paroxysmal sympathetic hyperactivity - bianj › ... › 05 › bianj-psh-presentation.pdf ·...
TRANSCRIPT
![Page 1: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/1.jpg)
Paroxysmal Sympathetic Hyperactivity and Considerations for Rehabilitation
Alphonsa Thomas DOBrain Injury Medicine FellowJFK Johnson Rehabilitation InstituteMay 17, 2018
![Page 2: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/2.jpg)
![Page 3: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/3.jpg)
Methods• Literature review of articles from 2007-2017
• Online databases used: • PUBMED, MEDLINE, COCHRANE and CINAL
• Terms used:• Paroxysmal sympathetic hyperactivity, dysautonomia, brain
injury, storming, traumatic brain injury, outcome and rehabilitation
![Page 4: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/4.jpg)
Paroxysmal Sympathetic Hyperactivity
• Characteristic traits were first described by Wilder Penfield in 1929• Initially thought to be from a seizure focus
• Over 31 other names identified for the syndrome
• Call for unified term came in 2007 by Alejandro Rabinstein, who suggested use of the term PSH
![Page 5: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/5.jpg)
Definition
“A syndrome, recognized in a subgroup of survivors of severe acquired brain injury, of simultaneous, paroxysmal transient
increases in sympathetic (elevated heart rate, blood pressure, respiratory rate, temperature, sweating) and motor (posturing)
activity.”
Baguley,etal.ParoxysmalSympatheticHyperactivityafterAcquiredBrainInjury:ConsensusonConceptualDefinition,Nomenclature,andDiagnosticCriteria.JournalofNeurotrauma.2014;31(17):1515-1520.
![Page 6: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/6.jpg)
Epidemiology
• 8-33% of acquired brain injuries develop PSH
• Incidence of 15-33% in severe TBI
• Lasts about 18-162 days and resolves within a year
80%
10%
5% 5%
Types of Brain Injury In PSH
TBIAnoxicStrokeOther
![Page 7: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/7.jpg)
Pathophysiology • Several proposed mechanisms
• No seizure activity was noted on electroencephalography and noted that the syndrome is not effectively treated with anticonvulsants
• There is no specific lesion designated as the causative factor for the development of PSH, but rather the overall burden of the injury
![Page 8: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/8.jpg)
Pathophysiology cont...
• Sympathetic surge• 40% increase from
baseline in serum adrenocortical hormones
• 200-300% increase in serum catecholamine levels during paroxysmal episodes
- Fernandez-Ortega et al. Catecholamines and Paroxysmal Sympathetic Hyperactivity afterTraumatic Brain Injury. Journal of Neurotrauma. 2017;34(1), 109-114
![Page 9: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/9.jpg)
Systemic Effects • Elevated catecholamine levels
• Extracranial manifestations • Cardiac arrhythmia• Pulmonary edema • Immunosuppression• Focal myocytolysis and myocardial necrosis
![Page 10: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/10.jpg)
Excitatory: Inhibitory Ratio (EIR) Model
• Latest concept is the excitatory: inhibitory ratio (EIR) model
• The model is not specific to PSH and takes into account several neurological disorders that can cause autonomic and muscular overactivity
• 2 part disconnect theory
![Page 11: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/11.jpg)
EIR cont...• Disconnect theory
• Injury of higher centers (cortex, diencephalon andupper brainstem)• Loss of inhibition over the now unopposed sympathetic outflow
from the lower brainstem and spinal cord
• Loss of ability to modulate the afferent sensoryinformation processed by the spinal cord.• Spinal cord circuits to create a positive feedback loop or an
amplification of non-noxious or mild noxious stimuli that result inallodynia
• Allodynic tendency
![Page 12: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/12.jpg)
![Page 13: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/13.jpg)
What is the diagnosis?
