1.Bjrn Brembs Universitt Regensburg http://brembs.net

2. operantclassical 3. PressLeverToneFoodFood 4. Eric Kandel 5. US pURaCSCS/US convergenceUR 6. Before:After:USCSURpre-synapse post-synapseAP Broadening: a pre-synaptic mechanism 7. URUS AP-BroadeningCSMolecular CS/US convergence point (coincidence detection) 8. PressLeverFood 9. Behavioral variability in a constant stimulus situation: Actions, not responses 10. Generate spontaneous actions (trying out) 11. Shape behavior by evaluating sensory feedbac 12. Action Outcome Evaluation 13. Torqueoperant self Colorsclassical worldHeat 14. Aplysia (Mollusks)Ntrutabaga cAMPDrosophila (Arthropods)Mouse (Chordates)Longterm memoryPKACREB > 530 MyaDNA CRENucleus CytoplasmModified from: "Comparative psychology: Evolution and development of behavior" (2nd Edition, Psychology Press, 2008) 15. rut-AC dependent Synaptic PlasticityProtein Kinase CTorqueColorsHeatworld rut2080 wtbHS noHS PKCi PKCiTorqueself Heat rut2080 wtb Brembs & Plendl (2008)HS noHS PKCi PKCi 16. TorqueHeat 17. Jack ByrneRomuald Nargeot 18. Generate spontaneous actions (trying out) 19. Nargeot & Simmers, 2012 20. Shape behavior by evaluating sensory feedbac 21. Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113 22. Brembs et al. (2002) 23. Brembs et al. (2002) 24. Brembs et al. (2002) 25. Brembs et al. (2002) Lorenzetti et al. (2008) 26. Nargeot & Simmers, 2012 27. Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113 28. Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113 29. AFTER BEFORENargeot & Simmers, 2012 30. Nargeot & Simmers, 2012 31. PKC involved in self-motion learning Rochefort C, Arabo A, Andr M, Poucet B, Save E, Rondi-Reig L. (2011) Science 334(6054):385-389 32. Aplysia (Mollusks)Drosophila (Arthropods)Mouse (Chordates)> 530 Mya 33. Generate spontaneous actions (trying out) 34. Shape behavior by evaluating sensory feedbac 35. FoxP2Action Outcome Evaluation 36. Torqueself ColorsHeatworldTorqueself HeatWTFoxPRNAictrl. 37. (to E.O. Wilson in 1987)The only genetic contribution providing a behavioral disposition is bringing the vocal musculature under operant control E.O. Wilson and B.F. Skinner: A Dialogue Between Sociobiology and Radical Behaviorism (Developments in Primatology: Progress and Prospects), Springer, 2009, Paul Naour 38. Nt Type II cyclasePKCHumans/mice/birds (Chordates)Drosophila (Arthropods)cAMPPKA FoxP DNA??? NucleusCytoplasm> 530 MyaAplysia (Mollusks) 39. Why have more than one learning system? 40. TrainingTestturningcomposite: turning + color 41. TrainingTest Self-Learning TestWTcomposite: turning + colorMBImpaired turningWT 16min OKOK 42. TrainingTest Self-Learning TestWTWT 16minMBImpairedOKOKturningWorld-Learning TestWTWT 16minOKImpaire Impaire d dcomposite: turning + colorcolorMB 43. TrainingTest Self-Learning TestWT 8min ImpairedWT 16minOKhabit formationturningMBOKWorld-Learning TestWT 8min composite: turning + colorOK colorWT 16minMBImpaire Impaired d 44. TrainingTest Self-Learning TestWT 8min ImpairedWTFoxP16min16minOKImpairedturningWorld-Learning TestWT 8min composite: turning + colorOK colorWT 16minMBImpaire Impaired d 45. TrainingTest Self-Learning TestWT 8min ImpairedWT 16minMB 8minOKOKturningWorld-Learning TestWT 8min composite: turning + colorOK Brembs, 2009WT 16minMB 8minImpaired Impaired MB247 or 17D driving TNTcolor 46. Brembs (2009) Curr Biol Colomb & Brembs (2010) Commun Integr Biol Brembs (2010) Proc Roy Soc Brembs (2011) Behav Proc 47. FoxP PCR: Ezequiel Mendoza and Constance Scharff (FU Berlin). FoxP mutants: Troy Zars, University of Missouri-Columbia. 48. 16 minutes training2 minutes test 49. Modified from: Lorenzetti FD, Baxter DA, Byrne JH (2008): Molecular mechanisms underlying a cellular analog of operant reward learning. Neuron 59(5):815-28.