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. CURRICULUM VITAE

University of Alabama at Birmingham (UAB) School of Medicine Faculty

DATE: November 2020 PERSONAL INFORMATION Name: Ashita Jiwat Tolwani Citizenship: U.S.A. Home Address: 2220 White Way Birmingham, AL 35226 Phone: (205) 823-0228 RANK/TITLE Position: Professor (October 1, 2011), tenured Division: Nephrology Department: Internal Medicine Business Address: ZRB 604 1720 2nd Ave S Birmingham, AL 35294 Business Phone: (205) 975-2021 Business Fax: (205) 996-2156 HOSPITAL AND OTHER (NON ACADEMIC) APPOINTMENTS: 5/2010 -10/2015, Medical Director of Nocturnal Dialysis at DaVita North Dialysis Unit 7/99 - 8/2003, Director of the DaVita Home Training Unit 8/2003 – 2008, Associate Director of the DaVita Home Training Unit EDUCATION: 9/1986 - 6/1990, B.S. Mathematics / Biology, Birmingham-Southern College 7/1990 - 6/1994, M.D., University of Alabama at Birmingham School of Medicine 7/1994 - 6/1997, Internal Medicine Residency, University of Alabama at Birmingham 7/1997 - 6/1999, Nephrology Fellowship, University of Alabama at Birmingham 7/2001 - 6/2004, Masters of Science in Epidemiology, Harvard School of Public Health LICENSURE: Alabama 19424, 9/1995 BOARD CERTIFICATION: Internal Medicine, 11/1997, recertified to 2018 Nephrology, 11/1999, recertified to 2019, recertified 2029 ACADEMIC APPOINTMENTS: 7/2016 – Inaugural Holder of the DCI Edwin A. Rutsky, MD, Endowed Chair in Nephrology (Initially Professorship until 2019) 10/1/2011 - present, Professor of Medicine, Division of Nephrology, UAB 10/2010 – present, Associate Director of ICU Nephrology, UAB 10/2006 – 9/30/2011, Associate Professor, Division of Nephrology, UAB 7/2004 - 9/2010, Nephrology Fellowship Director, Division of Nephrology, UAB 8/2002 - 6/2004, Interim Nephrology Fellowship Director, Division of Nephrology, UAB 10/2000 - 9/2006, Assistant Professor, Division of Nephrology, UAB 1999-2002, 9/2010 – present, Associate Director, Nephrology Fellowship Training Program, UAB 8/1999-9/2000, Instructor of Medicine, Division of Nephrology, UAB

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AWARDS/HONORS: 7/2002 - 6/2005, Pfizer Scholars Grant for Faculty Development in Clinical Epidemiology 2003-2011, 2013-2014, 2017-2020 UAB Department of Medicine's Top Ten Teacher Award for Excellence in Teaching 2004-2006, 2008-2018, 2020 UAB Department of Medicine's C. Glenn Cobbs, MD-Edwin A. Rutsky, MD Award for Clinical Excellence 2005-2006, Consumers' Research Council of America's "America's Top Physicians" 5/2007, UAB Argus Award for Excellence in Teaching, University of Alabama School of Medicine Class of 2008 2007-2018, Best Doctors in America 4/2008, UAB Argus Award for Best Lecturer in Urinary/Renal Correlative Pathology for Class of 2009 3/2009, UAB Argus Award for Best Lecturer in Urinary/Renal Correlative Pathology for Class of 2010 3/2009, UAB Argus Award for Best Lecturer for the Renal Module for the Class of 2011 2009, NxStage: Taking CRRT to the Next Stage 2009 Grant: A Pilot and Feasibility Study of Antimicrobial Dosing in CRRT 2010-2012, UAB Department of Medicine Education Excellence Award 2011, UAB Argus Award for Best Lecturer for the Renal Module for Class of 2013 2012, UAB Outstanding Teacher in Nephrology 2012, Argus Award for Best Lecturer for the UAB Renal Module for Class of 2015 2013, Argus Award for Best Lecturer for the UAB Renal Module for Class of 2017 2013, National Academy of Inventors Award 2014, Argus Award for Best Lecturer for the UAB Renal Module for Class of 2018 2015, Nephrology 2014 Research Supplement Award 2015, Accepted to the Center for Medical Simulation (CMS), Boston, MA’s Institute for Medical Simulation on the UAB campus for 8/11-8/14. This is a premier professional development experience. This course provides a comprehensive training for experienced educators with an interest in teaching clinical, behavioral and cognitive skills using medical simulation. 2015, Argus Award Nominee for Best Lecturer for the UAB Renal Module for Class of 2019 2015-2017, B-Metro Top Doctors 2016, President’s Award for Excellence in Teaching for the School of Medicine 2016, Unsung Hero Award in the Dept. of Medicine 2016, UAB DOM Teaching Excellence Award for 2014-2015 ($2,500) 2016, Argus Award Nominee for Best Educator in Renal for Class of 2020 2017, B-Metro magazine’s top women in medicine 8/2017, UAB Bill L Harbert Institute for Innovation and Entrepreneurship Faculty Innovation Award 2017, Argus Award Nominee for Best Educator in Renal for Class 2021 2018, Honoree Inductee, Alabama Chief Residents Society 2018, Castle Connolly Regional Top Doctor 2018 2018, Argus Award Winner for Best Educator in Renal for Class of 2022 2018, Best Doctors in America® List 2017 – 2018 2018, UAB Bill L Harbert Institute for Innovation and Entrepreneurship Faculty Innovation Award Finalist 2018, Castle Connolly Exceptional Women in Medicine 2018 2018, UAB Medicine “top-performing” provider with great skill in communicating with their patients in FY2018 2019, Castle Connolly 2019 Top Doctor and Exceptional Women in Medicine 2019, DOM $500 Teaching Excellence Award Academic Year 2017-2018 2019, Argus Award for Best Educator in Renal for Class 2023 2019-2020, Best Doctors in America 2019, Establishment of the Tolwani Innovation Fund in Nephrology to support investigators in their pursuit of product development and innovation for kidney-related diseases 2020, DOM $500 Teaching Excellence Award Academic Year 2018-2019 2020, Alabama Magazine Top Doctors Nephrologist 2020, American Society of Nephrology (ASN), Robert G. Narins Award (Lifetime Teaching Award in Education) 2020, Argus Award for Best Educator in Renal for Class 2024

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PROFESSIONAL SOCIETIES: 2000-present, National Kidney Foundation (NKF) 2001-present, Medical Association of the State of Alabama 2001-present, American Society of Nephrology (ASN) 2004-present, International Society of Nephrology (ISN) 2004-present, International Society for Peritoneal Dialysis (ISPD) 2/2007-present, Southern Society of Clinical Investigation (SSCI) COUNCILS AND COMMITTEES: Committees: UAB: Member, UAB Department of Medicine Appointments, Promotions, and Tenure Committee (DOM APTC), 3/2013 – present Chair of UAB Department of Medicine Appointments, Promotions, and Tenure Committee (DOM APTC), 9/1/2014 – present UAB Nephrology Fellowship Clinical Competency Committee, 2014-present UAB Nephrology Annual Program Evaluation Committee, 2014-present UAB Division of Nephrology Consult Champion, 2016-present UAB AKI Task Force for Patient & Safety Committee, 2019-present National/International: American Society of Nephrology (ASN) abstract reviewer. 2005, 2008, 2010-2017, 2020: Acute Kidney Injury Network Workgroup, Vancouver, Canada 9/2006 Gambro Speakers Bureau/Expert Forum, 1/2007-2014 Acute Dialysis Quality Initiative (ADQI) VI (AKI in Cardiac Surgery) Workgroup Chair: Treatment for CSA-AKI, Vicenza, Italy, 5/26-28, 2007 ASN In-Training Examination Question Writing committee, National Board of Medical Examiners (NBME), Philadelphia, PA 2008-2010 ASN Training Program Directors Executive Committee, 2008-2010 ASN Training Program Directors' Retreat, Chicago, Illinois, Co-Group Leader for Curriculum Workshop, May 15-16, 2009 National Kidney Foundation Organizing Committee 2010-2012: 2010 Program, Orlando, FL, May 29, 2009 2011 Program, Las Vegas, NV, July 9, 2010 National Kidney Foundation (NKF) Abstract Reviewer 2010: AKI, ICU, Nutrition

2011: AKI, Nutrition Acute Dialysis Quality Initiative (ADQI) VIII (Hepatorenal Syndrome), Kauai, 3/17-3/19/2010: Facilitator for Group 4: Device Management of HRS (CRRT, HD, LAD, MARS, etc.) Judge for the National Kidney Foundation 6th Annual National Young Investigators Forum for Clinical Research, 4/26/2011r

