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P2S2-2017 Programme Schedule

Day 1: Monday, 4th December 2017

9.00am-9.30am Conference Registration

9.30am – 9.40am SYMPOSIUM OPENING

9.30am – 9.40am

Professor Sir David Lane, PhD P2S2-2017 Conference Chair Chief Scientist Head of p53 lab Agency for Science, Technology and Research (A*STAR)

Dr. Ann-Marie CHACKO, PhD P2S2-2017 Conference Co-Chair Assistant Professor Head, Laboratory for Translational and Molecular Imaging (LTMI) Programme in Cancer & Stem Cell Biology Duke-NUS Medical School (Duke-NUS)

Opening address

9.40am – 11.00am SESSION 1: Keynote Lectures SESSION CHAIR: Sir David P. Lane, PhD (p53 Lab, A*STAR)

9.40am – 10.20am

Keynote Lecture: Dr. Bradley L. Pentelute, PhD Pfizer-Laubach Career Development Associate Professor Department of Chemistry Massachusetts Institute of Technology

Automated flow peptide synthesis: Toward amide bonds at nature’s pace

10.20am – 11.00am

Keynote Lecture: Dr. Richard Payne, PhD Professor Faculty of Science University of Sydney

Accelerated synthesis of modified proteins via novel ligation technologies

11.00am – 11.20am TEA BREAK

11.20am – 1.00pm SESSION 2 SESSION CHAIR: Chandra Verma, PhD (Bioinformatics Institute (BII), A*STAR)

11.20am – 11.40am

Dr. Ram Dasgupta, PhD Senior Principle Scientist Genome Institute of Singapore (GIS), A*STAR

Small Biologics (SmaB) against oncogenic signaling pathways

11.40am – 12.00pm Dr. Prakash Arumugam, PhD Principal Investigator BII, A*STAR

Using yeast 2-hybrid assay to screen for small-molecule inhibitors of protein-protein Interactions

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12.00pm – 12.20pm

Dr. Radoslaw Sobota, PhD Project Manager Institute of Molecular and Cell Biology (IMCB), A*STAR

“The time is now” - Advanced mass spectrometry and its application in biomedical research

12.20pm – 12.40pm

Dr. Ganesh Anand, PhD Associate Professor Department of Biological Sciences, National University of Singapore (NUS)

Lipid allostery in membrane proteins: Counting H-bonds for therapeutic discovery

12.40pm – 1.00pm

Dr. Chuan Fa Liu, PhD Associate Professor School of Biological Sciences, Nanyang Technological University (NTU)

Peptide drug discovery in the new era – the development of romiplostim

1.00pm – 2.20pm LUNCH AND POSTER PRESENTATION

2.20pm – 4.00pm SESSION 3 CHAIR: Charles Johannes, PhD (ICES, A*STAR)

2.20pm – 3.00pm

Keynote Lecture: Dr. Ratmir Derda, PhD Assistant Professor Department of Chemistry University of Alberta

Genetically-encoded glycopeptide libraries

3.00pm – 3.20pm Dr. Morinaka Brandon Isamu, PhD Assistant Professor Department of Pharmacy, NUS

Genome mining for posttranslational modifications

3.20pm – 3.40pm

Dr. Yihua Loo, PhD Research Scientist Institute of Bioengineering and Nanotechnology (IBN), A*STAR

Peptide bioinks for biofabrication of 3D organotypic tissue constructs

3.40pm – 4.00pm

Dr. Charles Johannes, PhD Head (Organic Chemistry) Institute for Chemistry and Engineering Sciences (ICES), A*STAR

Peptide Engineering Programme (PEP) at A*STAR

4.00pm – 4.20pm TEA BREAK

4.20pm – 6.20pm SESSION 4 CHAIR: Fernando Ferraro (p53 Lab, A*STAR)

4.20pm – 4.40pm

Dr. Tan Yaw Sing, PhD Postdoctoral Research Fellow BII, A*STAR

Stapling non-helical peptides

4.40pm – 5.00pm Dr. Raghav Kannan, PhD Senior Research Fellow BII, A*STAR

Stapling d-peptides: a novel strategy to improve peptide stability and function

5.00pm – 5.20pm Dr. Zee Upton, PhD Professor Institute for Medical Biology (IMB), A*STAR

Utility of small peptides in antagonising growth factor:ECM-mediated biological functions in cancer cells

5.20pm – 5.40pm Dr. Koh Cho Yeow, PhD Senior Research Fellow Yong Loo Lin School of Medicine, NUS

