overview of new therapies for ovarian cancer & prostate cancer · overview of new therapies for...
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Jonathan Harris
Institute of Health and Biomedical Innovation
Overview of New Therapies for
Ovarian Cancer & Prostate Cancer
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Overview of New Therapies for
Ovarian Cancer & Prostate Cancer
Prostate and Ovarian cancer
Big picture changes in cancer research
Old style chemo and the new approach
New drugs in the clinic and early phase
studies
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Prostate and ovarian
cancer Societal impact
20,000 men living with
advanced
prostate cancer
1400 women
diagnosed
with ovarian cancer
each year*
*PCFA/Ovarian Cancer Australia Statistics
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Prostate and ovarian
cancer Societal impact
20,000 men living with
advanced
prostate cancer
1400 women
diagnosed
with ovarian cancer
each year
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Prostate and ovarian cancer Similarities.......
and differences
•Hormone dependent
•Impact fertility
•“Hidden” cancers
•Difficult to treat when
advanced
•Side effects of treatment
•Surgical approaches
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cancer-info/cancerandresearch/progress/cancer_drugs
Cancer: One disease many drugs
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Strengthening ties between health
professionals and researchers
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Antibodies and immune
killer cells deal with
developing cancer
Your immune system and artificial
antibodies
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Whole genome screening and the
beginnings of personalised medicine
Welcome to the era of the
$5000 genome sequence
Cancer treatment is no
longer one size fits all
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The old chemotherapy: Molecular sledgehammer approach, one size fits all
Stopping cancer cells
divide and multiply
Genome damage
Starving tumour cells
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The New strategy: Highly specific drugs tuned to a particular cancer
Whole tumour genome scans identify weak points in
tumour biology.
Personalised medicine:
Define subpopulations of
patientswith specific
“druggable” mutations.
Tailor selective molecules
to individual or combined
targets
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New to the clinic: Abiraterone (Zytiga) for hormone resistant prostate cancer
Prevents resynthesis of testosterone that would otherwise
drive tumour growth.
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New to the clinic: Denosumab for protection of bone in advanced prostate cancer
Blocks osteoclast (bone chewing cells)
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In Clinical Trials: Olparib (AZD 2281) for late stage ovarian cancer
blocks DNA repair in tumour cells
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In Clinical Trials: Bevacizumab (Avastin) for late stage ovarian cancer
Prevents capillary network formation
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In the lab: Protease inhibitors for control of proliferation and metastasis
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In the lab: Cancer stem cells that lead to tumour regrowth: an important target for
new therapies
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With thanks to
Distinguished Professor Judith Clements
and her research group
Professor Frank Gardiner
Professor Andreas Obermair