overdose prevention and management in opioid treatment ... · overdose prevention and management in...
TRANSCRIPT
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Overdose Prevention and Management in Opioid Treatment
Programs
AATOD 20101:30pm Tuesday, October 26, 2010
Moderator:Amina Chaudhry
Faculty:Melinda Campopiano
Maya Doe-SimkinsAlexander Y. Walley
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Disclosures
•
Melinda Campopiano is a Treatment Advocate for Reckitt Benckiser
•
We have no additional commercial relationships to disclose
•
Naloxone is FDA approved as an opioid antagonist
•
Naloxone delivered as an intranasal spray with a mucosal atomizer device has not been FDA approved and is off label use
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Session Agenda
Overdose Epidemiology- Opioid & Methadone
Overdose Physiology & Naloxone Pharmacology
Overdose Prevention Education and Training in an OTP
Standing Order Model
Summary of Key Findings & Expansion
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•
Overdose deaths are up 5-fold since 1990–
26,400 deaths in 2006
–
For ages 35-54, exceed MVA death rates•
Emergency department visits in 2008–
306,000 involved pharmaceutical opioids
–
201,000 involved heroin
Overdose Epidemiology-
Opioid
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CDC Issue Brief. March 2010
Unintentional drug overdose deaths by major type of drug, United States:
1999-2006
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CDC Issue Brief. March 2010
Drug Overdoses by State, 2006
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•
1999 to 2002= 213% increase in fatalities
•
Opioid Treatment Program (OTP) patients not likely to be the source of increased opioid overdoses, compared to methadone prescribed for pain (though they are a group worthy of focus)
Overdose Epidemiology-
Methadone Associated Mortality On the Rise
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Paulozzi, 2006
Reports of opioid analgesics from selected DAWN Medical Examiners 1997-2002
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•
ONDCP–
2010 National Drug Control Strategy reduce OD deaths by 15%
–
Equip public safety w/ naloxone•
DEA, DOJ & EPA–
Rx Drug Take Back
Reducing Overdose Has Many Interested Parties
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•
Changes in tolerance•
Polysubstance
use-
benzos, alcohol &
cocaine•
Physical health
•
Previous experience of non-fatal overdose
•
Strength and content of ‘street’
drugs
What puts people at risk for ODs?
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•
Blue skin tinge•
Body very limp
•
Face very pale•
Pulse slow or not there at all
•
Passing out•
Choking sounds or a gurgling/snoring noise
•
Breathing is very slow, irregular, or has stopped
Overdose Physiology: Signs & Symptoms
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SAMHSA/CSAT TIP #40 page13
Withdrawal relief
Pain relief
Euphoria
Respiratory depression
Death
Progression of an Overdose
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Narcan
(naloxone) Reversing an Overdose
Opioid
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•
ODs often witnessed, occur over time•
911 is called <50% of the time
•
Naloxone reverses opioid-related sedation and respiratory depression–
Not psychoactive, no abuse potential
–
May cause withdrawal symptoms
Intervening in Opioid Overdose
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•
Pure opioid antagonist•
May be injected in the muscle, vein or under the skin or sprayed into the nose
•
Acts within 2 to 8 minutes•
Lasts 30 to 90 minutes, overdose may return
•
May be repeated•
Narcan®
= naloxone
•
naloxone ≠
Suboxone≠
naltrexone
Administering Naloxone
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OD Education and Naloxone Distribution (OEND) Programs
Number (#) 2007* 2010†
States w/ OENDs 9 17
Programs 42 131
People enrolled 20,950 ?
Reported OD reversals 2,642 ?
