chung, National University of Singapore
http://www.chbe.nus.edu.sg/faculty/chencts
• Professor En-Tang Kang, National University of Singapore
http://www.chbe.nus.edu.sg/faculty/cheket
• Professor Koon Gee Neoh, National University of Singapore
http://www.chbe.nus.edu.sg/faculty/chenkg
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Young Researcher Award :
Young Faculty Member
• Dr. Jianping XIE, National University of Singapore • http://www.chbe.nus.edu.sg/faculty/chexiejp
Luminescent Au/Ag NCs
• ~1 nm; tunable sizes
• Non-toxic
• Strong luminescence
• Size-tunable electronic
structures
• Strong radiosensitizing
• Antimicrobial activity
• etc…
Biomolecules
• Proteins or Peptides
• Excellent
biocompatibility
• Good in vivo stability
• Tailorable
pharmacokinetics
• Rich surface
functional groups
• Bioprobes
• etc…
Luminescent Biomolecule-Au NCs or Bio-NCs
• Small HD (<6 nm) Metabolizable
• Good biocompatibility Non-toxic
• Traceability (strong luminescence)
• Well-defined size, structure, surface, and
physicochemical properties; Easy characterizations
• Excellent tumor deposition (passive or active)
• Strong radiotherapy enhancement; etc…
Biomolecule-
Metal Nanoclusters
or Bio-NCs
Fluorescent Probes
Radiosensitizers
Antimicrobial Agents
Sensors
4
Engineering Ultrasmall Metal Nanoclusters for
Biomedical Applications @ XIE Group
Highly Fluorescent Metal Nanoclusters
Metal NCs with tunable properties (Synthesis
and Fundamentals)
•J. Am. Chem. Soc. 2015, 137, 2128
•J. Am. Chem. Soc. 2014, 136, 10577
•J. Am. Chem. Soc. 2014, 136, 1246 (Highly cited paper)
•J. Am. Chem. Soc. 2012,134, 16662 (Highly cited paper)
•J. Am. Chem. Soc. 2009, 131, 888 (Highly cited paper)
•Angew. Chem. Int. Ed. 2015, 54, 184
•Angew. Chem. Int. Ed. 2014, 53, 4623 (Highly cited)
•ACS Nano 2011, 5, 8800 (Highly cited paper)
•ACS Nano 2012, 6, 7920
•Chem. Mater. 2013, 25, 946 (Highly cited paper) …
Fluorescent Probes
Fluorescent metal NCs for bioimaging and
sensing applications
•Anal. Chem. 2013, 85, 1913 (Highly cited paper)
•Chem. Comm. 2014, 50, 5143 (Highly cited paper)
•ACS Appl. Mater. Interfaces 2014, 6, 21822
•Chem. Comm. 2010, 46, 961 (Highly cited paper)
•Nanoscale 2012, 4, 1968
•Chem. - Asian J. 2013, 8, 858 (Highly cited paper)
…
Traceable
Antimicrobial Agents
Highly efficient and traceable silver
NC antimicrobials
- Ultrasmall, < 1 nm
- High ratio of surface atoms, > 50%
- Tunable emission colors
•NPG Asia Mater. 2013 (Highly cited paper)
•Nano Research 2014, 7, 301
•Biomaterials 2014, 35, 6707…
Controlled drug delivery
& cancer therapy
-Ultrasmall, HD <3 nm
-Good biocompatibility
Adv. Mater. 2014 (Highly cited)
Small 2015; Adv. Funct. Mater.