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AVOID – HF (Aquapheresis Versus Intravenous Diuretics and Hospitalizations for Heart Failure) protocol Steering Committee for CHF Solutions, 7/16/2011 KDOQI Guideline Commentary Work Group for the KDIGO AKI Clinical Practice Guidelines, 6/2011-3/2013 MKSAP 17 Nephrology Committee for question writing, American College of Physicians, 11/2013-2015 AKI & CRRT International Conference on Advances in Critical Care Nephrology Organizing Committee, 2015-present Acute Disease Quality Initiative (ADQI) XVII Workgroup on CRRT: Solute Control, Vicenza, Italy, 6/10-13, 2016 (ADQI started in response to concerns about the quality of care delivered to patients with acute kidney disease. The ADQI strategy is to follow the path of Evidence Based Medicine by first achieving a critical analysis of the evidence available. The first goal of such critical analysis is to generate several consensus statements that describe, classify and interpret the available evidence and define the issues and areas of clinical and laboratory research which require priority attention. The second goal is to achieve dissemination of such consensus statements through publication in the literature. The third goal is to use the focus and impetus provided by such statements to facilitate or conduct focused research in the field) MKSAP 18 Nephrology Committee for question writing, American College of Physicians, 9/2016-2018 Acute Disease Quality Initiative (ADQI) XVIII Consensus Guideline Conference on “AKI in Developing Countries”; Work Group 4: Renal Support, Hyderabad, India, 9/27-30, 2016 National Policy Forum on critical care and acute renal failure, steering committee member and panelist, Washington DC, 2/7/2017 Co-chair of the ISN-ANIO (International Society of Nephrology- American Nephrologists of Indian Origin) India Committee's AKI Subcommittee, 4/2017 Acute Disease Quality Initiative (ADQI) XXI Consensus Conference on “Improving Care for Patients with AKI”; Work Group 4: Quality of care and safety measure of renal replacement therapy for AKI, San Diego, CA 10/2018 KDIGO Controversies Conference on Acute Kidney Injury. Work group 5: Renal Replacement Therapy, April 25-28, 2019, Rome, Italy Kidney Disease: Improving Global Outcomes (KDIGO) is an international organization whose mission is to improve the care and outcomes of kidney disease patients worldwide by promoting coordination, collaboration, and integration of initiatives to develop and implement clinical practice guidelines. Co-chair and Co-course Director of ASN Critical Care Nephrology Pre-Course 11-2019- present Acute Disease Quality Initiative (ADQI) XXV Consensus Conference on “COVID-19 AKI”; Work Group 5: Hemoperfusion, 5/2020 Workgroup Member: AKI!Now: Promoting Excellence in the Prevention and Treatment of Acute Kidney Injury; ASN Initiative, 2019 to present AJKD NephMadness 2021 Selection Committee EDITORIAL BOARD Baxter Renal CRRT Advisory Board, November 2009-present Guest Editor of Seminars in Dialysis: the Clinical Application of Continuous Renal Replacement Therapies-Current Status, March-April 2009, volume 22, Number 2

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Faculty for Critical Care & Emergency Medicine for F1000: Post-publication Peer Review: http://f1000.com/thefaculty/medicine; Faculty Members (FMs) evaluate, rate and classify articles for inclusion in F1000. Neph Ed Section of Clinical Nephrology: This section is devoted to manuscripts with educational value to trainees in nephrology. These include in-depth comprehensive review articles with pedagogical tables and figures, case reports and articles pertaining to novel methods of teaching and assessment in nephrology education, September 2009 to present Editorial Board of Clinical Journal of American Society of Nephrology, 2011-present Associate Editor of BioMed Centra (BMC) Nephrology 8/2013 – 4/2015 Kidney International Reports, 1/2016 - present MAJOR RESEARCH INTERESTS: Continuous Renal Replacement Therapy (CRRT) Citrate anticoagulation for CRRT Acute Kidney Injury in the ICU TEACHING EXPERIENCE:

UAB Courses Directed and Organized (International Course): UAB CRRT Academy: Chair, course director, coordinator, organizer and speaker (unrestricted educational grant provided by Baxter, DaVita and NxStage). This national course involves lectures, hands on workshops, simulations, interactive problem sessions, and a pre and post-test. Trainees and practicing physicians (nephrology, critical care surgery/anesthesiology/pulmonary/neurology, as well as nurses and pharmacists come from all over the United States as well as from Mexico, Pakistan, and India, 2007-2020 UAB Peritoneal Dialysis Academy, course co-director and organizer (2003-2012), and speaker:

1/29/2015: Lecture on PET 1/20/2016: Lecture on PET and Adequacy 1/19/2017: Lecture on PET and Adequacy

UAB Course Director, Nephrology Consult Elective for International Medical Students, 4/2015 to present MAJOR LECTURES AND VISITING PROFESSORSHIPS University of California at San Francisco (Renal Grand Rounds):Citrate Anticoagulation in Continuous Renal Replacement Therapy, 12/06/2000

Emory University, Atlanta, GA (Renal Grand Rounds): Citrate Anticoagulation in Continuous Renal Replacement Therapy, 2/17/2004

Dallas Nephrology Associates, Dallas, TX: Regional Citrate Anticoagulation for CRRT, 4/28/2005 - 4/29/2005 Carraway Methodist Center, Birmingham, AL: Medical Grand Rounds: Indications for Dialysis in the Intensive Care Unit 2/25/2003

Residents' Conference: Acute Renal Failure: What's New in the ICU, 4/13/2005

University of Chattanooga at Tennessee (Medical Grand Rounds): Renal Replacement Therapy for Acute Renal Failure: What's New in the ICU, 6/23/2005

Beth Israel Medical Center, NY (Renal Grand Rounds): Continuous Renal Replacement Therapy and Citrate Anticoagulation, 4/27/2006

William Beaumont Army Medical Center, El Paso, TX (Medical Grand Rounds):

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Acute Renal Failure: What's New in the ICU, 5/12/2006 Gambro Expert Panel:

Ohio State University, Columbus, OH 6/13/2006: CRRT: Techniques and Dose of Dialysis Kettering Medical Center in Dayton, OH, 5/03/07: CRRT: Dose Kettering Medical Center in Dayton, OH, 5/03/07: CRRT: Dose Ohio State University, Columbus, OH, 5/02/07: CRRT: Dose University of Tennessee Hospital, Knoxville, TN, 3/29/2007: Continuous Renal Replacement Therapy: Why Do It and How? Augusta University Hospital, Augusta, GA, 7/19/07: Continuous Renal Replacement Therapy: Why Do It and How? Piedmont Hospital, Atlanta, GA, 7/26/07: Continuous Renal Replacement Therapy: Why Do It and How? Dothan Hospital, Dothan, AL, 10/11/07: Continuous Renal Replacement Therapy: Why Do It and How? Hartford Hospital, Hartford, Connecticut 9/10/2008: CRRT and Anticoagulation Lakewood Hospital, Lakewood, Ohio 4/29/2010: Timing of AKI Interventions NE Georgia Hospital, Gainesville, GA 5/5/2010: CRRT: Patient Selection, Initiation, and Dose DCH, Tuscaloosa, AL 11/17/2011: Acute Renal Replacement Therapy Baptist Hospital, Nashville, TN 3/1/2012-3/2/2012: CRRT: Patient Selection, Initiation, and Dose Renal Associates, Little Rock, AR 4/3/2013: CRRT for AKI Trauma and Critical Care, Erlanger Hospital, Chattanooga, TN, 7/19/2013: CRRT and anticoagulation

South Carolina School of Medicine Medical Grand Rounds, Columbia, SC: Acute Renal Failure: What's New in the ICU, 10/15/2007

Medical Grand Rounds, Kadlec Medical Center, Pasco, Washington: Continuous Renal Replacement Therapy, 2/7/08

Educational Meeting, Tuscaloosa Lung & Sleep Consultants at DCH Regional Medical Center, Tuscaloosa, AL: Continuous Renal Replacement Therapy, 2/14/2008 University of Pennsylvania, Philadelphia, Pennsylvania, (Renal Grand Rounds):

Acute Kidney Injury: What's New in the ICU, 8/12/08

Drexel University, Philadelphia, PA (Renal Grand Rounds): Acute Kidney Injury: What's New in the ICU, 10/14/08

Rochester University- Strong Memorial Hospital, Rochester NY (Renal Grand Rounds): CRRT, May 27, 2009

Cleveland Clinic, Cleveland, OH (Renal Grand Rounds): Acute Kidney Injury: What's New in the ICU, 6/24/2009

University of Mississippi, Jackson, FL (Renal Grand Rounds): Dose of Dialysis in AKI, 4/23/2010

University of California at San Francisco, Nephrology Grand Rounds, San Francisco, CA: CRRT: Patient Selection, Indications, and Dose, 9/1/2010

