OVERVIEWThe course will provide clinicians with the most recent developments in the diagnosis and management of neurologic disorders, including stroke. It will cover the latest advances in the different fields of neurology and neuroscience including epilepsy, multiple sclerosis (MS), movement disorders, neuro-oncology, neuromuscular diseases and headache/migraine all of which are critical in solving clinical problems, diagnosing and treating patients and improving the quality of patient care.

Difficult diagnostic and therapeutic problems in epilepsy, multiple sclerosis, movement disorders, neuro-oncology, neuromuscular diseases and stroke will be presented, including an exchange of information between faculty and attendees with case presentations, dedicated discussion and questions and answers sessions after each presentation as well as panel discussions.

In addition, a dedicated stroke seminar on Saturday is designed as a stand-alone 8-hour CME activity. For those centers planning to seek stroke center status or already designated as a stroke center, this course will provide stroke teams with the most up-to-date evidence in the field of stroke diagnosis, treatment and prevention. TARGET AUDIENCEThe course is aimed primarily at neurologists, stroke specialists, neurosurgeons, psychiatrists, neuro-oncologists, hospitalists, intensivists, fellows, residents, nurses and allied healthcare professionals that participate in the care of neurological patients or work in stroke centers. Internists, general practitioners and cardiologists may also find the topics timely and useful.

ACCREDITATIONThe University of Miami Leonard M. Miller School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATIONThe University of Miami Leonard M. Miller School of Medicine designates this live activity for a maximum of 23.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

DISCLOSURE AND CONFLICT OF INTEREST RESOLUTIONAll conflicts of interest of any individual(s) in a position to control the content of this CME activity will be identified and resolved prior to this educational activity being provided. Disclosure about provider and faculty relationships, or the lack thereof, will be provided to learners.

SERVICES FOR THE DISABLED Please contact the Division of CME prior to December 18, 2019 should you have any special needs that may require additional assistance. A conference staff member will contact you to discuss these special requirements.

LEARNING OBJECTIVESAt the completion of the course, attendees will be able to:

EPILEPSY • Accurately diagnose PNES and distinguish them from epileptic seizures and paroxysmal organic non-epileptic events • Identify the common neurologic and psychiatric comorbid disorders associated with PNES • Recognize the complexity of PNES’ pathogenic mechanisms including their neurobiological mechanisms • Explain the diagnosis of PNES to the patient and family members to ensure acceptance of the diagnosis and recommendations for treatment • Outline the best treatment strategies for PNES based on evidence-based data

MULTIPLE SCLEROSIS/NEUROIMMUNOLOGY • Diagnose and treat MS patients according to their individual risk of disability progression by analyzing the pathogenesis of progressive MS sub-types • Assess the risk versus benefit of newly approved drugs for “active” secondary progressive MS by considering mechanism of action and evidence for efficacy

• Develop a clinical plan to diagnose early features suggestive of Neuromyelitis Optica Spectrum Disorders (NMOSD) based on knowledge of the current diagnostic criteria and how these differ from criteria to diagnose MS • Assess the risk versus benefit of available and pending disease modifying therapy (DMT) for NMOSD by considering mechanism of action and the pathogenetic role of complement and evidence for efficacy • Identify the clinical features of the anti-MOG syndrome and recognize presentations of optic neuritis that are more likely to involve antibody to myelin-associated glycoprotein (anti-MOG).

ALZHEIMER’S DISEASE • Determine which are clinically relevant and appropriate biomarkers in Alzheimer’s Disease and how to use them to assign an evidence-based biomarker staging • Evaluate the current evidence-based research criteria for diagnosing Alzheimer’s Disease • Determine which Alzheimer’s Disease preventative strategies to use in clinical practice based on current scientific evidence

SLEEP MEDICINE • Treat patients with common sleep disorders • Apply evidence-based interventions to identify the patient at-risk for a sleep disorder • Determine the best driven medical management to prevent or modify stroke risk through the treatment of sleep disorder • Determine the best driven medical management to prevent memory decline through the treatment of sleep disorders

