overlapping and pathophysiology in asthma and scd
TRANSCRIPT
Overlapping & Pathophysiology in Asthma &SCD:- Sickle Cell
Disease
Elevate the levels of;
Interferon-gama
TNF-α
Stimulates the action of
AHR
Increases LDH Level
Haemolysis
Air way Hyper -
reactivity
Activates
Phospholypase-A2
Enzyme
Arachidonic acid
5-Lipoxygenase Enzyme
LEUKOTRIENES
Increase during VOE & ACS
Leads to Bronchoconstricti
on
ASTHMA
Inflammation
Inflammation