* Knox, 2008 †
Unpublished NOPE data
Three models: Prescription, Standing Order, Distribution
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•
No increase in drug use •
No major medical side effects
•
Possible increase in drug treatment •
Feasibility–
Drug users & lay responders can recognize overdose and be trained to respond
Evaluations of OEND programs
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•
Discuss overdose in your community at staff meetings and provide referral resources
•
Invite outside speaker•
Facilitate discussion of any concerns among staff
•
Solicit staff input in development of Overdose Prevention Program at OTP
•
Involve the patients•
Engage innovative partners/allies-
law
enforcement/public safety, parent or family groups, religious institutions
Beginning OD Prevention in an OTP: Develop Awareness & Build Buy-In
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0
50
100
150
200
250
300
1998 2000 2002 2004 2006
OD DeathsMVA DeathsHomicides
Allegheny Co Overdose Death in Comparison to MVA Fatalities and
Homicides 1998-2007
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Allegheny County Coroner’s Office: Includes all deaths where drug was identified. Not necessarily cause of death
‐Accidental Drug Overdose Deaths by Drug 2000-2006
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0
1000
2000
3000
4000
5000
6000
7000
1999
/200
020
00/2
001
2001
/200
220
02/2
003
2003
/200
420
04/2
005
2005
/200
6Heroin
Cocaine
Other Opiates
All other drugs
Drug Use in Allegheny County by FY
Data from Pennsylvania Department Of Health
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•
Prevention Point Pittsburgh (PPP)•
Overdose prevention since 2005
•
7,541 Overdose Prevention trainings 05-09–
5,342 in county jail
–
1722 community members–
477 syringe exchange clients
Personal Communication
Collaborate with Community Agencies
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•
477 persons who received prescriptions collectively reported at the time of their training–
570 overdoses (self)
–
1,995 overdoses witnessed–
149 deaths
•
310 refills provided–
307 successful reversals
–
173 required rescue breathing–
2 deaths
–
1 unknown outcome Personal Communication
Naloxone Prescriptions by PPP
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•
Literature should be available and visible.
•
Overdose risk should be routinely discussed in case consultations
•
Past Medical History should document history of overdose
•
Provide regular opportunities to process grief, anger, guilt and other strong feelings about overdose
Normalize in OTP Milieu
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•
All patients offered training and naloxone
•
All new patients offered training and naloxone as part of orientation
•
Provide on-demand•
Target those with additional risk factors (co-occurring mental health disorders, positive UAs, previous overdose, etc)
Patient Targeting Strategies
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•
Present to any upper level medical and executive staff persons
•
Develop a written policy/guideline•
Discuss with hospital pharmacy
•
Present at Pharmacy and Therapeutics Committee meeting
•
Hint: Don’t expect them to know much about overdose or your patients.
Gain Institutional Approval
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•
Opiate users by definition•
Co-occurring mental health disorders
•
Polysubstance use•
Reside in families and communities where substance use is wide spread
•
Treatment may end abruptly
The OTP Patient
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•
OTP patients are more likely than the general population to have Axis I or II disorders
•
Up to half of OTP patients have a co- occurring disorder in their lifetime.
•
OTP patient demographics put them at riskolder age
urban area
homelessness medical illness incarceration low socioeconomic
status
TIP 43
Risk Factors
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OTP Patients with Polysubstance Use and Co-Occurring Disorders.
Substance With disorder
Without disorder
Alcohol 31.5% 18.6%
Benzodiazepines 21.8% 12.5%
Cocaine 48.5% 32.7%
TIP 43
OPT Patients with Polysubstance
Use and Co-Occurring Disorders
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•
Keep sign in lists•
Track naloxone prescriptions–
Prescribed
–
Picked-up–
Used
•
Head Count a couple questions–
How many have overdosed or witnessed one
–
How many have received overdose training before•
Consider a patient satisfaction survey
Collect Data on Your Program
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•
Teach other staff to provide training to patients
•
Hand over coordination of your overdose prevention program to one or more specific staff positions
•
Present data on your program to staff, patients and management
Achieving Sustainability
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0
200
400
600
800
1000
1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007
# of
Dea
ths
All Poisonings
Opioid-Related
Non-Opioid-related
Source: Registry of Vital Records and Statistics, MA Department of Public Health
0
200
400
600
800
1000
1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007
# of
Dea
ths
Non-Opioid-related
Standing Order Model: MassachusettsOpioid-Related Poisoning Deaths in
Massachusetts 1990-2007
