patrick soon-shiong innovation awards · anthropic contributions), dr. patrick soon-shiong is no...

November 26, 2012 • Advertising Supplement to the Los Angeles Business Journal

LOS ANGELES BUSINESS JOURNAL PRESENTS

PATRICK SOON-SHIONG INNOVATION AWARDS

This special advertising supplement did not involve the reporting or editing staff of the Los Angeles Business Journal.

Presenting Sponsors: Platinum Sponsors: Gold Sponsors:

AT&T ForHealthErnst & Young LLPFocus Media GroupUSC Viterbi School of EngineeringWedbush Bank

17_33_pss_innovation_awards.qxp 11/21/2012 3:29 PM 7

18 AN ADVERTISING SUPPLEMENT TO THE LOS ANGELES BUSINESS JOURNAL NOVEMBER 26, 2012

THE Los Angeles BusinessJournal is honored to onceagain present the annual

Patrick Soon-Shiong InnovationAwards for 2012. The greater LosAngeles region is home to many ofthe most exciting and groundbreak-ing companies in the world – eachstriving to become a “game changer”through ingenuity and innovation.We recognize that such creativityplays an essential role in enhancingthe economic competitiveness of theregion and injecting new levels oflife into our local economy.

It is with love and respect forgreat ideas that we at the LosAngeles Business Journal are particu-larly proud to present this year’sawards alongside Patrick Soon-Shiong, whose very name hasbecome synonymous with innova-tion. This special award program wascreated with the vision to celebratethe organizations that continue tostretch boundaries.

Dr. Soon-Shiong, a local exampleof a passionate and successful entre-preneur who has illustrated how theinnovative spirit can drive economicvalue, shares our desire to acknowl-edge and encourage innovation andhas once again made the commit-ment to underwrite this prestigiousaward program. The awards werehanded out at a ceremony onNovember 15th at the Four SeasonsHotel Los Angeles in Beverly Hills.

Congratulations to this year’sfive extraordinary honorees andeight exceptional finalists – each ofwhom continues to inspire us andprovide invaluable contributions tokeeping Los Angeles at the forefrontof innovation.

Matt ToledoPublisher & CEO

PATRICK SOON-SHIONG INNOVATION AWARDS 2012

Letterfrom thepublisher

A regular atop the Los Angeles Business Journal’slist of Wealthiest Angelenos, and a past recipi-ent of the LABJ’s “Business Person of the Year”

(thanks to his significant business successes and phil-anthropic contributions), Dr. Patrick Soon-Shiong isno stranger to the pages of our publication.

Dr. Patrick Soon-Shiong knows as well as anyonethat innovation, coupled with passion and hardwork, is the engine for success in business – not tomention a catalyst for life enhancing, or even life-sav-ing activity. His groundbreaking concepts for curingdiabetes led to the first nanotechnology-based breastcancer drug, Abraxane, which is credited with savingthousands of lives. He’s since made time to researchpersonalized drug therapies based on people’s genesets, one of the hottest trends in research.

Now, for the third year, his love of innovation hasprompted him to once again join the Business Journalin handing out Patrick Soon-Shiong InnovationAwards to deserving organizations that may in factremind Soon-Shiong a little bit of his own early stagesas a passionate entrepreneur and innovator.

We created this very special awards program toshowcase Los Angeles as a place of innovation forbusinesses – and innovation in business nearlyalways leads to growth.

Here’s a closer look at the inspiration and namesakeof our innovation award, Dr. Patrick Soon-Shiong.

Dr. Soon-Shiong was raised in apartheid South Africa

by his Chinese immigrant parents; his father fled Chinaduring World War II and practiced traditional Asianmedicine. Soon-Shiong was a stellar student in medicalschool, becoming a doctor at age 23, but had to acceptan internship at a major Johannesburg hospital at halfthe pay earned by his white counterparts.

He completed his surgical training at UCLA andwas a member of the medical school faculty by theage of 31, in 1983. Three years later, he performedthe first pancreas transplant on the West Coast.

He built his fortune by taking AmericanPharmaceutical Partners public in 2001 and sellingit in 2008. He spun off another company, Abraxis,in 2007, then sold it in 2010. He regularly donatesportions of his billions to philanthropic causes,including a $136-million donation to St. John’sHealth Center in Santa Monica and a $100-millionguarantee to underwrite efforts to reopen MartinLuther King Jr. Hospital.

He now has his hands in supercomputing, aug-mented intelligence and other industries through hisNantWorks company, which he founded in 2011.The year before, he helped launch the HealthcareTransformation Institute and currently heads the CSSInstitute for Advanced Health, which focuses onhuman genotyping. He hopes to create a nationalhealthcare information network and has taken overthe National LambdaRail, the high-speed connectorthat links academic researchers nationwide.

Dr. PatrickSoon-Shiong,Innovator

Dr. Patrick Soon-Shiong with Business Journal publisher Matt Toledo

17_33_pss_innovation_awards.qxp 11/21/2012 3:29 PM Page 18

NOVEMBER 26, 2012 AN ADVERTISING SUPPLEMENT TO THE LOS ANGELES BUSINESS JOURNAL 19

Congratulations to

on receiving the

2012 Patrick Soon-Shiong Innovation Award

CODA Holdings, Inc.Philip Murtaugh

Gamma Medica, Inc.James Hugg, Ph.D.

NanoH20, Inc.Jeff Green

Oblong Industries, Inc.Kwindla Hultman Kramer

John Underkoffler

Replenish, Inc.Sean Caffey, M.D.



