overview of peripheral neuropathy...sara austin, md, faan specialty: neuromuscular disease board...
TRANSCRIPT
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Overview of Peripheral Neuropathy
What is this?
And what can I do about it?
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Sara Austin, MD, FAAN
Specialty: Neuromuscular disease Board Certified in Neurology and EMG
711 F West 38th Street
Austin, TX 78705
512-637-5854
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Peripheral Neuropathy
Peripheral vs. Central
Neuro=nerve
‘pathy’=sickness
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Types of peripheral nerves
Motor nerves –from spinal cord to muscle
Sensory nerves – from sensory organelle to spinal cord
Small fiber (pain, temperature)
Large fiber (vibration, position, balance)
Autonomic nerves – control blood pressure, sweating, bladder function, heart rate, gut, etc. All the things you don’t have to think about
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Symptoms (how can I be numb and hurt at the same time?)
Weakness
Pain
Burning
Thick soles
Walking on stones
Tingling
Imbalance
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Distribution of numbness or weakness in peripheral neuropathy
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Causes of Neuropathy
Inflammatory (blood vessels or myelin)
Hereditary (Charcot Marie Tooth)
Metabolic (diabetes, liver, kidney)
Toxic (alcohol, chemical exposure)
Vitamin deficiency (B12, D, Thiamine…)
Drug related (chemo drugs)
Related to tumor (paraneoplastic)
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Most common neuropathies
Diabetic
Distal sensory motor, painful
Autonomic
Proximal amyotrophy (usually legs)
Vasculitic
Cranial nerve
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Most common neuropathies
Hereditary – CMT type 1, CMT type 2
B12 deficiency
Hypothyroid
Chronic inflammatory demyelinating polyneuropathy (CIDP)
Acute inflammatory demyelinating neuropathy (Guillian Barre syndrome)
Related to rheumatological diseases
Toxic – EtOH abuse
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Diagnosis
History and physical exam
Weakness? Proximal or distal?
Sensory loss? Small fiber or large fiber
Autonomic symptoms? Sweat? BP? bladder?
EMG/NCS
Lab tests: CBC, liver, kidney, electrolytes, ESR, thyroid, inflammatory markers, protein study, Vit D, B12, 2 hour diabetes test
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Chronic Inflammatory Demyelinating Neuropathy (CIDP)
Proximal and distal weakness and numbness
Usually responds to steroids or IVIG
Diagnosed by EMG/NCS
ICE study
Advice: calendar with dates, dose and drug maker
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Peripheral Nerve Myelinated vs. demyelinated
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Chemo Neuropathies
Most common with cisplatin, taxanes, ara-C, ifosfamide
Initial symptoms are numbness, paresthesias and pain in feet
Drug withdrawal, if possible, usually reverses symptoms- hard decision
Symptoms may continue to progress for weeks to months (coasting), then plateau and fade (hopefully)
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Neuropathy mimics
Restless Leg Syndrome (RLS)
Erthyromelalgia
Entrapment neuropathies (carpal tunnel, ulnar neuropathy, tarsal tunnel syndrome)
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Treatment
Try to find cause of neuropathy and reverse it
Treat symptoms
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Treatment of symptoms
Tricyclic antidepressants and SNRI’s Nortriptyline, Amitriptyline, Cymbalta, Effexor
Anti-seizure medications Gabapentin, Lyrica, Topamax, …..
Topical agents-lidocaine patch, creams, capsacin
Narcotics
NSAID’s
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Treatment of Symptoms
Alpha lipoic acid (?)
Stuff:
Good shoes
Practice balance
Rub feet
Watch weight
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Vitamins
If you are B12 deficient taking B12 helps
No proof that vitamins in general help/or hurt neuropathy except
B6 (pyridoxime) can cause neuropathy, don’t take more than 200mg per day
Vitamin D is getting some press recently, doesn’t hurt to take more
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Questions?