pain in the foot: a 52 yo man in misery
DESCRIPTION
Pain in the Foot: A 52 yo man in misery. Christie Seibert, MD September 21, 2005. No financial disclosures. The Patient. 52 yo man w/o sig PMH - PowerPoint PPT PresentationTRANSCRIPT
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Pain in the Foot: A 52 yo man in misery
Christie Seibert, MD
September 21, 2005
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No financial disclosures.
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The Patient
52 yo man w/o sig PMH 2 mo ago: sudden onset of 8/10 pain in
his R great toe and sole of foot, spreading toward his ankle. Occurs with rest and exertion. Worst when elevates R leg.
Treated with NSAIDS, which gave partial relief.
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The Patient
3 wks ago: Same sxs in L foot. Also, R foot developing red-blue discoloration at toes, dorsum of foot.
Pain so severe that he is unable to work and has sig diff sleeping. Sleeps sitting in a chair.
Treated with NSAIDs again, ruled out for DVT.
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The Patient
PMH: Nephrolithiasis x 1. No meds. SH: Works for a uniform rental company.
Smokes 1ppd x 36 yrs. 3-4 beers/wk. “Occasional” marijuana.
FH: No FH of cancer, CAD, VTE. ROS: Had URI about 2 wks prior to sxs.
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The Exam
VS: Afeb, BP 112/66, P 78 General: Comfortable with feet on floor CV, Lungs, Abd WNL MSK: no synovitis, no limits in ROM EXT: Non-pitting edema of both feet to
mid calf. 2+ PT and DP pulses
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Skin Exam
UptoDate.com Accessed 9/6/05
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Differential Diagnosis
Embolic Disease Peripheral Vascular Disease (arterial
insufficiency) Vasculitis Cryoglobulinemia Buerger’s Disease
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Diagnostic Testing
CBC, LFT, Cr ESR, CRP ANA, RF, C-ANCA, P-ANCA Hep B and C Antiphospholipid antibodies ECHO
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MRA of Lower Extremities:
Iliac, femoral and popliteal circulations are widely patent.
Several short segment moderate stenoses in posterior and anterior tibial arteries.
Warfel, JH. The Extremities, 5th edition 1985
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Skin Biopsy
Multiple small, highly cellular, inflammatory thrombi
Relative sparing of the blood vessel wall No vasculitis No evidence of atherosclerosis
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Buerger’s Disease (Thromboangiitis Obliterans) First described in 1879 In 1908, Leo Buerger described pathologic
findings in 11 amputated limbs Worldwide distribution Prevalence: Middles East/Far East > North
America/Western Europe 12.6 per 100,000 in Olmstead County
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Pathophysiology
Nonatherosclerotic segmental inflammatory disease of small and medium-sized arteries (skip lesions)
Distinguished from other vasculitis Sparing of blood vessel wall ESR, CRP normal Autoantibodies negative
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Diagnostic Criteria
Typically age less than 45 years and male Current or recent history of tobacco use Distal extremity ischemia in the absence of
proximal disease Exclusion of autoimmune and
hypercoaguable diseases
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Clinical Features Usually presents as claudication, rest pain
Features Atherosclerosis Buerger’s Ds
Age > 40yo 20-45yo
Other risk factors +++ no
Upper extremity involvement
rare Up to 90%
Proximal vessel involvement
+++ rare
Pulse exam decreased preserved
Superficial Thrombophlebitis
no Up to 40%
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Skin Exam
UptoDate.com Accessed 9/6/05
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Allen Test (+ in 65%)•Patient makes a fist
•Examiner’s thumbs occlude radial and ulnar arteries
•Patient opens hand into relaxed, partially flexed position
•Pressure on ulnar artery is released while radial artery is compressed
•Normally, hand should turn pink because of intact interconnecting arteries
•Can be repeated releasing pressure of radial artery
NEJM,2000;343(12):867.
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Treatment
Absolute abstinence of smoking 40% who continue to smoke will require
amputation, compared to 5% who quit Not amenable to surgery Negative studies regarding thrombolytic
therapy
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Oh by the way, doc…
Cannabis arteritis first described in the 1960’s.
Mainly case reports and series. Clinically and pathologically like Buerger’s
disease, occurring rarely in young adults.
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Objectives
Recognize Buerger’s disease Describe diagnostic criteria and clinical
features of the disease Describe the Allen Test Know that complete smoking cessation is
the only treatment
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References
Szuba a, Cooke JP. Thromboangiitis obliterans: An update on
Buerger’s disease. West J of Med 1998;168(4):255-61. Olin JW. Thromboangiitis Obliterans (Buerger’s Disease). NEJM
2000;343(12):864-9. Mohler ER, Olin JW. Thromboangiitis Obliterans (Buerger’s
Disease). Up to Date.com. Accessed 9/6/2005. Last updated 11/15/2004.
Combamale P, Consort T, Denis-Thelis L et al. Cannabis arteritis. Br J Dermatol 2005;152(1):166-9.
Disdier P, Granel B, Serratrice J et al. Cannabis arteritis revisited;ten new case reports. Angiology 2001;52(1):1-5.