WinnersPATRICK SOON-SHIONG INNOVATION AWARDS 2012

ODA’s mission is to make electric vehi-cles compelling and accessible to themass market and to commercialize sta-tionary energy storage applications thataccelerate the deployment of renewableenergy. CODA is a clean technologycompany that designs, develops and

sells all-electric vehicles, electric drive propulsion systemsand applications for stationary energy storage.

CODA has extensive expertise designing and engi-neering key electric vehicle powertrain components andhas leveraged this core competency to develop best-in-class battery and electric vehicle propulsion system tech-nologies. The company is also commercializing batteryapplications for propulsion systems to be sold to otherautomotive companies.

CODA’s core competency in electric vehicle propul-sion system technology has allowed it to develop andcommercialize the CODA sedan, the first all-electricvehicle that effectively addresses the driving needs of abroad base of consumers at an attractive price, whileaddressing concerns about fuel prices and volatility, andthe environmental and public health impacts of internalcombustion engine vehicles. CODA’s capital-efficientbusiness model leverages this core competency inpropulsion system technology and allows the companyto develop new electric vehicle technology.

Despite past efforts to encourage the acceptance andadoption of electric vehicles, prior generations of elec-tric vehicles did not adequately address the average

consumer’s driving needs, particularly with respect toprice and range. As a result, they were not adopted bya broad base of consumers. CODA’s unique propulsionsystem, including its proprietary Battery ManagementSystem (“BMS”) and Thermal Management System(“TMS”) addresses the historic barriers to entry formass electric vehicle adoption. This pioneering tech-nology ensures that the batterypack stays at an optimal tem-perature range, protecting thecells from damage, prolongingpack life and ensuring depend-able range performance acrossseasons and climates.

In March of this year, CODAsuccessfully brought to market acompetitively priced, mass-appeal, all-electric vehicle thatmeets consumer expectationsfor the extent and reliability ofrange and passenger comfort.The CODA sedan achieved arange of 134 miles (216 km)per charge in the U.S. UrbanDynamometer Driving Schedule. With these rangeattributes and the enhanced dependability provided bythe company’s proprietary BMS and TMS, the CODASedan offers the longest and most dependable rangeamong non-luxury all-electric vehicles available. TheCODA Sedan also has fewer moving components than

an internal combustion engine vehicle, thus requiringless general maintenance.

In addition to automotive applications, CODA hasapplied its battery system and electric vehicle propulsionsystem expertise to stationary applications such as largescale energy storage systems and residential power storage.CODA’s scalable energy storage solutions can address a

wide range of uses to improve theoperations of electric power grids andprovide greater utilization of renew-able and traditional energy resources.The systems will be highly flexibleand adaptable to a variety of cus-tomer needs.

As of May of this year, CODAhad 69 pending patent applicationswith the U.S. Patent Office, cover-ing selected features of its technolo-gy, and four issued foreign patents.CODA’s expertise in integratingcomponents of a powertrain for usein an all-electric vehicle includesexperience in redesigning andreengineering the power electronics

system, inverter, motor, trans-axle, suspensions, half-shafts, gearbox, and control software, which collectivelycomprise the powertrain. CODA has developed uniqueways to address these issues and has acquired expertisein electric vehicle integration that sets the companyapart from competitors.

AMMA Medica, Inc. (GMI) was foundedin 2001 in Northridge and is a rev-enue-stage private company thatdevelops and utilizes advanced solid-state digital detectors in healthcareimaging systems with leading-edgetechnology.

GMI’s FDA-approved Molecular Breast Imaging (MBI)device, the LumaGEM, is installed in 20 clinical sitesand uses mild immobilization of the breast between twodigital, solid-state gamma photon detectors that imagecancer lesions regardless of breast density. The patient isinjected intravenously with an extremely small amountof Tc-99m-sestamibi, which is taken up 20 times moreavidly by tumor cells than normal breast cells, andgamma photon imaging begins within five minutes.

Women with radiographically dense breasts carry a 6-fold increased risk for breast cancer. However, mammog-raphy fails to detect most cancers in these women. MBIis currently used for secondary diagnosis when mam-mography results are inconclusive or suspicious. The pri-mary future application for MBI will be screening ofradiographically dense breasts (40 percent of Americanwomen; 70 percent of Asian women). In a current MayoClinic 1,700-patient dense-breast screening trial, digitalmammography detected only 2 of 20 tumors, whileGMI’s LumaGEM MBI found 18 of 20!

The company and Mayo Clinic view the market forbreast cancer imaging in three segments: general screen-ing (best done by mammography), high-risk screening(dense breasts, BRCA genes, family history), and second-ary diagnosis. MBI utilization is predicted by Mayo Clinicand GMI to grow to 10.5 million high-risk screening and

5 million secondary diagnostic procedures per year.A Mayo Clinic 1,000-patient study demonstrated 91

percent sensitivity and 93 percent specificity in dense-breasted women, much better than mammography andwith similar high sensitivity to MRI but better specificity(fewer negative biopsies). The cost of MBI is less than1/3 the cost of MRI. The GMI LumaGEM system is 1.5to 2.0 times more efficient than competitors’ MBI sys-tems, which results in the lowest dose. In fact, the com-pany has lowered radiation doses to equal screening dig-ital mammography.

GMI has worked closely with researchers at the MayoClinic for over ten years to develop this remarkable newMBI technology to detect breast cancer earlier, and espe-cially in women with dense breasts. A number of NIH-funded grants have been awarded to GMI to develop thetechnology.

The cost of the MBI system hardware and procedureis less than one-third that of MRI. Average reimburse-ment is $450 (plus professional component and radio-tracer cost) and most payors have positive reimburse-ment policies or approve MBI with prior authorization.

