overview of the fnr luxembourg biomedical and health ... · 19/06/2017 · translational and...
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FNR
FRANK GLOD
LUXCOR HEALTH EVENT | MONDAY 19 JUNE 2017
Overview of the Luxembourg biomedical and health research ecosystem
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1P.
Luxembourg : a young research locationResearch in Luxembourg
Creating structures
• 1987 : First law on the public-sector research
• 1987 : First public Research Centres (LIH and LISER)
• 1999 : National Research Fund (FNR)
• 2003 : University of Luxembourg
• 2009 : Luxembourg Centre for Systems Biomedecine (LCSB)
• 2009 : Interdisciplinary Centre for Security Reliability and Trust (SnT)
• 2012 : Max-Planck Institute Luxembourg, dedicated to International and European Procedural Law
• 2015 : Creation of LIST (Luxembourg Institute of Science and Technology)
• 2015 : BELVAL Luxembourg Research and Innovation Campus
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2P.
Luxembourg : a young research locationResearch in Luxembourg
Sustained efforts…
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3P.
Belval – Luxembourg’s Research and Innovation CampusResearch in Luxembourg
• 120 hectares site of Luxembourg's largest steel foundry
• 750 MEUR urban renewal project
• 20 new buildings
• All major research and innovation actors
• Around 7,000 students and 3,000 teaching staff and
researchers
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4P.
Development of the Luxembourgish Economy
4
Ecoinnovation
Materials
Space
ICT
BioHealth
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5P.
(SCImago data for Field of Medicine)Scientific output
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6P.
Biomedical research from a Luxembourgish perspective
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7P.
Biomedical and Health researchResearch Actors
Systems BiomedicineParkinson’s
EnvironmentMaterialsHealth IT
Infection & Immunity Proteomics OncologyPopulation Health
Social Influences
PsychophysiologyHealth research
Tumor Biology
NeuropathologyGenetics
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8P.
Biomedical and Health researchResearch Actors
Systems BiomedicineParkinson’s
EnvironmentMaterialsHealth IT
Infection & Immunity Proteomics OncologyPopulation Health
Social Influences
PsychophysiologyHealth research
Tumor Biology
CANCER Neuro-
degeneration Parkinson’s
Immunology and
Inflammation
Population Health and Socio-environmental factors
NeuropathologyGenetics
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9P.
Biomedicine Quo vadis? From Data to Knowledge
Psycho-social Food Toxins GenesStress
Mechanistic models, Prediction
Individual level Population level
State of health and disease
Prevention Diagnosis Therapy Education Policy Development
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10P.
Personalized Medicine Consortium (PMC)
IBBLLung Cancer
Project
(PPM)
• Institute for Systems Biology (Seattle)
• Translational Genomics Research Institute (Arizona)
• Partnership in Personalised Medicine – Consortium of several U.S. centres
LCSB
~ 150M investment by Lux Gouvernment
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11P.
Patients Longitudinal
Cohorts Family
Studies
HumanYeast MouseZebrafish
Pathway and Network Analysis
Computational Models
Machine Learning
LCSB From systems biology to systems medicine
MicrobiomeOrgan on
a chip
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12P.
Integration of Clinical
and Non-Clinical Data
International Data
Hub
Computational
Disease Modelling
Bio- and Medical
Informatics
LCSB: At the interface of IT and medicine
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13P.
