pbio.0040369.sg005

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0 100 200 300 400 500 600 S tate 2 S tate 3 N aturalState 4 O ligo state 4 FCCP R ate ofoxygen consum ption (nm olO/m in/m g) 0 0.5 1 1.5 2 2.5 3 3.5 4 N aturalR C R O ligom ycin RC R RCR 0 20 40 60 80 100 120 140 160 180 200 120 140 160 180 200 M em bran e P o ten tial(m V) R e sp iratio n (n m olO/m in/m g) A B C

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Page 1: pbio.0040369.sg005

0

100

200

300

400

500

600

State 2 State 3 Natural State 4 Oligo state 4 FCCPRa

te o

f o

xy

ge

n c

on

su

mp

tio

n (

nm

ol

O/m

in/m

g)

0

0.5

1

1.5

2

2.5

3

3.5

4

Natural RCR Oligomycin RCR

RC

R

0

20

40

60

80

100

120

140

160

180

200

120 140 160 180 200

Membrane Potential (mV)

Respir

ati

on

(n

mol O

/m

in/m

g)

A

B

C