GMI is also developing an MBI-guided biopsy appara-tus and efficient procedure (early 2013 commercialrelease). The company expects to introduce a mobilegantry in 2013, and plans to combine ultrasound withMBI in 2014-15. GMI has a technology improvementplan to further reduce the radiation dose and shortenthe examination time to be more competitive withmammography. The GMI gamma photon detectors havebeen shown to operate well inside an MRI scanner andthey can be applied to clinical applications imagingprostate, brain, and other small organ cancer imaging,

with or without combining MRI. GMI has delivered oral presentations about their

innovative technology in the past year to internationalmedical research societies including: the RSNA(Radiological Association of North America), the ECR(European Congress on Radiology), the InternationalWorkshop on Molecular Radiology in Breast Cancer, theSNMMI (Society of Nuclear Medicine and MolecularImaging), and the AAPM (American Association ofPhysicists in Medicine).

C

g

coda holdings Inc.Los Angeles

gamma medica Inc.Northridge

Philip Murtaugh of Coda Holdings Inc.

Dr. James Hugg, PhD, of Gamma Medica Inc.



Merrill Lynch Wealth Management makes available products and services offered by Merrill Lynch, Pierce, Fenner & Smith Incorporated, a registered broker-dealer and member SIPC, and other subsidiaries ofBank of America Corporation. The Private Banking and Investment Group is a division of MLPF&S that offers a broad array of personalized wealth management products and services.© 2012 Bank of America Corporation. All rights reserved.AD-11-12-0176 AR34P3I5-09-12 Code 444621PM-1112

COMMITMENT, DEDICATIONAND A BETTER TOMORROW

THE PRIVATE BANKING AND INVESTMENT GROUP AT MERRILL LYNCH SALUTES THE PATRICK SOON–SHIONG INNOVATION AWARDS,RECOGNIZING INNOVATION AND ENTREPRENEURSHIP.

QUALITIES THAT ENRICH ALL OF US

Merrill Lynch Private Wealth Advisors are committed to helping those individuals and organizations who are invaluable assets to the community.

The Gray Group

Eric Gray, CFM Managing Director–Wealth Management Private Wealth Advisor

(310) 407-3979

Private Banking and Investment Group 2049 Century Park East Los Angeles, CA 90067




ANOH2O, Inc. develops, manufacturesand markets next-generation reverseosmosis (RO) membranes that lowerthe cost of desalination. The compa-ny’s patented thin-film nanocompos-ite (TFN) membranes leverage nan-otechnology to change the structure

of the thin-film of a reverse osmosis (RO) membrane. Itis this thin-film that dictates the permeability and saltrejection of the membrane and, therefore, the econom-ics of a desalination plant. Benign nanomaterials areintroduced during the synthesis process of a traditionalpolymer film to produce a nanocomposite RO mem-brane with exceptional properties.

By inserting nanomaterial into its patented TFNmembrane, NanoH2O has improved key performancecharacteristics by controlling membrane structure. Thepolymer thin film is formed when an aqueous monomersolution contacts an organic monomer solution and athin film is formed. Nanomaterials are added to themonomer solutions and are completely encapsulatedwithin the newly formed film.

NanoH2O’s QuantumFlux TFN membranes havedemonstrated a 50-100% increase in permeability whencompared to the installed base of RO membranes. Thisincreased permeability means less pressure is required toforce the migration of fresh water through the membrane,thus lowering a desalination plant’s energy costs. In addi-tion, the enhanced permeability of QuantumFlux mem-branes also leads to an increase in the amount of fresh waterproduced, given a certain pressure, over typical RO mem-branes. NanoH2O has further improved the membrane’s

chemistry to provide increased salt-rejection over traditionalmembranes, resulting in better fresh water quality.

As the innovative leader in RO membrane technolo-gy, NanoH2O is changing the economics of desalina-tion. Its QuantumFlux TFN seawater RO membranes canreduce energy usage by up to 20%, increase water pro-duction by up to 70% or reduce an RO plant’s footprintby as much as 40%.

QuantumFlux (Qfx) membranes have gained rapidacceptance within the desalination industry because oftheir potential to lower system operating costs. Since

launching into the marketplace in April 2011, Qfx mem-branes have been installed in over 50 seawater RO plantsacross thirty-three countries, producing more than 20million gallons per day of desalinated potable water.

One particular QuantumFlux installation is theCayman Brac facility in the Caribbean. Operated by theWater Authority Cayman, the 147,000 gallon per dayplant provides potable water to the Cayman Brac distri-bution system via a two-pass system that treats waterfrom inland feed wells. Prior to installing NanoH2O’shigh flux membranes, the facility used 13.14 kWh per1,000 gallons of water produced. Realizing the potentialincrease in efficiency offered by Qfx membranes overtypical SWRO membranes, Water Authority Caymaninstalled thirty 8-inch spiral-wound Qfx elements intheir system’s first-pass. The specific energy required todrive the feed water through the RO system was imme-diately reduced by 3.7 kWh/1,000 gallons, saving theWater Authority Cayman 28% in energy consumption .

Other recent installations include a desalination plantin Chile where NanoH2O was selected as the RO mem-brane supplier as a result of the 17% projected increase inwater production, as well as a retrofit of a Caribbean facili-ty where QuantumFlux membranes maintained the samelevel of water production as previously used competitormodels, but with 30% less membrane element units.

As energy can make up as much as 60% of a desalina-tion facility’s operating expenses and increasing plantcapacity typically requires major capital expenditures,NanoH2O has enabled the water sector to realize signifi-cant cost savings and further promote membrane desali-nation as a viable solution to address global water scarcity.

BLONG Industries is a design-driven software and hardwarecompany whose mission is toput a new user interface onevery computer in the world.Oblong transforms computingfrom a one person, one

screen, one device experience into a fully sharedand interactive experience.