MOVEMENT DISORDERS • Describe new pharmacological treatments for the motor fluctuations of Parkinson disease • Recognize the limitations in current evaluation of normal pressure hydrocephalus and its relation to neurodegenerative disease • Recognize the phenomenology of symptomatic myoclonus • Understand new ways of defining and treating neurogenic orthostatic hypotension • Describe the new developments in gene silencing as treatment for Huntington disease

NEUROMUSCULAR DISEASES • Differentiate the current classification and treatment options for the inflammatory myopathies • Review the current and prospective treatment landscape for Amyotrophic lateral sclerosis to treat and diagnose patients • Develop competence in the indication and strategies for molecular testing in Neuromuscular disorders • Manage patient expectations regarding end-of-life care in neuromuscular disease

MIGRAINE • Increase knowledge in the efficacy and safety of non-pharmacological and pharmacological treatments for migraine with a focus on newer and emerging therapies including neuromodulation • Outline emerging treatments for migraine in late stage development • Evaluate the principles of shared decision making and their applications to migraine management • Implement migraine management plans that optimize patient outcomes through case discussions

STROKE • Drive institutional quality improvement efforts and engage EMS as partners in the stroke care continuum based on benchmarked institutional performance metrics • Treat appropriate acute ischemic stroke patients with modern strategies that include the extended 24-hour treatment window based on current guidelines • Diagnose and manage lobar hemorrhages recognizing the role of cerebral amyloid angiopathy in intracerebral hemorrhage • Assess the role of medical and surgical approaches in hemorrhagic stroke to institute appropriate guideline-based anticoagulation reversal strategies and select those eligible for surgical interventions • Evaluate cryptogenic stroke based on the current understanding of pathophysiologic mechanisms • Institute appropriate antithrombotic treatment, including the novel oral anticoagulants, in cardioembolic stroke prevention • Establish effective treatment strategies to prevent recurrent events after TIA and minor stroke • Detect, counsel and establish management strategies for post-stroke cognitive impairment

COURSE DIRECTORS Andres M. Kanner, MD, FAAN, FANA, FAESProfessor of Clinical NeurologyDirector, Comprehensive Epilepsy CenterChief, Epilepsy DivisionDepartment of NeurologyUniversity of Miami Miller School of MedicineMiami, FL

Jose G. Romano, MD, FAHA, FAANProfessor of Clinical NeurologyVice-Chair of Clinical AffairsChief, Stroke Division, Department of NeurologyUniversity of Miami Miller School of MedicineChief, Comprehensive Stroke ProgramJackson Memorial HospitalMiami, FL

GUEST FACULTYMitchell S. V. Elkind, MD, MS, FAAN, FAHAProfessor of Neurology and EpidemiologyHead, Division of Neurology Clinical Outcomes Research and Population Sciences (NeuroCORPS)Columbia UniversityNew York, NY

Alberto J. Espay, MD, MScProfessor of NeurologyDirector and Endowed ChairJames J and Joan A Gardner Center for Parkinson’s Disease and Movement DisordersUniversity of Cincinnati Academic Health CenterCincinnati, OH

Tudor G. Jovin, MDChairman and Chief of NeurologyCooper University Health CareMedical Director, Cooper Neurological InstituteProfessor of Neurology, Cooper Medical School of Rowan UniversityStroke NeurologistCamden, NJ

W. Curt LaFrance, Jr., MD, MPH, FAAN, FANPA, DFAPAProfessor of Psychiatry and NeurologyAlpert Medical School, Brown UniversityDirector, Neuropsychiatry and Behavioral Neurology, Rhode Island Hospital (RIH)Providence, RI

Stephanie J. Nahas-Geiger, MDAssociate Professor of NeurologyDirector, Headache Medicine Fellowship ProgramAssistant Director, Neurology Residency ProgramVickie & Jack Farber Institute for NeuroscienceJefferson UniversityPhiladelphia, PA

UHEALTH/UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE FACULTYNegar Asdaghi, MD, MSc, FRCPCStroke DivisionDepartment of Neurology

Maria C. Botero, APRNMultiple Sclerosis DivisionDepartment of Neurology

Nicolas Brozzi, MDDepartment of SurgeryTransplant Surgery, Miami Transplant Institute

Christian J. Camargo, MDDivision of Cognitive NeurologyDepartment of Neurology

Olimpia Carbunar, MDGeneral Neurology Division

Marcella Coutts, MDNeurology DivisionMiami VA Medical Center

Victor J. Del Brutto-Andrade, MDStroke Division, Department of NeurologyJackson Memorial Hospital