2013; Biomaterials 2015;
Adv. Healthcare. Mater. 2014
(Highly cited paper)
5
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Young Researcher Award :
Young Faculty Member
• Dr. Jianping XIE, National University of Singapore • http://www.chbe.nus.edu.sg/faculty/chexiejp
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Young Researcher Award:
Postdoctoral Fellow
Dr. Qiu Guanglei, National University of Singapore
Struvite
Phosphorus recovery
TOC
NH4+
Mg2+
H2O
PO43-
Ca2+
H2O
Osmotic membrane bioreactor
Draw solution
Mixed liquor
PO43-
Mg2+
Ca2+
NH4+
NaOH addition
Recovery solids
FO m
em
bran
e
Municipal wastewater
Wate
r p
rod
uctio
n
Simultaneous Water and P Recovery from Municipal Wastewater
17
Direct P recovery from municipal wastewater achieved for the first time;
Obviates the need for biological P removal;
Obviates the need for Mg/Ca addition;
Simultaneous recovery of water;
Calcium phosphate
Recovered solids
0%
20%
40%
60%
80%
100%
0
10
20
30
40
50
60
70
80
0 10 20 30 40 50 60 70 80 90 100
Rem
ov
al r
ate
PO
43
- -P
, mg
/L
Operation time, day
Effluent Influent
Supernatant Overall removal rate
5
6
7
8
9
pH
Bioresour.Technol., 2014, 170, 221–
229.
US Patent, Application No.
61/860,935.
The AIChE-SLS Researcher Award 2015 Qiu Guanglei (Dr.) ChBE, NUS
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Young Researcher Award:
Postdoctoral Fellow
Dr. Qiu Guanglei, National University of Singapore
American Institute of Chemical Engineers
Singapore Local Section (AIChE-SLS) Awards 2015
Outstanding Graduate Student Researcher Award
Feng Guangxue
National University of Singapore Yap Swee Kun
National University of Singapore
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Graduate Student Researcher Award
• Feng Guangxue, National University of Singapore
G. Feng, C. Y. Tay, Q. Chui, R. Liu, N. Tomczak, J. Liu, B. Z.
Tang, D. T. Leong, and B. Liu, Biomaterials 2014, 35, 8669-
8677.
FENG Guangxue (Bachelor, NUS)
• Achievements – Modulation of the self-assemble behavior of conjugated polymers (CPs) inside
nanoparticles (NPs) to increase brightness for long term cell tracing. (Small 2014, 6, 1212).
– Utilizing fluorogens with aggregation-induced emission characteristics (AIE dots) to fabricate ultra-bright and stable organic dots for cell tracing and blood vascular imaging. (Biomaterials 2014, 35, 8669; and DOI: 10.1002/adfm.201500010)
– Introducing photochrome to the core of fluorescent organic dots for reversible turn on/off fluorescence for bioimaging. (Nanoscale 2014, 4, 4141)
– Introduce cell targeting ligands at organic dot surface for cancer cell recognition and photodynamic therapy. (Chem. Commun. 2014, 50, 8587)
– Control CP NPs sizes from 10 nm to 3 µm for selective detection and photothermal killing of cancer cells over normal cells. (J. Mater. Chem. B 2015, 3, 1135)
– Design light-up probes for imaging of cytoplasm and nucleus. (Chem. Commun. 2014, 50, 9497)
– Design antimicrobial conjugated polyelectrolytes or light-up probes for killing of bacteria.
American Institute of Chemical Engineers
Singapore Local Section (AIChE-SLS) Awards 2015
Outstanding Graduate Student Researcher Award
Yap Swee Kun, National University of Singapore
Rapid nanoparticle-catalyzed hydrogenations in triphasic millireactors
with facile catalyst recovery, Green Chem. 16, pp. 4654-4658, 2014
American Institute of Chemical Engineers
Singapore Local Section (AIChE-SLS) Awards 2015
Outstanding Graduate Student Researcher Award
Feng Guangxue
National University of Singapore Yap Swee Kun
National University of Singapore
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Undergraduate Dissertation/Research Project Award
• Ang Wei Jun, National University of Singapore
• Denise Ng, National University of Singapore
• Stella Seah, National University of Singapore
• Justin Wong, National University of Singapore
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Undergraduate Dissertation/Research Project Award
Ang Wei Jun, National University of Singapore
FYP Thesis Title: Influence of cationic and non-ionic surfactants on the kinetics of mixed hydrogen/tetrahydrofuran hydrates.