Oblong is the first company to bring togetherall your screens and all your devices into amulti-user, multi-device, multi-screen unifiedenvironment. It is also the only company tocombine data presentation and analytics capa-bilities with collaboration capabilities, enablingyou to turn big data into insight and intelli-gence. Oblong provides a new generation ofcomputing tools - a new technology platform -built around what the company sees as the threemost important trends in the tech world today:cheaper pixels, evolving device form factors, andincreasing amounts of accessible data.

Founded in 2006, Oblong’s technology has roots inmore than two decades of research at the MIT MediaLab and was the direct basis for the computers depictedin the film Minority Report, as designed by Oblong’sChief Scientist, John Underkoffler. Today, Oblong sellscommercial versions of the Minority Report computers.These are famously gestural systems, but their capabilitygoes beyond gestural interaction (and gesture is in factoptional). These systems are spatial, networked, multi-user, multi-screen, multi-device computing environ-ments. Oblong’s technology platform brings data sets,workspaces, and communications channels to life across

multiple screens. It allows interaction from any numberor type of input devices simultaneously, including touchscreens, phones, and tablets. The platform frees the userfrom sitting in one place, tied to one device.

The g-speak Spatial Operating Environment (SOE) isOblong’s core technology and application developmentand deployment platform. The platform enables intuitive,natural navigation of complex visual data and digital infor-mation of all kinds, letting people work together from any-where in the world, sharing the same unified experience.

It’s also the only general purpose platform designedfrom the ground up to give programmers access to theprinciples of spatial (and gestural) computing and real-world pixels, and to enable applications that are inherent-

ly multi-screen, multi-user, and multi-device.Customers use g-speak to solve big data problems,to collaborate more effectively, and to go fromlooking at pixels on a single screen to interactingwith pixels on every screen.

Oblong’s Mezzanine product, built atop theg-speak platform, introduces a multi-user,multi-screen, multi-device environment withnext-generation, real-time collaboration andintegrated telepresence. Mezzanine is a meet-ing- and conference-room system that offers aunique shared pixel collaboration space: multi-ple participants work across multiple screens,sharing data, live video, and applications – andexercising collaborative control – from everydevice (phones, tablets, laptop browsers) theybring with them into the room. Any partici-pant in a Mezzanine session can also “reachthrough” the shared workspace and interactdirectly with content running on any connect-

ed laptop or on the screens. Moving content from screen to screen is easily done

with the intuitive spatial wand, web client, or user’s ownportable devices, like smartphones and tablets. The spa-tial wand can also be used to capture data throughscreen grabs.

Oblong has used g-speak to help Global Fortune 500companies like Boeing, Saudi Aramco, and GE (as well asgovernment agencies and universities) build and deployprofoundly productive solutions in areas including mod-eling and simulation, logistics and supply chain man-agement, natural resource discovery and extraction,energy grid management, and financial and scientificdata navigation and visualization.

N

o

nanoh2O Inc.El Segundo

oblong industries Inc.Los Angeles

Jeff Green of NanoH2O Inc.

Kwindla Hultman Kramer and John Underkoffler of Oblong Industries Inc.



Miyachi Unitek is proud to be nominated for the 2012 Patrick Soon-Shiong Innovations Award.

This honor is made possible through the creative and innovative contributions of our employees and suppliers who, together, are committed to providing cutting-edge manufacturing solutions to our many loyal customers worldwide.

Miyachi Unitek Corp.

1820 S. Myrtle Ave.

Monrovia, CA 91017-7133

(626) 303-5676

www.miyachiunitek.com

Multi-Million Dollar Working Capital Line

(undisclosed amount)

&

Burbank, CA

$38,000,000Term Loan

Hollywood Towers198 Residential Units

Los Angeles, CA

BostonPrivateBank.com

$23,800,000Term Loan

Brentwood, CA

Owned and Operated by

K.C InvestmentCompany

Arranged by

$16,250,000Leveraged Buy Out

Rancho Dominquez, CA


N 2012, Replenish, Inc. successfullymanufactured and implanted theworld’s smallest, refillable andimplantable drug pump in 11patients’ eyes during the world’s firsttrial for a programmable ophthalmicpump. Implanted directly along the

eye’s sclera using only local anesthesia, Replenish’sMicroPump system can be programmed to dispense frac-tions of a drop of medication directly into the eye nearthe retina so that patients may avoid syringe injectionsby their doctor to treat macular degeneration and dia-betic edema conditions of the eye. The patient does notfeel the device and there was no discomfort during the 3months of implantation. Instead of monthly injectionsfrom a syringe for life, the 7-year MicroPump plans tooffer to patients refills every six months and weekly ormonthly programmable infusions of protein drugs totreat retina or glaucoma conditions.

Basically, drug companies can’t sell medications thatpatients forget to take. Replenish’s mission is to providean easier, dependable, and more effective route of drugadministration into their eye with its intraocularMicroPump. An automated, refillable drug pumpimplanted under the eye’s skin is able to intermittentlyinject drugs directly inside the eye to prevent blindnessand improve sight for diseases such as glaucoma andwet age-related macular degeneration (wAMD). Withoutthe need for drug companies to reformulate their drug,up to nine months of medication can be filled andrefilled into the Replenish intraocular MicroPump dur-

ing a normal visit to the clinic. The physician can wire-lessly program the pump to inject the right amount ofmedication at the right time.