Silvia Delgado, MDMultiple Sclerosis DivisionDepartment of Neurology

Kamil Detyniecki, MDEpilepsy DivisionDepartment of Neurology

Salim Dib, MD, FAAN, FAASMDepartment of NeurologySleep Division

Crystal Dixon, MDMultiple Sclerosis DivisionDepartment of Neurology

Melissa Fellman, MDNeuromuscular DivisionDepartment of Neurology

Neeta Garg, MDMultiple Sclerosis DivisionDepartment of Neurology

Volkan Granit, MDNeuromuscular DivisionDepartment of Neurology

Jeffrey Hernandez, APRNMultiple Sclerosis DivisionDepartment of Neurology

Nicole Hughes, APRNMultiple Sclerosis DivisionDepartment of Neurology

Hong Jiang, MD, PhDGeneral Neurology Division

Sebastian Koch, MDStroke DivisionDepartment of Neurology

Maria Raquel Lopez, MDGeneral Neurology DivisionEpilepsy Center of ExcellenceVeterans Health Administration

Merredith Lowe, MDEpilepsy DivisionDepartment of Neurology

Amer Malik, MD, MBA, FAHA, FSVINStroke Division, Department of NeurologyNeurohospitalist Section, Jackson Memorial Hospital

Jason Margolesky, MDMovement Disorders DivisionDepartment of Neurology

Erika Marulanda-Londono, MDStroke and Neurohospitalist DivisionDepartment of Neurology

Micheline McCarthy, MD, PhDMultiple Sclerosis DivisionDepartment of Neurology

Miguel Melo-Bicchi, MDMultiple Sclerosis DivisionDepartment of Neurology

Teshamae Monteith, MD, FAHS, FAANHeadache DivisionDepartment of Neurology

Henry P. Moore, MDMovement Disorders DivisionDepartment of Neurology

Jacques Morcos, MDCranial Neurosurgery DivisionDepartment of Neurological Surgery

Kristine O’Phelan, MDNeurocritical Care DivisionNeuroscience Intensive Care Unit, Jackson Memorial Hospital

Melissa R. Ortega, MDMultiple Sclerosis DivisionDepartment of Neurology

Kottil W. Rammohan, MDMS Center of ExcellenceMultiple Sclerosis DivisionDepartment of Neurology

Alberto Ramos, MD, MSPH, FAASMUHealth Sleep Medicine ProgramSleep Medicine Division

Ramses Ribot, MDEpilepsy Division, Department of NeurologyUniversity of Miami Hospital

Tatjana Rundek, MD, PhDEvelyn F. McKnight Brain InstituteDepartment of Neurology

Ralph L. Sacco MD, MS, FAAN, FAHAProfessor and Olemberg Chair of Neurology Executive Director, McKnight Brain InstituteChief of Neurology, Jackson Memorial HospitalDirector, UM Clinical and Translational Science InstituteSenior Associate Dean for Clinical & Translational Science

Mario A. Saporta, MD, PhD, MBA, FAANMDA Care CenterCharcot-Marie-Tooth Center of ExcellenceNeuromuscular Division, Department of Neurology

Danielle C. Shpiner, MDMovement Disorders DivisionDepartment of Neurology

Carlos Singer, MDMovement Disorders DivisionDepartment of Neurology

Nicole Sur, MDStroke DivisionDepartment of Neurology

Leticia Tornes, MDMultiple Sclerosis and Epilepsy DivisionsDepartment of Neurology

Basim M. Uthman, MDDepartment of NeurologyDepartment of Neurology, Miami VA Medical Center

Naymee Velez-Ruiz, MDEpilepsy Division, Department of NeurologyEEG Monitoring Unit and EEG Lab, Jackson Memorial Hospital

Ashok Verma, MD, DMNeuromuscular DivisionDepartment of Neurology

Dileep R. Yavagal, MD, FAHA, FAAN, FSVINInterventional Neurology Division, Department of NeurologyInterventional NeurologyJackson Memorial & University of Miami Hospitals