University of Utah, Nephrology Grand Rounds, Salt Lake City, Utah: CRRT: The Technical Issues, 9/8/2010

University of Chattanooga at Tennessee (Renal Grand Rounds): Renal Replacement Therapy for Acute Kidney Injury: When and How? 4/13/2011

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University of Arizona in Tucson, Division of Nephrology, CRRT symposium: Fundamentals of CRRT, 2/19/2013 University of Louisville, Medical and Renal Grand Rounds, Louisville, KY: Medical Grand Rounds: AKI: the Growing Threat, 5/16/2013 Renal Grand Rounds: RRT for AKI, 5/17/2013 Winthrop-University Hospital, Mineola, NY: Renal Grand Rounds: CRRT in Critical Care, 10/10/2014 University of Arizona, Tucson, AZ: CRRT workshop for fellows, 3/30/2016 Toronto, Canada:

Keynote speaker for Uldall Day, 6/21/2017: Keys to a Successful Acute Dialysis Program: Lessons Learned

Nephrology fellow conference, 6/21/2017: CRRT cases Mt. Sinai, New York, NY: Mount Sinai Special Clinical Conference, 12/8/2017 Educational Lectures for National and International Professional Organizations and Societies: Gambro Information Technology Group, Gambro, Lakewood, CO: Presentation on the usefulness of a Gambro physician website for improving patient care, 11/2001 Gambro Operations Division, Orange County, CA: The Gambro Patient Information Website: the Physician's Perspective, 4/17/2002 3rd International Course on Critical Care Nephrology, Vicenza, Italy: A Randomized Controlled Prospective Study Comparing High Dose CVVHDF to Standard Dose CVVHDF in Critically Ill Patients with Acute Renal Failure—Lessons Learned, 6/1/2004 - 6/4/2004 Non-Renal Indications for CRRT Symposium, GAMBRO Western Division Annual Meeting, Las Vegas, Nevada, 6/24/2004:

Liver Support Systems Extracorporeal Blood Treatment: Practical Aspects and Challenges

Sunnybrook and Women’s College Health Science Centre, Toronto, Ontario, Canada: The Seven Questions when starting a CRRT Program, Initiating and Maintaining a Continuous Renal Replacement Therapy Program, 10/3/2004 Nurses Society National Academy, Indian Wells, CA: Fluid and Electrolyte Disturbances in the Renal Patient, Infusion, 11/6/2004 American Nephrology Nurses Association:

Botanical Gardens, Birmingham, AL: CRRT, 10/1999 Care of the Hospitalized End Stage Renal Disease Patient, 20th Annual Nephrology Update, 11/18/2004 Fall Meeting 2004, New Orleans, LA: Modality of Choice for Acute Renal Failure, 10/16/2004 -10/18/2004 Carraway Davie House, Birmingham, AL: CRRT: Delivery and Dose, 11/13/2007, 23th Annual Nephrology Update

International Continuous Renal Replacement Therapy Conference, San Diego, CA: Organizer: Fundamentals of CRRT 2010-present Abstract Reviewer: 2015, 2016, 2017, 2018, 2019, 2020

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Lectures: Dose of Dialysis in CRRT: Results of a Randomized Controlled Trial, 3/10/2007 The Changing Face of AKI: Snapshots from Around the World, 2/15/2013 Adapting to Adversity: Drug Shortages in CRRT, 3/2014 Fundamentals of CRRT Lectures 2009-2020

American Society of Nephrology Critical Care Nephrology PGE Course, Philadelphia, PA:

Renal Replacement Therapy in Acute Renal Failure: Technical Issues: CRRT, ICU Nephrology and Acute Renal Failure: What the Nephrologist Must Know, 11/2005

National Kidney Foundation, Chicago, IL: The How to and What's New with Acute Kidney Injury and Failure: CRRT: Techniques and Dose of Dialysis, 4/22/2006 American Society of Nephrology Critical Care Nephrology PGE Course, San Diego, CA:

Renal Replacement Therapy in AKI: Technical Issues: CRRT, 11/15/2006 Vasopressors and Natriuretic Peptides, 11/14/2006

6th Annual Best Clinical Practice Symposium at Sacred Heart Hospital, Pensacola, FL: Approach to the Older Patient with Kidney Dysfunction, 1/20/2007 National Kidney Foundation, Orlando, FL: Technology Update in Dialytic Care: CRRT Up Date: Dose, 4/13/2007 16th International Vicenza Course on Critical Care Nephrology, Vicenza, Italy, 5/29/07-6/1/07: Sustained Low Efficiency Dialysis (SLED), 5/31/2007

14th Annual Geriatric Conference by the Medical Council of Pensacola in joint sponsorship with West Florida Hospital Education & Professional Development Services and the Florida Geriatrics Society, Pensacola, FL: Care of the Aging Kidney, 2/22/2008 National Kidney Foundation, Dallas, TX: Management of AKI: CRRT vs. IHD for AKI: CRRT is Better, 4/04/08 Update in Critical Care Conference: Implementing Bedside Practice, Providence, RI: Acute Kidney Injury: What’s New in the ICU? 6/06/08 Continuous Renal Replacement Therapy: CRRTeams, University of Pittsburgh, Pittsburgh, PA, 10/2/08 – 10/22/10: Catheters and Anticoagulation Workshop 10/2/08, 11/9/09, 11/10/09, 10/22/2010

CVVH, CVVHD, CVVHD: The Technical Issues 10/3/08, 11/9/09, 10/21/2010 National Kidney Foundation, Nashville, TN: Electrolytes Workshop, 3/26/09, 3/27/09 American Society of Nephrology Highlights (SLANH 2009): Acute Kidney Injury, Mexico City, Mexico, 4/15/09 American Society of Nephrology, San Diego, CA:

Literature Review: ICU Nephrology, October 29, 2009 Anticoagulation for CRRT (Critical Care Nephrology: 2009 Update), October 28, 2009

Society of Critical Care Medicine, Miami, FL 1/9/2010: Anticoagulation for CRRT

National Kidney Foundation, Orlando, FL: Co-Chair: Extracorporeal Support: Where Are We Now? 4/14/2010 Lectures:

Dose in AKI, 4/14/2010 Critical Care Update, 4/16/2010

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Anticoagulation for CRRT, 4/17/2010

American Society of Nephrology Board Review Course Faculty 2010-2020: American Society of Nephrology, Denver, Co: Anticoagulation for CRRT (Critical Care Nephrology Course), 11/17/10 Society of Critical Care Medicine-Clinical Focus: Clinical Aspects of Acute Kidney Injury and Treatment Protocols, Atlanta, GA, 3/11/2011: Back to basics - CRRT 101 Anticoagulation, citrate, and vascular access National Kidney Foundation, Las Vegas, NV: Acute Renal Replacement Therapies, 4/29/2011 MGH Nephrology Update 2011, Boston, MA, 6/09/2011, 6/14/2012: Dialytic Management of AKI AKI Cases The New Orleans Conference Perfusion Society, New Orleans, LA, 2009-2013:

American Society of Nephrology, Philadelphia, PA: Critical Care Nephrology Early Program: Practical Considerations in the Management of CRRT 11/09/2011 Anticoagulation Strategies in RRT: Can Citrate Anticoagulation Improve Outcomes? 11/12/2011 Florida Society of Nephrology Annual Conference, Manalapan, FL: Renal Replacement Therapy for Acute Kidney Injury 9/22/2012 American Society of Nephrology, San Diego, CA: Critical Care Nephrology Early Program: Practical Considerations in the Management of CRRT 10/31/2012 Chair/Moderator: AKI in the Wards Session 11/1/2012 33rd International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium: March 19-22, 2013: Anticoagulation for CRRT: Improvements in the Delivery of Regional Citrate Anticoagulation, 3/19/2013

Moderator for session on liver failure, 3/21/2013 Continuous renal replacement therapy tutorial, 3/22/2013

Citrate anticoagulation for CRRT, 3/22/2013

31st Annual American Association of Physicians of Indian Origin Convention May 23-May 27, 2013: Acute Kidney Injury: A Growing Threat, 5/25/2013

World Congress of Nephrology Satellite Symposium on Acute Kidney Injury, Shanghai, China June 6, 2013: Anticoagulation Strategies for Continuous Renal Replacement Therapy Continuous Renal Replacement Therapy for Acute Kidney Injury CRRT Symposium, Chengdu, China June 5, 2013: CRRT for Rhabdomyolysis American Society of Nephrology, Atlanta, GA: Critical Care Nephrology Early Program: Practical Considerations in the Management of CRRT 11/6/2013