Replenish is a complex wireless and programmablesystem including the implantable MicroPump, externalprogramming unit (in form of wearable glasses) a drugrefill system, and surgical tools to implant the pump.Utilizing innovative manufacturing processes borrowedfrom the semi-conductor industries (such as offered by

Intel), the MicroPump is constructed using state-of-the-art fabrication techniques that including sensors, valvesand miniature diaphragms to all fit inside the eye. Withtwo separate chambers, the Replenish pump is one ofthe simplest and efficient pump designs possible: itslowly squeezes drug out a one-way drug reservoir bycreating pressure in its electrolysis chamber, which ismechanically coupled to a drug chamber above using adiaphragm. By running electrical current (from arechargeable battery and controlled by a microcon-troller) through electrodes submerged in saline, thepump can “electrolyze” water into hydrogen (H2) andoxygen (O2) gas, which then propels the expansion ofmolecules to 1,000 times their liquid volume, thus gen-erating a very efficient pressure generator. After approxi-mately ten minutes of active electrolysis, enough drughas been injected into the eye, and the gas forms backinto water within 60 minutes—ready for its next dose.The drug volume is recorded and calibrated by thepump system’s sensor and embedded electronics. Thebattery is rechargeable wirelessly and an alarm is avail-able to remind the patient. The device has four sutureholes for anchoring under the subconjunctiva, prefer-ably in one of the temporal pockets of one or both eyes.

Replenish has quickly grown into one of the largestindustrial R&D facilities in Pasadena including morethan 4500 sq. ft of cleanrooms. The Replenish technolo-gy was originally invented at Caltech and USC, and thereliability of the device is currently being enhanced forupcoming Phase II trials with a major pharma company.

Ireplenish Inc.Pasadena

Sean Caffey of Replenish Inc.



Fight on!

The USC Viterbi School of Engineering applaudes

its association withDr. Patrick Soon-Shiong,

visionary innovator,surgeon, philanthropist,

member of theUSC Viterbi Board of

Councilors andTrojan family.

T HE thorough understanding ofsurgeon and patient requirementsboth in the operating room and

through the post-operative recoveryphase is what drives AdvancedOrthopaedic Solutions (AOS). Foundedin 2001, the company develops traumaorthopedic implants and instrumenta-tion that are as minimally invasive, costeffective, and user friendly as possible.The company understands the impor-tance of minimizing the time that apatient is in surgery, and to that endworks closely with orthopedic surgeonsduring the design process to createinstrumentation and implants that areboth innovative and intuitive to use.

AOS focuses on the needs of areas thatlarger orthopedic companies tend to over-look, such as the smaller community sur-geons and international markets lackingadvanced equipment. The companydeveloped a Distal Targeting Device for itsTibial Nail System that allows surgeons inforeign markets lacking C-arm technolo-gy to target screws at the distal end of thenail without x-ray. The company is in theprocess of developing a Femoral DistalTargeting Device intended for similar usewith its Modular Femoral Nail System. Increating new implants and instrumenta-

tion, AOS keeps in mind what designwould be best suited for and easiest to usein smaller community hospitals wherestate-of-the-art technology may not bereadily available.

While striving to make the surgery assimple and quick for the surgeon as pos-sible, AOS also focuses on innovativedesigns that help increase patient safetyand comfort. The company’s biggest sell-er is its Trochanteric Nail System, a col-lection of intramedullary devices intend-ed to treat fractures of the femur.

finalistsPATRICK SOON-SHIONG INNOVATION AWARDS 2012

advanced orthopAedicsolutions Torrance

aline inc. Rancho Dominguez

THE application of microfluidics tocreate “Lab-on-a-Chip” medicaldevices for commercial point of

care diagnostic products is a challengethat ALine addresses through itsmicrofluidic device fabrication platform,Polymer Laminate Technology, or PLT.PLT was developed to meet the need fora rapid prototyping and a scalable pro-duction process for commercialization.The company was founded to helpbiotech organizations quickly movefrom proof of concept to clinical trialsand onto product launch with microflu-idic device technology that is scalable forcommercial volume production at aprice point acceptable in the point ofcare market.

ALine offers its know-how and expert-ise to companies developing products forpoint-of-care applications, including thehospital laboratory, doctor’s office, fieldhospital, ambulance, or even at home.The types of products ALine has helpeddevelop include a field portable screenfor testing samples for DNA fragmentsthat positively identify an infectiousagent in a remote location; a genetic testfor patients being prescribed the bloodthinner warfarin to personalize theirtherapeutic regimen and avoid lifethreatening complications; a diagnosticfor patients who call 911 with chest pain

and are tested while en route to the hos-pital for telltale markers of a heart attack,allowing the emergency room doctors toknow how to treat the patient as theyenter the hospital.

Some of ALine’s greatest innovationshave come from meeting the challengesof building the business. The companydeveloped and used tools and tech-niques that did not require a huge capi-tal investment, but could still providethe sophistication necessary formicrofluidic devices.

Gary Sohngen of Advanced Orthopaedic

Solutions Leanna Levine of ALine Inc.



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WHEN they started their compa-ny, the founders of C-Premedid an enormous amount of

research in an effort to come up withdesigns for innovative new bicycle hel-mets. Their creations were much differ-ent then anything in the market becausethey used 3D components to createcharacters on the helmets and makethem more fun for kids to wear. C-Premecalled the line of 3D Helmets Raskullz!

The founders launched their productat the Interbike Tradeshow in Las Vegaswith four helmet samples on a cardtable. The hit of the show, C-Premequickly found themselves meeting with

Walmart, Target, Toy’s R Us, REI andmany other retailers and started ship-ping Raskullz soon after!