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•
Lessons learned from underground OEND in 2004
•
Media coverage of fatal ODs in 2005
Massachusetts Timeline
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•
BPHC BOD passes regulation in 8/06, naloxone availability through needle exchange program (NEP) begins 9/06
Massachusetts Timeline
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•
BPHC also operates OTP-
in 2006, it became the first additional site beyond NEP
Massachusetts Timeline
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MA Naloxone Distribution Pilot Sites
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• Pilot program conducted under DPH/Drug Control Program regulations (M.G.L. c.94C & 105 CMR 700.000)
• Medical Director issues standing order for the distribution
• Naloxone may be distributed by public health workers
Implementing the Massachusetts Public Health Pilot: Standing Order Model
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September 2006 to present: •
Enrollment form: –
At time of training and naloxone distribution, program staff collect potential bystander demographics and OD risk factors
•
Refill form:–
Upon return to program, staff collect data on ODs reversed
Data Collection
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People in treatment, in
recovery, or using
Family and Professionals
Enrollments (N=7490) 5351 2589Mean age (SD) 34 (11) 43 (13)Gender: Male 64% 38%
Female 36% 62%Race: White 81% 77%
Black/ AA 8% 12%Other race 11% 11%
Ethnicity: Hispanic 17% 13%Witnessed OD ever? 78% 47%
Enrollee characteristics: 2006-2010
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0
20
40
60
80
100
Polydru
g
Heroin
Benzo
/ Barb
sMeth
adon
eCoc
aine
Alcoho
lSub
oxon
eP
erce
nt u
sing
Daily Intermittent
Data only from people with current or ever substance use N= 5351
Enrollee past 30 day opioid use: 2006-2010
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0 200 400 600 800 1000 1200 1400 1600
Home visit/ shelter
Inpatient/ ED/ Outpatient
Other SA treatment
Methadone Clinic
Community meeting
Drop-In Center
Needle Exchange
Detox
Number enrolled
Opioid Users Non Users
Enrollment Locations: 2008-2010
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N Witness OD?
Personal OD? †
Total enrollment 7940 68% 50%
OTP Patients* 887 82% 53%
Non-patients (staff) 54 43% -
Overdose Experience of OTP Patients and Staff
* Patients = people enrolled at a methadone clinic + people enrolled elsewhere who report daily methadone use†only current or ever substance users N=5351
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N Reverse OD?
Heroin use?
Benzo use?
Methadone use?
Total enrollment 7940 755 97% 26% 1%
OTP Patients 887 114 94% 25% 3%
Non-Patients 53 1 100% 0 0
Overdose Reversals
Possible that rate of methadone involvement is actually that low
Also, possible under reporting due to:
•OD bystanders may tend to only name “primary”
drug
•Methadone’s long half-life = OD bystander might not know
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Clinic staff train and distribute
1 OTP clinic using this model
Clinic staff train, refer to OEND for distribution
6 OTP clinics
OEND staff regularly come on site to train and
distribute3 OTP clinics
OEND staff recruit from clinic without collaborative
agreement7 OEND programs using this
model
*many people are on methadone and choose to separate OEND and methadone svcs= 5th
model
Standing Order Allows Varied Models to Emerge*
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• OTP patients also access:
–
Needle exchanges–
Other HIV prevention services
–
Homeless services•
Top 3 most common sites for OTP patient naloxone refills:
1.
Needle Exchange Program (40%)2.
Drop-in Center (30%)
3.
Methadone Clinic (9%)
OTP Client Interaction With Other Systems
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•
Participants commonly witness ODs•
Participants can recognize ODs and use intranasal naloxone successfully
•
OD prevention programs can train and distribute without a medical provider encounter
Summary of Findings -
General
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•
Methadone patients commonly have OD history
•
OD training and naloxone distribution is feasible at OTPs–
Several models are available
•
Daily methadone users are enrolled at needle exchange, drop-in centers and community sites near methadone clinics
•
Heroin and heroin mixed with other drugs are the most common drugs involved in overdose–
Methadone is unusual (3%)
Summary of Findings –
Methadone-related
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•
Advocate for overdose prevention at any local provider meeting.
•
Approach local or state chapters of AMA or ASAM to adopt policy in support of overdose prevention.
•
Consider coprescription of naloxone with all opioids
for pain or addiction.
•
Support Good Samaritan & Overdose Reduction legislation.
Expansion
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•
Eileen Brigandi-
BPHC OPT Director•
Donna Beers-
BPHC OPT RN
•
Adam Butler-
MA OD Prevention Trainer
•
MDPH OHA & BSAS•
Alice Bell-
PPP OD Prevention Manager
Acknowledgements
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Melinda Campopiano: [email protected] Chaudhry: [email protected] Doe-Simkins: [email protected] Y Walley: [email protected]