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Lecture: Catheters in the AKI Setting: Where to Place and How to Lock, 11/7/2013 Chair/Moderator: AKI oral abstract session, 11/7/2013 Gambro-Baxter Visiting Speakers Series, Deerfield,IL 8/7/2014: Lecture: Regional Citrate Anticoagulation for CRRT American Society of Nephrology, Philadelphia, PA: Critical Care Nephrology Early Program: Practical Considerations in the Management of CRRT, 11/12/2014 Chair/Moderator: AKI: Interventions, Biomarkers, Genetics, and More Abstract Session 11/13/2014 World Congress of Nephrology, Capetown, South Africa 3/16/2015: Renal Support in the ICU: What Works? National Kidney Foundation, Dallas, TX: 3/25/2015: Renal Replacement Therapy in AKI: Timing, Modality, and Dose 33rd Vicenza Course on Critical Care Nephrology, Vicenza, Italy: 6/10/2015: Lecture: RRT in AKI and Critical Illness: Treatment Modality Selection 6/10/2015: Co-Chair of Multiple Organ Support Therapies Session 6/11/2015: Lecture: RCA with post dilution RF and FF 1st Singapore Society of Nephrology CRRT Course 2015 10/16-10/18/2015:

Lectures on Dose, Modality of CRRT, Antibiotic Dosing in CRRT, CRRT Fluid Management and Invasive Monitoring, CRRT Citrate Intolerance and Toxicity, Case Scenarios

American Society of Nephrology, San Diego, CA: Critical Care Nephrology Early Program: Practical Considerations in the Management of CRRT, 11/4/2015 Master Class: How to Teach Dialysis Modality Selection and Prescription in the ICU Setting 11/6/2015 MKSAP 17 Audio Companion Contributor: Nephrology Section, 12/2015 36rd International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium: March 15-18, 2016 Lectures: Hemofiltration techniques, 3/18/2016

Anticoagulation: The various options, 3/18/2016

Kidney Con Conference, University of Arkansas Medical Sciences, 4/9/2016, Lecture: CRRT: Early or Late? 4/8/2017, Lecture: CRRT: Early or Late?

34th Vicenza Course on AKI&CRRT, Vicenza, Italy, June 8-June 10, 2016:

Lectures: CRRT in AKI and Sepsis, June 9, 2016 Chair: Session on RRT in AKI Chair: Session on New Technologies

CRRT Highlights, Hyderabad, India, September 30- October 1, 2016; CRRT pre and post Test, 9/30/2016 CRRT: Access, Membrane, Circuit, Anticoagulation, Modality, Dose, 9/30/2016 CRRT: Circuit, Anticoagulation Regimens, and Monitoring Hands-on Workshop, 9/30/2016 What’s New in RRT for AKI, 10/1/2016

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American Society of Nephrology, Chicago, IL: Lecture: Critical Care Nephrology Early Program: Practical Considerations in the Management of

CRRT, 11/16/2016 Moderator: Nephrology Faculty Development 2016: Art and Science of Teaching 11/18/2016

Baxter ATI Summit on AKI and CRRT in LA, CA: CRRT Fundamentals 5/12/2017 American Society of Nephrology, New Orleans, LA:

Lecture: Critical Care Nephrology Early Program: Practical Considerations in the Management of CRRT, 11/1/2017

Lecture: Timing of AKI Dialysis-Why the Answer is Not That Simple 11/2/2017

1ST ASIA PACIFIC AKI & CRRT 2017 Congress, Kuala Lumpur, Malaysia, August 20-23, 2017: CRRT pre and post test CRRT: Back to Basics Anticoagulation for CRRT Circuit, Anticoagulation and Monitoring Hands on Session Strategies for Optimizing the CRRT Circuit-Citrate Anticoagulation Workshop Meet the Experts: Forget the Evidence-When Do I Start CRRT

Measuring Outcomes in AKI and CRRT: Which Benchmarks Should We Use?

UCSF Management of the Hospitalized Patient Course, San Francisco, October 20, 2017 Diagnosis and Management of AKI Tough Cases in Nephrology Baxter ATI Summit on AKI and CRRT in LA, CA: CRRT Prescription Workshop 5/19/2018 2nd Asia Pacific AKI CRRT Congress (AP AKI CRRT 2018), 9/21-9/24/2018, Taipei, Taiwan: Abstract reviewer Lectures:

CRRT: Back to Basics Workshop: Circuit, Anticoagulation, and Monitoring Workshop: Strategies for Optimizing the CRRT Circuit How to define clinical excellence of CRRT 3rd Annual Selections from AKI & CRRT 2018, 9/26-9/27/2018, Hyderabad, India: Which anticoagulant for CRRT?

Update on trials for AKI and Critical Care Nephrology: Literature Review Establishing Benchmarks for Quality for AKI and CRRT CRRT pre and post Test CRRT Basics Circuit, Anticoagulation and Monitoring Interactive Clinical Cases

2nd SSN CRRT & ECBP COURSE 2018, 10/5-10/6/2018, Singapore: Precision CRRT Dose and Modality of CRRT

Anticoagulation for CRRT – Heparin & Regional Citrate Regional Citrate Anticoagulation Workshop

American Society of Nephrology, San Diego, CA: Lecture: Critical Care Nephrology Early Program: Practical Considerations in the Management of

CRRT, 10/24/2018

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Baxter ATI Summit on AKI and CRRT in Louisville, KY: CRRT Fundamentals, Timing of Initiation of RRT, CRRT Prescription Workshop 11/8/2018 National Kidney Foundation, Boston, MA: 5/8/2019: Lecture: CRRT Quality Metrics (Updates in Critical Care)

5/10/2019: Moderator for Session: Acute Renal Replacement Therapy: Best Practices and Special Circumstances 5/10/2019: Lecture: Now or Later? Optimal Timing of Acute RRT Initiation

37th Vicenza Course on AKI & CRRT, Vizenza, Italy: 5/28/2019: Co-chair of session: Basics of CRRT 5/28/2019: Lecture: Anticoagulation in CRRT 5/29/2019: Meet the Experts Path: Managing anticoagulation in CRRT 5/30/2019: Preserving circuit patency in CRRT Cleveland Clinic 2019 Nephrology Update, Cleveland, OH: 9/20/2019: Practical Considerations of CRRT 9/20/2019: Timing of RRT in Critically Ill Patients with Acute Kidney Injury Baxter ATI Summit on AKI and CRRT in Boston, MA: CRRT Fundamentals, CRRT Prescription Workshop 10/4/2019 3nd Asia Pacific AKI CRRT Congress (AP AKI CRRT 2019), 10/11-10/14/2019, Kuala Lumpur, Malaysia: Abstract reviewer Lectures: Anticoagulation Principles Workshop: Circuit, Anticoagulation, and Monitoring Workshop: Strategies for Optimizing the CRRT Circuit Session Chair: Organ Cross Talk in Critically Ill Patients 4th Annual Selections from AKI & CRRT 2019, 10/15-10/16/2019, Hyderabad, India: CRRT pre and post Test

CRRT Basics Circuit, Anticoagulation and Monitoring Interactive Clinical Cases

American Society of Nephrology 2019, 11/5-11/10/2019, Washington DC: Co-Director of Critical Care Nephrology pre-course: 11/5, 11/6 Lectures: Practical Consideration of CRRT; Timing of CRRT 11/6 Moderator: Update on Acute Dialytic Modalities in Nephrology: What Are the Data? 11/10 Society of Critical Care Medicine 2020, Orlando, FL Lecture: What the ICU Team Should Know About Acute Renal Replacement Therapy 2/2020 National Kidney Foundation 2020, Virtual Conference, March 2020: Updates in Critical Care Nephrology: Dialysis: CRRT and SLED Basics Updates in Critical Care Nephrology: Tough CRRT Cases Sepsis-Associated AKI: RRT in Sepsis-Associated AKI: Timing, Dose, and Modality

Transplanting New Guidelines into Practice in HRS and AKI: Everything is Fixed, Right?: New Guidelines for Proactive Identification of HRS/AKI: Putting Them Into Practice

Co-Chair: Long-Term Outcomes after AKI: How can Nephrologists Help? NuGoKidney (The Northwestern University George M. O’Brien Kidney Research Core Center) Webinar, Northwestern University, 4/20/2020: CRRT for AKI During COVID-19 Pandemic

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Baxter Virtual Brazilian Fluids and PrisMax Launch Event: Citrate Anticoagulation for CRRT, 9/18/2020 Baxter Critical Care Institute Virtual Summit, 9/29-9/30, 2020: Fundamentals of CRRT lecture and Meet the Experts Q & A American Society of Nephrology Virtual Meeting 2020,