Three years later, C-Preme today is mak-ing bicycles, protective gear, skateboards,kick boards and a lot more. With the goalto create products that inspire the imagi-nation by taking products that kids needto have and turning them into productsthat kids want to have, they have seen fastsuccess. The company has shipped over amillion bike helmets in two years and itcontinues to push design and innovation.C-Preme just launched a new brand calledVideo Head, the first helmet to integrate avideo camera into a helmet.


c-preme limited llc Torrance hh2 energy inc. &hydrolectric power llc Canoga Park

HH2 Energy & HydroLectricPower is the company responsi-ble for the HH2 and HH2+

Hydrogen Water Fuel Cells. Extensivescientific research and testing hasenabled the company to design and cre-ate a clean air hydrogen fuel cell systemfor use in vehicles that provides safe,low-pressure hydrogen induction intothe engine air intake chamber.

By providing a catalyst that increasescombustion of fuel by increasing it’soctane, this technology removes carbonand cleans the exhaust, all while boost-ing the power of the engine. Hydrogen-enhanced clean burning fuel results infewer harmful emissions, and carbon isremoved from the engine, catalytic con-verter and tailpipe.

This hydrogen fuel cell clean air gener-ator system provides safe, efficient, cleanburning hydrogen for any vehicle, fromwater. The technology produces safeclean HH2 Wet Hydrogen from waterthat instantly disperses, blending into theair in the event of a leak or accident. Thesafe, low-pressure system does not buildup or store any hydrogen in the vehicle.

This technology also reduces wearand tear on the engine due to fast and

complete combustion of fuels. It alsoreduces engine heat. The technologyalso yields fuel economy savingsupwards of 40%. Any care or vehicle canhave the system put in place and all sys-tems use relays and fuses to protect theunits and the existing vehicle electricalsystems.

Conan

Hayes of

C-Preme

Limited

LLC

Derek Zupancic of HH2 Energy Inc. &

HydroLectric Power LLC



At AT&T we know businesses depend ongroundbreaking technology. In Los Angeles andacross the nation, we’ve launched innovations suchas our wireless network with access to the nation’slargest Wi-fi network. It’s just another way we helpbusinesses in Los Angeles grow and stay connectedto their communities - and their world. Always.

AT&T is proud to support the 2012 Soon-ShiongInnovation Awards.

we’re wired(and wireless)for business

© 2012 AT&T Intellectual Property. All rights reserved.


30 AN ADVERTISING SUPPLEMENT TO THE LOS ANGELES BUSINESS JOURNAL NOVEMBER 26, 2012©

2012

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We understand that great leaders are driven to achievemore than what’s beenachieved before. Patrick Soon-Shiong and all ofthe honorees are great examples of that spirit ofEntrepreneurship. Find out how we nurture that spiritand help you turn good intogreat. www.ey.com

See More | Entrepreneurship

The greats,without the spirit

of adventure, wouldjust be the goods.

BUILDING on a legacy of innovationthat spans more than half a centu-ry, Los Angeles Biomedical

Research Institute (LA BioMed) atHarbor-UCLA Medical Center is one ofthe country’s leading non-profit biomedical researchinstitutes.

If you’ve ever won-dered where the very ideaof paramedics or nursepractitioners come from,or why babies born pre-maturely these days don’tdie shortly after birth, or ifthere is any hope of pre-venting the deaths of100,000 Americans whowill die this year fromhospital acquired infec-tions, the answer to all ofthese questions and manymore boils down to the remarkableinnovation efforts and achievementsbeing worked on daily at LA BioMed.

Over the past six decades, LABioMed’s clinician-researchers have beenresponsible for some of the most innova-tive medical breakthroughs including

the paramedic model for emergency carethat is now a life-saving standard nation-wide; the first human ovum transfer, lay-ing the groundwork for a procedurethat’s resulted in more than 171,000

births to infertile couplesin the U.S. alone; andthe development ofrefined synthetic lungsurfactants that haveenabled prematurebabies with underdevel-oped lungs to breathe.

As well as conductingmany clinical trials onbehalf of pharmaceuticalcompanies and its investi-gators own researchefforts, LA BioMed alsomaintains a strong com-mitment to making avail-able medical technologies

and inventions developed by its physician-researchers for public use and benefit. LABioMed currently has licenses, industrypartnerships, and agreements for researchfunding support in the areas of infectiousdiseases, molecular medicine, endocrinolo-gy, medical genetics, and medical devices.


the los angeles biomedicalresearch institute at harbor-uclamedical center Torrance

miyachi unitek corp. Monrovia

MIYACHI Unitek’s roots were estab-lished in 1948 in a businessspecifically created to weld den-

tal braces using basic resistance weldingequipment. Since that time the companyhas grown into the world’s leading sup-plier of equipment and systems forresistance welding, laser welding, lasermarking, laser cutting, hermetic sealing,and hot bar reflow soldering.

While in the early days, the companyoffered just one kind and type of resist-ance welding machine, today it offersfour kinds and numerous types, eachaddressing a specific joining requirementthat provides the best solution for theend user. The company pioneeredclosed-loop feedback technology for itsresistance welding power supplies thatmakes corrections to the supplied weldenergy based on part variance. This dra-matically improves weld quality and partyield. Another invention for weld headsmaintains consistent force during theweld cycle using pneumatics, again pro-viding superior welding performance.

Miyachi Unitek’s resistance weldingpower supplies have become the de factochoice for many medical, electronics andenergy devices manufacturing compa-nies worldwide. In the early 1990’s thecompany entered into the laser microwelding market, having solid success.Towards the end of the 1990’s a re-

design of the laser offered an industryfirst with real time power feedback thatproved timely as its laser became a keypart of photonic device manufacturewhich has some of the most demandingwelding applications.

With over 60 years of experience inresistance joining and over 20 years inlaser processing, Miyachi Unitek offers aunique capability to its customers that isthe genesis of any system.