7:00-7:55 AM Registration and Continental Breakfast

7:55-8:00 AM Welcome and Introductory Remarks Andres M Kanner, MD

EPILEPSY: When is a Patient Considered to Suffer from Treatment-Resistant Epilepsy?Moderator: Andres M. Kanner, MD

8:00-8:15 AM Introductory Remarks: Epilepsy Andres M. Kanner, MD

8:15-8:45 AM Are You Sure It Is a PNES? Recognition of PNES and Epileptic and Organic Non-Epileptic Events that Mimic PNES Kamil Detynieki, MD

8:45-9:45 AM KEYNOTE: Advances in Neurobiologic Aspects of PNES and Evidence-Based Treatment Strategies W. Curt LaFrance, Jr., MD, MPH

9:45-10:00 AM Discussion and Q&A

10:00-10:30 AM Coffee Break and Visit Exhibits

10:30-11:00 AM Neurologist’s Role in the Management of Patients with PNES Maria Raquel Lopez, MD

11:00-11:45 AM Controversial Issues in the Evaluation and Management of Patients with PNES: A Round Table Discussion Moderator: Andres M. Kanner, MD Panelists: Marcela Coutts, MD, Merredith Lowe, MD Ramses Ribot, MD, Naymee Velez-Ruiz, MD Basim M. Uthman, MD

11: 45-12:45 PM Buffet Lunch

MIGRAINE AND OTHER HEADACHESModerator: Teshamae S. Monteith, MD

12:45-1:30 PM KEYNOTE: 2020 Headache Update and the Road to Progress Stephanie J. Nahas-Geiger, MD

1:30-1:45 PM Discussion and Q&A

1:45-2:05 PM Shared Decision Making and Therapeutic Implementation to Optimize Migraine Outcomes Teshamae S. Monteith, MD

2:05-2:15 PM Discussion and Q&A

MULTIPLE SCLEROSIS/NEUROIMMUNOLOGY Update on Multiple Sclerosis (MS)Moderator: Kottil Rammohan, MD

2:15-2:35 PM Overview of MS Pathogenesis Kottil Rammohan, MD

2:35-2:55 PM Secondary Progressive MS and Siponimod Silvia Delgado, MD

2:55-3:15 PM Secondary Progressive MS and Cladribine Kottil Rammohan, MD

3:15-3:45 PM Coffee Break and Visit Exhibits

Update on Neuromyelitis Optica Spectrum Disorders (NMOSD) Moderator: Micheline McCarthy, MD, PhD

3:45-4:00 PM NMOSD Pathogenesis and Complement Leticia Tornes, MD

4:00-4:15 PM Eculizumab in NMO Neeta Garg, MD

4:15-4:30 PM Pipeline Drugs for NMOSD Micheline McCarthy, MD, PhD

4:30-4:45 PM Anti–MOG Antibody Syndrome Hong Jiang, MD, PhD

4:45-5:15 PM Case Presentations and General Discussion/Q&A Maria C. Botero, APRN, Crystal Dixon, MD Jeffrey Hernandez, APRN, Nicole Hughes, APRN Miguel Melo-Bicchi, MD, Melissa Ortega, MD

5:15 PM Adjourn

AGENDA THURSDAY, JANUARY 16, 2020

*Agenda Subject to Change

7:00-7:55 AM Registration and Continental Breakfast

MOVEMENT DISORDERSModerator: Carlos Singer, MD

8:00–8:25 AM New Treatments for Parkinson Disease Danielle Shpiner, MD

8:25–8:30 AM Discussion and Q&A

8:30–9:10 AM KEYNOTE: Normal Pressure Hydrocephalus: Ventriculomegaly as an Early Manifestation of Neurodegeneration Alberto J. Espay, MD, MSc

9:10-9:15 AM Discussion and Q&A

9:15–9:40 AM Gene Silencing in Huntington Disease: The New Frontier Henry Moore, MD

9:40-9:45 AM Discussion and Q&A

9:45-10:15 AM Coffee Break and Visit Exhibits

10:15–10:40 AM Neurogenic Orthostatic Hypotension: Clinical and Treatment Pointers Carlos Singer, MD

