pasteurellaceae  haemophilus influenzae  haemophilus ducreyi  oppurtunists: haemophilus...

Download Pasteurellaceae  Haemophilus influenzae  Haemophilus ducreyi  Oppurtunists: Haemophilus parainfluenzae Haemophilus spp.  Pasteurella multocida 

Post on 17-Dec-2015

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  • Slide 1
  • Slide 2
  • Pasteurellaceae
  • Slide 3
  • Haemophilus influenzae Haemophilus ducreyi Oppurtunists: Haemophilus parainfluenzae Haemophilus spp. Pasteurella multocida Actinobacillus actinomycetemcomitans Human Pathogens
  • Slide 4
  • Pasteurellaceae General Overview Taxonomic Confusion in Family Pasteurellaceae Three Genera: Haemophilus: Most Common in Human Disease Actinobacillus Pasteurella Haemophilus Common Characteristics of Family Small (0.2 x 0.3-2.0 mm) Gram-negative Nonmotile bacilli Aerobic or facultatively anaerobic Fastidious growth requirements
  • Slide 5
  • Pasteurellaceae Differential Characteristics X factor = hemin (hematin) V factor = (NAD or NADP) nicotinamide adenine dinucleotide
  • Slide 6
  • Slide 7
  • Haemophilus
  • Slide 8
  • Haemophilus General Overview Gram-negative bacilli liking blood (as per genus name) Obligate Parasites of Man and Animals Major pathogens for which humans are natural hosts Haemophilus influenzae Acute pyogenic, normally invasive infections Chronic infections with H. influenzae as 2 o pathogen Haemophilus ducreyi True pathogen (i.e., not found in healthy individuals) STD; Soft chancre (chancroid )
  • Slide 9
  • Haemophilus Diseases
  • Slide 10
  • Haemophilus Infections PRP = polyribitol phosphate (see others in text)
  • Slide 11
  • Haemophilus Infections (cont.) NOTE: Polysaccharide PRP is weakly immunogenic Pediatric immunity not mature for processing polysaccharide antigens until ~18 months Conjugated Vaccine: PRP conjugated to protein carrier induces protective immunity (carriers may include: diphtheria toxoid, tetanus toxoid or meningococcal OMP)
  • Slide 12
  • Haemophilus influenzae Incidence NOTE: Dramatic decrease in children

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