![Page 14: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/14.jpg)
Diagnosis• Diagnosis of exclusion!• No standard criteria or measure • Symptoms & Signs
• Tachycardia• Tachypnea• Hypertension• Fever• Diaphoresis• Posturing
![Page 15: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/15.jpg)
Differential Diagnoses Most Common Causes Least Common Causes
Constipation Heterotopic Ossification
Urinary retention Neuropathic pain (ie: CRPS)
Infection Fractures
Wounds Deep venous thrombosis
Respiratory Nephrolithiasis
Metabolic derangements Cholelithiasis
![Page 16: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/16.jpg)
PSH
Sepsis
Hypoxia
Urinary retention
![Page 17: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/17.jpg)
Key features of PSH• Features are paroxysmal in nature
• Simultaneity of clinical features
• Sympathetic overactivity to normally non-painful stimuli
• Absence of intra-paroxysmal parasympathetic features during episodes
• Features persist ≥ 3 consecutive days
• Features persist ≥ 2 weeks post-injury
• Features are persistent despite treatment of alternative differential diagnosis
• Medication administered to decrease sympathetic features
• Lack of alternative explanations
• Antecedent acquired brain injury
![Page 18: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/18.jpg)
PSH-Assessment Measure• PSH-AM
• Clinical tool devised to estimate the probability a patient has PSH and the severity of their symptoms
• Helps to monitor and track patients through their recovery and response to treatments
• Two components• Clinical Features Scale (CFS)• Diagnosis Likelihood Tool (DLT)
![Page 19: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/19.jpg)
![Page 20: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/20.jpg)
![Page 21: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/21.jpg)
![Page 22: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/22.jpg)
Supportive Treatment• Avoid or treat possible triggers
• Proper positioning
• Pain management
• Suctioning
• Nutrition• Energy expenditure in PSH has been noted up to three times
from baseline• Decreases in body weight as much as 25-29% in the acute period
![Page 23: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/23.jpg)
TreatmentCategory Medication
IV sedatives Dexmedetomidine , Propofol
α2 agonists Clonidine
β-blockers Propranolol
Opiods Morphine, Fentanyl
Neuromodulators Baclofen, Gabapentin, Bromocriptine
Peripherally Acting Muscle Relaxants Dantrolene
Benzodiazepines Diazepam, Lorazepam, Clonezapam
![Page 24: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/24.jpg)
Acute PSH Episodes• Send in the storm
troopers!
• Goal is to quiet the sympathetic surge• Rule out other causes• Few meds to keep in
mind• Opioids• Propranolol
![Page 25: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/25.jpg)
Outcomes• There are a handful of studies that have looked into
outcome of PSH patients
• Type of brain injury matters
• Lower Glasgow Outcome Scale scores and functional independence measures compared to similar patients
• Greater need of enteral nutrition and tracheostomies which lend itself toward further complications
• Higher DRS scores, disorders of consciousness, longer LOS, and mortality in this patient group
![Page 26: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/26.jpg)
Publication Brain Injury Setting # of Cases with PSH
Incidence Length of stay (Hosp)
Disability Rating Scale
Glasgow Outcome Scale
Functional Independence Measure
Mortality
Mathew et al9 TBI ICU 29/343 8% Longer Higher Worse NA Higher
Lv et al10 TBI ICU 16/79 20.3% NA NA NA NA NA
Laxe et al11 TBI Rehab 13/39 33.3% Longer No significant difference
No significant difference
No significant difference* NA
Hinson et al12 TBI ICU 19/167 11% Longer NA NA NA NA Baguley et al 13 TBI ICU 6/79 8% Longer No significant
difference Worse NA NA
Fernandez-Ortega et al14
TBI ICU 18/80 22.5% NA NA NA NA NA
Fernandez-Ortega et al15
TBI ICU 18/179 10.1% Longer NA No significant difference
NA NA
Hendricks et al16 TBI Acute care
9/76 11.8% NA NA NA NA NA
Rabinstein et al4 Varied TBI,SAH,ICH, anoxia
NICU 17/93 18% NA NA NA NA NA
Dolce et al18 Vegetative ICU 87/333 26.1% Longer NA Worse NA Higher Pozzi et al6 Varied Rehab 26/407 6.4% NA Higher NA NA Higher
![Page 27: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/27.jpg)
Rehabilitation• Multidisciplinary approach
• Uncontrolled PSH episodes interfere with therapy and can cause long term consequences
• Nursing and therapy staff can help point triggers
• Identify parameters of when to hold therapy
![Page 28: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/28.jpg)
Key Takeaways• Severe brain injury can result in episodes of sympathetic
hyperactivity
• Nomenclature varies but PSH is rising as the preferred term
• Diagnosis of exclusion
• Several options for management
• Negative impact on LOS, medical course, and functional outcome measures
![Page 29: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/29.jpg)
References- Baguley IJ. The excitatory:inhibitory ratio model (EIR model): An integrative explanation of acute autonomicoveractivity syndromes. Medical Hypotheses. 2008;70(1):26-35.
- Baguley IJ, Perkes IE, Fernandez-Ortega J-F, Rabinstein AA, Dolce G, Hendricks HT. Paroxysmal SympatheticHyperactivity after Acquired Brain Injury: Consensus on Conceptual Definition, Nomenclature, and DiagnosticCriteria. Journal of Neurotrauma. 2014;31(17):1515-1520.
- Choi HA, Jeon S-B, Samuel S, Allison T, Lee K. Paroxysmal sympathetic hyperactivity after acute brain injury.Current Neurology and Neuroscience Reports. 2013;13:370.
- Fernandez-Ortega, J., Baguley, I., Gates, T., Garcia-Caballero, M., Quesada-Garcia, J. and Prieto-Palomino, M.Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury. Journal ofNeurotrauma. 2017;34(1), 109-114
- Fernandez-Ortega JF, Prieto-Palomino MA, Garcia-Caballero M, Galeas-Lopez JL, Quesada-Garcia G, Baguley IJ.Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury: Clinical and Prognostic Implications.Journal of Neurotrauma. 2012;29(7):1364-1370.
- Hoarau X, Richer E, Dehail P, Cuny E. A 10-year follow-up study of patients with severe traumatic brain injuryand dysautonomia treated with intrathecal baclofen therapy. Brain Injury. 2012;26(7-8):927-940
- Laxe, S., Terré, R., León, D. and Bernabeu, M. (2013). How does dysautonomia influence the outcome oftraumatic brain injured patients admitted in a neurorehabilitation unit?. Brain Injury, 27(12), pp.1383-1387.
![Page 30: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/30.jpg)
- Lv L, Hou L, Lu Y, et al. Risk factors related to dysautonomia after severe traumatic brain injury. JournalOf Trauma. September 2011;71(3):538-542.
- Mathew, M., Deepika, A., Shukla, D., Devi, B. and Ramesh, V. (2016). Paroxysmal sympathetichyperactivity in severe traumatic brain injury. Acta Neurochirurgica, 158(11), pp.2047-2052.
- Meyfroidt, Geert, et al. “Paroxysmal Sympathetic Hyperactivity: the Storm after Acute Brain Injury.” TheLancet Neurology, vol. 16, no. 9, 2017, pp. 721–729.
- Patel M.B., McKenna J.W., Alvarez J.M., et al: Decreasing adrenergic or sympathetic hyperactivity aftersevere traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocolfor a randomized controlled trial. Trials 2012; 13: pp. 177.
- Perkes, I., Baguley, I. J., Nott, M. T. and Menon, D. K. (2010), A review of paroxysmal sympathetichyperactivity after acquired brain injury. Ann Neurol., 68: 126–135.
- Pozzi M, Conti V, Locatelli F, et al. Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation:Clinical Factors and Acute Pharmacological Management. Journal of Head Trauma Rehabilitation.2015;30(5):357-363.
- Pozzi M, Conti V, Locatelli F, et al. Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation:Pathological Features and Scheduled Pharmacological Therapies. Journal of Head TraumaRehabilitation. 2017;32(2):117-124..
- Rabinstein AA,Benarroch EE.Treatmentofparoxysmalsympathetichyperactivity.CurrentTreatmentOptionsinNeurology.2008;10(2):151-157.
- Schroeppel TJ,SharpeJP,Magnotti LJ,etal.Traumaticbraininjuryandβ-blockers.JournalofTraumaandAcuteCareSurgery.2014;76(2):504-509.
![Page 31: Paroxysmal Sympathetic Hyperactivity - BIANJ › ... › 05 › BIANJ-PSH-Presentation.pdf · Catecholamines and Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury](https://reader034.vdocuments.net/reader034/viewer/2022042401/5f101bfc7e708231d4477dc1/html5/thumbnails/31.jpg)
Thank you.