Supervisor: Dr. Praveen Linga
GHRL
DTAC concentration
0 wt% 0.05 wt% 0.5 wt%
Norm
aliz
ed R
ate
of
Hydra
te F
orm
ation,
NR
15 (
mm
ol s
-1 m
-3)
0
200
400
600
800
Methane/THF system
Hydrogen/THF system
Achievements and Highlights of Study
No
Sur
factan
t
0.01
wt%
DTA
C
0.05
wt%
DTA
C
0.5
wt%
DTA
C
1.0
wt%
DTA
C
0.01
wt%
T-2
0
0.05
wt%
T-2
0
0.1
wt%
T-2
0
Norm
aliz
ed R
ate
of
Hydra
te F
orm
ation,
NR
15 (
mm
ol s
-1 m
-3)
0
50
100
150
200
250
Results
•Effect of surfactant on the kinetics of mixed THF hydrate formation is characteristic of the gas
Implications
•Further studies required to explore the behaviour of surfactants in presence of water soluble promoters during hydrate formation
• Search for alternate chemicals that can promote kinetics of hydrate formation in presence of THF
•Synergistic effect required between thermodynamic and kinetic promoters for efficient hydrate formation
Time (min)
0 10 20 30 40 50 60
Pre
ssure
(kP
a)
0
100
200
300
400
500
0 wt% DTAC
0.05 wt% DTAC
0.5 wt% DTAC
1 wt% DTAC
Surfactant effect on mixed H2/THF hydrate formation kinetics
Surfactant effect on mixed H2/THF hydrate dissociation kinetics
Surfactant effect on H2/THF and CH4/THF mixed hydrate formation kinetics
Results
•Surfactant did not significantly influence the dissociation kinetics of mixed H2/THF hydrates
Implications
• Similar to during hydrate formation, there is a need to examine if the presence of THF along with surfactant affects the kinetics of dissociation
Results
•Minor promoting effect of surfactants on hydrate formation rates in presence of THF
Implications
•THF, a well-established thermodynamic promoter of sII hydrate structures (that mixed H2 hydrates form), has ability to suppress the kinetic promoting effect of surfactants
•Future studies need to look into the use of other promoters for mixed H2 hydrate formation
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Undergraduate Dissertation/Research Project Award
Denise Ng, National University of Singapore
FYP Thesis Title : Effects of Polymer Excipients in ROY-excipient Co-formulated Spherical Agglomerates.
Supervisor: Associate Prof. Saif Khan
Effects of Polymer Excipients in ROY-excipient Co-formulated Spherical Agglomerates
Batch crystallization, a common purification method in the pharmaceutical industry, results in poor morphological and polymorphic control. Thus, it requires energy intensive processes, such as milling, grinding and compounding, which may lead to polymorphic transformations. The co-formulation of drug and excipient(s), with the aid of microfluidic capillary emulsion generation, circumvents the need for these processes. In this project, the role of selected excipient(s) in enhancing the homogeneity and polymorphic selectivity of co-formulated drug-excipient spherical agglomerates is investigated. The effects of different excipients reveal that PLGA is able to yield better polymorphic selectivity and structural homogeneity for ROY, our hydrophobic drug model.
100 μm
Polymorphic selectivity of Y/YT04 under 1mm film conditions
Excipient loading (mg/ml)
Ethyl cellulose
PLGA (50:50)
PLGA (75:25)
20 90.8% 100% 97.6%
40 94.0% 99.4% 99.5%
Figure 2: Polymorphic selectivity in various ROY-excipient co-formulated SAs. Y and YT04 are polymorphs of ROY. The bracketed ratios refer to the ratio of lactic to glycolic acid in PLGA.
