Genetic Mutation

DJ-1 a-synuclein

a-synuclein

PINK-1 LRRK2 UHCL1 SAT1

(Dorfin)(SIAH)

N Ring 2Ring 1 CIBR(Parkin) Tyr143O-linked

UBL

Parkin

FBXO7

mitochondrial

dysfunction

misfoldedprotein

glycosylation

ProtofibrilsfibrilsCa2+

p25

Cdk5

CAK p35c-Abl

Cdk5

Ub

Ub

Ub

Ub

Ub

Ub

Death stimuli

Calpains Cdk5-p25

aSP16

P

Beclin 1

Cdk5 - CK1

p53

E1

ATPAmp+PPi

Ub

Ub

Ubch8 E2 Ubch7

mitochondrialDNA polymorphisms

DJ-1

aggregation

UPS substrates

Ub Ub Ub Ub Ub Ub Ub UbUb

UbUb

UbUb

degradedprotein

Lewy bodyDorfin

Dopamineoxidation

DA DA DA

tubulins

p38

Synphilin-1

cdcrel-1Cyclin E

CHIP Skp1Synaptotagmin XI

PACRG

Toxicity Neurodegeneration

AutophagyCell

survival

Oxidativestress

Sp22a

Nucleartargets

e.g MEF2 p53

NMDAR

Cytoplasmictargetse.g tau

PGP9.5

Ub

PINK-1

www.abcam.com

Pathways of Parkinson’s Disease

Related antibodies and proteins from Abcam: See more products at: www.abcam.com

156-10/10-PW

Antibodies Clonality Applications Host Species DatasheetReactivity www.abcam.com/ab… Featured antibodies

alpha Synuclein (phospho Y125) antibody P - Rb - 10789Beclin 1 antibody [EPR1733Y] M ICC/IF, IHC-P, IP, WB Rb Hu 51031c Abl antibody P ICC/IF, WB Rb Hu 85947Calpain 1 antibody - Domain I P ICC/IF, WB Rb Hu, Ms, Rat 28258Cdk5 antibody [2G2] M ELISA, IP, WB Ms Hu, Ms, Rat 28441Cyclin E antibody P WB Rb Hu, Ms 88259Dopamine antibody P ELISA, ICC, ICC/IF Rb - 6427DORFIN antibody P - Rb - 10889FBXO7 antibody P WB Rb Hu 84129LRRK2 antibody P ELISA, WB Rb Hu, Ms 38003NMDAR1 antibody - Neuronal Marker P ICC/IF, IHC (PFA fixed), WB Rb Rat 17345NMDAR2B (phospho S1480) antibody P IHC-FoFr, WB Rb Ms, Rat 18533NMDAR2C antibody [G218B5] M WB Ms Rat 78133p35 antibody P ELISA, ICC/IF, WB Rb Hu, Ms, Rat 64960p38 (phospho T180 + Y182) antibody P ICC/IF, WB Rb Hu 38238p53 (acetyl K382) antibody P WB Rb Hu 3731PACRG antibody P WB Rb Hu 4090Parkin antibody P WB Rb Hu, Rat 87198PGP9.5 antibody - Neuronal Marker P ICC/IF, IHC-Fr, IHC-P, WB Rb Hu, Ms, Rat 27053PGP9.5 antibody [13C4 / I3C4] M ICC, ICC/IF, IHC-FoFr, IHC-Fr, Ms Hu, Ms, Rat, Dog, 8189- Neuronal Marker IHC-P, WB Gpig, Pig, Rb, ShpPINK1 antibody P ICC/IF, IHC-FoFr, IHC-P, WB Rb Hu, Ms, Rat 65232SEPT5 antibody [SP18] M WB Ms Hu, Ms, Rat 69538Skp1 antibody [EPR3303] M Flow Cyt, IHC-P, WB Rb Hu, Ms, Rat 80586STUB1 antibody P ICC/IF, WB Rb Hu, Ms 39559Synphilin 1 antibody P IHC-Fr, IHC-P, WB Rb Hu, Ms, Rat 6179Ube2L3 antibody M ICC/IF, WB Ms Hu 58262Ube2L6 antibody - N-terminal P ELISA, IHC-P, WB Rb Hu 71800Ubiquitin antibody P ELISA, ICC/IF, IF, IHC-FoFr, Rb Hu, Chk, Cow, 8134

IHC-Fr, HC-P, IP, WB DmUCHL1+3 antibody P WB Rb Hu, Ms, Rat 75275

alpha Synuclein protein SDS-PAGE E. coli Hu 51189c Abl protein (Active) FuncS, SDS-PAGE Sf9 Hu 69810Calpain 1 protein (Active) FuncS, SDS-PAGE Erythrocytes Hu 91019Cdk5 protein (Tagged) FuncS, SDS-PAGE E. coli Hu 56282NMDAR1 peptide BL CHO Rat 17568p38 protein (Active) FuncS, SDS-PAGE Sf9 Hu 60710p53 protein (Tagged) FuncS E. coli Hu 43615PARK7/DJ1 protein (His tag) SDS-PAGE E. coli Hu 51198PGP9.5 protein ELISA, Inhib, WB E. coli Hu 75957SEPT5 protein (Tagged-His Tag) MS, SDS-PAGE E. coli Hu 91710Skp1 protein SDS-PAGE E. coli Hu 90687STUB1 protein SDS-PAGE E. coli Hu 82791Ube2L3 protein SDS-PAGE E. coli Hu 73540Ube2L6 protein SDS-PAGE E. coli Hu 80713Ubiquitin protein (His tag) Conjugation, SDS-PAGE E. coli Hu 81662

Proteins/Peptides Applications Expression Species DatasheetSystem www.abcam.com/ab…

Cyclin E antibody [HE12] (ab3927)

Clonality Applications Host Species cross reactivityM Flow Cyt, ICC/IF, IHC-Fr, Ms Hu

IHC-P, WB

NMDAR2A (phospho Y1325) antibody (ab16646)

Clonality Applications Host Species cross reactivityP IHC-FoFr, IHC-P, WB Rb Ms, Rat

p38 antibody (ab7952)

Clonality Applications Host Species cross reactivityP ICC, ICC/IF, IHC-Fr, Rb Hu, Ms, Rat

IHC-P, IP, WB

PARK7/DJ1 antibody (ab18257)

Clonality Applications Host Species cross reactivityP ICC/IF, IHC-P, WB Rb Hu, Ms, Rat

Tubulin antibody [YOL1/34] - Microtubule Marker (ab6161)

Clonality Applications Host Species cross reactivityM ELISA, ICC/IF, IHC-FoFr, Rt Hu, Ms, Rat, Allg, Dog,

RIA, WB Sc, S pom