New ELIXIR node in Luxembourg
LCSB
Luxembourg became nodefor translational medicinedata
• Repository of biological data
• Decentralised Hub & Nodes structure for hosting data
• Assessed among the 3 strategically most important European infrastructures
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DEPARTEMENT OF POPULATION HEALTH
DEPARTEMENT OF INFECTION AND IMMUNITY
DEPARTEMENT OF ONCOLOGY
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Translational and personalized medicine in Luxembourg,
Clinical research in close collaboration with other national partners (hospitals, university, IBBL…) and become recognized in this domain at an EU level,
To implement a state-of-the-art public health research firmly implemented in the EU context and serving the needs of the country,
To develop research-oriented training & higher education activities in close collaboration with the University of Luxembourg
LIH current strategy
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16
Clinical and Epidemiological Investigation
Center
Observational
Healthy volunteers
Exploratory
Trials with IMP
Phase II & III
Registries
CTU for Belgium & Luxembourg
Coordination of EU trials
LUXEMBOURG – CHLSTRASSEN – r. Thomas Edison
CIEC
VISION-DMD
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Integrated BioBank of Luxembourg
Offering a full range of bioservicesto academia, industry and EU consortia
IBBL is an autonomous Institute organised within the Luxembourg Institute of Health (LIH)
An accredited & certifiedbiobanking infrastructure
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Integrated BioBank of Luxembourg• Preferred partner in EU projects:
• MINDACT study (Microarray In Node negative Disease may Avoid ChemoTherapy)• BIOMARKAPD project of the EU Joint Programme for Neurodegenerative Disease (JPND)
Research• STORE (for Sustaining access to Tissue and data frOm Radiobiological Experiments), FP7
Programme• IMI Cancer ID and IMI Litmus• H2020 SPIDIA4P
• EATRIS host institution for Luxembourg
• 70+ active projects (40+ fee for service contracts)
• Key projects in LU:• National centre for Excellence in Research on Parkinson's Disease (NCER-PD) (with LCSB, LIH,
CHL)• Plan National Cancer (with LNS, LU Hospitals)
• Key projects outside of LU:• EORTC (European Organisation for Research and Treatment of Cancer):
• Scientific partner and biobank infrastructure
• BIG (Breast International Group, BIG)• Aurora study 18
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19P.
FNR’s National Centre of Excellence in Research (NCER)
Joint Research Program on Earlier Diagnosis of Parkinson’s Disease
20M€ invest over 8 years
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20P.
Finance
ICT, Media, gaming
Digital health
Making use of current infrastructures and competencesFrom banking and media to digital health
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21P.
The Luxembourg Life Sciences environmentThe Luxembourg Life Sciences ecosystem
70 Cluster members
o 46 companies
o 14 service providers
o 6 public research organisations
o 4 strategic partners
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22P.
Medicine of tomorrow
Need for systemic change in the healthcare system
• Data-driven• Personalised• Patient-centered• Preventive
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23P.
Luxembourg – Healthcare System
• 1 Payor
• 4 major hospitals for acute care and 5 smallerhospitals for specialized care
• ~ 98 public Pharmacies
• ~ 2200 Practitioners (incl. Dentists)
• Laboratories:
• 3 private Laboratory groups
• 1 national Laboratory (LNS)
• Each hospital has a laboratory
• 2 major providers for the home care domain
(cover 97%)
• Up to 60 institutions for long term care
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24
Exchange and sharing of medical data
Define a national strategy (SDSI) promoting interoperability between
healthcare information management systems.
– Develop and implement a common interoperability platform to support
such data sharing and exchange
eHealth Agency in Luxembourg
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25
Agence eSanté – Platform and DSP goal
Support for enhanced diagnostic and patient treatment
High level of quality and security
Usage of more structured data
Reduction of costs
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26P.
Teaming proposal within H2020 wideningCLINNOVA
The Gap: Clinical research in Luxembourg
The Aim: Bridging between research and healthcare
Saving Time: Through teaming up with strong partners
• Strong IT component: digital medicine, eHealth records, big data analytics
• Infrastructure for clinical research: research ward, clinical imaging, phase 1 CTC, etc.…
• Firmly establish clincian-researchers in Luxembourg
Complete the value-added chain for biomedicine in Luxembourg the continuum from basic research to patient application
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27P.
FNR’s international cooperation
http://fnr.lu/fnr-international-cooperation/
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28P.
INTER: Multi-lateral international Collaborations
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29P.
Thank you for your attention
29/XX