A novel thrombin-inhibiting peptide as peri-procedural anticoagulant during percutaneous coronary intervention

5.40pm – 6.00pm Dr. Dilraj Lama, PhD Senior Post-Doctoral Research Fellow BII, A*STAR

Tailored stapled-peptides targeting eIF4E

6.00pm – 6.20pm Dr Bee Hui Liu, PhD Senior Postdoctoral Fellow Cancer Science Institute of Singapore (CSI)

Structural basis for the design of a therapeutic SALL4-NuRD inhibitor for liver cancer

6.30pm onwards NETWORKING AND DINNER RECEPTION AT Duke-NUS Level 2 Atrium

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Day 2: Tuesday, 5th December 2017,

9.00am – 10.20am SESSION 5: Keynote Lectures SESSION CHAIR: Ann-Marie Chacko, PhD (Duke-NUS)

9.00am – 9.40am

Keynote Lecture: Dr. Mark Bradley, PhD Professor of High-Throughput Chemical Biology University of Edinburgh

Peptides for optical molecular imaging – and the real-time in situ detection of bacteria in man

9.40am – 10.20am

Keynote Lecture: Dr. Tony Lahoutte, MD PhD Professor Vrije Universiteit Brussel Head of Nuclear Medicine Department, University Hospital Brussel

Molecular imaging and targeting using nanobodies

10.20am – 10.40am TEA BREAK

10.40am – 12.40am SESSION 6 SESSION CHAIR: Ann-Marie Chacko, PhD (Duke-NUS)

10.40am – 11.00am

Dr. Adam Bader, PhD Senior Scientist, Sales & Business Development, MILabs, Netherlands

Single platform integrated PET-SPECT-OI-CT imaging supporting macromolecule R&D

11.00am – 11.20am

Dr. Ooi Eng Eong, MBBS PhD Professor and Deputy Director Emerging Infectious Disease Signature Research Programme, Duke-NUS

Development of a framework for accelerated translation of therapeutics against emerging disease epidemics

11.20am – 11.40am Dr. Surajit Bhattacharyya, PhD Associate Professor School of Biological Sciences, NTU

Rational design of functional mini-proteins

11.40am – 12.00pm

Dr. Eftychia Koumarianou, PhD Senior Research Fellow Cancer and Stem Cell Biology Programme, Duke-NUS

Regulatory pathway for Peptides and Proteins as Diagnostic Imaging Agents

12.00pm – 12.20pm Dr. Ali Miserez, PhD Assistant Professor School of Biological Sciences, NTU

Liquid-liquid phase separation of biomimetic peptides from the hard squid beak: From biology to biomedical applications

12.20pm – 12.40pm

Dr. Anthony Partridge, PhD Principal Scientist MSD Research Laboratories, MSD, Singapore

Macrocyclic peptide permeability: Concept, tools & lessons learned

12.40pm – 2.00pm LUNCH AND POSTER PRESENTATIONS

2.00pm – 3.20am SESSION 7 SESSION CHAIR: Rachel Ee, PhD (NUS)

2.00pm – 2.20pm

Dr. Brian Chia, PhD Group Leader Peptide Chemistry, Experimental Therapeutics Centre (ETC), A*STAR

Discovery & development of an ultra-short antimicrobial peptide with bactericidal activity

2.20pm – 2.40pm

Dr. Gavin Dawe, PhD Associate Professor and Deputy Head of Department of Pharmacology, Yong Loo Lin School of Medicine, NUS

Potential of relaxin-3 B-chain stapled peptides for treatment of neuropsychiatric disorders

2.40pm – 3.00pm Dr. Shuhui Lim, PhD Senior Scientist MSD, Singapore

Diphtheria toxin mediated delivery of engineered E3 ligases for targeted protein degradation

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3.00pm – 3.20pm Dr. Jeff Chang, PhD Research Fellow Lee Kong Chian School of Medicine, NTU

Peptide inhibitors from food against the Kv1.3 channel as therapeutics for autoimmune diseases

3.20pm – 3.40pm TEA BREAK

SESSION 8: Students/Trainee Short Talks and Poster Awards (Sponsored by MSD International) SESSION CHAIR: James Tam, PhD (NTU)

3.40pm – 4.55pm Student presentations and Awards

5.00pm SESSION 9: Closing Remarks Charles Johannes, PhD (ICES, A*STAR) P2S2-2017 Conference Co-Chair

Programme subject to changes without prior notice. Please be informed that photography and videography may be taken during the event for publicity purposes.

Organized by:

Sponsorship generously provided by: