Department of Chemistry

Part II Chemistry:A Guide to the Course

Academic Year 2013/2014

Part II Chemistry

A Guide to the Course

Introduction

This booklet describes the third-year (Part II) course which is offered by the Department.This course builds on the ideas which you have studied in the first and second year, andoffer you the opportunity to both broaden and deepen your knowledge of chemistry. Asthe year progresses there is the opportunity to narrow your focus somewhat, for exampletowards chemical biology or chemical physics; however, you can equally well choose topursue a broad range of topics across all areas of chemistry.

Practical work is given a prominent place, and you will continue to develop your skillsin this area by tackling more sophisticated and open-ended experiments. The practicalskills which you will acquire this year will be very useful to you if you decide to stay onnext year and undertake a research project. In addition to conventional practicals, therewill be the opportunity to do other kinds of continuously assessed work such as learning alanguage.

If you are intending to stay on for Part III, you should be aware that the class you areawarded in Part III will take into account the marks you received for Part II, i.e. marks willbe carried forward from Part II to Part III. Further details are given on p. 27. Please alsorefer to the details given on p. 27 concerning the requirements for admission to Part III.

Introductory Talk and Welcome Party

On Wednesday 9th October at 1200 in the Wolfson Lecture Theatre there will be anintroductory talk about the course; it is vital that you attend.

There will be a ‘Welcome Party’ in the foyer above the entrance to the Bristol–MyersSquibb Lecture Theatre for all new Part II students on Friday 11th October from 5 pm.We do hope that you will be able to come along and mark the beginning of the year in asuitable way!

The image on the cover is taken from Prof. David Wales’ website and shows a octamer of water moleculeswhich has been investigated in the gas phase using a combination of terahertz vibration–rotation tunnelingspectra and computer modelling.

2 Careers for Chemists

Careers for Chemists

On Tuesday 22nd October at 1700 in the Wolfson Lecture Theatre Katie Hewitt, from theCareers Service, will give a short talk on Careers for Chemists. Even if you are thinkingof returning for Part III, this is a good opportunity to find out about your career options.Katie’s talk is highly recommended for all the class.

Outline of the Course

The course consists of a set of lectures alongside a package of continuously assessed work(principally practical work). Prior to this year, two Part II courses, called Option A andOption B, were offered. However, these have now been discontinued and have beenreplaced by a single Part II course.

For convenience the lectures are organised into three ‘Levels’. To complete the courseyou need to obtain:

four credits at Level 1

three credits at Level 2

three credits at Level 3.

One credit is equivalent to a course of 12 lectures. Of course, if you wish you can take morelecture courses than this minimum and if you look at the structure of the examinations youmay feel that it is to your advantage to do so.

If you have taken Chemistry A and Chemistry B in Part IB you must take the followingfour courses at Level 1, each for one credit:

A1: Inorganic I – structure and bonding;

A2: The foundations of organic synthesis;

A3: High-resolution molecular spectroscopy;

A4: Theoretical techniques.

If you have taken only Chemistry B in Part IB you have the alternative of taking thefollowing combination of courses at Level 1:

A1: Inorganic I – structure and bonding (one credit);

A2: The foundations of organic synthesis (one credit);

A6: Concepts in physical chemistry (two credits).

No special arrangements are made for those who have taken only Chemistry A in PartIB. However, with some focused reading over the preceding vacation and some additionalsupervisions, you should find it possible to complete courses A1 and A2 in a satisfactoryway. You should consult the Director of Teaching and your Director of Studies if you fallinto this category.

At Levels 2 and 3 you can take any courses you feel prepared for. The requirements forcontinuously assessed work are given on page 18.

Lecture Course Synopses 3

Lecture Course Synopses

Level 1

Courses A1–A4 are for one unit, courses A5 and A6 are for two units.

A1: Inorganic I – Structure and Bonding

This course focuses on the bonding models that are currently used to rationalise maingroup and transition metal inorganic complexes and how these bonding models can helpus to understand their structures.

Dr S. R. Boss: 6 lectures

The first half of the course introduces the types of bonding models displayed by polyhedralarchitectures (electron-deficient, electron-precise and electron-rich bonding models). Theinteresting class of electron deficient compounds is discussed in depth and used to ratio-nalise the structures of cluster molecules of the p and d block. The course will recapdiborane and the failure of the 2c,2e-bond. The structures of higher boranes will beconsidered and the course will present Wade’s rules and their limitations. Carboranes, met-alloboranes, Zintl phases, and some transition metal clusters will also be considered.Theisolobal, isoelectronic and isostructural principles will be introduced as will the (v + x − 12)rule. The synthesis and reactivity of electron deficient compounds will be described and youwill be introduced to the physical methods by which the structures of these species may bedetermined.

Topics Electron-deficient, -precise, and -rich cluster complexes. Electron-counting. Cluster shapes.Wade’s Rules. Main Group clusters. Transition Metal clusters. Synthesis and reactivity ofelectron deficient compounds. Characterisation.

Dr D. A. Beauregard and Dr M. J. Duer: 6 lectures

The second half of this course examines the heavier transition metals and f-block elements,focusing on the availability (or otherwise) of valence d and f orbitals in bonding. A hugebody of experimental data supports the more extensive participation of the d orbitals in thebonding of the second and third row transition metals. The more expanded nature of the 4dand 5d orbitals of the second and third row transition metals leads to significantly strongercovalency in bonding which leads to greater prevalence for metal–metal as well as metal–ligand multiple bonding for the heavier elements. These aspects will be investigated from aprimarily structural view point, reinforced with bonding and thermodynamics arguments.Whilst the lanthanide and actinides comprise almost a quarter of the periodic table, theyreceive comparatively little attention despite their intrinsically interesting properties andwidespread applications. A comparison of the chemistry of the lanthanide and actinidesreveals strongly differing behaviour which is attributed to the extent of f orbital avail-ability. The effect on bonding and structures is discussed: predominantly ionic bondingin lanthanides and significant covalency in actinide complexes. A good knowledge of IBcoordination chemistry is desirable.

Topics Metal–metal multiple bonding in the d block. Metal–ligand multiple bonding in d block chemistry.Ionic vs covalent bonding in the f block. Metal–ligand multiple bonding in f block chemistry.

4 Lecture Course Synopses

Recommended books

N. N. Greenwood and A. Earnshaw, Chemistry of the Elements, Butterworth-Heinemann Ltd,2nd Edn.F.A. Cotton and G. Wilkinson, Advanced Inorganic Chemistry, Wiley 5th Edition, 1988.J. E. Huheey, Inorganic Chemistry, Longman, 4th Edn.N. C. Norman, Periodicity in the s– and p–block Elements, Oxford Primer, 2nd Edn.N. Kaltsoyannis The f elements, OUP, 1999.S.A. Cotton and F.A. Hart, The Heavy Transition Metals, Macmillan, 1975.S.F.A. Kettle, Physical Inorganic Chemistry, Spectrum Books, 1996.

A2: The Foundations of Organic Synthesis

Dr W. P. Nolan

This course will apply the basic organic chemistry courses, Key Organic Reactions andShape and Reactivity taught in IB Chemistry B to organic synthesis. You will see howa molecule can be logically dissected into simple building blocks by working backwards(retrosynthetic analysis) and how using these tools you will be able to devise syntheticstrategies towards new molecules.

Topics Retrosynthetic Analysis and the Language of Synthesis: Target Molecules. Disconnections.Synthetic equivalents. Criteria for Good Synthetic Planning

C–X Disconnections: Synthesis of halides, ethers, sulphides and amines (considered as one-group –X disconnections). Two-group disconnections illustrated by the synthesis of 1,1-, 2,2-and 1,3-difunctionalised compounds.

C–C Disconnections and Synthesis using the Carbonyl Group: Carbonyl group as an a1 (ac-ceptor) reagent. Alkene synthesis and the Wittig reaction.

Carbonyl group as a d2 (donor) reagent. Enolate alkylations. The aldol condensation. Syntheticcontrol in carbonyl condensations.

α,β-unsaturated carbonyl compounds as a3 (acceptor) reagents. Synthesis of 1,5-dicarbonylcompounds. Construction of 1,4-difunctionalised compounds.

Construction of 1,4-difunctionalised compounds using synthons of “unnatural” polarity.

More Tools of the Trade: Synthesis of More Complex Systems. Control of Mixed Functionality.Use of Latent Functionality

Concepts and Methods for Ring Synthesis: Heterocyclic. Carbocyclic

Recommended books

Warren, S., Organic Synthesis – The Disconnection Approach, Wiley 1982.Clayden J., Greeves N., Warren S. and Wothers P. Organic Chemistry, OUP, 2001.Clayden J., Greeves N. and Warren S. Organic Chemistry, 2nd Edn, OUP, 2012. (either editionis fine)

A3: High-Resolution Molecular Spectroscopy

Dr J. H. Keeler

This course will be concerned with the high-resolution spectra of small molecules, mostly inthe gas phase. We will look at rotational, vibrational and electronic spectroscopy (includingthe Raman effect), and the kinds of detailed structural information that can be obtainedfrom each kind of spectrum. The course draws extensively on material previously coveredin Part IB Chemistry A, showing how the concepts introduced there can be used andextended to more complex cases.

Lecture Course Synopses 5

Topics Electromagnetic radiation and its interaction with molecules. Transition moments andEinstein coefficients. Linewidths. Lasers.

Instrumentation. Dispersive spectrometers: diffraction gratings, sources and detectors. Fouriertransform instruments: advantages. Spectroscopy with lasers.

Rotational spectroscopy. Classification of molecules and the resulting spectra. Intensities.Centrifugal distortion. Electric field effects (Stark effect).

Vibrational spectroscopy. Classification of normal modes and vibrational wavefunctions ac-cording to symmetry. Selection rules. Overtones and combination lines. Rotational fine struc-ture: parallel and perpendicular bands.

Raman spectroscopy. Origin of the Raman effect. Practicalities. Rotational and vibrationalRaman spectroscopy of linear molecules and symmetric tops. Rule of mutual exclusion. Mole-cular identification using IR and Raman spectra.

Electronic spectroscopy. Diatomic molecules. Electronic structure and term symbols. Selec-tion rules and the Franck Condon principle. Vibrational structure in absorption and emission.Electronic spectroscopy of larger molecules: Jablonski diagram.

Recommended books

J M Hollas, Modern Spectroscopy, 4th edit (Wiley, 2004).C N Banwell and E M McCash, Fundamentals of Molecular Spectroscopy, 4th edit, (McGraw–Hill, 1994).

the following texts are for reference.D A McQuarrie and J D Simon, Physical Chemistry, a Molecular Approach, (University ScienceBooks, 1997).J M Hollas, High Resolution Spectroscopy, 2nd edit, (Wiley, 1998)P F Bernath, Spectra of Atoms and Molecules, (Oxford,1995).P W Atkins and R S Friedman, Molecular Quantum Mechanics, 3rd. edit, (Oxford, 1997).

A4: Theoretical Techniques

Prof. M. Sprik

Rationalising molecular properties such as reactivity is a central goal of theoretical chem-istry. Much qualitative insight can be obtained from molecular orbital theory, whichyou have already encountered in the Part IB Symmetry and Bonding lectures. In thiscourse we expand on this topic introducing some theoretical techniques and ideas, suchas perturbation theory, applied to MO calculations, which enable one to extract chemicalinsight.

The interaction between electrons is ignored in this qualitative treatment or implicitlyassumed when experimental input is used, for example, when orbital energies are approxi-mated by ionization energies and electron affinities measured by experiment. However, formore quantitative understanding electron–electron repulsion must be taken into accountand we therefore also continue the more rigorous treatment of the Part IB QuantumMechanics course with a brief introduction of self consistent field (SCF) theory.

Topics Recap of Hückel theory; symmetry; linear and ring systems; population and bond-order analy-sis; alternant hydrocarbons; perturbation theory and heteroconjugated systems; Hartree–Focktheory of two and three electron systems; electron correlation and molecular dissociation;molecular vibrations.

Recommended books

Atkins, P.W. and Friedman, R.S., Molecular Quantum Mechanics, 3rd edit., OUP, 1997 (othereditions are fine)Cotton, F.A., Chemical Applications of Group Theory, Wiley, 1990.

6 Lecture Course Synopses

Leach, A. R., Molecular Modelling: Principles and Applications, Prentice Hall, 2001 (Longmansedition of 1996 is acceptable).House, J. E., Fundamentals of Quantum Chemistry, Elsevier.Murrell, J. M., Kettle, S. F. A. and Tedder, J. M., Valence theory,(Wiley).

A6: Concepts in physical chemistry

Dr P. T. Griffiths and Dr J. H. Keeler

This course is aimed at giving you a more detailed understanding of chemical bondingthan was possible in the Part IA course. This will require us to introduce some quantummechanics, which we will do by taking an approach which is always firmly rooted inyour chemical understanding and avoids excessive formality or mathematical detail. Wewill develop the key principles of quantum mechanics using simple model systems, whichinvolve relatively easy mathematics, and then go on to see how these ideas can be appliedin atoms and molecules.

The course concludes by showing how molecular symmetry, in the form of grouptheory, can be used to great effect in drawing up MO diagrams of simple molecules.

Topics Revision of some basic mathematics. Functions and curve sketching (polynomials andtrigonometric functions). The exponential function and logarithms. Differentiation: the chainrule; differentiation of a product. Integration. Introduction to complex numbers and the complexexponential.

Introducing quantum mechanics. What is quantum mechanics and why is it useful? Wave-functions, operators and energy levels. Exemplifying these ideas for two simple systems.

Atomic orbitals. Review of AOs, their shapes and energies. Multi-electron atoms: the energiesof singlets and triplets. Term symbols.

Molecular orbitals. The two orbital problem. Homo- and hetero-nuclear diatomics. Extendedarrangements of orbitals (π systems) in rings and chains. Computational aspects.

Symmetry. The description of symmetry. Symmetry elements operations. Point groups.Character tables. Representations and reduction of representations. Constructing molecularorbital diagrams using symmetry as an aid. Transition metal complexes.

Recommended books

P W Atkins, Concepts in Physical Chemistry, any edition, Oxford University Press.A Vincent, Molecular Symmetry and Group Theory, 2nd edition, Wiley 2001.

Level 2

B1: Inorganic II – Transition Metal Reactivity andOrganometallic Catalysis

Dr P. T. Wood: 6 lectures

In the first part of this course we examine the mechanisms of substitution, electron–transferand photochemical reactions in coordination compounds. In the second half of the coursewe extend our arguments to examine metal-promoted organic transformations which playa fundamental role in catalytic processes such as alkene polymerization and enantioselectivesynthesis. Well-defined transition metal systems are particularly effective homogeneous cat-alysts due to the ability of the metal to adopt different geometries, coordination numbers,

Lecture Course Synopses 7

and oxidation states. By considering a variety of catalytic processes, we shall examine theexact role of the metal in such cycles and discuss how it is possible to ‘tune’ the metalcentre by varying both the steric and electronic properties of its ancillary ligands in orderto favour a specific reaction outcome. The course will also consider several stoichiometricmetal-assisted organic transformations and again examine the particular traits of the metalthat allow such reactions to occur.

A good knowledge of both the IB courses Coordination Chemistry and OrganometallicChemistry is assumed.

CO Reactions. Alkene carbonylation, hydroformylation; alcohol carbonylation; the Monsantoand BP Cativa processes.

H2 & HX reactions. Hydrogenation; hydrosilylation; hydrocyanation.

Alkene reactions. Isomerization; polymerization with heterogeneous and metallocene cata-lysts; chain-end and ligand control in stereospecific propene polymerizations; late transitionmetal catalysts; alkene dimerization and trimerization; ethene oligomerization; SHOP process;alkene oxidation.

Metathesis reactions. Alkene and alkyne metathesis; Ring-Opening Metathesis Polymerisa-tion (ROMP), Ring-Closing Metathesis (RCM) etc.

Selective Catalysis. αβ-unsaturated aldehyde hydrogenation; epoxidation/aziridination withSALEN- & Sharpless-type catalysts.

Modern Hybrid Systems. Examples of single-site heterogeneous catalysts with enhancedturnover rates, product selectivities and recovery.

Dr E. Reisner: 6 lectures

Inorganic coordination chemistry can be broadly typified by the following types of reac-tions: substitution chemistry, redox chemistry and photochemistry. We initially focus onthe two extrema substitution chemistry (associative and dissociative reaction mechanisms)although experimental evidence often suggests the role of the outer coordination sphere issignificant leading to so-called interchange processes. The roles of the inner and outercoordination spheres are also important in electron-transfer processes and we considerfactors affecting the rate of electron transfer in both inner sphere and outer sphere mecha-nisms. The last lecture will focus on uni- and biomolecular photochemistry of coordinationcompounds.

Topics Dissociative reaction mechanisms in octahedral complexes; crystal field stabilization energy:inert and labile complexes; the influence of auxiliary ligands on transition state geometry andthe geometric outcome of the reaction.

Associative reaction mechanisms in square-planar complexes; the trans-influence and trans-effect.

Outer-sphere electron-transfer between substitutionally inert complexes; Marcus–Hush theory.

Inner-sphere electron-transfer: rate determining steps.

Uni- and biomolecular photochemistry, photo-induced redox chemistry.

Recommended books

D. F. Schriver, P. W. Atkins and C. H. Langford, Inorganic Chemistry, 2nd Edn., OUP, 1995I. S. Butler and J. F. Harrod, Inorganic Chemistry: Principles and Applications, Benjamin Cum-mings, 1989.S. F. A. Kettle, Inorganic Chemistry: A Coordination Chemistry Approach, Spektrum, 1996.K. F. Purcell and J. C. Kotz, Inorganic Chemistry, Holt & Saunders., 1977.M. L. Tobe and J. Burgess, Inorganic Reaction Mechanisms, Longman, 1999.

8 Lecture Course Synopses

C. Elschenbroich and A. Salzer, Organometallics, 2nd Edn,VCH, 1992.R. H. Crabtree. The Organometallic Chemistry of the Transition Metals, 3rd Edn,Wiley, NewYork, 2001.G. W. Parshall, Homogeneous Catalysis, 2nd Edn , Wiley, New York, 1992.F. A. Cotton, G. Wilkinson, C. A. Murillo and M. Bochmann, Advanced Inorganic Chemistry,6th Edn, Wiley, New York, 1988.G. O. Spessand, and G. L. Miessler, Organometallic Chemistry, Prentice Hall, New Jersey, 1996

B2: Structure and Reactivity

Dr W. R. J. D. Galloway and Prof. I. Paterson

In the first half of this lecture series (Dr Galloway), molecular orbital theory will be applied,without mathematics, to explain the preferred structures and conformations of organicmolecules, and then extended to explain the reactivity and stereochemistry of a wide rangeof organic reactions. New reactions having interesting features will be added, greatly ex-tending the range from those already presented in Part IB (Chemistry B) and building uponsome of the ideas presented in the Part II course The Foundations of Organic Synthesis.

The focus will shift during the second part (Prof. Paterson) to build on last year’swork on NMR spectroscopy and on the relationship between molecular geometry andreactivity. It will introduce powerful new methods for structure determination that haverevolutionised NMR spectroscopy. These will be applied to problems of conformation andconfiguration, both in simple ring systems and bicyclic structures.

1–6 The fundamental ideas of molecular orbital theory are used as the basis for understanding reac-tivity. Through space and through-bond (HOMO/LUMO) interactions, hard/soft nucleophiles andelectrophiles are explored in detail, as applied to ambident systems and nucleophilic substitutionreactions.

Stereoelectronic effects on fundamental organic reactions are thoroughly bexamined, as ap-plied to the following: cyclisation (Baldwin’s rules and the Thorpe-Ingold effect), elimination,fragmentation, rearrangement (migration). Electronic strain and the topic of carbene chemistryare also introduced.

An introduction to pericyclic reactions is given: cycloadditions and electrocyclic reactions areexamined in detail in the context of the Woodward-Hoffman Rules.

7–12 NMR Spectroscopy. Pulsed NMR. Chemical exchange. Shift reagents. Nuclear Overhausereffect. Two-dimensional spectra.

Conformational Analysis. Conformation of six-membered rings, including ketones, alkenes andheterocycles. Larger and smaller rings. Fused ring systems including steroids. Cis- and trans-ring-fusion. Axial and planar chirality.

Structure determination. How to determine absolute configuration and enantiomeric excess.Combined use of spectroscopic techniques to determine structure and conformation.

Recommended books

Kirby, A. J., Stereoelectronic Effects, OUP 1996.Moody, C. J. and Whitham, G. H., Reactive Intermediates, OUP, 1992.Eliel, E. L., Wilen S.H. and Mander, L.N., Stereochemistry of Organic Compounds, Wiley, 2ndEdn. 1994.Fleming, I., Pericyclic Reactions, OUP, 1999.Fleming, I., Frontier Orbitals and Organic Chemical Reactions, Wiley, 1996.Fleming, I., Molecular Orbitals and Organic Chemical Reactions, Wiley, 2009.Available online via Newton catalogue:http://linux02.lib.cam.ac.uk:2048/login?url=http://dx.doi.org/10.1002/9780470689493

Clayden, J., Greeves, N., Warren, S. and Wothers, P., Organic Chemistry, OUP, 2001.Williams, D. H. and Fleming, I. Spectroscopic methods in Organic Chemistry, McGraw-Hill, 5thEdn 1995.Sanders, J, K, M. and Hunter, B. K., Modern NMR Spectroscopy, OUP, 2nd Edn., 1993

Lecture Course Synopses 9

B3: Chemical Biology I – Biological Catalysis

Prof. C. Abell and Prof. D. R. Spring

Enzymes are the main catalysts in the cell. They catalyse an amazing array of reactions,with high chemo-, regio- and stereoselectivity and at rate enhancements of up to 1015!Consequently, about half of the drugs currently being developed in the pharmaceuticalindustry are targeted at enzymes. It is therefore very important for us to understand howenzymes achieve catalysis, and how to use this information to design specific inhibitors.

In IB some of the basic concepts behind enzymatic catalysis were introduced. Now wewill build on that foundation and explain the diversity of chemical reactions that enzymescatalyse. The examples are chosen to illustrate how enzymes are studied and to introduceconcepts that you will need for subsequent biological courses in Part III.

Prof. C. Abell

Topics Enzymes basics (a reprise); carbon-carbon bond forming reactions: the biological SN1 reaction,the biological aldol reaction; decarboxylation and elimination reactions; one carbon transfer;activation of oxygen.

Prof. D. R. Spring

Topics Enzymes and Coenzymes. Vitamins; Reduction and Oxidation, NAD(P)H and Flavins; Thi-amine Pyrophosphate (TPP)-Dependent Enzymes; Enzymatic Transformations of Amino Acids,PLP; Glucose Metabolism, Enzymes Work Together.

Recommended books

T D H Bugg, An Introduction to Enzyme and Coenzyme Chemistry Blackwell Science 2004.the following texts are for referenceR B Silverman, Organic Chemistry of Enzyme-Catalysed Reactions Academic Press 2002.R B Silverman, The Organic Chemistry of Drug Design and Drug Action Academic Press 1992.A Fersht, Structure and Mechanism in Protein Science, Freeman 1999

B4: Diffraction Methods in Chemistry

This course is given entirely in the Michaelmas Term

Dr D. A. Jefferson

This course provides the background knowledge for the main use of diffraction methodsin chemistry, namely the solution of structures by single-crystal x-ray diffraction. It is notintended to be a course in formal crystallography, and no prior knowledge is assumed,but instead it illustrates the basic principles of diffraction, the fundamental relationshipbetween diffracted x-ray amplitudes and the crystal structure, and the problems arisingfrom the measurement of x-ray intensities rather than amplitudes, together with the mannerin which these may be circumvented.

All the main methods of structure determination will be dealt with, ranging from therelatively simple approach used in structures containing heavy atoms, through the so-called“Direct Methods” used for medium sized molecules in Organic and Inorganic Chemistry,to the advanced isomorphous replacement methods used in the determination of proteinstructures. In all these cases the aim is to provide, via selected worked examples, theunderlying principles behind the techniques.

10 Lecture Course Synopses

The course concludes with an introduction to methods of crystal structure refinement,an assessment of what constitutes a “correct” structure, and an outline of some of theadditional information which may be gained from the use of neutron diffraction.

Recommended books

Dunitz, J.D., X-ray Analysis and the Structure of Inorganic Solids, Cornell Univ. Press.Guinier, A., X-ray Diffraction, W.H.Freeman and Co.Cowley, J.M., Diffraction Physics, North Holland PublishersGiacovazzo, C., Fundamentals of Crystallography, O.U.P.Woolfson, M.M., X-ray Crystallography, C.U.P.Stout, G.H. and Jensen, L.H., X-ray Structure Determination – A Practical Guide, John Wiley &Sons

B5: The Chemistry of Materials

Prof. W. Jones and Dr M. J. Duer

So far you have not had any specific lectures on materials (at least not within ChemistryDepartment courses). We are surrounded, however, by (and indeed ourselves composedof) materials that function because of their specific solid state structures. Importantly, theproperties of these solids are not just a result of the molecular structure of their constituentsbut more significantly the ‘collective’ solid state effects.

This course will examine a range of organic, metal-organic and inorganic materialsand demonstrate their varied uses. We will, in particular, identify important structuralfeatures relevant to such areas as the pharmaceutical and petrochemical industries and tonaturally occurring biomaterials such as bone. The underlying chemistry and propertieswill be shown to be often sensitive to the way that the constituent atoms and moleculesare packed together. This aspect of solid state control will be examined in some detail.The development and design of new materials, incorporating structural characteristics ofinorganic solids and functionality of organic molecules will be described.

Leading on from this, biological materials, such as bone, hair, skin etc. present anopportunity to learn from Nature how to build functional materials that have differentfunctions on different lengthscales. For instance, on a macroscopic lengthscale, boneprovides structural support whilst on a nanoscopic lengthscale, it provides a home forcells and on an even smaller lengthscale, the molecules that make up the tissue are key inproviding a communication system between cells.

Currently, man-made materials generally are designed to perform on one lengthscaleonly, so studying biological materials gives us insight into designing a new generation ofmaterials. We will study these materials to gain perspective on how they perform theirvarious material roles.

Dealing with complex materials like these however means that we have to investigatedifferent ways of examining their structure from the more conventional diffraction tech-niques. Thus this part of the course will begin with an overview of solid-state NMRand how it can be applied to determine molecular structures, then lead on to a detailedexamination of keratin tissues (hair, nails etc.), and collagenous tissues (bone, tendon, skin,muscle, etc.), to focus throughout being on understanding how the underlying molecularstructures and dynamics lead to the required material properties.

From paracetamol to petrol to proteins to bone – the importance of the Chemistry ofMaterials will be explored in these lectures.

1–4 Polymorphism in molecular crystals and implications for solid-state reactivity. Impact on devel-opment of new pharmaceutical materials. Nature of intermolecular interactions and the hydro-

Lecture Course Synopses 11

gen bond; implications for crystal structure. Crystal engineering. Supramolecular chemistry.Methods of studying materials I: XRD

5–6 Introduction to inorganic-organic composites. Intercalation and formation of inorganic-organiccomposites. Ion exchange materials. Microporous aluminosilicates and zeolites. Applicationsof zeolites, especially in catalysis and shape selective control.

7–8 Solid-state NMR spectroscopy; applications to studying molecular structure and dynamics.

9–10 Keratin (“dead”) tissues; basic protein structures, primary and secondary structures. Compositestructure of keratin tissues. The importance of fibril structures for mechanical strength; the roleof the α-helix protein structure in mechanical properties

11–12 Collagen tissues; their composite structure, and self-assembly of collagen fibrils; the role ofproteoglycans in organizing collagen fibrils. Mineralization of collagen matrices.

Recommended books

Basic Solid State Chemistry, A R West, John Wiley and Sons Ltd. (2nd Edition)Molecular Crystals, J D Wright, Cambridge University Press. (1st or 2nd Edition).Reactions and Characterisation of Solids, S E Dann, RSC, Tutorial Chemistry Texts.Structural Biomaterials, Julian Vincent, Princeton University Press, 1990.Biomineralization, S. Mann, Oxford Chemistry Masters, OUP, 2001.Organic Molecular Solids: Properties and Applications, Edited by W Jones, CRC Press.An Introduction to Solid-State NMR, M.J. Duer, Blackwell Science Ltd, 2004.Core Concepts in Supramolecular Chemistry and Nanochemistry, J. W. Steed, D. R. Turner &K.J̃. Wallace. Wiley, 2007.

B6: Statistical Mechanics

Prof. D. Frenkel

The IB Course Molecular Energy Levels and Thermodynamics showed how the thermo-dynamic properties of a macroscopic sample of matter can be expressed in terms of theenergy levels of individual molecules and the interactions between them. To move on fromhere, we need to introduce the concept of Gibbs ensembles, and then we can express thethermodynamic and transport properties of a macroscopic sample of matter in terms ofthe basic interactions between molecules. Except for some limiting situations like theideal gas, approximations must be introduced to allow explicit calculations. One of thegeneric approximations is mean-field theory, which provides a reasonable description ofmany systems and phenomena, such as phase transitions, magnetism and electrical doublelayers around membranes. The course will provide an introduction to ensemble theory,classical statistics, mean field methods and the basic theory of transport phenomena. Theconcepts will be illustrated by applications to Physical Chemistry and Condensed MatterScience.

Recommended books

McQuarrie, D.A, and Simon, J.D, Physical Chemistry: A Molecular Approach, University ScienceBooks, 1997.Dill, K.A., and Bromberg, S., Molcular Driving Forces: Statistical Mechanics in Chemistry andBiology, Garland Science, 2002.For referenceChandler, D., Introduction to Modern Statistical Mechanics, O.U.P., 1987.Huang, K., Statistical Mechanics, John Wiley, 1987.McQuarrie, D., Statistical Mechanics, Harper and Rowe, 1976.

12 Lecture Course Synopses

B7: Symmetry and Perturbation Theory

Dr G. H. Booth and Prof. A. Alavi

Perturbation theory is an important technique in quantum chemistry. Although few systemscan be solved exactly, we can study the effects of a small change to the Hamiltonian of asystem, and using this technique we can predict, for example, how a molecule responds toan applied electric field or to the presence of a neighbouring molecule. The method providesa framework for understanding anharmonic effects in vibrational spectra, intensities inspectra generally, and many other phenomena.

The methods by which symmetry can be used to simplify calculations have been intro-duced in earlier courses. Here we shall examine some of the theory that underlies thesemethods, and extend it to further applications.

Dr G. H. Booth

1–6 Nondegenerate perturbation theory. The first order wavefunction. Polarisability of the hydrogenatom. Rayleigh–Schrödinger perturbation theory. Variation perturbation theory. Degenerateperturbation theory e.g. the H atom in an electric field. Molecular vibrations. Anharmonic vibra-tions. Fermi resonance for CO2. Time dependent perturbation theory. Transition probabilities.Frequency dependent polarisabilities. Dispersion forces.

Prof. A. Alavi

7–12 Introduction and basic ideas. Representations. What is a representation? Equivalent rep-resentations. Characters and classes. The Great Orthogonality Theorem. The symmet-ric representation. Symmetry and physical properties of molecules. The projection formula.Spherical harmonics and the full rotation group. Direct product representations. Calculation ofintegrals. The symmetrized and antisymmetrized square. The Jahn Teller theorem. Choosingthe symmetry group. What symmetries can be ignored? Approximate symmetries. Selectionrules. Rotational spectroscopy. Vibration–rotation spectroscopy. Electronic spectroscopy.

Recommended books

Atkins, P.W. and Friedman, R.S., Molecular Quantum Mechanics, OUP,Johnson, C.S. and Pedersen, L.G., Problems and Solutions in Quantum Chemistry and Physics,Dover, 1986.

B8: Investigating Organic Mechanisms

This course is given entirely in the Lent Term

Dr P. D. Wothers

How do we know how a reaction proceeds? How much faith should we put in themechanisms we so readily draw? In this course we will investigate the different methodsavailable to the chemist in order to understand exactly how species react in solution. Wewill look at the ways of determining and manipulating the reaction pathways from startingmaterials, through transition states and intermediates to products. The crucial role of thesolvent in controlling the outcome of a reaction is also examined.

Topics Kinetics, potential energy surfaces for reactions, interpretation of enthalpy, entropy and volumeof activation, interpretation of kinetic isotope effects, acid and base catalysis, linear free energyrelationships (Brønsted and Hammett equations). Noncovalent interactions, solvation, water asa solvent and hydrophobic effects and solvent effects on organic reactivity.

Lecture Course Synopses 13

Please note that all of the lectures for this course will be given in the Lent Term.

Recommended books

Organic and Bio-organic Mechanisms, M. Page and A. Williams, Longman, 1997.Structure and Reactivity in Organic Chemistry, Howard Maskill, Oxford Chemistry Primer 81,1999.Modern Physical Organic Chemistry, E. V. Anslyn and D. A. Dougherty, University ScienceBooks, 2004.

Level 3

C1: Inorganic III – Characterisation Methods

Prof. C. P. Grey, Dr E. Reisner and Dr D. A. Beauregard

The range of atoms encompassed by inorganic chemistry presents opportunities for charac-terisation and analysis with techniques that are not always employed in organic chemistry.In this course we focus on electron paramagnetic resonance spectroscopy, electrochemicaltechniques, and multinuclear NMR spectroscopy. The use of EPR spectroscopy to probethe electronic structure of paramagnetic complexes of the d- and f-block elements will beexplored. Electrochemical measurements underpin our understanding of redox processesand the stability of different oxidation states. Basic electrochemical methods and someapplications will be described. Multinuclear NMR spectroscopy will be investigated, par-ticularly for the characterisation of main group compounds and diamagnetic transitionmetal complexes. It is likely that a combination of classes and supervisions, will be offeredfor this course.

Prof. C. P. Grey: 4 lectures

These lectures examine a technique that is used to characterize the electronic structureof a paramagnetic complex, namely EPR spectroscopy. Magnetic responses of (isolated)paramagnetic molecules are briefly reviewed.

Topics Paramagnetism and diamagnetism: Spin (S ), orbital (L) and total angular momentum (J)contributions to magnetism.Magnetism of the free ion: Term symbols and magnetism of the lanthanides.Quenching of orbital angular momentum; Term symbols for common Oh and Td complexes; theVan Vleck formula and spin-only magnetic moment for d-block metals.Basics of EPR spectroscopy focusing on S = 1

2 systems: electron-Zeeman, nuclear-Zeemaninteractions and electron- nuclear interactions.The g-value and hyperfine coupling.Information that can be extracted from EPR spectra: localized and delocalized magnetic or-bitals; spin-polarisation.

Recommended books

Magnetochemistry, A. F. Orchard, Oxford Chemistry Primers, 2003.Introduction to Magnetic Resonance, A. Carrington and A. D. McLachlan, Harper InternationalEdition, 1967.Chemical and Biochemical Aspects of Electron Spin Resonance Spectroscopy, M. Symons, VanNostrand Reinhold Co. Ltd, 1978.General Inorganic text books such as: Inorganic Chemistry, Shriver and Atkins, Inorganic Chem-istry: Principles of Structure and Reactivity, Huheey, Keiter and Keiter and Chemical Applicationsof Group Theory, Cotton.

14 Lecture Course Synopses

Dr E. Reisner: 4 lectures

The lectures will give an introduction to electrochemistry and its use to study inorganicredox processes in solution and the solid state.

Topics Overview of electrode processes. Potentials and thermodynamics of cells. Kinetics of electrodereactions. Techniques: Cyclic voltammetry, Film voltammetry, Chrono-amperometry, spec-troelectrochemistry. Applications: Electrode reactions with coupled homogeneous chemicalreactions, Protein film voltammetry.

Recommended books

Electrochemical Methods, Fundamentals and Applications, 2nd Edition. A. J. Bard and L. R.Faulkner, Wiley, 2001.Understanding Voltammetry, 2nd Edition. R. G. Compton, C. E. Banks, ICP, 2011.Inorganic Electrochemistry, Theory, Practice and Application, 2nd Edition. P. Zanello, F. Fabrizide Biani, C. Nervi, RSC Publ., 2012.Electrode Dynamics. A. C. Fisher, Oxford Chemistry Primers, 1996.

Dr D. A. Beauregard: 4 lectures

The focus is on the characterisation of inorganic compounds through multinuclear NMRspectroscopy.

Topics Pulse sequences.Structural information from relaxation times.NMR using nuclei other than 1H and 13C for inorganic structure determination.Chemical shifts: shielding, extended chemical shift ranges in inorganic systems.Scalar coupling magnitudes for structure determination.Two-dimensional NMR spectroscopy techniques for inorganic chemistry.

Recommended books

NMR Spectroscopy in Inorganic Chemistry, J.A. Iggo, Oxford University Press, 1999.

C2: Chemical Biology II – Proteins and Metalloproteins

Dr S. E. Jackson and Dr P. D. Barker

Proteins are the most diverse of biological macromolecules from both a structural andfunctional point of view. Starting with just the twenty naturally occurring amino acidsit is possible to form massive structures such as the 34,350 residue long, 2M Da giantmuscle protein titin, in addition to small but potent structures such as the 60-residue longTextilinin-1 snake venom.

The first part of the course describes in detail the three-dimensional structures of pro-teins and how it is determined, and lays a strong foundation for the rest of this andother Part III lecture courses. A very wide range of examples will be used to illustratehow the structure and function of proteins are linked, and the underpinning non-covalentchemistry. The importance and widespread use of protein engineering techniques, includingrecently developed methods for the incorporation of non-natural amino acids into proteins,will be discussed including the engineering of antibodies for use as therapeutic agents tothe engineering of haem-containing proteins for nano-electrical circuitry! The marginalthermodynamic stability of the native states of many proteins will be highlighted in additionto the chemical methods that have been used to study it. The consequences of proteininstability and the link with disease will be illustrated with a few key examples.

Lecture Course Synopses 15

The second half of the course will discuss the interplay between protein structure/stabilityand metal binding from fundamental inorganic perspective, exploring how metal bindingcan be used to determine protein structure and conversely how protein structure determinesmetal function. After a brief overview of the principles for which biology has selectedmetals for different functions, we will examine in more detail, the cases of zinc, iron andcopper as structural elements and catalysts.

lectures 1–6 Introduction to protein structure, Probes of protein structure: NMR, x-ray crystallography,CD and fluorescence; Manipulating protein structure and function: protein engineering tech-niques; Measuring protein stability; Factors that govern protein stability; The importance ofprotein stability: instability, misfolding and disease.

lectures 7–12 Metals in biology - binding selectivity and thermodynamics; Zinc proteins; Iron enzymes -harnessing dioxygen chemistry; Copper proteins; Electron transfer in biology.

Recommended books

A. R. Fersht, Structure and Mechanism in Protein Science, FreemanT. Creighton, Proteins: Structures and Molecular Properties, FreemanS. J. Lippard and J. M. Berg, Principles of Bioinorganic Chemistry, University Science BooksT. D. H. Bugg, An introduction to Enzyme and Coenzyme Chemistry, Blackwell Science

C3: Control in Organic Chemistry

Dr J. M. Goodman and Prof. D. R. Spring

What controls organic reactions? Is it the reagent, the functional group, the catalyst?Questions like this will be explored in the course leading to an analysis of the differenttypes of control - chemo- regio- and stereo- (not enantio-). Reactions you have met earlierthis year will be examined in a new light. Building on these more familiar examples, themechanisms of new reactions will be introduced.

This course will involve a fundamental analysis of organic chemistry and have a strongmechanistic content. This analysis is vital for a mature understanding of the whole of PartII organic chemistry.

Recommended books

Clayden, J., Greeves, N., Warren, S. and Wothers, P., Organic Chemistry, OUP 1st Edn, 2000 or2nd Edn, 2012.

C4: Chemistry in the Atmosphere

Dr A. T. Archibald and Dr M. Kalberer

This course will introduce key ideas about the chemistry of the atmosphere. It will discussthe chemical processes which control the abundances of ozone, and other trace constituentsin the troposphere, and the rather different chemistry of the stratospheric ozone layer. Wewill use examples to reinforce ideas about reaction rates, gas and solution phase kineticsand spectroscopy.

Topics The physical and chemical structure of the atmosphere: composition and temperature as afunction of pressure. Sources, sinks and variability. The concept of lifetimes and steady state.The role of ozone in the atmosphere.

Chemistry of the stratospheric ozone layer. The Chapman reactions. Catalytic cycles for ozonedestruction and the idea of ‘families’, including NOx, HOX, ClOx.

16 Lecture Course Synopses

Chemistry of the troposphere. Local air quality. Oxidizing and reducing smogs, photochemicaloxidants. The role of nitrogen oxides and volatile organics. The global troposphere. Productionand destruction of ozone. The role of OH. Sulphur compounds and acid rain

Reactions of atmospheric interest. Some important gas phase atmospheric reactions will beconsidered in detail. Heterogeneous reactions of important gas phase compounds on at-mospherically relevant aerosol particles surfaces will discussed. Sources, formation processesand chemical composition of tropospheric aerosol particles.

Measurements of atmospheric composition and their applications. Remote sensing. Rovi-brational spectroscopy. Ultraviolet spectroscopy. Laser studies of the atmosphere. Chemicalmethods: chemiluminescence, laser induced fluorescence. Electrochemical methods. Chro-matographic techniques. Online and offline aerosol sampling and characterization techniques.

Recommended books

Chemistry of atmospheres, Wayne, R P, OUP

Further reading/reference:

Atmospheric change – an earth system perspective, Graedel, T and Crutzen, P Freeman and Co,NY

The physics of atmospheres, Houghton, J T, OUP

Chemistry of the upper and lower atmospheres, Finlayson-Pitts and Pitts, Academic Press

Aeronomy of the middle atmosphere, Solomon and Brasseur, Reidel

Reaction kinetics, Pilling and Seakins,OUP

C6: Electronic Structure

Dr A. J. Cohen

The aim of this course is to provide an introduction to Electronic Structure theory, and inparticular to go beyond the non-interacting, one-electron picture which has been implicitlyassumed in the molecular orbital theory used in nearly all earlier courses. The inclusionof electron–electron repulsion is crucial for the quantitative prediction of molecular prop-erties. Self-consistent field theory provides a way to include e–e repulsion, albeit at anapproximate level maintaining a one-electron picture. Two varieties of SCF theory ex-ist: wavefunction-based methods based on Hartree–Fock and density-functional methods.The former provides the traditional starting point to more systematic theories of electroncorrelation, and is the bedrock of quantum chemistry. The latter have proven a highlypopular and efficient alternative to Hartree–Fock, but unlike Hartree–Fock, still accountfor electron correlation in an approximate way. Both topics will be covered.

Topics Basis functions, hydrogenic (Slater) orbitals, atomic orbitals, Gaussian functions, and con-tracted functions; the secular equations from which orbitals are determined; self-consistentfield theory, and its numerical implementation; beyond Hartree–Fock, electron correlation; theenergy functional, the importance of electron density, Hohenberg–Kohn theorems; The Kohn–Sham equations and orbitals; comparison with Hartree–Fock theory; the exchange correlationfunctional; electronic structure calculations as research tool.

Recommended books

A. Szabo and N. S. Ostlund, Modern Quantum Chemistry, 2000, Dover publications.

W. Koch and M. C. Holthausen, A Chemist’s Guide to Density Functional Theory, 2001, Wiley-VCH.

Lecture Course Synopses 17

C7: Chemical Biology III – Nucleic Acids

Prof. S. Balasubramanian, Prof. J. Chin and Dr G. Bernardes

Nucleic acids are fundamental to life and to the study and exploitation of the life sciences.Understanding the chemistry of nucleic acids is as important now as it has ever been giventhe recent groundbreaking discoveries that relate to DNA, RNA and genome function.These lectures will provide detailed insights into the chemistry of nucleic acids and howthis relates to their structure and function in living systems.

Specific themes will include: DNA/RNA structure; the chemical synthesis of DNA andRNA Nucleic acids analogues as therapeutics; the recognition of nucleic acids by organic(drug) molecules, and by natural proteins; chemical modification of DNA; the chemical bi-ology of enzymes that mediate DNA- or RNA-related transactions (e.g. synthesis, cleavageand repair); the chemistry of DNA sequencing; and nucleic acids-based molecular medicine.

Lecture 1 (GB) Introduction to nucleic acids

Lecture 2 (GB) Chemical synthesis of nucleic acids

Lecture 3 (GB) Chemical analogues of DNA/RNA therapuetics

Lecture 4 (GB) Recognition of DNA by syntheic organic molecules

Lecture 5 (JC) RNA secondary structure and protein recognition

Lecture 6 (JC) Chemical and enzymatic cleavage of nucleic acids

Lecture 7 (JC) RNA enzymes

Lecture 8 (JC) Ribosomes and translation

Lecture 9 (SB) Chemical reactions on DNA, DNA damage and repair

Lecture 10 (SB) Enzymatic synthesis of DNA – Polymerases

Lecture 11 (SB) DNA replication and medicinal chemistry

Lecture 12 (SB) Chemistry of DNA sequencing

Recommended books

Eds G. M. Blackburn, M. J. Gait, D. Loakes and D. M. Williams, Nucleic Acids in Chemistry andBiology, 3rd edition, RSC Publishing Cambridge, 2006.R. B. Silverman, The Organic Chemistry of Drug Design and Drug Action, 2nd edition, ElsevierAcademic Press 2004.

C8: Surfaces

Dr S. Clarke, Dr S. M. Driver and Dr V. Fiorin

The behaviour of atoms and molecules at surfaces has a central role in many areas of greatacademic and industrial importance from everyday problems (such as corrosion, lubricationand detergency) to high added value technologies (such as oil recovery, heterogeneouscatalysis and novel sensors). Many biological systems also have behaviour that is ultimatelydominated by interactions at, or across interfaces. Therefore it is clearly essential thatwe understand surfaces and interfaces if we are to optimise and control these importantprocesses.

In this course we aim to provide an insight into the key issues that underpins cur-rent understanding and characterization of surfaces. We will describe the structure and

18 Continuously assessed work

properties of interfaces, both ‘wet’ (solid–liquid and liquid–vapour interfaces) and ‘dry’(solid–vapour interfaces). We will consider the behaviour over a range of lengthscales,from the atomistic mechanisms involved in surface mediated reactions to the macroscopic,thermodynamic description of adsorption. The material will be of use in its own right andas a firm foundation for those considering a deeper study of surfaces and related topicssuch as nanoscience, bioscience, colloids and catalysis.

Recommended books

G. Attard and C. Barnes, Surfaces, Oxford Chemistry Primer No 59, Oxford Science Publications,1998.R. J. Hunter, Introduction to Modern Colloid Science, Oxford Science Publications, 1996.D. J. Shaw, Introduction to Colloid and Surface Chemistry, 3rd Ed, Butterworth (out of print).E. M. McCash, Surface Chemistry, Oxford University Press, 2001.M. Bowker, The Basis and Applications of Heterogeneous Catalysis, Oxford Chemistry PrimerNo 53, Oxford Science Publications 1998.P. W. Atkins, Physical Chemistry, Oxford University Press, 7th Ed, 2001.

Continuously assessed work

You are required to complete a portfolio of continuously assessed work taken from a rangeof options on offer. Naturally, conventional practical work features heavily as chemistry isabove all an experimentally based subject, and to describe yourself as a chemist you needto know how to design and carry out experiments.

Chemists also need to develop a wider range of skills, such as how to find out andsift information, how to write, how to use computers in different contexts and how tocommunicate your ideas. You will have to opportunity to develop these skills as part ofyour portfolio of continuously assessed work. It is important to realise that even if you arenot intending to carry on as a professional chemist, these skills will nevertheless be veryuseful to you in your future career. The continuously assessed work you need to completeis made up in the following way:

• The two core practical courses which consist of Techniques in Modern SyntheticChemistry (organic and inorganic) and the joint Physical & Theoretical Chemistrycourse.

• The three exercises associated with the Chemical Informatics course.

• Six ‘advanced’ experiments.

Other continuously assessed work can be substituted for some of the advanced experimentsas follows:

• The Language Option (substitutes for four advanced experiments)

• The Computing Option (substitutes for two advanced experiments)

• The Mathematical Methods course (substitutes for three advanced experiments)

Only one of these substitutions can be made i.e. you can only take one out of the threelisted above.To produce a final mark for the continuously assessed work, each component will beweighted as follows:

Special arrangements for those taking course A6 19

Component % of final mark

Core practical course 60

Informatics 10

Each advanced experiment 5

The marks for the continuously assessed component contribute 25% to the overall markfor Part II.

Special arrangements for those taking course A6

If you are taking the A6 course then you will be required to complete the Techniques inModern Synthetic Chemistry course and the following experiments

1. Experiments A, B and D from the joint Physical & Theoretical Chemistry core course;you are not expected to do any of the theoretical exercises.

2. Exercises 1, 5 and 10 from the Part IB Chemistry A course.

3. Physical experiment X (Kinetics of protein folding), which is available in the LentTerm.

4. There are no restrictions on the advanced experiments you need to offer.

Core Practical course

This will consist of two parts, each lasting five weeks. The first part, Techniques in ModernSynthetic Chemistry, covers preparative organic and inorganic chemistry, and the secondpart is concerned with experiments and computation relating to physical and theoreticaltopics. The courses will build on and extend the practical skills you acquired in the secondyear, and you will also do experiments which illustrate the ideas and concepts presented inlast year’s and this year’s lecture courses.

The class will be divided into two groups; Group 1 will follow the Techniques inModern Synthetic Chemistry course for the first five weeks of the Michaelmas Term andthen change to physical and theoretical experiments for the remaining three weeks of termplus the first two weeks of the Lent Term. Group 2 will do the courses the other way round.

Due to restriction on the number of computers and apparatus available, the part of thecourse relating to physical and theoretical chemistry is timetabled rigidly. You must workon the days allocated to you when you at the start of Term. As in Part IB, your practicalwrite-ups will be assessed in the class by one of the Senior Demonstrators.

Techniques in Modern Synthetic Chemistry

Location Each end of the Organic & Inorganic Practical Laboratory which is on the groundfloor of the Department on the Union Road side of the building. Please enter thelaboratory by the doors which open onto the foyer outside Lecture Theatre 1.

20 Chemical Informatics (Michaelmas and Lent Term)

Time The laboratory is open weekdays, 11 am to 6 pm; you are free to complete yourwork during this time.

Attendance There will be an Induction Day, in the Part II Laboratory, during which safetyissues will be covered, the layout of the laboratory will be explained and sometechniques demonstrated. For Group 1 the Induction Day will commence at 1115 onThursday 10th October and practical work for this group will run until Wednesday13th November. For Group 2 the Induction Day will commence at 1400 on Monday18th November and practical work for this group will run until Friday 6th November.The course will then continue in the Lent Term for two weeks until Wednesday 29thJanuary 2014. You must attend the Induction Day assigned to your group; you willbe required to attend in the laboratory from the start of the induction session to theend of the day.

Personnel The technician in change of the class is Mykola Karabyn and he is assisted byMaria Cascone. The members of staff responsible are Dr Sally Boss, Dr DeborahLongbottom and Dr Bill Nolan.

Joint Physical & Theoretical Chemistry Course

Physical chemistry experiments

Location Part IB/II Physical Chemistry Laboratory on the first floor, Lensfield Rd side ofthe building.

Time The laboratory is open weekdays, 11 am to 6 pm; on your allotted day you are freeto complete your work during this time.

Rough books As last year, you must record any measurements, as you make them, ina rough book; you need to bring your rough book with you when you have anexperiment marked off.

Personnel the technician in change of the class is Chris Brackstone and he is assisted byGary Herrington. The member of staff responsible is Dr Peter Wothers.

Theoretical chemistry exercises

Location PWF (room G30), by the lift on the Lensfield Rd side of the building.

Time Weekdays, 2 pm to 5 pm; on your allotted day you are free to complete your workduring this time, but it is recommended that you attend at the start of the session tobe briefed about the exercise.

Personnel The member of staff responsible is Dr Andreas Bender (ab454@cam.ac.uk).

Chemical Informatics (Michaelmas and Lent Term)

This part of the course consists of six lectures; you will be required to complete threeassessed exercises. Further details will be given out in the first lecture.

Advanced Experiments (Lent Term) 21

Lectures 1–3: Chemical Information (Dr Jonathan Goodman)

How do you write a recipe for a reaction? The answer might be in the chemistry departmentlibrary which contains reports of molecular experiments performed over more than acentury, or in an on-line database. The lectures will describe how this huge quantity ofinformation can be searched and analysed, using the main databases available to us (Webof Knowledge, SciFinder, Reaxys (Beilstein), CSD, etc.). The problems and challenges offinding and analysing chemical information will be discussed.

Lectures 4–6:Computer Representation of Molecules and Molecular Data Analysis (Prof. Robert Glen)

How can large collections of molecules be described and analysed? Is it possible to design anew molecule with specific physical or biological properties? Some methods of representingmolecules in computers will be described, showing how different approaches are best fordifferent contexts. Molecular data can be generated and analysed from these molecularrepresentations. Methods of property generation and analysis will be described.

Advanced Experiments (Lent Term)

There will be a wide range of more advanced and open-ended experiments for you toattempt, in all areas of Chemistry. These experiments will utilise the skills that you havebeen acquiring throughout the second and third years, and will draw on ideas and conceptsfrom the lecture courses.

If you are offering two or three of these advanced experiments, then of these at leastone must be taken from those on offer in the Organic/Inorganic laboratory and at least onefrom those on offer in the Physical/Theoretical laboratory.

If you are offering four or more of these advanced experiments, then of these at leasttwo must be taken from those on offer in the Organic/Inorganic laboratory and at least twofrom those on offer in the Physical/Theoretical laboratory.

If you have taken the A6 course then there is no restriction on the type of advancedexperiments you can offer.

Language Option (Michaelmas and Lent Terms)

The Language Option is made possible by generous funding provided by the Department’sCorporate Associates Scheme: www-cas.ch.cam.ac.uk.

There are around twenty places on offer to study Chinese, French, German, Japaneseor Spanish in the Department of Engineering’s excellent Language Unit:

www.eng.cam.ac.uk/teaching/language

The courses are aimed at enabling you to understand both the written and spoken word;the emphasis is not on technical vocabulary but rather on the day-to-day language thatyou might need when working overseas. The courses cope with a wide range of startingabilities, from beginners to A-level standard.

The Language Unit is very well set up and has two full-time lectors (one French, oneGerman), a part-time Director and many skilled language teachers who work alongside the

22 Computer programming

permanent staff. Teaching is through the medium of conventional classes and computer-based audio-visual material, much of which has been written specifically for the courses.The Unit is housed in the Baker Building at the Lensfield Rd end of Trumpington St andthose who are registered for the course will have unrestricted access to the Unit’s facilities.

At 1400 on Tuesday 8th October (in the Pfizer Lecture Theatre) Casimir d’Angelo, theDirector of the Language Programme, will give an introductory talk on the courses offeredby the Language Unit. If you are thinking of taking one of these, it is vital that you attendthis introduction.

If, after hearing the talk you wish to take up one of the places you need to EMAILthe Director of Teaching, Dr James Keeler (jhk10@cam.ac.uk), giving a short explanationof why you want to follow the course which language you would like to study. TheseEMAILs must arrive by 0900 on Wednesday 9th October. If the course is oversubscribed,names will be selected by drawing lots. The names of those successful in gaining a placewill be announced, by EMAIL, on Wednesday morning.

If you are allocated a place on the Language Course you will need to take a selfassessment test (LASSIE) lasting a maximum of 30 mins in the Language Unit. Thesetests will take place in two sessions at 1400 and at 1500 on Wednesday 9th October.

You will also need to be issued with a swipe-card so that you can access the LanguageUnit outside normal hours. Details of how this will be done will be announced in theintroductory lecture. Classes will commence in Week 2, starting Thursday 11th October,and continue for the rest of the Michaelmas Term and all of the Lent Term – the startingdate will be confirmed to you when you register.

The Language option will be challenging and will demand self discipline as each weekyou need to complete a number of hours of unsupervised work. There may be somedifficulties in fitting the Language classes in with your timetable for practical work; wewill do our best to be accommodating, but some compromises may have to be made. Youare expected to attend the classes and complete the homework assigned; if you fail to dothis, you will be withdrawn from the course.

There will be a formal assessment of your progress at the end of both the Michaelmasand Lent Terms. You must attend these assessments. Details will be announced nearer thetime.

Computer programming

We will give credit for acquiring computing skills, particularly in the area of high-levelprogramming languages such as Visual Basic, C, Fortran or Java. Different starting levelswill be accommodated. Typically, you would agree to produce a properly documentedprogram which has chemically oriented content or applications. For example, in the pastpeople have developed programs for illustrating oscillating reactions and for web-basedanimations. This option will be entirely self taught. If you wish to pursue this option youshould contact Dr James Keeler no later than the first week of the Lent Term.

Mathematical methods

This course covers mathematical methods which are relevant for those interested in ad-vanced courses in theoretical and physical chemistry. Part of the course will involve re-

Assessment of practical work 23

visiting topics covered in Part IB NST Mathematics, and part will involve the extensionof this material and the study of some new material. If you have not done Part IB NSTMathematics, then this course will still be accessible to you.

The course will consist of eight two-hour sessions, held weekly during the Lent Term(exact times to be announced). Professor Michele Vedruscolo (mv245@cam.ac.uk) andDr Alex Thom (ajwt3@cam.ac.uk) will lead the course: please address any questions youhave to them. Assessment will be via weekly take-home problem sets, which you will beasked to complete.

Topics to be covered include: linear algebra; probability theory and inference methods;tensors; series; integral transforms; ordinary and partial differential equations; stochasticprocesses; and optimization theory.

Assessment of practical work

Most of your practical work will be assessed in front of you on a week-by-week basis, soyou will know your marks as the year progresses. All marks awarded for continuouslyassessed work are subject to moderation by the relevant member of staff in charge of thatpart of the course and/or the Examiners. This is done so that comparability between kindsof work can be maintained.

All continuously assessed work must either have been assessed (in the case of conven-tional practical) or be submitted for assessment (in the case of other work) by the endof the Term in which it was undertaken. You must not accumulate unmarked practicalsthroughout the Term and then expect to have them marked in the last few days. There willbe penalties imposed on work of any kind which is submitted after the deadline.

At the end of the year you must hand in a folder containing all of your continuouslyassessed work. It is therefore important that you keep your write-ups etc. together and ina safe place.

Plagiarism

Plagiarism is defined as submitting as one’s own work that which derives in part or in itsentirety from the work of others without due acknowledgement. It is both poor scholarshipand a breach of academic integrity. The University views plagiarism as a serious matter and,under Discipline Regulation 6, has the power to take disciplinary action against those foundguilty of plagiarising the work of others.

The general university statement on plagiarism, and further general advice on plagia-rism and how to avoid it, is given on the University’s plagiarism and good academic practicewebsite www.cam.ac.uk/plagiarism. Generally the Department follows the advice andpolicies set out by the University. This section gives further guidance as to how thesepolicies apply to study in the Department of Chemistry.

Supervision work and Tripos questions

The majority of questions set as supervision work and in Tripos examinations take the formof problems to be solved. In presenting their solutions to these problems students are notexpected to quote the source or authority of the facts, theories and concepts they use toformulate their solutions.

24 Examinations

Continuously assessed work (principally practical work)

Here the rules against plagiarism are especially relevant as they prohibit copying andcolluding. Basing a write-up on data or answers provided by another student is an exampleof plagiarism (or, more simply, cheating). The following rules apply to all continuouslyassessed work

• Unless otherwise instructed, you must work alone. Where you are permitted to workin a group, the names of those you have worked with must be stated on your practicalwrite-up.

• The write-up must be entirely your own work. In particular, you may not usespreadsheets or templates prepared by others.

• It is expressly forbidden to invent, falsify or modify data, spectra or observations, orto use data, spectra or samples obtained from other persons unless authorised to doso by a Senior Demonstrator.

• Where data from other sources is quoted in a write-up, the source must be identified.

The following summarizes succinctly the key point:

The Golden Rule: The examiners must be in no doubt as to which partsof your work are your own original work, and which are the rightfulproperty of someone else.

Examinations

Please be aware that the designation of the exam papers changed last year. The onlycomplication with the examinations is that a slightly different set of papers is offered ifyou have only taken Chemistry B in Part IB.

The basic rules are

• Candidates must offer four papers in total.

• Candidates must offer either Paper 1A or Paper 1B, Paper 2, Paper 3 and eitherPaper 4A or Paper 4B.

Next come the rules about which out of Papers 1A & 1B, and which out of Papers 4A &4B you can do.

• Candidates who have taken Part IB Chemistry A and Part IB Chemistry B must takePaper 1A and Paper 4A

• Candidates who have taken only Part IB Chemistry B may take either Paper 1A andPaper 4A or Paper 1B and Paper 4B

The point of these is that they allow students who have only done Chemistry B to attemptall the core courses if they wish, or to take the alternative course (A6) especially designedfor them.

Examinations 25

Format of the papers

Paper 1A will contain questions relating to the Level 1 courses A1 – A4. There will be foursections, one relating to each of the courses A1 – A4; each section will contain twoquestions. Candidates must answer four questions in total, one from each section.

Paper 1B will contain questions relating to the Level 1 courses A1, A2 and A6. SectionsA and B will relate to courses A1 and A2, respectively; each of these sections willcontain two questions. Section C will relate to course A6 and will contain threequestions. Candidates must answer four questions in total: one from section A, onefrom section B and two from section C.

Paper 2 will contain questions relating to the Level 2 courses. There will be as manysections as there are Level 2 courses, each section will relate to one of the Level 2courses and will contain two questions. Candidates must answer four questions fromat least three different sections.

Paper 3 will contain questions relating to the Level 3 courses. There will be as manysections as there are Level 3 courses, each section will relate to one of the Level 3courses and will contain two questions. Candidates must answer four questions fromat least three different sections.

Paper 4A is a short answer paper and will consist of two sections; candidates are advisedto devote an equal amount of time to each section.

Section A will contain eighteen compulsory questions, which will cover the materialfrom the Level 1 courses A1 – A4.

Section B will consist of as many questions as there are Level 2 and Level 3 courses.There will be one question relating to each of these courses, and candidates will berequired to answer six questions.

Paper 4 B is a short answer paper and will consist of two sections; candidates are advisedto devote an equal amount of time to each section.

Section A will contain eighteen compulsory questions relating to the Level 1 coursesA1, A2 and A6.

Section B will consist of as many questions as there are Level 2 and Level 3 courses.There will be one question relating to each of these courses, and candidates will berequired to answer six questions.

In all of the examinations you will be provided with a Data Book which contains asimple Periodic Table, values of physical constants, certain mathematical formulae anddefinitions and selected character tables. If you do not already have one, you will beprovided with a copy of the Data Book when you register for the course, and it can also bedownloaded from

www.ch.cam.ac.uk/teaching/data-book.

You may take (unassembled) molecular models into the examinations.Material from the Part IB course will not be examined explicitly in the Part II examina-

tions. However, you should be aware that a sound understanding and firm grasp of the IBmaterial is essential for success in the Part II papers.

In addition to the written papers, all candidates must submit the specified amount ofcontinuously assessed course work as described above.

26 Examinations

Example exam entries

1. If you have taken Chemistry A and B at Part IB you should be entered for Papers 1A,2, 3 & 4A.

2. If you have taken Chemistry A but have nevertheless decided to tackle the four Level 1courses A1 – A4 you should be entered for the papers as in 1.

3. If you have only taken Chemistry B and followed the Level 1 course A6, then youshould be entered for Papers 1B, 2, 3 & 4B.

4. All candidates must be entered for the ‘six units of further work’ – this is the contin-uously assessed part of the course.

Timetable

Although the Examination timetable will not be announced formally until early in theEaster Term, our understanding is that the papers will be scheduled as follows: Papers 1A& 1B Monday 2nd June, Paper 2 Wednesday 4th June, Paper 3 Thursday 5th June, andPapers 4A & 4B Friday 6th June, all at 9 am. You will be given an extra 10 minutes ofreading time for all of these papers.

We also expect that oral examinations, if required, will be held on the morning ofTuesday 17th June, and that the class list will be posted on Wednesday 18th June. Youmust be in Cambridge and available for an oral examination on the day announced.

Please note that these dates are all provisional and subject to confirmation.

Past papers

Past papers can be downloaded from the Teaching Website (Raven authentication required):

www.ch.cam.ac.uk/teaching/past-tripos-papers

Pass marks

The marks obtained on the written papers are combined with marks obtained from thecontinuously assessed work; the intention is that 75% of the final mark is for the theory and25% for the continuously assessed work. The Examiners may, however, at their discretionalter the weight given to different papers or different parts of the continuously assessedwork. The Examiners may also scale the raw marks obtained in any component of theexamination e.g. the continuously assessed part.

Please note that to be awarded a pass in the whole examination candidates will need toachieve: (1) a pass mark (40%) in the combined total of the theory papers, and (2) a passmark (40%) in the total from the continuously assessed work.

The Senior Examiner for Part II Chemistry is Dr James Keeler.

Disclosure of examination marks

It is the responsibility of your College to disclose to you the marks which you have beenawarded in the examinations. This information is provided to your College by the Exam-iners; it is not available to you directly from the Department.

Carrying forward marks 27

In the case of Part II Chemistry, the marks which are disclosed are those for each of thepapers, a total mark for the continuously assessed component of the course and the finaloverall total.

Carrying forward marks

Exam regulations allow the Part III examiners to take into account a candidate’s perfor-mance in Part II from the previous year. In effect, this means that marks will be ‘carriedforward’ from Part II to Part III.

The expectation is that the Part III examiners will, in the first instance, draw up theclass list by combining the Part II and Part III marks, with a weighting of around 25% forthe Part II marks. However, the final allocation of a class will not simply be done by amechanical process. Rather, the Examiners will consider each candidate’s mark profile andwill give particularly careful consideration to candidates who fall on class boundaries orfor whom there is a large discrepancy between their Part II and Part III marks.

Admission to Part III Chemistry for the academic year 2014/15

The Departmental Teaching Committee has recently approved a change to the regulationsgoverning entry to Part III by which the minimum standard required will be a II.1 in PartII Chemistry for entry in 2013/14.

The new regulation also allows for students who have not achieved the required stan-dard to appeal to the Faculty Board of Physics and Chemistry to be admitted to Part III,notwithstanding the fact that they have not achieved the required standard. The TeachingCommittee expects that the Faculty Board will be liberal in giving permission to enter PartIII to those students who were very close to achieving the required standard, or whoseexamination performance was inhibited by factors outside their control. Such cases will,however, need the strong support of the student’s Tutor or Director of Studies.

The appeals procedure is set out at

www.ch.cam.ac.uk/teaching/admission-part-ii-and-part-iii

Part II Physical Sciences: Half Subject Chemistry

This paper is offered in NST Part II Physical Sciences, the full details of which can be foundat

www.cam.ac.uk/about/natscitripos/students/thirdps.html

Students taking this option also need to complete a 5000 word dissertation on an approvedtopic (the word limit does not include: acknowledgements, contents lists, figure captions).

You should consult your Director of Studies early in the Michaelmas Term to discussthe selection of the topic. Your topic needs to be agreed with the Director of Teaching bythe end of the Michaelmas Term, and your dissertation (three copies, soft bound) needs tobe handed in by the first day of the Easter Term.

28 Mobile Phones

The programme of work for Half Subject Chemistry is a sub-set of that set out for PartII. You are required to take two of the Level 1 courses A1 – A4, two Level 2 courses andtwo Level 3 courses.

You will sit Papers 1A, 2 and 3 (as described above) but with the following modifiedrubrics: (a) you will be given 90 minutes to write the examination and (b) for each paperyou will be required to answer two questions, taken from different sections.

The requirements for continuously assessed work are:

• EITHER the joint Physical & Theoretical Chemistry core course OR the Techniquesin Modern Synthetic Chemistry course.

• The three exercises associated with the Chemical Informatics course.

• Two ‘advanced’ experiments, chosen without restriction.

Under exceptional circumstances, it may be possible to substitute the two advancedexperiments by the Language Option. If you wish to do this, you should consult theDirector of Teaching at the start of the year.

Mobile Phones

As a courtesy to others, please ensure that your mobile phone is switched off in lectures.The use of mobile phones is not permitted in practical classes.

Chemistry Teaching Web Site

You can find up-to-date information on the course and other related matters from theteaching web site:

www.ch.cam.ac.uk/teaching

In common with other Part II NST courses, we will also be using CamTools

camtools.cam.ac.uk

Chemistry Consultative Committee

The Chemistry Consultative Committee consists of representatives of students and acad-emic staff. It meets towards the end of each term and is a forum for the discussion of allaspects of the teaching of Chemistry in the Department. Student representatives are electedduring the Michaelmas term; comments and suggestions can be passed on to them so thatthey can be discussed at the meetings.

The minutes of previous meetings and the composition of the committee can be foundon the teaching website:

www.ch.cam.ac.uk/teaching/raven/student-consultative-committee

Library 29

Library

www-library.ch.cam.ac.uk

The Departmental Library, which is located in the Unilever Building (linked to the mainbuilding), is available for you to use when the department is open. You will need yourUniversity Card to gain access to the library.

Extended library access is available to Part II Chemistry students after 6pm, Mondayto Friday and during the weekend on application to Susan Begg, room UG 05 (Unileverbuilding - ground floor below library). It will be necessary to sign an assurance that youwill not contravene the rules specified in the department safety handbook; you will notwork in any laboratory; you will sign in and out of the book in the entrance hall after 6 pmweekdays and anytime at the weekend. All must leave the building before midnight. Thisprivilege will be withdrawn if the agreement is breached. Please note that no food or drinkmay be consumed in the library at any time.

The ‘Blue Book’ collection of core texts is shelved in Unit 17, on the right-hand side asyou enter the library. Most of this collection is reference only but a short-loan collectionis in development. Recommendations for additional copies of texts for short loan arewelcome. The rest of the book collection is shelved on the wall to the left and on theshelves behind the periodical display.