David Meyer of Los Angeles

Biomedical Research Institute

Dave Fawcett of Miyachi Unitek Corp.



For advertising information,please call 323.549.5225

Enhance your positioning andvisibility by advertising adjacent to

the list that best represents yourindustry in the 2013 Book of Lists,

published on December 31, 2012.

Our readers refer to the Book of Listsan average of 13.2 times per year.

Los Angeles Business Journal’s 2013

Book of ListsBEST PLACES TO WORK IN L.A. continued

Rank NameLocal

Headquarters

Address

Corporate Web siteCompany overview

Total

number of

employees

in California,

full and

part time*

Average annual

salary for exempt

employees

(including partners

if salaried)

Average

annual

salary for

non-exempt

employees

Top executive

title

MEDIUM SIZED COMPANIES (50 to 249 employees)

5 uSamp16501 Ventura Blvd.,

Suite 250,

Encino, CA 91436

usamp.commarket research

5385,822

32,000 Matt Dusig /

Gregg Lavin

ceo/president

6 Wpromote Inc. 999 N. Sepulveda Blvd.,

El Segundo, CA 90245wpromote.com

marketing

7058,171

38,480 Michael

Mothner

ceo, president

7 RBZ LLP11755 Wilshire Blvd.,

Ninth Floor,

Los Angeles, CA 90025

rbz.comaccounting firm

111 106,000 56,000 David Roberts

managing

partner

8 Wong Doody

Crandall Wiener

8500 Steller Drive,

Suite 5,

Culver City, CA 90232

wdcw.comadvertising

57NA

NA Ben Wiener

ceo

9 Morley Builders 2901 28th St.,

Santa Monica, CA

90405

morleybuilders.comconstruction

161 110,900 43,000 Mark Benjamin

ceo, president

10 GNW-Evergreen

Insurance Services

LLC

16030 Ventura Blvd.,

Suite 500,

Encino, CA 91436

gnw-evergreen.cominsurance broker

75128,000 64,000 Andrew Forchelli

president

11 P2S Engineering

Inc.

5000 E. Spring St.,

Eighth Floor,

Long Beach, CA 90815

p2seng.comengineering

8295,930

46,237 Kevin Peterson

ceo, president

12 The Phelps Group 901 Wilshire Blvd.,

Santa Monica, CA

90401

thephelpsgroup.com advertising and public relations68

74,900NA Joe Phelpsceo

13 Cal Net

Technology Group9241 Reseda Blvd.,

Suite 200, Northridge,

CA 91324

calnettech.cominformation technology

5290,282

47,155 Zack Schuler

ceo, president

14 CaseStack Inc. 2850 Ocean Park Blvd.,

Suite 100, Santa

Monica, CA 90405

casestack.comlogistics outsourcing services

6765,000

41,000 Dan Sanker

ceo, president

15 TravelStore Inc. 11601 Wilshire Blvd.,

Los Angeles, CA 90025travelstoreusa.com

travel services

56100,000 50,151 Wido L. Schaefer

chairman, ceo

16 Windes &

McClaughry

Accountancy Corp.

111 W. Ocean Blvd.,

22nd Floor,

Long Beach, CA 90802

windes.comaccounting firm

100 105,000 54,000 John L. Di Carlo

president,

managing partner

17 NorthStar

Moving Corp.

9120 Mason Ave.,

Chatsworth, CA 91311northstarmoving.com moving company

77NA

NA Ram Katalan

founder,

president

18 Partners Trust

Real Estate

Brokerage

9378 Wilshire Blvd.,

Second Floor,

Beverly Hills, CA 90212

thepartnerstrust.com real estate

62500,000 40,000 Nick Segal

president

19 Rutter Hobbs

& Davidoff

1901 Avenue of the

Stars, Suite 1700,


rutterhobbs.comlaw firm

65255,850

54,034 Brian Davidoff

managing

director

20 ProsumTechnology

Services

2321 Rosecrans Ave.,

Suite 4225,

El Segundo, CA 90245

prosum.cominformation technology consultant

8999,382

45,609 Ravi Chatwani

ceo

21 Leads360 Inc. 222 N. Sepulveda Blvd.,

Suite 1850,

El Segundo, CA 90245

leads360.comsoftware developer

5970,000

45,000 Nick Hedges

president

22 CPEhr9000 Sunset Blvd.,

West Hollywood, CA

90069

cpehr.comhuman resources outsourcing

8087,036

47,176 Harold Walt

ceo

23 Cydcor Inc. 3011 Townsgate Road,

Suite 400, Westlake

Village, CA 91361

cydcor.comoutsourced sales

6098,365

40,345ceo

24 Green Hasson

Janks

10990 Wilshire Blvd.,

16th Floor,


greenhassonjanks.com accounting firm

95112,000 63,000

managing

partner

25 iolo technologies

LLC

7470 N. Figueroa St.,

Los Angeles, CA 90041iolo.com

software developer70

75,00026,000

26 VHA & Eureka 17038 Evergreen Place,

City of Industry, CA

91745

vhacorp.compre-paid wireless sales and distribution

6161,000

36,000

27 Giroux Glass Inc. 850 W. Washington

Blvd., Suite 200,


girouxglass.comconstruction

6396,300

36,800 Anne-Merelie

Murrell

ceo

28 Los Angeles

Federal Credit Union300 S. Glendale Ave.,

Glendale, CA 91205

lafcu.orgfinancial services

147 89,35738,264 John T. Dea

ceo, president

36 LOS ANGELES BUSINESS JOURNAL • THE LISTS 2012

Reprinted from the August 15, 2011 issue

*rankings are by number of full-time employees

Continued on page 38

LOS ANGELES BUSINESS JOURNAL • THE LISTS 2012 37

www.pointb.com

ALASKA AIRLINES | ARIZONA STATE UNIVERSITY | CIGNA | CHICAGO

PUBLIC SCHOOLS | DENVER PUBLIC SCHOOLS | EXPEDIA | FRED

MEYER | MICROSOFT | MULTICARE HEALTH SYSTEM | OPUS BANK

PATH PETSMART | PUGET SOUND ENERGY | SEATTLE CHILDREN’S

HOSPITAL | STARBUCKS COFFEE COMPANY | STATE OF OREGON

UNIVERSITY OF WASHINGTON | WALGREENS

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clients.

