pathology of hematolymphoid system
TRANSCRIPT
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By the Name of Allah, The Most Gracious, The Most Merciful
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Hereditary spherocytosis blood smear.
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Sphere shape allow a much smaller surface area to volume ratio than biconcave shape
Scanning electron micrograph of a normal biconcave erythrocyte
Scanning electron micrograph of a spherocyte. The spherocyte is smaller, round, and lacks concavities
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Sickle RBCs
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A.Peripheral blood smear from a patient with sickle cell anemia.showing sickle cells, anisocytosis, poikilocytosis, & target cells .B , Higher magnification shows an
irreversibly sickled cell
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Target cells
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Target cells(arrows) anisocytosis poikilocytosis.
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Peripheral blood smear (Heinz bodies) revealed by supravital staining.
"bite cells".
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PCV
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Polycythemia –blood film
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PCV-bone marrow
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ALL-Lymphoblasts have fewer nucleoli than do myeloblasts, and the nuclear chromatin is more condensed.
Cytoplasmic granules are absent
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AML-Myeloblasts have delicate nuclear chromatin, prominent nucleoli, and
fine azurophilic granules in the cytoplasm (arrows).
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Acute lymphoblastic leukemia (ALL) blood smear.
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ALL-L3
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ALL- bone marrow aspirate.
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AML-Auer rods
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AML-bone marrow
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Acute promyelocytic leukemia (FAB AML-M3) blood smear. Note the
cytoplasmic granules in the cell at the top and the multiple Auer rods in the cell at the bottom.
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AML-M3 bone marrow
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CML-Peripheral blood smear shows many mature neutrophils, some
metamyelocytes, and a myelocyte and a myeloblast.
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CLL-blood smear Lymphocytosis of small mature-appearing lymphocytes. Numerous “smudge” cells are present.
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. CLL
Condensed “soccer ball” nuclear chromatin; one “smudge cell” is present.
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Diffuse large B-cell lymphoma, medium power.
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Diffuse large B-cell lymphoma, high power.
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Diffuse large B-cell lymphoma, high power.
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Follicular lymphoma
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Follicular lymphoma
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Small Lymphocytic Lymphoma
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MALT lymphoma
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Burkitt’s Lymphoma “starry sky” appearance.
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Hodgkin’s lymphoma RS cell
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Hodgkin disease, lymphocyte-predominance type. Numerous mature-looking lymphocytes surround scattered, large, pale-staining lymphocytic
and histiocytic variants ("popcorn" cells).
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Hodgkin lymphoma, nodular sclerosis type. A low-power view shows well-defined
bands of pink, acellular collagen that have subdivided the tumor cells into nodules
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Hodgkin lymphoma, nodular sclerosis type. A distinctive "lacunar cell" with multilobed nucleus containing many small nucleoli is seen lying within a clear space created by retraction of its
cytoplasm. It is surrounded by lymphocytes.
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Hodgkin disease, mixed-cellularity type. A diagnostic, binucleate Reed-Sternberg cell is surrounded by multiple cell types, including eosinophils (bright-red cytoplasm), lymphocytes,
and histiocytes.
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Multiple Myeloma
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Multiple myeloma blood smear. Rouleaux formation.
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Multiple myeloma bone marrow aspirate. Numerous plasma cells, many of
which have prominent nucleoli (normal plasma cells lack nucleoli), are present