All Chemistry books are listed in the Newton catalogue and there is a dedicated terminalfor searching the catalogue. Part II students may borrow from the library and should callin to the library office to set up a borrowing account on the automated system. Shortundergraduate induction sessions are held in October. Please see notice board outsidelibrary for further information.

You are invited to use the library wiki to recommend resources, make suggestions, sharetips and discuss all matters relating to the library. You can access the library wiki using yourRaven ID and password:

www-library.ch.cam.ac.uk/wiki

Photocopying

There is a photocopier in the library – situated in the print room next to the libraryoffice, and a second copier by the lift on the second floor on the Lensfield Rd side of theDepartment. Photocopy cards can be purchased from a vending machine in the library printroom (25 unit cards for £1 coin – no change given). Higher value cards can be purchasedin the library office.

Further Details of the Department

The Department is open from 8 am to 6 pm on weekdays and from 8 am to 1 pm onSaturdays. During these times the front doors which lead into the foyers outside the lecturetheatres will be open. However to access any other part of the building you will need yourUniversity card. Once you are recognised correctly by the system, your card will give youaccess to those parts of the building to which you need to go (e.g. practical laboratories).

30 Further Details of the Department

We hope that during the registration process for the practical classes we will be able tocollect all of the information we need to make sure that everyone has the appropriate access.If you find you that your access rights are different to others in your year group, pleasecontact Susan Begg (smb28@cam.ac.uk) who can make authorised changes. However,please do not do this until after the first week of term, as it will take some time in order forthe whole system to settle down.

Please note that undergraduates will not be given access to research areas. If you needto meet supervisors and so on, you will need to arrange for them to meet you in a publicarea.

If you would like access to the Departmental library outside normal working hours youwill need to go and see Susan Begg to arrange this (her office is on the ground floor of theUnilever building). She will ask you to sign the following declaration before enabling yourcard.

I understand that my security access is being increased to allow entry to theDepartment of Chemistry via the main entrance, to enable me to use the libraryafter 1800 Monday to Friday and during weekends.

I hereby confirm that I will not contravene the rules laid down in the Depart-ment Safety Handbook, and will not undertake any work in any laboratory. Iwill sign in and out in the book at the front entrance when I am here after 18:00weekdays or at anytime over the weekend. I am aware that I cannot be in anypart of the building after midnight. I accept that the privilege will be withdrawnif I am found to have breached this agreement.

Computing facilities

Computers attached to the PWF network are available in the PWF room (G30, by the lift onthe Lensfield Rd side of the building), in the computing room inside the Part IB/II PhysicalLab, in the Library and in the Cyber Café. When practicals are being run, access to thecomputers in the PWF room and the Physical Lab. may be restricted.

Tea room

You are most welcome to use the Departmental tea room (Cyber Café) which is located onthe top floor of the Unilever Building. Service is available from 9.30 am to 3.45 pm; youmay also use the room outside these hours. Hot and cold drinks, as well as a selection ofsnack foods are available. At busy times, please make sure that you are not occupying toomuch space i.e. by spreading out all your books and papers.

Part II students may also use the small common room located in the centre of theOrganic and Inorganic Part II Laboratory at any time that the lab. is open. The room isset out with tables and food may be eaten there. Facilities are provided for making tea andcoffee.

Part II Chemistry 2013/2014: Titles of Courses

Period Code Title Lecturer(s)

Level 1

M 1–5 A1 Inorganic I: Structure and bonding SRB, MJD & DAB

M 1–5 A2 The foundations of organic synthesis WPN

M 1–5 A3 High resolution molecular spectroscopy JHK

M 1–5 A4 Theoretical techniques MS

M 1–5 A6 Concepts in physical chemistry PTG & JHK

Level 2

M 6–8 & L 1–3 B1Inorganic II: Transition metalreactivity and organometallic

catalysis

PTW & ER

M 6–8 & L 1–3 B2 Structure and reactivity WRJDG & IP

M 6–8 & L 1–3 B3 Chemical biology I: Biological catalysis CA & DRS

M 5–8 B4 Diffraction methods in chemistry DAJ

M 6–8 & L 1–3 B5 The chemistry of materials WJ & MJD

M 6–8 & L 1–3 B6 Statistical mechanics DF

M 6–8 & L 1–3 B7 Symmetry and perturbation theory AA & GHB

L 1–5 B8 Investigating organic mechanisms PDW

Level 3

L 4–8 C1 Inorganic III: Characterisation methods CPG, ER & DAB

L 4–8 C2 Chemical biology II – Proteins and metalloproteins SEJ & PDB

L 4–8 C3 Control in organic chemistry JMG & DRS

L 4–8 C4 Chemistry in the atmosphere MK & ATA

L 6–8 & E 1–2 C6 Electronic structure AJC

L 4–8 C7 Chemical biology III: Nucleic acids SB, JC & GB

L 6–8 & E 1–2 C8 Surfaces and interfaces SC, SMD & VF

Other

M 6–8 CI Chemical informatics JMG & RCG

L 1–8 MM Mathematical Methods MV & AJWT

All lectures are held in the Pfizer Lecture Theatre unless otherwise stated

Part II Chemistry : Michaelmas Term 2013Week Date Day 9 10 11 12 Courses Other activities / comments

0 8/10 Tu Registration 9–1, 2–4; Lang. Intro. 1400 (PLT)9/10 We Introductory Lect. 1200 (WLT); 1400 LASSIE tests

1 10/10 Th A3/A6 A4/A6 A1 1115 Group 1 induction11/10 Fr A1 A2 A214/10 Mo A1 A315/10 Tu A3/A6 A4/A6 A416/10 We A1 A2 A6*

2 17/10 Th A3/A6 A4/A6 Language courses start18/10 Fr A1 A221/10 Mo A1 A222/10 Tu A3/A6 A4/A623/10 We A1 A2

3 24/10 Th A3/A6 A4/A625/10 Fr A1 A228/10 Mo A3/A6 A229/10 Tu A3/A6 A4/A630/10 We A1 A2

4 31/10 Th A3/A6 A4/A61/11 Fr A3/A6 A24/11 Mo A1 A4/A65/11 Tu A3/A6 A4/A66/11 We A1 A2

5 7/11 Th A3/A6 A4/A6 B48/11 Fr A2

11/11 Mo A1 A4/A6 B412/11 Tu A3/A6 A4/A6 B413/11 We A1 A2 Group 1 laboratory course ends

6 14/11 Th B1 B4 B7 B115/11 Fr B3 B2 B5 CI B218/11 Mo B1 B2 B4 B6 B3 1400 Group 2 induction19/11 Tu B3 B4 B7 CI B420/11 We B5 B6 B5

7 21/11 Th B1 B4 B7 CI B622/11 Fr B3 B2 B5 B725/11 Mo B1 B2 B4 B626/11 Tu B3 B4 B7 CI27/11 We B5 B3 B6 B7/C

8 28/11 Th B1 B4 B7 CI29/11 Fr B3 B2 B5

2/12 Mo B1 B2 B4 B63/12 Tu B4 B7 CI4/12 We B5 B6 B7/C

*A6 is given in the Todd–Hamied roomXX/Cindicates a class associated with lecture course XX

All lectures are held in the Pfizer Lecture Theatre unless otherwise stated

Part II Chemistry : Lent Term 2014Week Date Day 9 10 11 12 Courses Other activities / comments

1 16/1 Th B1 B7 B1 Group 2 practical course continues17/1 Fr B3 B2 B5 B220/1 Mo B1 B2 B8 B6 B321/1 Tu B3 B7 B522/1 We B5 B8 B6 B6

2 23/1 Th B1 B7 B724/1 Fr B3 B2 B5 B8 B827/1 Mo B1 B2 B8 B628/1 Tu B3 B729/1 We B5 B8 B6 B7/C Group 2 laboratory course ends

3 30/1 Th B1 B731/1 Fr B3 B2 B5 B8

3/2 Mo B1 B2 B8 B64/2 Tu B3 B75/2 We B5 B8 B6 B7/C

4 6/2 Th C4 C7 C2 C17/2 Fr C1 C4 C3 B8 C2

10/2 Mo C1 C2 B8 C311/2 Tu C4 C3 C7 C412/2 We C1 C3 B8 C7

5 13/2 Th C4 C7 C214/2 Fr C1 C4 C3 B817/2 Mo C1 C2 C718/2 Tu C4 C319/2 We C1 C3

6 20/2 Th C4 C121/2 Fr C6 C2 C3 C8 C224/2 Mo C1 C2 C7 C7 C325/2 Tu C4 C6 C7 C426/2 We C1 C2 C3 C8

7 27/2 Th C4 C7 C628/2 Fr C6 C2 C3 C8 C7

3/3 Mo C1 C2 C7 C84/3 Tu C4 C6 C75/3 We C1 C2 C3 C8

8 6/3 Th C4 C7 C37/3 Fr C6 C2 C3 C8

10/3 Mo C1 C2 C711/3 Tu C4 C612/3 We C1 C8 Organic and Inorganic advanced practical ends

XX/Cindicates a class associated with lecture course XX

All lectures are held in the Pfizer Lecture Theatre unless otherwise stated

Part II Chemistry : Easter Term 2014Week Date Day 9 10 11 12 Courses Other activities / comments

1 24/4 Th C8 C625/4 Fr C6 C8 C828/4 Mo C629/4 Tu C830/4 We C6

2 1/5 Th C82/5 Fr C6 C85/5 Mo C66/5 Tu C87/5 We C6

3 8/5 Th9/5 Fr

12/5 Mo13/5 Tu14/5 We

4 15/5 Th16/5 Fr19/5 Mo20/5 Tu21/5 We

5 22/5 Th23/5 Fr26/5 Mo27/5 Tu28/5 We

6 29/5 Th30/5 Fr

2/6 Mo Paper 1A/1B*3/6 Tu4/6 We Paper 2*

7 5/6 Th Paper 36/6 Fr Paper 4A/4B*9/6 Mo

10/6 Tu11/6 We

8 12/6 Th13/6 Fr16/6 Mo17/6 Tu Orals (if required)*18/6 We Class list posted

*Provisional dates