Co-Director of Critical Care Nephrology pre-course: 10/19, 10/20 Lecture: Advanced CRRT Practices: A Case-Based Approach Moderator: Coronavirus Panel 10/20 Managing Electrolyte Abnormalities on CRRT. The Burton D. Rose, Endowed Lectureship Moderator: Nephrology Quiz and Questionnaire 10/25

38th Vicenza Course on AKI & CRRT: a week of virtual meetings, 11/2-6, 2020: Lecture: Moving from acute RRT to chronic RRT, 11/6, 2020 AKI & CRRT Virtual Course: Sao Paulo, Brazil, 11/12-13, 2020

Lectures: Timing of RRT in AKI, Clinical Case Discussion, Practical Considerations in the Management of CRRT Baxter Satellite Symposium: Citrate Anticoagulation in the CRRT

GRANT SUPPORT: Active: Sponsor: University of California, San Diego Strategy for Timely Intervention of Renal Support (STIRS) Role: PI 7/20/2017 to present IRB Project Number (IPN): IRB-300005107 Sponsor: Shruti Gupta, MD, MPH, and David E. Leaf, MD, MMSc (Division of Renal Medicine, Brigham and Women's Hospital) IRB Project Title: Multicenter Study of COVID-19 Disease in Critically Ill Patients in the US: Examination of the Incidence, Risk Factors, Clinical Features, and Outcomes of Acute and Chronic Kidney Disease Role: Co-Site PI 3/2020 to present Other Ongoing Studies: Epidemiology of AKI in ICU (multi-center AKI registry) Role: PI 2009 to present Biological characterization of acute kidney injury in patients in the intensive care unit (Multi-center AKI repository) Role: PI Normal Ranges of biomarkers of kidney injury in a healthy population (Multi-center registry). Role: PI Ultrasound Assessment of Volume in Patients on Continuous Dialysis (IRB#F160407004) UAB Pilot Study (PI Dr. Eric Judd) Role: Sub-Investigator 6/2016-present The Role of Intravenous Fluids and Vasoactive Agents Resuscitation in the Development of Early Acute Kidney Dysfunction in Two Cohorts of ICU Patients UAB Pilot Study (PI Dr. Ahmed Zaky in the Division of Anesthesiology) Role: Co-Investigator MANUSCRIPTS:

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1. Miller, P.E., Tolwani, A.,Luscy, C. P., Deierhoi, M. H., Bailey, R., Redden, D. T., Allon, M. Predictors of adequacy of arteriovenous fistulas in hemodialysis patients. Kidney Int 56, 275-280 (1999).

2. Tolwani RJ, Waggie KS, Green SL, Tolwani AJ, Lyons DM, Schatzberg AF, Dilative cardiomyopathy

leading to congestive heart failure in a male squirrel monkey (Saimiri sciureus), J Med Primatol 2000: 29:42-45.

3. Tolwani, A.J., Campbell, R.C., Schenk, M.B., Allon, M. & Warnock, D.G. Simplified citrate

anticoagulation for continuous renal replacement therapy. Kidney Int 60, 370-374 (2001).

4. Lopez-Ben, R., Tolwani, A., Chatham, W., Pitt, M.J. & Alarcon, G.S. Normal radiographs in patients with persistent "hip pain"--value of magnetic resonance imaging. J Rheumatol 29, 2463-2465 (2002).

5. Uchino, S., Doig, G. S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C.,

Nacedo, E., Gibney, N., Tolwani, A., Ronco, C., Kellum, J. A. Diuretics and mortality in acute renal failure. Crit Care Med 32, 1669-1677 (2004).

6. Warnock, D.G., Tolwani, A.J., Gallichio, M. & Allon, M. Vascular grafts for hemodialysis: types, sites

and techniques. Contrib Nephrol 142, 73-93 (2004).

7. Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Doig, G. S., Oudemans van Straaten, H., Ronco, C., Kellum, J. A. External validation of severity scoring systems for acute renal failure using a multinational database. Crit Care Med 33, 1961-1967 (2005).

8. Uchino, S., Kellum, J. A., Bellomo, R., Doig, G. S., Morimatsu, H., Morgera, S., Schetz, M., Tan, I.,

Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Ronco, C.. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294, 813-818 (2005).

9. Tolwani, A. Renal replacement therapies for acute renal failure: does dose matter? Am J Kidney Dis 45,

1139-1143 (2005).

10. O'Reilly, P. & Tolwani, A. Renal replacement therapy III: IHD, CRRT, SLED. Crit Care Clin 21, 367-378 (2005).

11. Tolwani, A.J., Prendergast, M.B., Speer, R.R., Stofan, B.S. & Wille, K.M. A practical citrate

anticoagulation continuous venovenous hemodiafiltration protocol for metabolic control and high solute clearance. Clin J Am Soc Nephrol 1, 79-87 (2006).

12. Tolwani, A. & Wille, K.M. Citrate-based replacement solutions with continuous venovenous

hemofiltration: not as simple as it sounds. Am J Kidney Dis 47, 1086; author reply 1086-1087 (2006).

13. Bagshaw, S.M., Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H. M., Ronco, C., Kellum, J. A.. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol 2, 431-439 (2007).

14. Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E.,

Gibney, N., Tolwani, A., Oudemans-van Straaten, H., Ronco, C., Kellum, J. A.. Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators. Intensive Care Med 33, 1563-1570 (2007).

15. Uchino, S., Bellomo, R., Kellum, J. A., Morimatsu, H., Morgera, S., Schetz, M. R., Tan, I., Bouman, C.,

Macedo, E., Gibney, N., Tolwani, A., Oudemans-Van Straaten, H. M., Ronco, C.. Patient and kidney

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survival by dialysis modality in critically ill patients with acute kidney injury. Int J Artif Organs 30, 281-292 (2007).

16. Tolwani, A.J., Wheeler, T.S. & Wille, K.M. Sustained low-efficiency dialysis. Contrib Nephrol 156, 320-

324 (2007).

17. Pisoni, R., Wille, K.M. & Tolwani, A.J. The epidemiology of severe acute kidney injury: from BEST to PICARD, in acute kidney injury: new concepts. Nephron Clin Pract 109, c188-191 (2008).

18. Tolwani, A.J., Campbell RC, Stofan BS, Lai KR, Oster RA, Wille KM. Standard versus high-dose

CVVHDF for ICU-related acute renal failure. J Am Soc Nephrol 19, 1233-1238 (2008).

19. Tolwani, A., Paganini E, Joannidis M, Zamperetti N, Verbine A, Vidyasagar V, Clark W, Ronco C. Treatment of patients with cardiac surgery associated-acute kidney injury. Int J Artif Organs 31, 190-196 (2008).

20. Tumlin, J., Wali, R., Williams, W., Murray, P., Tolwani, A. J., Vinnikova, A. K., Szerlip, H. M., Ye, J.,

Paganini, E. P., Dworkin, L., Finkel, K. W., Kraus, M. A., Humes, H. D.. Efficacy and safety of renal tubule cell therapy for acute renal failure. J Am Soc Nephrol 19, 1034-1040 (2008).

21. Davenport, A., Bouman, C., Kirpalani, A., Skippen, P., Tolwani, A., Mehta, R. L., Palevsky, P. M..

Delivery of renal replacement therapy in acute kidney injury: what are the key issues? Clin J Am Soc Nephrol 3, 869-875 (2008).

22. Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E.,

Gibney, N., Tolwani, A., Straaten, H. O., Ronco, C., Kellum, J. A.. Discontinuation of continuous renal replacement therapy: a post hoc analysis of a prospective multicenter observational study. Crit Care Med 37, 2576-2582 (2009).

23. Tolwani, A.J. & Wille, K.M. Anticoagulation for continuous renal replacement therapy. Semin Dial 22,

141-145 (2009).

24. Tolwani, A.J. & Palevsky, P.M. Introduction. The clinical application of CRRT--current status. Semin Dial 22, 107 (2009).

25. Davenport A, Tolwani A. Citrate anticoagulation for continuous renal replacement therapy (CRRT) in

patients with acute kidney injury admitted to the intensive care unit. NDT Plus (2009) 2: 439–447

26. Bagshaw, S.M., Uchino, S., Cruz, D., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H. M., Ronco, C., Kellum, J. A.. A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury. Nephrol Dial Transplant 24, 2739-2744 (2009).

27. Hayes, L.W., Oster, R.A., Tofil, N.M. & Tolwani, A.J. Outcomes of critically ill children requiring

continuous renal replacement therapy. J Crit Care 24, 394-400 (2009).

28. Bagshaw, S.M., Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H. M., Ronco, C., Kellum, J. A. Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury. J Crit Care 24, 129-140 (2009).

