1. Parkinsons Disease Steven J. Zuckerman, M.D. Diagnosis and Treatment 2. James Parkinson 3. The Shaking Palsy 4. Anatomy 5. Basal Ganglia Direct and Indirect Pathways 6. Basal Ganglia Direct Pathway 7. Basal Ganglia Indirect Pathway 8. Epidemiology 9. Epidemiology 10. Pathogenesis 11. Braak Hypothesis 12. Clinical Features Both Motor and Non-Motor 13. Four Cardinal Motor Features: 14. 1. Tremor 15. Cogwheeling Rigidity 16. Bradykinesia 17. Abnormal Gait 18. Postural Instability 19. Glabellar Reflex 20. DAT Scan 21. Non-Motor Symptoms 22. All that shakes is not PD PD vs Essential Tremor 23. All that shakes is not PD Parkinson Plus Syndromes 24. Treatment 25. Carbidopa/Levodopa Sinemet Sinemet CR Apokyn Parcopa Rytary Stalevo 26. Dopamine Agonists Mirapex (Pramipexole) Mirapex ER Requip (Ropinirole) Requip XL Neupro (Rotigatine) 27. MAO-B & COMT Inhibitors Azilect (Rasagiline) Zelapar (Selegeline) Comtan (Entacapone) 28. Others Anti-Cholinergic Artane (Trihexyphenidyl) Cogentin (Benztropine) Amantadine 29. Motor Complications 30. Algorithm 31. Surgical Intervention 32. Intestinal Infusion 33. Treatment of Non-Motor Symptoms