“ Point B did a tremendous job of executing our strategy to dramatically increase

the accessibility and quality of early childhood education.”

— MICHAEL BENNET, U.S. Senator of Colorado, Former Superintendent

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gave all team members a sense of confidence and trust in their ability to deliver on a key

organizational project.”

— MADY MURREY, Vice President and Administrator, Mary Bridge Children’s Hospital and Health Center

“ Point B brought in a way of thinking that elevated the internal mindset…”

— DARA KHOSROWSHAHI, CEO, Expedia

“Point B brought us the clear path and leadership to move forward.”

— KATHERINE ANDERSON, Chief Financial Officer, Seattle Opera

“ It was like open-heart surgery, and Point B was our lead surgeon.”

— ANN ARDIZZONE, Former Managing Director of Customer Experience, Alaska Airlines

Bay Area : Chicago : Denver : Phoenix : Portland : Seattle : Southern California

12/8/2011 6:41:25 PM

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Replenish, Inc.Ophthalmic MicroPumps

THROUGH innovation, RationalTherapeutics brings clarity andfocus to the disorder that is human

tumor biology. Rational Therapeuticsreverse engineers human biology usingcellular systems under stress to exploreresponse. The company’s laboratory plat-form has the capacity to examine humantumors in their native state using micros-pheroids isolated directly from patients’tumor specimens.

Investigators at Rational Therapeuticsdeveloped the Ex Vivo Analysis ofProgrammed Cell Death (EVA-PCD).Working first with conventionalchemotherapies, this approach consistent-ly improved response rates, time to pro-gression and survival for patients with avariety of hematologic and solid tumors.Following successes in blood borne can-cers like leukemia, Rational Therapeuticsapplied the EVA-PCD platform to themore common solid tumors to identify anovel drug combination that today isamong the most widely used treatmentsfor breast, ovarian, bladder, pancreatic,and lung cancers around the world.

To test its hypothesis, the companyconducted prospective studies first inadvanced breast cancer patients and lateradvanced recurrent ovarian carcinoma.These seminal observations were thenevaluated in the cooperative group settingresulting in the broad application and

FDA approval of the drug combinationspioneered by Rational Therapeutics.

The company then undertook anambitious trial that used the EVA-PCDtechnique for the upfront selection ofdrug combinations for newly diagnosedwidely metastatic lung cancer patients.The results of this study, published inthe October 6, 2012 issue of AntiCancerResearch show a two-fold improvementin response rate and a near doubling ofthe median overall survival for this uni-formly lethal disease. This suggests thatthe laboratory selection of clinical thera-pies can change the natural history ofthis disease.


rational therapeutics inc. Long Beach tribogenics inc. Marina Del Rey

T RIBOGENICS develops next-genera-tion X-ray sources that transformsolutions in industrial, military

and medical imaging industries through-out the global X-ray market. The compa-ny creates low cost, miniature, ultra-portable X-ray sources that eliminate theneed for high-voltage power and enablethe use of X-rays in a variety of applica-tions not currently possible with existingtechnology.

In 2007, the Defense AdvancedProjects Research Agency (DARPA) andthe US Army’s Telemedicine andAdvanced Technology Research Center(TATRC) funded an effort at UCLA toexplore new methods of generating X-rays. During the research effort, theteam, including Dr. Carlos Camara, nowChief Scientist at Tribogenics, discoveredthat peeling adhesive tape in a con-trolled environment generated X-rays ina new way through an effect called “tri-bocharging.” The process is similar tothe electrical static charge that peoplemay experience when touching certainobjects on a cold, dry or windy day. Thisprocess creates a surprisingly high sur-face charge density, which under theright conditions can be harnessed to pro-duce a powerful flux of X-rays.

Tribogenics was formed in 2011 toadvance this technology and revolution-ize the X-ray world by bringing smaller,

less expensive solutions to the market-place. Tribogenics has an exclusive licenseon the patents created at UCLA and hasdeveloped additional patents since its for-mation. As the technology develops,Tribogenics hopes to potentially offercost-effective X-ray imaging systems toemerging countries that lack reliablepower or infrastructure for fully equippedclinics. This technology has the ability totransform and reduce the cost of routinemedical care throughout the world.

Dr. Robert Nagourney, MD,

of Rational Therapeutics Inc.

Dale Fox of Tribogenics Inc.



Event scenePATRICK SOON-SHIONG INNOVATION AWARDS 2012

Attendees networking at the Patrick Soon-Shiong Innovation Awards event.

Business Journal publisher Matt Toledo and Patrick Soon-Shiong with award winners; master of ceremonies Frank Mottek; Toledo with the solid bronze Innovation Award.

Patrick Soon-Shiong and wife

Michelle B. Chan.

Hillel Cohn, left, of event sponsor Morrison & Foerster

with event attendees.

Eric Gray and Matt Calman of event sponsor Merrill Lynch Wealth

Management.


patrick soon-shiong innovation awards · anthropic contributions), dr. patrick soon-shiong is no...

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