29. Rosner, M.H., Berns, J. S., Parker, M., Tolwani, A., Bailey, J., DiGiovanni, S., Lederer, E., Norby, S.,

Plumb, T. J., Qian, Q., Yeun, J., Hawley, J. L., Owens, S. Development, implementation, and results of the ASN in-training examination for fellows. Clin J Am Soc Nephrol 5, 328-334 (2010).

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30. Humes, H.D., Sobota, J.T., Ding, F. & Song, J.H. RAD Investigator Group. A selective cytopheretic inhibitory device to treat the immunological dysregulation of acute and chronic renal failure. Blood Purif 29, 183-190 (2010).

31. Shingarev R, Wille K, Tolwani A. Management of complications in renal replacement therapy. Semin Dial. 2011 Mar;24(2):197-202. doi: 10.1111/j.1525-139X.2011.00827.x.

32. Cerdá J, Tolwani A, Gibney N, Tiranathanagul K. Renal replacement therapy in special settings: extracorporeal support devices in liver failure. Semin Dial. 2011 Mar;24(2):197-202. doi: 10.1111/j.1525-139X.2011.00827.x

33. Kang SW, Shih PA, Mathew RO, Mahata M, Biswas N, Rao F, Yan L, Bouchard J, Malhotra R, Tolwani A, Khandrika S, Mehta RL, Oconnor DT. Renal kallikrein excretion and epigenetics in human acute kidney injury: Expression, mechanisms and consequences. BMC Nephrol. 2011 Jun 16;12(1):27

34. Cerdá J, Tolwani AJ, Warnock DG. Critical care nephrology: management of acid-base disorders with CRRT. Kidney Int. 2011 Aug 3. doi: 10.1038/ki.2011.243.

35. Lyndon WD, Wille K, Tolwani AJ. Solute clearance in CRRT: prescribed dose versus actual delivered dose Nephrol. Dial. Transplant. (2011) first published online September 5, 2011 doi:10.1093/ndt/gfr480

36. Bauer SR, Salem C, Connor MJ Jr, Groszek J, Taylor ME, Wei P, Tolwani AJ, Fissell WH. Pharmacokinetics and Pharmacodynamics of Piperacillin-Tazobactam in 42 Patients Treated with Concomitant CRRT. Clin J Am Soc Nephrol. 2012 Jan 26. [Epub ahead of print]

37. Nadim MK, Kellum JA, Davenport A, Wong, F, Davis, C, Pannu N, Tolwani A, Bellomo R, Genyk Y.

Hepatorenal syndrome: the 8th international consensus conference of the Acute Dialysis Quality Initiative (ADQI) group. Critical Care 2012, Feb 9;16(1):R23. doi: 10.1186/cc11188

38. Tumlin JA, Chawla L, Tolwani AJ, Mehta R, Dillon J, Finkel KW, Dasilva JR, Astor BC, Yevzlin AS,

Humes HD. The Effect of the Selective Cytopheretic Device on Acute Kidney Injury Outcomes in the Intensive Care Unit: A Multicenter Pilot Study. Semin Dial. 2012 Oct 29. doi: 10.1111/sdi.12032

39. Tolwani A, Wille KM. Advances in continuous renal replacement therapy: citrate anticoagulation update. Blood Purification. 2012;34(2):88-93.doi: 10.1159/000342378. Epub 2012 Oct 24

40. Tolwani A. Continuous renal-replacement therapy for acute kidney injury. N Engl J Med. 2012 Dec 27;367(26):2505-14. doi: 10.1056/NEJMct1206045

41. Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD.KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury. Am J Kidney Dis. 2013 Mar 14. doi:pii: S0272-6386(13)00471-X. 10.1053/j.ajkd.2013.02.349.

42. Bagshaw SM, Uchino S, Kellum JA, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Oudemans-van Straaten HM, Ronco C, Bellomo R; Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T. Kidney) Investigators. Association between renal replacement therapy in critically ill patients with severe acute kidney disease and mortality. J Crit Care. 2013 Dec; 28(6):1011-8. doi: 10.1016/j.jcrc.2013.08.002. Epub 2013 Sep 24

43. Tolwani AJ. A Patient with AKI after Cardiac Surgery. Clin J Am Soc Nephrol. 2014 Mar 20. PMID: 24651071

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44. Ong SC, Wille KM, Speer R, Tolwani AJ. A continuous veno-venous hemofiltration protocol with anticoagulant citrate dextrose formula A and a calcium-containing replacement fluid. Int J Artif Organs. 2014 Apr 15;0(0):0. doi: 10.5301/ijao.5000323

45. Prins KW, Wille KM, Tallaj JA, Tolwani A. Assessing continuous renal replacement therapy as a rescue strategy in cardiorenal syndrome 1. Clin Kidney J. 2014: 0:1-6; doi: 10.1093/ckj/sfu123 (in press)

46. Bouchard J, Malhotra R, Shah S, Kao YT, Vaida F, Gupta A, Berg DT, Grinnell BW, Stofan B, Tolwani AJ, Mehta RL. Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study. PLoS One. 2015 Mar 19;10(3):e0120770. doi: 10.1371/journal.pone.0120770. eCollection 2015. PMID:25790110

47. Bouchard J, Acharya A, Cerda J, Maccariello ER, Madarasu RC, Tolwani AJ, Liang X, Fu P, Liu ZH, Mehta RL. A Prospective International Multicenter Study of AKI in the Intensive Care Unit. Clin J Am Soc Nephrol. 2015 Aug 7;10(8):1324-31. doi: 10.2215/CJN.04360514. Epub 2015 Jul 20. PMID:26195505

48. Tumlin JA, Galphin CM, Tolwani AJ, Chan MR, Vijayan A, Finkel K, Szamosfalvi B, Dev D, DaSilva JR, Astor BC, Yevzlin AS, Humes HD; SCD Investigator Group. A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury. PLoS One. 2015 Aug 5;10(8):e0132482. doi: 10.1371/journal.pone.0132482. eCollection 2015. PMID: 26244978

49. Karakala N, Tolwani A. We Use Heparin as the Anticoagulant for CRRT. Semin Dial. 2016 Apr 15. doi: 10.1111/sdi.12503. PMID:27082940

50. Shotwell MS, Nesbitt R, Madonia PN, Gould ER, Connor MJ, Salem C, Aduroja OA, Amde M, Groszek JJ, Wei P, Taylor ME, Tolwani AJ, Fissell WH. Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT. Clin J Am Soc Nephrol. 2016 May 19. PMID:27197907

51. Bagshaw SM, Chakravarthi MR, Ricci Z, Tolwani A, Neri M, De Rosa S, Kellum JA, Ronco C; ADQI Consensus Group. Precision Continuous Renal Replacement Therapy and Solute Control. Blood Purif. 2016;42(3):238-247. Epub 2016 Aug 26

52. Villa G, Neri M, Bellomo R, Cerda J, De Gaudio AR, De Rosa S, Garzotto F, Honore PM, Kellum J, Lorenzin A, Payen D, Ricci Z, Samoni S, Vincent JL, Wendon J, Zaccaria M, Ronco C; Nomenclature Standardization Initiative (NSI) Alliance. Collaborators (52): Bagshaw SM, Balducci A, Baldwin I, Barbarigo F, Bellomo R, Braganò P, Braunsky J, Calletti F, Cerda J, Chawla L, De Rosa S, Di Somma S, Doi K, Dosil Rosende P, Emmett M, Fecondini L, Galavotti D, Garzotto F, Gibney N, Goldstein SL, Guadagni G, Honoré P, Hoste E, Inadome S, Kashani K, Katz N, Kellum J, Kenley R, Kobayashi Y, Lannoy J, Lewington A, Lorenzin A, Mariano F, McCullough PA, Mehta RL, Menneguerre J, Mettifogo M, Neri M, Ostermann M, Pani A, Pirazzoli P, Pohlmeier R, Pouchoulin D, Ricci Z, Ronco C, Rosner M, Seamann M, Shaw A, Tolwani A, Villa G, Vincent JL, Wendon J. Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications. Crit Care. 2016 Oct 10;20(1):283

53. Bagshaw SM, Darmon M, Ostermann M, Finkelstein FO, Wald R, Tolwani AJ, Goldstein SL, Gattas DJ, Uchino S, Hoste EA, Gaudry S Current state of the art for renal replacement therapy in critically ill patients with acute kidney injury. Intensive Care Med. 2017 Mar 13. doi: 10.1007/s00134-017-4762-8.

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54. Judd E, Tolwani A. Managing Issues in Dialysis for the Patient with AKI. CJASN CJN.02270217; published ahead of print June 21, 2017, doi:10.2215/CJN.02270217

55. Annigeri RA, Ostermann M, Tolwani A, Vazquez-Rangel A, Ponce D, Bagga A, Chakravarthi R, Mehta RL. Renal Support for Acute Kidney Injury in the Developing World. Kidney International Reports. 2017;2(4):559-578. doi:10.1016/j.ekir.2017.04.006.