10:40-10:45 AM Discussion and Q&A

10:45-11:10 AM Symptomatic Myoclonus Jason Margolesky, MD

11:10–11:15 AM Discussion and Q&A

DEMENTIA/ALZHEIMER’S DISEASE

11:15-12:00 PM Diagnosing Alzheimer’s Disease: Current Clinical Practice and a Biomarker-Based Framework Christian J. Camargo, MD

12:00-12:15 PM Discussion and Q&A

12:15-1:15 PM Buffet Lunch

SLEEP MEDICINEModerator: Alberto Ramos, MD, MSPH

1:15-1:40 PM Update in the Treatment of Sleep Disorders in Stroke and Its Risk Factors Alberto Ramos, MD, MSPH

1:40-1:45 PM Discussion and Q&A

1:45-2:10 PM The Role of Sleep in Memory Disorders Salim Dib, MD

2:10-2:15 PM Discussion and Q&A

NEUROMUSCULAR DISEASESModerator: Mario A. Saporta, MD, PhD, MBA

2:15–2:45 PM Current Classification and Treatment of Inflammatory Myopathies Olimpia Carbunar, MD

2:45-2:55 PM Discussion and Q&A

2:55–3:25 PM New Therapies and Clinical Trials for Amyotrophic Lateral Sclerosis Volkan Granit, MD

3:25-3:35 PM Discussion and Q&A

3:35–4:05 PM Coffee Break and Visit Exhibits

4:05-4:35 PM Genetic Testing for Neuromuscular Disorders – How to Order and How to Interpret It Mario A. Saporta, MD, PhD, MBA

4:35-4:45 PM Discussion and Q&A

4:45–5:15 PM Neuromuscular Complications of HIV Infection Ashok Verma, MD, DM

5:15–5:25 PM Discussion and Q&A

5:25–5:55 PM Palliative Care for Neuromuscular Diseases Melissa Fellman, MD

5:55-6:05 PM Discussion and Q&A

6:05 PM Adjourn

AGENDA FRIDAY, JANUARY 17, 2020

*Agenda Subject to Change

AGENDA SATURDAY, JANUARY 18, 2020

STROKE REVIEW SEMINAR7:00-8:00 AM Registration and Continental Breakfast

7:50-8:00 AM Welcome Jose G. Romano, MD

8:00-8:30 AM Thrombolysis for Acute Ischemic Stroke and Stroke Mimics Erika Marulanda-Londoño, MD

8:30-9:00 AM Imaging-Guided Thrombolysis Beyond 4.5 Hours Negar Asdaghi, MD, MSc

9:00-9:45 AM New Frontiers in Endovascular Therapy Tudor Jovin, MD

9:45-10:05 AM Panel Discussion and Q&A Dileep Yavagal, MD

10:05-10:35 AM Coffee Break and Visit Exhibits

10:35-11:05 AM Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy Sebastian Koch, MD

11:05-11:35 AM Reversal of Anticoagulation in Intracerebral Hemorrhage Kristine O’Phelan, MD

11:35-12:05 PM Surgical Approaches to Intracerebral Hemorrhage Jacques Morcos, MD

12:05-12:25 PM Panel Discussion and Q&A

12:25-12:55 PM Box Lunch

12:55-1:25 PM Cognitive Impairment in Stroke Tatjana Rundek, MD, PhD

1:25-1:55 PM Quality Improvement in Acute Stroke Care in Florida- the Florida Stroke Registry Ralph L Sacco, MD, MS

1:55-2:40PM KEYNOTE: Embolic Stroke of Undetermined Source: 40 min Mitchell S. V. Elkind, MD, MS, MPhil

2:40-3:10 PM Coffee Break and Visit Exhibits

3:10-3:40 PM Secondary Stroke Prevention in Atrial Fibrillation Nicole Sur, MD

3:40-4:10 PM Stroke in Left Ventricular Assist Device Nicolas Brozzi, MD, Amer Malik, MD, MBA

4:10-4:40 PM Antithrombotic Therapy for Non-Cardioembolic Stroke Victor J. Del Brutto-Andrade, MD

4:40-5:30 PM Panel Discussion and Q&A Amer Malik, MD

5:30-5:40 PM Closing Remarks Jose G. Romano, MD

5:40 PM Conference Adjourns

*Agenda Subject to Change

REGISTRATION CANCELLATION POLICYRefunds will be made only if written notice of cancellation is received prior to December 17, 2019. A $100 fee is charged for all refunds. After this date, no refunds will be made. In cases where a course is cancelled due to insufficient registrations, a full tuition refund will be made.

