PATHOLOGY of ENDOCRINE, SKELETAL SYSTEM

and SKIN (Diabetes mellitus – kidney, Goiter, Feochromocytoma, Carcinoid.

Osteomyelitis, Osteodystrophy.

Dermatomyositis, Verruca vulgaris, Molluscum contagiosum, Atheroma,

Basal cell papilloma)

General medicine

Prof. MUDr. Pavel Babál, CSc.

Department of Pathology FM CU

Sasinkova 4, Bratislava

Prof. MUDr. Ľudovít Danihel, CSc.

PATHOLOGY of ENDOCRINE SYSTEM

Diabetes mellitus (159)

= chronic disease with permanent hyperglycemia in relative

or absolute absence of insuline

1.) Type I DM (total insuline deficiency)

2.) Type II DM (relative insuline deficiency)

3.) Other types of DM

4.) Gestational DM

Intercapillary glomerulosclerosis and artheriolosclerosis

calcifiication

artheriolosclerosis

Interkapilárna glomeruloskleróza a artérioloskleróza Intercapillary glomerulosclerosis and artheriolosclerosis

Interkapilárna glomeruloskleróza a artérioloskleróza Intercapillary glomerulosclerosis and artheriolosclerosis

Intercapillary glomerulosclerosis leading to glomerular fibrosis

PATHOLOGY of ENDOCRINE SYSTEM

GOITER (STRUMA) (69, 70, 240)

• Hashimoto disease (thyroiditis)

• Graves disease (Basedow struma,

autoimmune hyperthyreodism)

• Nontoxic goiter - diffuse

- nodular

Hashimoto disease

Hashimoto disease

Hashimoto disease

Graves disease

Graves disease

Nodular goiter

Nodular goiter

PATHOLOGY of ENDOCRINE SYSTEM

Feochromocytoma (193)

• more frequent in adults

chromaffinity of cytoplasm (catecholamines)

• in children prevalence of neuroblastoma (sympatoblastoma)

Feochromocytoma

Kôra nadobličky

Feochromocytoma

PATHOLOGY of ENDOCRINE SYSTEM

Neuroendocrine tumor (carcinoid) (184)

• large intestine, small intestine, bronchi, pancreas, other...

• (serotonin, callicrein... „carcinoid syndrome“)

Carcinoid in large intestine

mucosa

C A R C I N O I D

Carcinoid in large intestine

Carcinoid in large intestine

CARCINOID

mucosal gland

PATHOLOGY of SKELETAL SYSTEM

Osteomyelitis (139)

= infectious bone inflammation

• nonspecific (purulent)

• specific, granulomatous (Tbc, syphylis, sarcoidosis; brucellosis, typhoid)

Osteomyelitis

Osteomyelitis

leukocytes

PATHOLOGY of SKELETAL SYSTEM

Osteodystrophy (156)

(ostitis deformans Paget)

(paramyxovirus)

- osteoclasts (large), later osteoblasts ... chaotic remodelling of bone tissue

- resorptive lacunae, osteoid, irregularly thickened compact bone,

fibrous bone marrow

- complication – osteosarcoma (IL6)

Paget disease

Paget disease

Bone

trabecule

Fibrosis

Paget disease

BT

F

BT

F

PATHOLOGY of SKELEAL SYSTEM

Dermatomyositis (polymyositis) (226)

• autoimmune disease (Ag ... capillary endothelium ?)

• in the skin - perivascular and periadnexal lymphocytic infiltrates

• lymphocyte-plasmocytic infiltrate, degenerative changes of muscle

fibres, fibrosis (scarring)

Dermatomyositis

Dermatomyositis

SKIN PATHOLOGY

Viral infections

• Verruca vulgaris (HPV 2,4,7) (197)

• Molluscum contagiosum (poxvirus) (142)

Verruca vulgaris

Verruca vulgaris

Molluscum contagiosum

SKIN PATHOLOGY

Psoriasis (318)

• hyperkeratosis with scales

• PMN pseudoabscesses

in stratum corneum

• papilomatosis

• acanthosis

Psoriasis

SKIN PATHOLOGY

Atheroma (200)

• epidermal cyst from skin adnexal epithelium

• hair follicle cyst, from sebaceous gland

Atheroma

Atheroma

SKIN PATHOLOGY

Basal cell papiloma (178)

• benign tumor

• senile verruca, seborrheic keratosis

Senile verruca

Senile verruca

Senile verruca