56. Wang Y, Gallagher M, Li Q, Lo S, Cass A, Finfer S, Myburgh J, Bouman C, Faulhaber-Walter R, Kellum

JA, Palevsky PM, Ronco C, Saudan P, Tolwani A, Bellomo R. Renal replacement therapy intensity for acute kidney injury and recovery to dialysis independence: a systematic review and individual patient data meta-analysis. Nephrol Dial Transplant. 2017 Nov 23. PMID:29186517

57. Cerdá J, Tolwani A, Palevsky P. Controversies in Clinical Nephrology: Challenges of performing renal replacement therapy in the intensive care unit - The nephrologist perspective. Clin Nephrol. 2018 Apr 10. doi: 10.5414/CN109243. PMID: 29633701

58. Karakala N, Tolwani AJ. Timing of Renal Replacement Therapy for Acute Kidney Injury. J Intensive Care Med. 2018 Jan 1:885066618774257. doi: 10.1177/0885066618774257. [Epub ahead of print] PMID:29739260

59. Jang SM, Gharibian KN, Lewis SJ, Fissell WH, Tolwani AJ, Mueller BA. A Monte Carlo Simulation Approach for Beta-Lactam Dosing in Critically Ill Patients Receiving Prolonged Intermittent Renal Replacement Therapy. J Clin Pharmacol. 2018 May 10. doi: 10.1002/jcph.1137. [Epub ahead of print]. PMID: 29746711

60. Li W, Sanders B, Tolwani A. Pneumaturia and nephrotic syndrome caused by a hidden pelvic malignancy. Am J Med. 2018 Jun 15. pii: S0002-9343(18)30519-9. PMID:29913123

61. Kashani K, Rosner MH, Haase M, Lewington AJP, O'Donoghue DJ, Wilson FP, Nadim MK, Silver SA, Zarbock A, Ostermann M, Mehta RL, Kane-Gill SL, Ding X, Pickkers P, Bihorac A, Siew ED, Barreto EF, Macedo E, Kellum JA, Palevsky PM, Tolwani AJ, Ronco C, Juncos LA, Rewa OG, Bagshaw SM, Mottes TA, Koyner JL, Liu KD, Forni LG, Heung M, Wu VC. Quality Improvement Goals for Acute Kidney Injury. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):941-953. PMID: 31101671

62. Centor RM, Tolwani A. Web Exclusive. Annals On Call - Care of Patients With Acute Kidney Injury. Ann Intern Med. 2019 Jun 4;170(11):OC1. PMID: 31158878

63. Redant S, Beretta-Piccoli X, Mugisha A, Attou R, Kaefer K, De Bels D, Tolwani A, Honoré PM. Hyperammonemia, the Last Indication of High-Volume Hemodiafiltration in Adult and Children: A Structured Review. Blood Purif. 2019 Jul 10:1-6. PMID: 31291618

64. Rewa OG, Tolwani A, Mottes T, Juncos LA, Ronco C, Kashani K, Rosner M, Hasse M, Kellum J,

Bagshaw S, ADQI Census Meeting Members on behalf of ADQI XXII. Quality of care and safety measures of acute renal replacement therapy: Workgroup statements from the 22nd acute disease quality initiative (ADQI) consensus conference. Journal of Critical Care 54 (2019) 52–57. PMID: 31349160

65. Neyra JA, Tolwani AJ. A Quality Improvement Initiative Targeting CRRT Delivered Dose: The What, the How, and the Why. Am J Kidney Dis. 2019 Oct 15. pii: S0272-6386(19)30979-5. doi: 10.1053/j.ajkd.2019.08.015. PMID: 31627940

66. Barbance O, De Bels D, Honoré PM, Bargalzan D, Tolwani A, Ismaili K, Biarent D, Redant S. Potassium Disorders in Pediatric Emergency Department: Clinical Spectrum and Management. Arch Pediatr. 2020 Apr;27(3):146-151. PMID: 31955956

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67. Hatamizadeh P, Tolwani A, Palevsky P. Revisiting Filtration Fraction as an Index of the Risk of Hemofilter Clotting in Continuous Venovenous Hemofiltration. Clin J Am Soc Nephrol. 2020 May 13:CJN.02410220. doi: 10.2215/CJN.02410220. Online ahead of print. PMID: 32404338

68. Neyra JA, Connor MJ Jr, Tolwani A. Preparedness of Kidney Replacement Therapy in the Critically Ill During COVID-19 Surge. Version 2. Kidney Int Rep. 2020 Jun 7;5(7):961-964. PMID: 32642604

69. Gupta S, Hayek SS, Wang W, et al. and STOP-COVID Investigators. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US [published online ahead of print, 2020 Jul 15]. JAMA Intern Med. 2020;e203596. doi:10.1001/jamainternmed.2020.3596

70. STARRT-AKI Investigators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group and Collaborators; Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury [published correction appears in N Engl J Med. 2020 Jul 15;:]. N Engl J Med. 2020;383(3):240-251. doi:10.1056/NEJMoa2000741

71. Ostermann M, Bellomo R, Burdmann EA, et al. and Collaborators. Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int. 2020;98(2):294-309. doi:10.1016/j.kint.2020.04.020

72. Mir N, D'Amico A, Dasher J, Tolwani A, Valentine V. Understanding the andromeda strain - The role of cytokine release, coagulopathy and antithrombin III in SARS-CoV2 critical illness [published online ahead of print, 2020 Jul 3]. Blood Rev. 2020;100731. doi:10.1016/j.blre.2020.100731

73. Flythe JE, Assimon MM, Tugman MJ, Chang EH, Gupta S, Shah J, Sosa MA, DeMauro Renaghan A, Melamed ML, Wilson FP, Neyra JA, Rashidi A, Boyle SM, Anand S, Christov M, Thomas LF, Edmonston D, Leaf DE; STOP-COVID investigators. Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States. Am J Kidney Dis. 2020 Sep 19:S0272-6386(20)30999-9. doi: 10.1053/j.ajkd.2020.09.003. Online ahead of print. PMID: 32961244

74. Hayek SS, Brenner SK, Azam TU, Shadid HR, Anderson E, Berlin H, Pan M, Meloche C, Feroz R, O'Hayer P, Kaakati R, Bitar A, Padalia K, Perry D, Blakely P, Gupta S, Shaefi S, Srivastava A, Charytan DM, Bansal A, Mallappallil M, Melamed ML, Shehata AM, Sunderram J, Mathews KS, Sutherland AK, Nallamothu BK, Leaf DE; STOP-COVID Investigators. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. BMJ. 2020 Sep 30;371:m3513. doi: 10.1136/bmj.m3513.PMID: 32998872

75. Ricci Z, Tolwani A, Lumlertgul N. Precision renal replacement therapy. Curr Opin Crit Care. 2020 Dec;26(6):574-580. doi: 10.1097/MCC.0000000000000776.PMID: 33002973

76. Nadim MK, Forni LG, Mehta RL, Connor MJ Jr, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020 Dec;16(12):747-764. doi: 10.1038/s41581-020-00356-5. Epub 2020 Oct 15.PMID: 33060844

77. Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE; STOP-COVID Investigators. AKI Treated with Renal Replacement Therapy in

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Critically Ill Patients with COVID-19. J Am Soc Nephrol. 2020 Oct 16:ASN.2020060897. doi: 10.1681/ASN.2020060897. Online ahead of print.PMID: 33067383

78. Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE; STOP-COVID Investigators. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Intern Med. 2020 Oct 20:e206252. doi: 10.1001/jamainternmed.2020.6252. Online ahead of print.PMID: 33080002

79. Zeidman AD, Heung M, Connor M Jr, Tolwani A, Yessayan L. The Workforce in Critical Care Nephrology: Challenges and Opportunities. Adv Chronic Kidney Dis. 2020 Jul;27(4):328-335.e1. doi: 10.1053/j.ackd.2020.07.003. Epub 2020 Oct 24.PMID: 33131646

TEXTBOOKS/CHAPTERS:

1. Epidemiology and Biostatistics Secrets. Robert Nordness, MD, MPH, Elsevier, Inc. 2006: Chapter 7: Research Model Designs, Ashita Tolwani, MD, MSc Chapter 19: Survival Analysis, Ashita Tolwani, MD, MSc

2. Tolwani A and Wille K. Extracorporeal Liver Support and the Kidney (Chapter 196), in Ronco C and

Bellomo R (Editors), Critical Care Nephrology, 2nd Ed. 2009. Saunders Elsevier, Philadelphia, PA.