SERVICES FOR THE DISABLEDPlease contact the Division of CME prior to December 17, 2019 should you have any special needs that may require additional assistance. A conference staff member will contact you to discuss these special requirements.

FOR MORE INFORMATION, CONTACTDivision of Continuing Medical EducationTel: 305-243-6716 /Fax: 305-243-5613cme@med.miami.edu

HOTELINTERCONTINENTAL MIAMI100 Chopin PlazaMiami, FL 33131Tel. 305-577-1000www.icmiamihotel.comHotel Class: 4 Stars

SPECIAL CONFERENCE RATEA block of rooms has been reserved for conference participants at a discounted rate: • US $219/night + 13% tax/day for a Single/Double City View room (Up to 2 adults) • US $259/night + 13% tax/day for a Bayview room for a Single/Double (Up to 2 adults)

The rate is guaranteed only until Tuesday, December 17, 2019 based on availability. The hotel extends the group rate 3 days pre- and post-conference dates based on availability. After this date, reservation requests will be considered on a space-available basis.

RESERVATIONSRoom reservations will be made by individual attendees directly by clicking on the following direct link to online reservations at the hotel or call 1-800-327-3005 and use the group code QSF or ask for “Neurology Update/Stroke” Conference group rate.

For online reservations, click on: Neurology Update 2020

All reservations must be received by the hotel no later than December 17, 2019. All individual reservations must be accompanied by a first night room deposit or guaranteed with a major credit card. The hotel will not hold any reservations unless secured by one of the above methods.

PARKING RATESValet Overnight Parking: $35.00/night with in and out privilegesValet Daily Conference Parking: $16/day (no in/out privileges)

REGISTRATION FORM TO REGISTER, please visit www.cme.med.miami.edu or complete this form and mail/fax (with payment) to:

First Name __________________________Last Name _____________________________ Degree (MD, DO, PhD, ARNP, etc.) _____________________________

Affiliation ______________________________________________________________________________________________________________________

Specialty _________________________________________________________________ Month & Day of Birth (mm/dd):______________ (for CME recording purposes only)

Mailing Address _________________________________________________________________________________________________________________

City _______________________________State Zip/Postal Code ______________________ Daytime Telephone ______________________________________

Fax ________________________________Email (mandatory) _____________________________________________________________________________

TUITION**

Before As of Onsite Stroke Review Seminar Before As of Onsite 12/19/2019 12/19/2019 (Saturdy) 12/19/2019 12/19/2019 cPhysicians (MDs/DOs) $740 $840 $900 cPhysicians (MD/DOs) $390 $490 $550 cFellows $150 $250 $300 cARNPs/Nurses $250 $350 $400 cResidents $150 $250 $300 cAllied Healthcare Professionalsa $250 $350 $400 cNurse Practitioners/ARNPs $250 $350 $400 cNurses/RNs (Non-UM/JMH) $200 $300 $350 cAllied Healthcare Professionals $200 $300 $350 cNon-Physician/Researchers $400 $500 $550 cNon-UM Residents/Fellows $150 $150 $150 cResearchers $400 $400 $400 cMedical Students (w/Proof of ID) $ 50 $100 $150 cIndustry Representative $1,000 $1,100 $1,200

**Continental Breakfast, coffee breaks, lunch and syllabus are included in Registration fee.

PAYMENT METHODCheck: Please make check payable to UM/Division of CME (reference Account #PG007109 on the check)

Charge my registration fee in the amount of $ _____________ to my:

cVisa® cMasterCard® cAmerican Express

Name on Card ___________________________________________________________________________________________________________________

Card Number ______________________________________________________________Expiration Date __________________________________________

How did you hear about this program?

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30% Discount available for groups of 10+ for entire 3-day program or stroke seminar day

University of Miami Miller School of Medicine Division of Continuing Medical Education P.O. Box 016960 (D23-3) Miami, FL 33101-6960

JANUARY 16-18, 2020InterContinental Miami, Miami, FL

Register today at:www.cme.med.miami.edu

PRSRT FIRST CLASS

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