Figure 4: Microscopic images of a) ROY 120 mg/ml EC 40 mg/ml b) ROY 120 mg/ml PLGA (75:25) 40 mg/ml c) ROY 120 mg/ml PLGA (50:50) 40 mg/ml dry particles formed under 1 mm film conditions showing structural homogeneity in ROY-PLGA particles and Janus in ROY-EC particles.
a) b) c)
Figure 1: Glass capillary microfluidic setup used to create ROY-excipient spherical agglomerates (SAs)
Figure 3: FESEM images of dry particles a) ROY 120 mg/ml EC 40 mg/ml b) ROY 120 mg/ml PLGA (50:50) 40 mg/ml formed under 1 mm film conditions showing Janus in ROY-EC particles and structural homogeneity in ROY-PLGA particles
ROY and Ethyl
Cellulose or PLGA in
DCM
1.5 wt% PVA water
solution
Evaporative crystallization in a glass
well of 1mm/2mm of pre-dispensed
1.5 wt% PVA water at 25°C
Circular capillary with tapered end Square capillary
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Undergraduate Dissertation/Research Project Award
Justin Wong, National University of Singapore
FYP Thesis Title: MULTI-OBJECTIVE OPTIMISATION OF SHELL-AND-TUBE HEAT EXCHANGERS USING THE ELITIST NON-DOMINATED SORTING GENETIC ALGORITHM.
Supervisor: Prof. G.P. Rangaiah
Multi-Objective Optimisation of Shell-And-Tube Heat Exchangers Using the Elitist Non-Dominated Sorting Genetic Algorithm
• Implementation of real coded NSGA-II
• A chi-squared test-based termination criterion (ChiTC)
• A novel termination criterion based on steady-state detection (SSTC).
• This work builds upon the Excel-based Multi-Objective Optimisation Program (EMOO)
• EMOO was previously developed using the binary-coded elitist non-dominated sorting genetic algorithm (NSGA-II)
• The Performance of EMOO was significantly improved through:
Figure 1: EMOO Main Interface
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Undergraduate Dissertation/Research Project Award
Stella Seah, National University of Singapore
FYP Thesis Title “DENSITY SEGREGATION OF WET GRANULAR MIXTURES IN GAS FLUIDIZED BEDS”.
Supervisor: Dr. Eldin Wee Chuan Lim
Novelty of Study
Novel approach to study density segregation of wet
mixtures in gas-fluidized beds through dynamic force analyses using computational fluid dynamics with
discrete element method
Mechanisms of mixing/segregation of wet binary mixtures
not addressed adequately in literature reported to date
Novel simulation of initial packed bed consisting of a layer of well-mixed region between two flotsam layers as
this was thought to impose no bias on subsequent mixing/segregation behaviors
Force analyses of particles were carried out based on
their initial positions within the packed bed
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• Outstanding Undergraduate Dissertation/Research Project Award
• Ang Wei Jun, National University of Singapore
• Denise Ng, National University of Singapore
• Stella Seah, National University of Singapore
• Justin Wong, National University of Singapore
American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS) Awards 2015
• AIChE SLS Service Awards
Dr. Praveen Linga, Secretary, AIChE Singapore local Section, 2014-2015
Mr. Terence Tan, President, AIChE NUS Student Chapter, 2014-2015
Acknowledgements • American Institute of Chemical Engineers Singapore Local Section (AIChE-SLS)
acknowledges the inputs by the following review panel members.
• Prof. Bing-Hung Chen (National Cheng Kung University, Taiwan)
• Dr. Ann Chow (Institute of Chemical Engineering Science)
• Prof. Clive Davis (Massey University, New Zealand)
• Dr. Rensheng Deng (Institute of Bioengineering and Nanotechnology)
• Dr. Fong Yew Leong (Institute of High Performance Computing)
• Associate Prof. Raymond Lau (Nanyang Technological University)
• Prof. IA Karimi (National University of Singapore)
• Mr. Ng Chee Wai (Petrochemical Corporation of Singapore)
• Prof. Raj Srinivasan (Indian Institute of Technology, Gandhinagar)
• Prof. Chi-Hwa Wang (National University of Singapore)
• Mr. Kenny Yip Kai Pui (Mitsui Phenols Singapore)
• Prof. Hua Chun Zeng (National University of Singapore)