3. Tolwani A. Citrate Anticoagulation for CRRT in Encyclopedia of Intensive Care Medicine. Vincent, Jean-Louis; Hall, Jesse B. (Eds.). Version: print (book) 1st Edition., 2012, Approx. 5000 p. 1000 illus. In 5 volumes, ISBN: 978-3-642-00417-9 Available: March 2012

4. Michael L. Bentley, PharmD, FCCM, and Ashita J. Tolwani, MD, MSc. Acute and Chronic Renal Failure and Management (Chapter 31). Comprehensive Critical Care: Adult. Society of Critical Care Medicine. 2012. by Pamela R. Roberts, MD, FCCM, Editor; S. Rob Todd, MD, FACS, Editor. ISBN: 978-0-936145-80-8

5. Jorge Cerdá, Ashita Tolwani, Shamik Shah, Claudio Ronco. Continuous Renal Replacement Therapy (Chapter 18). Modeling and Control of Dialysis Systems: Volume 2: Biofeedback Systems and Soft Computing Techniques of Dialysis. 2013. Ed. Ahmad Azar. ISBN 978-3-642-27557-9

6. Part V Acute Kidney Injury Section Editor for Chapters 17-22 in textbook: Clinical Decisions in Nephrology, Hypertension, and Kidney Transplantation. Editors: Edgar Lerma, MD and Mitchell Rosner, MD. 2013. ISBN 978-1-4614-4453-4: Specific authorship: Chapter 17: Acute kidney Injury: Definitions and General Approach, Ashita J Tolwani Chapter 21: Specific Etiologies: Eric K Judd, Shikha Mehta, Ashita J Tolwani

7. Nakshatra Saxena, Ashita J. Tolwani, Keith M. Wille. Annual Update in Intensive Care and Emergency Medicine 2013 [Paperback]. Editor: Jean-Louis Vincent: Does The Choice of Renal Replacement Therapy Affect Renal Recovery?

8. Ashita J Tolwani, Keith M. Wille. Anticoagulation for continuous renal replacement therapy. In: UpToDate, Schwab, SJ (Ed), UpToDate, Waltham, MA, 2013.

9. Rolando Claure, Ashita J Tolwani, Ravindra Mehta. Clinical Decision Support System on Nephrology and Hypertension (Digital Educational Support System): Chapter: Acute Kidney Injury: Role of Acute Dialysis (CRRT, SLED, intermittent hemodialysis, other) May, 2013

10. Specific Gene Expression and Epigenetics: The Interplay Between the Genome and Its Environment Hardcover by Kasirajan Ayyanathan (Editor). March 18, 2014 by Apple Academic Press

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Part I: Eukaryotic DNA Methylation: Renal Kallikrein Excretion and Epigenetics in Human Acute Kidney Injury: Expression, Mechanisms and Consequences; Authors: Sun Woo Kang, Pei-an Betty Shih, Roy O. Mathew, Manjula Mahata, Nilima Biswas, Fangwen Rao, Liying Yan, Josee Bouchard, Rakesh Malhotra, Ashita Tolwani, Srikrishna Khandrika, Ravindra L. Mehta, and Daniel T. O’Connor. ISBN-13: 978-1771880367 ISBN-10: 1771880368 Edition: 1st

11. Perioperative Kidney Injury: Principles of Risk Assessment, Diagnosis and Treatment. Thakar, Charuhas V., Parikh, Chirag R. (Eds.) 2015, XVII Part I, Chapter 4: Clinical Pearls: Renal Replacement Therapy for Acute Kidney Injury in the Postoperative Period. Authors: Ashita J. Tolwani and Paul M. Palevsky.

12. Chapter: Dialysis for the Trauma Patient with Acute Kidney Injury. Encyclopedia of Trauma Care. Edited by Peter J. Papadakos, Mark L. Gestring. Authors: Ashita Tolwani, MD, Paul Palevsky MD; 10/2015 ISBN 978-3-642-36200-2

13. Medical Knowledge Self-Assessment Program® (MKSAP) – MKSAP 17 Nephrology Section Chapters

and MCQs on AKI, Potassium Disorders, Phosphate Disorders; available 7/31/2015. Author: Ashita Tolwani MD.

14. Chapter: Complications of Continuous Renal Replacement Therapy (CRRT). Core Concepts in Dialysis and Continuous Therapies. Edited by Colm C. Magee, J. Kevin Tucker, Ajay K. Singh. Authors: James Harms MD, Keith Wille MD, Ashita Tolwani MD; 2016 ISBN 978-1-4899-7657-4

15. Chapter 29: Anticoagulation for Continuous Renal Replacement Therapy (CRRT). Handbook of Dialysis Therapy, 5th Edition. Edited by By Allen R. Nissenson, MD, FACP and Richard E. Fine, MD. Authors: Vinay Narasimha Krishna MD, Keith Wille MD, Ashita Tolwani MD; 2017 ISBN 9780323391542

16. Part 7: Renal: Chapter 104: Metabolic Acidosis & Alkalosis. Textbook of Critical Care, 7th Edition by Jean-Louis Vincent MD PhD, Edward Abraham MD, Patrick Kochanek MD MCCM, Frederick A. Moore MD MCCM, Mitchell P. Fink MD. Authors: Ashita Tolwani MD, Manish Saha MD, Keith Wille MD; 2017 ISBN 9780323376389

17. Michael L. Bentley, PharmD, FCCM, and Ashita J. Tolwani, MD, MSc. Acute and Chronic Renal

Failure and Management (Chapter 33). Comprehensive Critical Care: Adult 2nd Edition 2017.

18. Michael J. Connor MD, Ashita J Tolwani MD. Prescription of continuous renal replacement therapy in acute kidney injury in adults In: UpToDate, Alice Sheridan (Debuty Ed), UpToDate, Waltham, MA, 2018.

19. Michael L. Bentley, PharmD, FCCM, and Ashita J. Tolwani, MD, MSc. Acute and Chronic Renal Failure and Management (Including Hemodialysis and Continuous Renal Replacement Therapies) (Chapter 15). Multiprofessional Critical Care Review: Adult, in production by the Society of Critical Care Medicine 2018.

20. Chapter 22: Dialytic Therapy of Acute Kidney Injury. Alian A. Al-balas, Keith M. Wille, Ashita J Tolwani. Core Concepts in Acute Kidney Injury. Editors: Waikar, Sushrut S., Murray, Patrick, Singh, Ajay K. (Eds.), 2018

21. Chapter 49: Renal Replacement Therapy for Acute Kidney Injury. Ashita J Tolwani, MD, MS, Michael J. Connor, Jr, MD, Paul M. Palevsky, MD. Chronic Kidney Disease, Dialysis, and Transplantation: A Companion to Brenner and Rector’s The Kidney. Editors: Jonathon Himmelfarb, MD, T. Alp Ikizler, MD, 2019

OTHER PUBLICATIONS:

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1. Tolwani A, Wille KM. Citrate-based replacement solution with continuous venovenous hemofiltration: not as simple as it sounds. Am J Kid Dis 2006 June; 47 (6):1086. (Correspondence)

2. Tolwani, A, Speer, R. Heparin Lock for Dialysis Catheters. UAB Synopsis (November 6 2006; Vol 25;

No. 28. (A UAB Health System Publication)

3. Tolwani, A. Continuous Renal Replacement Therapy: Modality of Choice in the Intensive Care Unit? ASN Kidney News. February 2010. Volume 2, No. 2.

4. Tolwani, A. Approach to the Patient with Asymptomatic Microscopic Hematuria. UAB Synopsis, 2/6/2012. UAB Synopsis is the weekly e-newsletter for the UAB Medicine community.

5. Tolwani A, Wille KM. Regional citrate anticoagulation for continuous renal replacement therapy: the better alternative? Am J kid Dis 2012 June; 59 (6), p. 745.

6. Tolwani A. Continuous renal-replacement therapy for acute kidney injury. N Engl J Med. 2013 Mar 21;368(12):1160-1. doi: 10.1056/NEJMc1301071. Comment on.

7. Bellomo R, Tolwani A, Reilly I. Patient Case Studies. Acute Kidney Injury: Recognition & Risk Assessment in Critically Ill Patients. (A Self-study accredited monography). Presented by Educational Review Systems (ERS), Medavera, Inc, and supported by an educational grant from Astute, Inc., August 2013

8. Saxena N, Tolwani A, Wille, K. The Kidney: Anticoagulation in Continuous Renal Replacement Therapy. ICU Management: The Official Management and Practice Journal 2013 Autumn 13;3:12-14

PATENTS: Patent Number

Title Of Patent Date Issued

8147698 Process for metabolic control and high solute clearance and solutions for use therein (Citrate solution) (known as Regiocit and Prismocitrate 18:0

April 3, 2012

7884132 Process for metabolic control and high solute clearance and solutions for use

therein (Method of citrate delivery) February 8, 2011