pathology of tubercolosis
TRANSCRIPT
UNIVERSITY OF KHARTOUM
institute of endemic diseases
PATHOLOGY:
presentation of assignment two
prepared by:ahmed abdirahman jama
supervised by:prof. althahir Awad Gasim
(1) chronic inflammation ab initio
example:
TUBERCULLOSIS
INTRODUCTION chronic inflammation is body’s to injury
and tissue damage in prolonged duration:weeks, months etc
There are two main types of chronic inflammation :
(1) chronic supervening on acute (2) chronic ab initio : with no initial
acute phase
Traditionally, chronic inflammation ab initio is known (GRANULOMATOUS INFLAMMATION).
It is distinct type of chronic inflammation there is focal collection of activated macrophages called epithilliod cells.
It is consist of :(1) epithelliod cells(2) lymphocytes (3) plasma cells and(4) giant cells – formed by fusion of
epithelliod cells.
Granuloma
Caseous Necrosis
Epithelioid Macrophage
Langhans Giant cells Cell
Lymphocytic Rim
Types of granulomas
Based on mechanism Immune granuloma : is cell mediated
immune response a giant an insoluble particle like microbe .
eg. Tuberculosis , fungal infections
Foreign body granuloma: they result from a relatively inert substances.
.
Based on morphology:
Caseating granuloma: there are areas of caseous necrosis ( seen as cheesy white areas) in the affected tissues seen in case of tuberculosis.
Non caseating : there is no central caseation, it seen sarcoidosis and fungal infection.
Granulomatous inflammation is seen
When an organism is of low pathogenicity but excites an immune response e.g.
Mycobacterium tuberculosis Mycobacterium leprae Fungus Virus Parasite.
EXAMPLE:
TUBERCULOSIS
INTRODUCTION
Tuberculosis is a chronic infectious disease caused by mycobacterium of the “tuberculosis”. Mainly mycobacterium tuberculosis and mycobacterium bovis.
Mycobacterium tuberculosis is : Rod-shaped Slow-growing bacterium Non-spore forming Thin aerobic bacterium Neutral in Gram’s stainingbecause of it’s content in huge cell-wall lipids .
Sings and symptoms When disease is quite advanced,
sings and symptoms that arose include:
Loss of weight Loss of energy Poor appetite Fever Productive cough Night sweets.
Types of tuberculosis Pulmonary tuberculosis :
it is most initial infections either may develop of sings and symptoms discribed before or not.
That is seen to chest X-ray and 50%-60% of disease can return to it.
Pleural tuberculosis it may occur in 10% of people who have lung disease from tuberculosis. Also it occurs from rupture of diseased area into the pleural space, that is between lung and abdominal cavity. These peoples non productive cough, chest pain and fever. The disease may go away and then come back at the later date.
Miliary tuberculosis: In a minority of the people with weakened immune system. Tb bacteria may spread through their blood to various parts of the body and produces the mensioned sings and symptoms but cough and difficult breathing is less common.
About 15% of people may develop tuberculosis in an organ other than their lungs. The most common sites include the following:
Lymph nodes Genitourinary tract Bone and joint sites Meninges and Gastrointestinal tract lining.
Image credit : http://sitemaker.umich.edu/medchem13/files/tb.htm
TB Brain – Caudate n.
Prostate TB
TB Intestine
TB Peritonitis + liver Miliary TB
Testes TB Orchitis.
Adrenal TB - Addison Disease
Systemic Miliary TB
Transmission Pulmonary tuberculosis is a disease
of respiratory transmission, Patients with the active disease (bacilli) expel them into the air by: coughing, sneezing, shouting, or any other way that will expel bacilli
into the air
Who is at risk for getting Tb? Peoples that have:
HIV infections Low socio-economic diseases Alcoholism Homelessness Over crowded living condition Any disease that weakened immune system.
Migration country with high rate of infections of Tb.
Health care workers.
EPIDIMIOLOGY GLOBAL INCIDENCE AND
PREVELENCE The world health
organization(WHO) estimates that one-third of the global community is infected M.tuberculosis.
In 2000, the estimation was 8-9 millions incident cases 3 million of them was dead due to Tb occurred world-wide.
Tuberculosis: Global epidemiology
1.7 billion people
8.4 million cases, 1.9 million deaths each year
WHO TB fact sheet 2005
2 billion people ,equal to a third of world's population, are infected with TB bacilli.
2 million people die every year due to TUBERCULOSIS
TB is curable but kills 5000 people everyday.98% of TB deaths are in developing world affecting mostly young adults in their most productive years
Global TB incidence is still growing at 1% a year .TB is a worldwide pandemic; though the highest rates per capita are in Africa, half of all new cases are in 6 asian countries(Bangladesh, China, India, Indonesia, Pakistan, Philippines)
Diagnosis of TB Clinical features are not confirmatory. Zeil Nielson Stain - 1x104/ml, 60% sensitivity Release of acid-fast bacilli from cavities
intermittent. 3 negative smears to assure low infectivity* Culture most sensitive and specific test.
Conventional Lowenstein Jensen media 3-6 wks. Automated techniques within 9-16 days
PCR is available, but should only be performed by experienced laboratories
PPD for clinical activity / exposure sometime in life.
PPD Tuberculin Testing Sub cutaneous Weal formation Itching – no scratch. Read after 72 hours. Induration size. 5-10-15mm (non-
ende) < 72 hour is not
diag* +ve after 2-4 weeks. BCG gives + result.
PREVENTION By far the best way to prevent
tuberculosis is to diagnose infectious cases rapidly and administer appropriate treatment until cure. Additional strategies include BCG vaccination and treatment of persons with latent tuberculosis infection who are at high risk of developing active disease.
Prevention Maintain good personal and environmental
hygiene. Adopt a healthy lifestyle, i.e., have balanced
diet, adequate exercise and rest. Keep hands clean and wash hands properly. Wash hands when they are dirtied by
respiratory secretions e.g. after sneezing. Cover nose and mouth while sneezing or
coughing and dispose of nasal and mouth discharge properly.
Seek treatment promptly if symptoms similar to tuberculosis appear, particularly persistently cough for more than one month.
Receive BCG immunization according to immunization schedule. (Please refer to programme of immunization)
In spite of several advances Tuberculosis continues to be a difficult disease
رؤوس فوق تاج الصحةال األصحاء
المرض إال ىيراها
و “ الصحة على لله الحمد ”العافية
إستماعتكم بحسن Jشكرا .